LOCUS       NM_001261               2483 bp    mRNA    linear   PRI 27-MAR-2025
DEFINITION  Homo sapiens cyclin dependent kinase 9 (CDK9), mRNA.
ACCESSION   NM_001261
VERSION     NM_001261.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2483)
  AUTHORS   Chen,W., Chu,J., Miao,Y., Jiang,W., Wang,F., Zhang,N., Jin,J. and
            Cai,Y.
  TITLE     MOF-mediated acetylation of CDK9 promotes global transcription by
            modulating P-TEFb complex formation
  JOURNAL   FEBS J 291 (21), 4796-4812 (2024)
   PUBMED   39250546
REFERENCE   2  (bases 1 to 2483)
  AUTHORS   Kwon,N., Lu,Y.C., Thompson,E.N., Mancuso,R.I., Wang,L., Zhang,P.X.
            and Krause,D.S.
  TITLE     CDK9 phosphorylates RUNX1 to promote megakaryocytic fate in
            megakaryocytic-erythroid progenitors
  JOURNAL   Blood 144 (17), 1800-1812 (2024)
   PUBMED   39102635
  REMARK    GeneRIF: CDK9 phosphorylates RUNX1 to promote megakaryocytic fate
            in megakaryocytic-erythroid progenitors.
REFERENCE   3  (bases 1 to 2483)
  AUTHORS   Walker,R.L., Hornicek,F.J. and Duan,Z.
  TITLE     Transcriptional regulation and therapeutic potential of
            cyclin-dependent kinase 9 (CDK9) in sarcoma
  JOURNAL   Biochem Pharmacol 226, 116342 (2024)
   PUBMED   38848777
  REMARK    GeneRIF: Transcriptional regulation and therapeutic potential of
            cyclin-dependent kinase 9 (CDK9) in sarcoma.
            Review article
REFERENCE   4  (bases 1 to 2483)
  AUTHORS   Eaton,J.D., Board,J., Davidson,L., Estell,C. and West,S.
  TITLE     Human promoter directionality is determined by transcriptional
            initiation and the opposing activities of INTS11 and CDK9
  JOURNAL   Elife 13, 92764 (2024)
   PUBMED   38976490
  REMARK    GeneRIF: Human promoter directionality is determined by
            transcriptional initiation and the opposing activities of INTS11
            and CDK9.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2483)
  AUTHORS   Yalala,S., Gondane,A., Poulose,N., Liang,J., Mills,I.G. and
            Itkonen,H.M.
  TITLE     CDK9 inhibition activates innate immune response through viral
            mimicry
  JOURNAL   FASEB J 38 (8), e23628 (2024)
   PUBMED   38661032
  REMARK    GeneRIF: CDK9 inhibition activates innate immune response through
            viral mimicry.
REFERENCE   6  (bases 1 to 2483)
  AUTHORS   Zhou,Q. and Sharp,P.A.
  TITLE     Tat-SF1: cofactor for stimulation of transcriptional elongation by
            HIV-1 Tat
  JOURNAL   Science 274 (5287), 605-610 (1996)
   PUBMED   8849451
REFERENCE   7  (bases 1 to 2483)
  AUTHORS   Yang,X., Herrmann,C.H. and Rice,A.P.
  TITLE     The human immunodeficiency virus Tat proteins specifically
            associate with TAK in vivo and require the carboxyl-terminal domain
            of RNA polymerase II for function
  JOURNAL   J Virol 70 (7), 4576-4584 (1996)
   PUBMED   8676484
REFERENCE   8  (bases 1 to 2483)
  AUTHORS   Best,J.L., Presky,D.H., Swerlick,R.A., Burns,D.K. and Chu,W.
  TITLE     Cloning of a full-length cDNA sequence encoding a cdc2-related
            protein kinase from human endothelial cells
  JOURNAL   Biochem Biophys Res Commun 208 (2), 562-568 (1995)
   PUBMED   7695608
REFERENCE   9  (bases 1 to 2483)
  AUTHORS   Herrmann,C.H. and Rice,A.P.
  TITLE     Lentivirus Tat proteins specifically associate with a cellular
            protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal
            domain of the large subunit of RNA polymerase II: candidate for a
            Tat cofactor
  JOURNAL   J Virol 69 (3), 1612-1620 (1995)
   PUBMED   7853496
REFERENCE   10 (bases 1 to 2483)
  AUTHORS   Grana,X., De Luca,A., Sang,N., Fu,Y., Claudio,P.P., Rosenblatt,J.,
            Morgan,D.O. and Giordano,A.
