LOCUS       NM_004064               2411 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens cyclin dependent kinase inhibitor 1B (CDKN1B), mRNA.
ACCESSION   NM_004064
VERSION     NM_004064.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2411)
  AUTHORS   Weinberg,J., Whitcomb,E., Bohm,A., Chekkilla,U.K. and Taylor,A.
  TITLE     The E3 ligase SMURF1 stabilizes p27 via UbcH7 catalyzed K29-linked
            ubiquitin chains to promote cell migration SMURF1-UbcH7 K29
            ubiquitination of p27 and cell migration
  JOURNAL   J Biol Chem 300 (3), 105693 (2024)
   PUBMED   38301893
  REMARK    GeneRIF: The E3 ligase SMURF1 stabilizes p27 via UbcH7 catalyzed
            K29-linked ubiquitin chains to promote cell migration SMURF1-UbcH7
            K29 ubiquitination of p27 and cell migration.
REFERENCE   2  (bases 1 to 2411)
  AUTHORS   Kim,H., Jung,S.Y., Yun,H.H., Yoo,K., Lee,J.S. and Lee,J.H.
  TITLE     UBE4B regulates p27 expression in A549 NSCLC cells through
            regulating the interaction of HuR and the p27 5' UTR
  JOURNAL   Biochem Biophys Res Commun 695, 149484 (2024)
   PUBMED   38211530
  REMARK    GeneRIF: UBE4B regulates p27 expression in A549 NSCLC cells through
            regulating the interaction of HuR and the p27 5' UTR.
REFERENCE   3  (bases 1 to 2411)
  AUTHORS   Miao,K., Xie,F. and Lin,J.
  TITLE     MicroRNA-221-3p promotes post-burn HUVEC proliferation, migration,
            and angiogenesis by regulating CDKN1B
  JOURNAL   Acta Biochim Pol 70 (4), 785-790 (2023)
   PUBMED   37991262
  REMARK    GeneRIF: MicroRNA-221-3p promotes post-burn HUVEC proliferation,
            migration, and angiogenesis by regulating CDKN1B.
REFERENCE   4  (bases 1 to 2411)
  AUTHORS   Occhi,G., Regazzo,D., Trivellin,G., Boaretto,F., Ciato,D.,
            Bobisse,S., Ferasin,S., Cetani,F., Pardi,E., Korbonits,M.,
            Pellegata,N.S., Sidarovich,V., Quattrone,A., Opocher,G., Mantero,F.
            and Scaroni,C.
  TITLE     A novel mutation in the upstream open reading frame of the CDKN1B
            gene causes a MEN4 phenotype
  JOURNAL   PLoS Genet 9 (3), e1003350 (2013)
   PUBMED   23555276
  REMARK    GeneRIF: This study adds the CDKN1B gene to the short list of genes
            for which mutations that either create, delete, or severely modify
            their regulatory uORFs have been associated with human diseases
REFERENCE   5  (bases 1 to 2411)
  AUTHORS   Pellegata,N.S., Quintanilla-Martinez,L., Siggelkow,H., Samson,E.,
            Bink,K., Hofler,H., Fend,F., Graw,J. and Atkinson,M.J.
  TITLE     Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia
            syndrome in rats and humans
  JOURNAL   Proc Natl Acad Sci U S A 103 (42), 15558-15563 (2006)
   PUBMED   17030811
  REMARK    GeneRIF: Data demonstrate that germ-line mutations in p27(Kip1) can
            predispose to the development of multiple endocrine tumors in both
            rats and humans.
            Erratum:[Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19213]
REFERENCE   6  (bases 1 to 2411)
  AUTHORS   Gopfert,U., Kullmann,M. and Hengst,L.
  TITLE     Cell cycle-dependent translation of p27 involves a responsive
            element in its 5'-UTR that overlaps with a uORF
  JOURNAL   Hum Mol Genet 12 (14), 1767-1779 (2003)
   PUBMED   12837699
REFERENCE   7  (bases 1 to 2411)
  AUTHORS   Kullmann,M., Gopfert,U., Siewe,B. and Hengst,L.
  TITLE     ELAV/Hu proteins inhibit p27 translation via an IRES element in the
            p27 5'UTR
  JOURNAL   Genes Dev 16 (23), 3087-3099 (2002)
   PUBMED   12464637
REFERENCE   8  (bases 1 to 2411)
  AUTHORS   Hall,M., Bates,S. and Peters,G.
