LOCUS       NM_004196               5402 bp    mRNA    linear   PRI 17-FEB-2025
DEFINITION  Homo sapiens cyclin dependent kinase like 1 (CDKL1), transcript
            variant 1, mRNA.
ACCESSION   NM_004196 XM_017021729
VERSION     NM_004196.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5402)
  AUTHORS   Shao,S., Ju,M., Lei,J., Lu,X., Li,H., Wang,D. and Xia,C.
  TITLE     Egr-1 inhibits colon cancer cell proliferation, migration and
            invasion via regulating CDKL1 at the transcriptional level
  JOURNAL   Oncol Rep 46 (2) (2021)
   PUBMED   34165179
  REMARK    GeneRIF: Egr1 inhibits colon cancer cell proliferation, migration
            and invasion via regulating CDKL1 at the transcriptional level.
REFERENCE   2  (bases 1 to 5402)
  AUTHORS   Li,K., Meng,Z., Jiang,L., Xia,C., Xu,K., Yuan,D., Chen,H., Zhang,B.
            and Liu,S.
  TITLE     CDKL1 promotes the chemoresistance of human oral squamous cell
            carcinoma cells to hydroxycamptothecin
  JOURNAL   Mol Cell Probes 44, 57-62 (2019)
   PUBMED   30802495
  REMARK    GeneRIF: CDKL1 overexpression decreased the chemosensitivity of
            oral squamous cell carcinoma cells to hydroxycamptothecin.
REFERENCE   3  (bases 1 to 5402)
  AUTHORS   Hu,X., Li,Z., Ding,Y., Geng,Q., Xiahou,Z., Ru,H., Dong,M.Q., Xu,X.
            and Li,J.
  TITLE     Chk1 modulates the interaction between myosin phosphatase targeting
            protein 1 (MYPT1) and protein phosphatase 1cbeta (PP1cbeta)
  JOURNAL   Cell Cycle 17 (4), 421-427 (2018)
   PUBMED   29262732
  REMARK    GeneRIF: Chk1 directly interacts with MYPT1 and preferentially
            phosphorylates MYPT1 at Ser20, which is essential for
            MYPT1-PP1cbeta interaction and subsequent Plk1 dephosphorylation.
REFERENCE   4  (bases 1 to 5402)
  AUTHORS   Shaffer,J.R., Polk,D.E., Wang,X., Feingold,E., Weeks,D.E.,
            Lee,M.K., Cuenco,K.T., Weyant,R.J., Crout,R.J., McNeil,D.W. and
            Marazita,M.L.
  TITLE     Genome-wide association study of periodontal health measured by
            probing depth in adults ages 18-49 years
  JOURNAL   G3 (Bethesda) 4 (2), 307-314 (2014)
   PUBMED   24347629
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5402)
  AUTHORS   Tang,L., Gao,Y., Yan,F. and Tang,J.
  TITLE     Evaluation of cyclin-dependent kinase-like 1 expression in breast
            cancer tissues and its regulation in cancer cell growth
  JOURNAL   Cancer Biother Radiopharm 27 (6), 392-398 (2012)
   PUBMED   22804458
  REMARK    GeneRIF: CDKL1 was overexpressed in breast cancer patients and had
            a positive detection efficiency of 77% (144/186).
REFERENCE   6  (bases 1 to 5402)
  AUTHORS   Cirulli,E.T., Kasperaviciute,D., Attix,D.K., Need,A.C., Ge,D.,
            Gibson,G. and Goldstein,D.B.
  TITLE     Common genetic variation and performance on standardized cognitive
            tests
  JOURNAL   Eur J Hum Genet 18 (7), 815-820 (2010)
   PUBMED   20125193
  REMARK    Erratum:[Eur J Hum Genet. 2010 Jul;18(7):820]
REFERENCE   7  (bases 1 to 5402)
  AUTHORS   Tao,J., Van Esch,H., Hagedorn-Greiwe,M., Hoffmann,K., Moser,B.,
            Raynaud,M., Sperner,J., Fryns,J.P., Schwinger,E., Gecz,J.,
            Ropers,H.H. and Kalscheuer,V.M.