  TITLE     PITALRE, a nuclear CDC2-related protein kinase that phosphorylates
            the retinoblastoma protein in vitro
  JOURNAL   Proc Natl Acad Sci U S A 91 (9), 3834-3838 (1994)
   PUBMED   8170997
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB120461.1, BC001968.1,
            BX091973.1, BE549667.1 and AL162586.26.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001261.3.
            
            Summary: The protein encoded by this gene is a member of the
            cyclin-dependent protein kinase (CDK) family. CDK family members
            are highly similar to the gene products of S. cerevisiae cdc28, and
            S. pombe cdc2, and known as important cell cycle regulators. This
            kinase was found to be a component of the multiprotein complex
            TAK/P-TEFb, which is an elongation factor for RNA polymerase
            II-directed transcription and functions by phosphorylating the
            C-terminal domain of the largest subunit of RNA polymerase II. This
            protein forms a complex with and is regulated by its regulatory
            subunit cyclin T or cyclin K. HIV-1 Tat protein was found to
            interact with this protein and cyclin T, which suggested a possible
            involvement of this protein in AIDS. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.80290.1,
                                           SRR1803615.115236.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373264.5/ ENSP00000362361.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               DB120461.1         9-215
            208-1775            BC001968.1         153-1720
            1776-2320           BX091973.1         119-663             c
            2321-2464           BE549667.1         1-144               c
            2465-2483           AL162586.26        42749-42767
FEATURES             Location/Qualifiers
     source          1..2483
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..2483
                     /gene="CDK9"
                     /gene_synonym="C-2k; CDC2L4; CTK1; PITALRE; TAK"
                     /note="cyclin dependent kinase 9"
                     /db_xref="GeneID:1025"
                     /db_xref="HGNC:HGNC:1780"
                     /db_xref="MIM:603251"
     exon            1..207
                     /gene="CDK9"
                     /gene_synonym="C-2k; CDC2L4; CTK1; PITALRE; TAK"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1234
                     /gene="CDK9"
                     /gene_synonym="C-2k; CDC2L4; CTK1; PITALRE; TAK"
                     /EC_number="2.7.11.23"
                     /EC_number="2.7.11.22"
                     /note="serine/threonine protein kinase PITALRE; cell
                     division protein kinase 9; CDC2-related kinase; cell
                     division cycle 2-like protein kinase 4; tat-associated
                     kinase complex catalytic subunit"
                     /codon_start=1
                     /product="cyclin-dependent kinase 9"
                     /protein_id="NP_001252.1"
                     /db_xref="CCDS:CCDS6879.1"
                     /db_xref="GeneID:1025"
                     /db_xref="HGNC:HGNC:1780"
                     /db_xref="MIM:603251"
                     /translation="MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQK
                     VALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLV
                     FDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRD
                     GVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCI
                     MAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVK
                     DRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTS
                     MFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF"
     exon            208..289
                     /gene="CDK9"
                     /gene_synonym="C-2k; CDC2L4; CTK1; PITALRE; TAK"
                     /inference="alignment:Splign:2.1.0"
     exon            290..380
                     /gene="CDK9"
                     /gene_synonym="C-2k; CDC2L4; CTK1; PITALRE; TAK"
                     /inference="alignment:Splign:2.1.0"
     exon            381..547