  TITLE     Evidence for different modes of action of cyclin-dependent kinase
            inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to
            cyclins
  JOURNAL   Oncogene 11 (8), 1581-1588 (1995)
   PUBMED   7478582
REFERENCE   9  (bases 1 to 2411)
  AUTHORS   Bullrich,F., MacLachlan,T.K., Sang,N., Druck,T., Veronese,M.L.,
            Allen,S.L., Chiorazzi,N., Koff,A., Heubner,K., Croce,C.M. et al.
  TITLE     Chromosomal mapping of members of the cdc2 family of protein
            kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor,
            p27Kip1, to regions involved in human cancer
  JOURNAL   Cancer Res 55 (6), 1199-1205 (1995)
   PUBMED   7882308
REFERENCE   10 (bases 1 to 2411)
  AUTHORS   Brock,P. and Kirschner,L.
  TITLE     Multiple Endocrine Neoplasia Type 4
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37733893
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008115.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_004064.4.
            
            Summary: This gene encodes a cyclin-dependent kinase inhibitor,
            which shares a limited similarity with CDK inhibitor CDKN1A/p21.
            The encoded protein binds to and prevents the activation of cyclin
            E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle
            progression at G1. The degradation of this protein, which is
            triggered by its CDK dependent phosphorylation and subsequent
            ubiquitination by SCF complexes, is required for the cellular
            transition from quiescence to the proliferative state. Mutations in
            this gene are associated with multiple endocrine neoplasia type IV
            (MEN4). [provided by RefSeq, Apr 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001971.1, AY004255.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000228872.9/ ENSP00000228872.4
            RefSeq Select criteria :: based on single protein-coding transcript
            regulatory uORF        :: PMID: 12837699
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-947               AC008115.4         147337-148283
            948-1077            AC008115.4         148794-148923
            1078-2411           AC008115.4         151005-152338
FEATURES             Location/Qualifiers
     source          1..2411
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.1"
     gene            1..2411
                     /gene="CDKN1B"
                     /gene_synonym="CDKN4; KIP1; MEN1B; MEN4; P27KIP1"
                     /note="cyclin dependent kinase inhibitor 1B"
                     /db_xref="GeneID:1027"
                     /db_xref="HGNC:HGNC:1785"
                     /db_xref="MIM:600778"
     exon            1..947
                     /gene="CDKN1B"
                     /gene_synonym="CDKN4; KIP1; MEN1B; MEN4; P27KIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             473..1069
                     /gene="CDKN1B"
                     /gene_synonym="CDKN4; KIP1; MEN1B; MEN4; P27KIP1"
                     /note="cyclin-dependent kinase inhibitor 1B (p27, Kip1)"
                     /codon_start=1
                     /product="cyclin-dependent kinase inhibitor 1B"
                     /protein_id="NP_004055.1"
                     /db_xref="CCDS:CCDS8653.1"
                     /db_xref="GeneID:1027"
                     /db_xref="HGNC:HGNC:1785"
                     /db_xref="MIM:600778"
                     /translation="MSNVRVSNGSPSLERMDARQAEHPKPSACRNLFGPVDHEELTRD
                     LEKHCRDMEEASQRKWNFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVP
                     AQESQDVSGSRPAAPLIGAPANSEDTHLVDPKTDPSDSQTGLAEQCAGIRKRPATDDS
                     STQNKRANRTEENVSDGSPNAGSVEQTPKKPGLRRRQT"
     exon            948..1077