  TITLE     Mutations in the X-linked cyclin-dependent kinase-like 5
            (CDKL5/STK9) gene are associated with severe neurodevelopmental
            retardation
  JOURNAL   Am J Hum Genet 75 (6), 1149-1154 (2004)
   PUBMED   15499549
REFERENCE   8  (bases 1 to 5402)
  AUTHORS   Taglienti,C.A., Wysk,M. and Davis,R.J.
  TITLE     Molecular cloning of the epidermal growth factor-stimulated protein
            kinase p56 KKIAMRE
  JOURNAL   Oncogene 13 (12), 2563-2574 (1996)
   PUBMED   9000130
REFERENCE   9  (bases 1 to 5402)
  AUTHORS   Yen,S.H., Kenessey,A., Lee,S.C. and Dickson,D.W.
  TITLE     The distribution and biochemical properties of a Cdc2-related
            kinase, KKIALRE, in normal and Alzheimer brains
  JOURNAL   J Neurochem 65 (6), 2577-2584 (1995)
   PUBMED   7595554
REFERENCE   10 (bases 1 to 5402)
  AUTHORS   Meyerson,M., Enders,G.H., Wu,C.L., Su,L.K., Gorka,C., Nelson,C.,
            Harlow,E. and Tsai,L.H.
  TITLE     A family of human cdc2-related protein kinases
  JOURNAL   EMBO J 11 (8), 2909-2917 (1992)
   PUBMED   1639063
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359397.3.
            
            On Jun 26, 2020 this sequence version replaced NM_004196.6.
            
            Summary: This gene product is a member of a large family of
            CDC2-related serine/threonine protein kinases that accumulates
            primarily in the nucleus. [provided by RefSeq, Nov 2018].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.3949748.1,
                                           SRR7346977.1210474.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000395834.6/
                                                ENSP00000379176.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AL359397.3         146051-146108       c
            59-687              AL359397.3         144928-145556       c
            688-809             AL359397.3         108255-108376       c
            810-882             AL359397.3         94213-94285         c
            883-973             AL359397.3         91359-91449         c
            974-1174            AL359397.3         90259-90459         c
            1175-1257           AL359397.3         88174-88256         c
            1258-1314           AL359397.3         83792-83848         c
            1315-1485           AL359397.3         81489-81659         c
            1486-5402           AL359397.3         75492-79408         c
FEATURES             Location/Qualifiers
     source          1..5402
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.3"
     gene            1..5402
                     /gene="CDKL1"
                     /gene_synonym="KKIALRE; P42"
                     /note="cyclin dependent kinase like 1"
                     /db_xref="GeneID:8814"
                     /db_xref="HGNC:HGNC:1781"
                     /db_xref="MIM:603441"
     exon            1..58
                     /gene="CDKL1"
                     /gene_synonym="KKIALRE; P42"
                     /inference="alignment:Splign:2.1.0"
     exon            59..687
                     /gene="CDKL1"
                     /gene_synonym="KKIALRE; P42"
                     /inference="alignment:Splign:2.1.0"
     CDS             520..1593
                     /gene="CDKL1"