                     /gene="CDK9"
                     /gene_synonym="C-2k; CDC2L4; CTK1; PITALRE; TAK"
                     /inference="alignment:Splign:2.1.0"
     exon            548..719
                     /gene="CDK9"
                     /gene_synonym="C-2k; CDC2L4; CTK1; PITALRE; TAK"
                     /inference="alignment:Splign:2.1.0"
     exon            720..868
                     /gene="CDK9"
                     /gene_synonym="C-2k; CDC2L4; CTK1; PITALRE; TAK"
                     /inference="alignment:Splign:2.1.0"
     exon            869..2483
                     /gene="CDK9"
                     /gene_synonym="C-2k; CDC2L4; CTK1; PITALRE; TAK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1749..1754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK9"
                     /gene_synonym="C-2k; CDC2L4; CTK1; PITALRE; TAK"
                     /note="hexamer: ATTAAA"
     polyA_site      1778
                     /gene="CDK9"
                     /gene_synonym="C-2k; CDC2L4; CTK1; PITALRE; TAK"
                     /note="major polyA site"
ORIGIN      
        1 gtggaggcgg aagtggcgcg gccgcggagg ggcctggagt gcggcggcgg cgggacccgg
       61 agcaggagcg gcggcagcag cgactggggg cggcggcggc gcgttggagg cggccatggc
      121 aaagcagtac gactcggtgg agtgcccttt ttgtgatgaa gtttccaaat acgagaagct
      181 cgccaagatc ggccaaggca ccttcgggga ggtgttcaag gccaggcacc gcaagaccgg
      241 ccagaaggtg gctctgaaga aggtgctgat ggaaaacgag aaggaggggt tccccattac
      301 agccttgcgg gagatcaaga tccttcagct tctaaaacac gagaatgtgg tcaacttgat
      361 tgagatttgt cgaaccaaag cttcccccta taaccgctgc aagggtagta tatacctggt
      421 gttcgacttc tgcgagcatg accttgctgg gctgttgagc aatgttttgg tcaagttcac
      481 gctgtctgag atcaagaggg tgatgcagat gctgcttaac ggcctctact acatccacag
      541 aaacaagatc ctgcataggg acatgaaggc tgctaatgtg cttatcactc gtgatggggt
      601 cctgaagctg gcagactttg ggctggcccg ggccttcagc ctggccaaga acagccagcc
      661 caaccgctac accaaccgtg tggtgacact ctggtaccgg cccccggagc tgttgctcgg
      721 ggagcgggac tacggccccc ccattgacct gtggggtgct gggtgcatca tggcagagat
      781 gtggacccgc agccccatca tgcagggcaa cacggagcag caccaactcg ccctcatcag
      841 tcagctctgc ggctccatca cccctgaggt gtggccaaac gtggacaact atgagctgta
      901 cgaaaagctg gagctggtca agggccagaa gcggaaggtg aaggacaggc tgaaggccta
      961 tgtgcgtgac ccatacgcac tggacctcat cgacaagctg ctggtgctgg accctgccca
     1021 gcgcatcgac agcgatgacg ccctcaacca cgacttcttc tggtccgacc ccatgccctc
     1081 cgacctcaag ggcatgctct ccacccacct gacgtccatg ttcgagtact tggcaccacc
     1141 gcgccggaag ggcagccaga tcacccagca gtccaccaac cagagtcgca atcccgccac
     1201 caccaaccag acggagtttg agcgcgtctt ctgagggccg gcgcttgcca ctagggctct
     1261 tgtgtttttt ttcttctgct atgtgacttg catcgtggag acagggcatt tgagtttata
     1321 tctctcatgc atattttatt taatccccac cctgggctct gggagcagcc cgctgagtgg
     1381 actggagtgg agcattggct gagagaccag gagggcactg gagctgtctt gtccttgctg
     1441 gttttctgga tggttcccag agggtttcca tggggtagga ggatgggctc gcccaccagt
     1501 gactttttct aagagctccc ggcgtggtgg aagaggggac aggtccctca cccacccaca
     1561 atcctattct cgggctgaga accctgcgtg gggacagggc tcgcctcagg aatgggctgt
     1621 ttttggccta accctcagaa acactggggc tggcacaaac tcttggtttc ttcaacagga
     1681 gaattttact gtgtttcttt tggttccatt gtttggagac attcctgggc acagtttggt
     1741 ccgttagaat taaaagttga attttttttt tttttaaatt tttttttttc ctccaggact
     1801 tgtgtgtttt gttctgcgca cacaccgcca actgttcccc cacagtcagc agcaggttgg
     1861 gcctgaccat tgggacttga ttgtcaagtc actggaggtc ttgacttttt tatctcagtt
     1921 catgttctct tccataattg gaaaggacct ttgtctgttt ttcctcttgg gtgccttcca
     1981 gaacgcatct catgtccctg gtgagggaat tggtgagggc ctgctgtgag ctgctgtggc
     2041 tgcgatggtc acccagctgg gcaaatcact ggagtgacaa tttgacctgt cacctgagaa
     2101 ggatggtccc tcagactgct gggtagaggg cctggggcag gctggagaga gaaagtgggc
     2161 agagggtgaa gggatcacag gggtcttgga aggtggcagt agtttggacg ggggtgggga
     2221 gtatgtggga gaaaaaaaca gactgaaggt agaatccttg ggaacctttg aggagcggca
     2281 cattctggca ggcacgtttt ctgtgagcct gaagttagga agagacattc tggaggtcaa
     2341 tttcctacat cctcttacag gcggagacct tgaagtgggg ccaggaagga aggttggcaa
     2401 aacctttgac cagaactgtc cttcatttac agaaactgac ccagaccaca acacaaaagg
     2461 ccagtaaaag taagaaaaaa aaa
//