                     /gene="CDKN1B"
                     /gene_synonym="CDKN4; KIP1; MEN1B; MEN4; P27KIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..2411
                     /gene="CDKN1B"
                     /gene_synonym="CDKN4; KIP1; MEN1B; MEN4; P27KIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2389..2394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDKN1B"
                     /gene_synonym="CDKN4; KIP1; MEN1B; MEN4; P27KIP1"
                     /note="hexamer: AATAAA"
     polyA_site      2411
                     /gene="CDKN1B"
                     /gene_synonym="CDKN4; KIP1; MEN1B; MEN4; P27KIP1"
                     /note="major polyA site"
ORIGIN      
        1 cttcttcgtc agcctccctt ccaccgccat attgggccac taaaaaaagg gggctcgtct
       61 tttcggggtg tttttctccc cctcccctgt ccccgcttgc tcacggctct gcgactccga
      121 cgccggcaag gtttggagag cggctgggtt cgcgggaccc gcgggcttgc acccgcccag
      181 actcggacgg gctttgccac cctctccgct tgcctggtcc cctctcctct ccgccctccc
      241 gctcgccagt ccatttgatc agcggagact cggcggccgg gccggggctt ccccgcagcc
      301 cctgcgcgct cctagagctc gggccgtggc tcgtcggggt ctgtgtcttt tggctccgag
      361 ggcagtcgct gggcttccga gaggggttcg ggctgcgtag gggcgctttg ttttgttcgg
      421 ttttgttttt ttgagagtgc gagagaggcg gtcgtgcaga cccgggagaa agatgtcaaa
      481 cgtgcgagtg tctaacggga gccctagcct ggagcggatg gacgccaggc aggcggagca
      541 ccccaagccc tcggcctgca ggaacctctt cggcccggtg gaccacgaag agttaacccg
      601 ggacttggag aagcactgca gagacatgga agaggcgagc cagcgcaagt ggaatttcga
      661 ttttcagaat cacaaacccc tagagggcaa gtacgagtgg caagaggtgg agaagggcag
      721 cttgcccgag ttctactaca gacccccgcg gccccccaaa ggtgcctgca aggtgccggc
      781 gcaggagagc caggatgtca gcgggagccg cccggcggcg cctttaattg gggctccggc
      841 taactctgag gacacgcatt tggtggaccc aaagactgat ccgtcggaca gccagacggg
      901 gttagcggag caatgcgcag gaataaggaa gcgacctgca accgacgatt cttctactca
      961 aaacaaaaga gccaacagaa cagaagaaaa tgtttcagac ggttccccaa atgccggttc
     1021 tgtggagcag acgcccaaga agcctggcct cagaagacgt caaacgtaaa cagctcgaat
     1081 taagaatatg tttccttgtt tatcagatac atcactgctt gatgaagcaa ggaagatata
     1141 catgaaaatt ttaaaaatac atatcgctga cttcatggaa tggacatcct gtataagcac
     1201 tgaaaaacaa caacacaata acactaaaat tttaggcact cttaaatgat ctgcctctaa
     1261 aagcgttgga tgtagcatta tgcaattagg tttttcctta tttgcttcat tgtactacct
     1321 gtgtatatag tttttacctt ttatgtagca cataaacttt ggggaaggga gggcagggtg
     1381 gggctgagga actgacgtgg agcggggtat gaagagcttg ctttgattta cagcaagtag
     1441 ataaatattt gacttgcatg aagagaagca attttgggga agggtttgaa ttgttttctt
     1501 taaagatgta atgtcccttt cagagacagc tgatacttca tttaaaaaaa tcacaaaaat
     1561 ttgaacactg gctaaagata attgctattt atttttacaa gaagtttatt ctcatttggg
     1621 agatctggtg atctcccaag ctatctaaag tttgttagat agctgcatgt ggctttttta
     1681 aaaaagcaac agaaacctat cctcactgcc ctccccagtc tctcttaaag ttggaattta
     1741 ccagttaatt actcagcaga atggtgatca ctccaggtag tttggggcaa aaatccgagg
     1801 tgcttgggag ttttgaatgt taagaattga ccatctgctt ttattaaatt tgttgacaaa
     1861 attttctcat tttcttttca cttcgggctg tgtaaacaca gtcaaaataa ttctaaatcc
     1921 ctcgatattt ttaaagatct gtaagtaact tcacattaaa aaatgaaata ttttttaatt
     1981 taaagcttac tctgtccatt tatccacagg aaagtgttat ttttcaagga aggttcatgt
     2041 agagaaaagc acacttgtag gataagtgaa atggatacta catctttaaa cagtatttca
     2101 ttgcctgtgt atggaaaaac catttgaagt gtacctgtgt acataactct gtaaaaacac
     2161 tgaaaaatta tactaactta tttatgttaa aagatttttt ttaatctaga caatatacaa
     2221 gccaaagtgg catgttttgt gcatttgtaa atgctgtgtt gggtagaata ggttttcccc
     2281 tcttttgtta aataatatgg ctatgcttaa aaggttgcat actgagccaa gtataatttt
     2341 ttgtaatgtg tgaaaaagat gccaattatt gttacacatt aagtaatcaa taaagaaaac
     2401 ttccatagct a
//