                     /gene_synonym="KKIALRE; P42"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine protein kinase KKIALRE; protein kinase
                     p42 KKIALRE; cyclin-dependent kinase-like 1 (CDC2-related
                     kinase)"
                     /codon_start=1
                     /product="cyclin-dependent kinase-like 1 isoform 1"
                     /protein_id="NP_004187.3"
                     /db_xref="CCDS:CCDS9699.2"
                     /db_xref="GeneID:8814"
                     /db_xref="HGNC:HGNC:1781"
                     /db_xref="MIM:603441"
                     /translation="MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVI
                     KKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHL
                     VKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYTD
                     YVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTL
                     GDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTQRL
                     TCEQLLHHPYFENIREIEDLAKEHNKPTRKTLRKSRKHHCFTETSKLQYLPQLTGSSI
                     LPALDNKKYYCDTKKLNYRFPNI"
     exon            688..809
                     /gene="CDKL1"
                     /gene_synonym="KKIALRE; P42"
                     /inference="alignment:Splign:2.1.0"
     exon            810..882
                     /gene="CDKL1"
                     /gene_synonym="KKIALRE; P42"
                     /inference="alignment:Splign:2.1.0"
     exon            883..973
                     /gene="CDKL1"
                     /gene_synonym="KKIALRE; P42"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1174
                     /gene="CDKL1"
                     /gene_synonym="KKIALRE; P42"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1257
                     /gene="CDKL1"
                     /gene_synonym="KKIALRE; P42"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1314
                     /gene="CDKL1"
                     /gene_synonym="KKIALRE; P42"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1485
                     /gene="CDKL1"
                     /gene_synonym="KKIALRE; P42"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..5402
                     /gene="CDKL1"
                     /gene_synonym="KKIALRE; P42"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2076
                     /gene="CDKL1"
                     /gene_synonym="KKIALRE; P42"
                     /note="major polyA site"
     regulatory      5301..5306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDKL1"
                     /gene_synonym="KKIALRE; P42"
                     /note="hexamer: AATAAA"
     polyA_site      5326
                     /gene="CDKL1"
                     /gene_synonym="KKIALRE; P42"
                     /note="major polyA site"
     regulatory      5385..5390
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDKL1"
                     /gene_synonym="KKIALRE; P42"
                     /note="hexamer: AATATA"
     polyA_site      5402
                     /gene="CDKL1"
                     /gene_synonym="KKIALRE; P42"
ORIGIN      
        1 gagctgggcg gaagaaggcg aggcgggagc caggcccgtc cctgaccgcc gcggcgccga
       61 ccgtgacaaa cactcatcgt tgggtggggc tctagtgcag tccgttggtg ccaatatttt
      121 ataagcgacg ttttcaaact atgtgaagat cctttctttt cttttctttc tttctttttt
      181 tttttttttt tttttttttt ttgagacgga atctcgctct gtcgcccggg ctggagtgca
      241 gtggcgcgat ctcggctcac tgcaacctgc gcctcccagg ttcacgcgat tctcctgcct
      301 cagtctcctg agttgctggg actacgggcg cccatcacca cacccggcta attttttgta
      361 tctttagtag agacggagtt tcagtatgtt ggccagactg gtctcgaact cctgacctca
      421 ggtgatctgc ccgcctcagc ctcccaaagt gctgggatta caggcgtgag ccaccattct
      481 cggctgaaga tccattttaa gaagatttat tcctctatga tggagaagta tgaaaaaatt
      541 gggaaaattg gagaaggatc ctatggagtt gttttcaaat gtagaaacag ggacacgggt
      601 cagattgtgg ccatcaagaa gtttctggaa tcagaagatg accctgtcat aaagaaaatt
      661 gcccttcggg aaatccgaat gctcaagcaa ctcaagcatc ccaaccttgt taacctcctg
      721 gaagtcttca ggaggaaacg gaggcttcac ctggtgtttg aatattgtga ccacacagtt
      781 ctccatgagt tggacagata ccaaagaggg gtaccagaac atctcgtgaa gagcataact
      841 tggcagacac tgcaagctgt aaatttttgc cataaacaca attgcataca tagagacgtg
      901 aagccagaaa atatcctcat cacgaaacat tccgtgatta agctttgtga ctttggattt
      961 gctcggcttt tgactggacc gagtgactac tatacagact acgtggctac caggtggtac
     1021 cgctcccctg agctgctggt gggggacacg cagtacggcc ccccggtgga tgtttgggca
     1081 attggctgtg tctttgctga gctgctgtca ggagtgcctc tgtggccagg aaaatcggat
     1141 gtggatcagc tgtatctgat taggaagacc ttgggggatc tcattcctag gcaccagcaa
     1201 gtgtttagca cgaatcagta cttcagtgga gtgaaaattc cagaccctga agatatggaa
     1261 ccacttgaat taaaattccc aaacatctct tatcctgccc tggggctcct aaagggctgt
     1321 ctccacatgg accctactca aaggctgaca tgtgaacagc tgttgcatca cccatatttt
     1381 gaaaacatca gagaaataga ggatttggca aaagaacaca acaaaccaac aaggaagacc
     1441 ctaagaaaga gccgaaagca ccactgcttt acagaaacat ccaagttgca gtacctaccc
     1501 cagctaactg gcagcagcat ccttccagct ttggataata agaagtacta ctgtgatacc
     1561 aagaaactta actaccgttt tccaaacatt taaaggagct aggagacatg attttaaaaa
     1621 aggaatcaat agatgctttg aagaaaataa aacttataca gttgattgaa aacaattaca
     1681 atgttgaaaa cacaccagga gaaaacataa gcaagaaact gggaggccaa ctggcaagat
     1741 atgaagggaa attccagatc cagtcttcca tgcttgatga tggtgtccag aaaagaaaaa
     1801 acctgtttgg agttgcactt gtatttcagt ttatgtaagt agccgaactt atggacagaa
     1861 tatgaactgt cccatacctc tggcaaaact agatgatatc aaaaagattt atgcttcagt
     1921 tgtaccacat gccacacaag aaaaatgaac cacaaaatgc ccatatatat ttcctcggat
     1981 ctctgttgcc tgagtcctat ctcctgcctc tcagattgtt tcagcatcat atttaagata
     2041 gttctatttc ttgaaatcaa aatgtttaaa atcccatttc ctgcttgctc tatttcttga
     2101 tttttatatt ttaaaacatt ttgagggtaa cacttaggtt caaaatattt aaaagcatat
     2161 gaattatcac aaaagcttgg taatttataa tttaattata tgtttccaca tttcatcctt
     2221 actttatcag taaaggatac accttagtca cttttgcagg caacgtggat ttactgtaat
     2281 ctgtctacat ttattcaccc aattcccctt gtaaacaatg gcatgaagct cggcagctga
     2341 ttaaggcagt caaagggtag agcaagacct acaggctttg caggaactga acctatcagc
     2401 ctgaaaataa ttagtatttc attctctctg gcacagcctt tgacctggta catctatagg
     2461 caaacctgta attcagtgat ctgggtttca gaagaaatta cttgtgagct tttacttgag
     2521 tcatgaaaga cattatgttg taaactgatg ttttccctga aacatctttt tgcactatgt
     2581 ttgtatgtgt atgtatgtgt atgtatatat atatatatat atatatatat gctattctaa
     2641 caactaatat attacactaa gtagtccaaa gtattgagga ctcatagctt tgcacagtga
     2701 gacttaaaat gatgacacac acacacatat atatatatgt gttttttata tatatatata
     2761 aaacctgcca cctcagcctc ccaagtagct gggactgcag gcatgtgcca ctatactggc
     2821 taattttttt gtattttttg gtagaggcag ggttttgcca tgttccccag gctggtcttg
     2881 aactcctggg ctcacgtgat ctgagcgcct tggccttcca aagtgctggc attacaggca
     2941 tgagccactg cgcctggcca aaatgacata attagctttg atttggtcta ctgctcttaa
     3001 tcaaaaagct ttttcatcct tgtcccctgg acacaagggc aatatgaagc ctgacgtctg
     3061 tttcttacag ctcaacacca tttctggttg atgtgctgcc actattccta gcacttctca
     3121 gccatggtct tcaaagttgt atttcactct attttcaaaa catttcttct gtactctcat
     3181 tttcttcctg ttaattttct tcatgatgac atctgacccc atttacttaa gtaatccact
     3241 gaggtctggt gtctactcaa taattttgac taccctaggc agtttaatga tatcctaagg
     3301 cttcctaatg tatgtctttt cttgcctaga cctgatatgg gttaaatgct agtccctgaa
     3361 ttattcaatt cctgttagac ggccttgatt caaatgacaa ggaagaacat ccagcttccg
     3421 tgaatagtta aaaaaaaatt tttttttcct taacccaaga aaatacactt gacggaggca
     3481 gattactata acagcctaat aattcagcca atagttttac caaaaactat tcagaataga
     3541 aaagtagctc tagactaaat cgtggtgaat cagttgtctc accatacagt aatgaaacaa
     3601 acctgagaaa aaaggcttat ttttttctaa tgagttccgt taaatttatg cttatgttca
     3661 atttaaccat atttataatg cttttattcg gtatgaaatc tccactgtat cacatgagac
     3721 tcttccacat ccttttattt actattttct gatttttaaa atgacagtgg caattaccat
     3781 ttatactgtg ttatttgtat aagctgttaa acacaacatt gttaaacaca acgaaaattc
     3841 atttttctac ctgaaagctg tatcatagaa aattattttc aagtttatat tcaacagctt
     3901 aataatgttc aaaccaggct gggcgcggtg gctcccagca ctttgggagg ccgaggcggg
     3961 tggatcctga ggttaggagt tcaagaccag tctggccaag atggtgaaac cctgtctcta
     4021 ctaaaagtac aaaaattagc tgggcgtggt ggtgggcgcc tgtaatccca gctacctggg
     4081 acgctgcgac agagaactgc ttgaacccgg gaggcagagg ttgcagtgaa ctgagatcac
     4141 accactgcac tccaacctgg gcaacagagt gagagtctgt ctcaaaaaaa aaaaaaaaaa
     4201 aaaaaaagtt caaatcaaac acacagaaat ctataaacaa actggcatat aagagtaata
     4261 gaatcagggc catttctcac aggtaacaat gaagacctgt tttatctatt tttcactttt
     4321 tttttttttt ttgagacagg gtcttaatct gttgcccagg ctggagtgca gtggtgccaa
     4381 catggctcac tgcagcctcg acttcccggg ctcaactgat cctcctacct cagactcctg
     4441 agtagttggg actacaggca tgtgccacta cacccagcta ttttttattt tttaattttt
     4501 tggtagagac agggttttgc catgttgccc aggctcgtcc tgaactcctg ggctcaaatg
     4561 atctgcctgc cttggccttc aaaagtgctg ggattacagg ccagcccttt tttttaagag
     4621 acagggtctc cccctttcac ccaggctacc aggctggtgt gcagtggccg tgatcatagc
     4681 ttactgcagc ctcaaactcc tgagctcaag caatcctacc acctcaacct cccaagtatc
     4741 tgagattaca ggtatgcacc accatgcctg cctaattttt aaaatttttt tagagatggg
     4801 gtctcactgt gttgcccaaa ttggtctcaa actcctggtc tcaagtgatc ctcccacctc
     4861 agcctcccaa agcactggga ttacaggcac gagccacggc acccagccta aagcaatgtt
     4921 aggtttcaag aaaaacctaa gcatagccca ctagttttta ctgtttcctt tattatattg
     4981 caatctgcaa aactatttgt attcagccaa gtatctatgt ccagttttaa taaaatagta
     5041 gcctaagctt acaaaataga caaattaagc agcaactgtt gattctgagt aagtctgtat
     5101 gctatcaaga acacaagaat gcaggatcat gggaaatgca cgcaaatcct gttgaagcaa
     5161 tgcatgcttc aacaaccact gaccactttg cataattgac tccatcaatg aatctgtaat
     5221 ttagcttcta atttttcata attgtgcatt tatggtagta tgcttcacta actttaaagt
     5281 taaatgtaaa ttactgttat aataaaaaca tctgttgtac aaataacttt aaaggattct
     5341 aaatatctac atcaagagat atctatagat ttacatatta aatgaatata ttagaattaa
     5401 aa
//
