LOCUS       NM_001799               1426 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens cyclin dependent kinase 7 (CDK7), transcript variant
            1, mRNA.
ACCESSION   NM_001799
VERSION     NM_001799.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1426)
  AUTHORS   Shirasawa,M., Nakajima,R., Zhou,Y., Zhao,L., Fikriyanti,M.,
            Iwanaga,R., Bradford,A.P., Kurayoshi,K., Araki,K. and Ohtani,K.
  TITLE     Activation of the CDK7 Gene, Coding for the Catalytic Subunit of
            the Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) and
            General Transcription Factor II H, by the Trans-Activator Protein
            Tax of Human T-Cell Leukemia Virus Type-1
  JOURNAL   Genes (Basel) 15 (8), 1080 (2024)
   PUBMED   39202439
  REMARK    GeneRIF: Activation of the CDK7 Gene, Coding for the Catalytic
            Subunit of the Cyclin-Dependent Kinase (CDK)-Activating Kinase
            (CAK) and General Transcription Factor II H, by the Trans-Activator
            Protein Tax of Human T-Cell Leukemia Virus Type-1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1426)
  AUTHORS   Duster,R., Anand,K., Binder,S.C., Schmitz,M., Gatterdam,K.,
            Fisher,R.P. and Geyer,M.
  TITLE     Structural basis of Cdk7 activation by dual T-loop phosphorylation
  JOURNAL   Nat Commun 15 (1), 6597 (2024)
   PUBMED   39097586
  REMARK    GeneRIF: Structural basis of Cdk7 activation by dual T-loop
            phosphorylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1426)
  AUTHORS   Velychko,T., Mohammad,E., Ferrer-Vicens,I., Parfentev,I.,
            Werner,M., Studniarek,C., Schwalb,B., Urlaub,H., Murphy,S.,
            Cramer,P. and Lidschreiber,M.
  TITLE     CDK7 kinase activity promotes RNA polymerase II promoter escape by
            facilitating initiation factor release
  JOURNAL   Mol Cell 84 (12), 2287-2303 (2024)
   PUBMED   38821049
  REMARK    GeneRIF: CDK7 kinase activity promotes RNA polymerase II promoter
            escape by facilitating initiation factor release.
REFERENCE   4  (bases 1 to 1426)
  AUTHORS   Gong,Y. and Li,H.
  TITLE     CDK7 in breast cancer: mechanisms of action and therapeutic
            potential
  JOURNAL   Cell Commun Signal 22 (1), 226 (2024)
   PUBMED   38605321
  REMARK    GeneRIF: CDK7 in breast cancer: mechanisms of action and
            therapeutic potential.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1426)
  AUTHORS   Schutz,M., Wangen,C., Sommerer,M., Kogler,M., Eickhoff,J.,
            Degenhart,C., Klebl,B., Naing,Z., Egilmezer,E., Hamilton,S.T.,
            Rawlinson,W.D., Sticht,H. and Marschall,M.
  TITLE     Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97
            undergoes regulatory interaction with human cyclin H and CDK7 to
            codetermine viral replication efficiency
  JOURNAL   Virus Res 335, 199200 (2023)
   PUBMED   37591314
  REMARK    GeneRIF: Cytomegalovirus cyclin-dependent kinase ortholog
            vCDK/pUL97 undergoes regulatory interaction with human cyclin H and
            CDK7 to codetermine viral replication efficiency.
REFERENCE   6  (bases 1 to 1426)
  AUTHORS   Aprelikova,O., Xiong,Y. and Liu,E.T.
  TITLE     Both p16 and p21 families of cyclin-dependent kinase (CDK)
            inhibitors block the phosphorylation of cyclin-dependent kinases by
            the CDK-activating kinase
  JOURNAL   J Biol Chem 270 (31), 18195-18197 (1995)
   PUBMED   7629134
REFERENCE   7  (bases 1 to 1426)
  AUTHORS   Shiekhattar,R., Mermelstein,F., Fisher,R.P., Drapkin,R.,
            Dynlacht,B., Wessling,H.C., Morgan,D.O. and Reinberg,D.
  TITLE     Cdk-activating kinase complex is a component of human transcription
            factor TFIIH
  JOURNAL   Nature 374 (6519), 283-287 (1995)
   PUBMED   7533895
REFERENCE   8  (bases 1 to 1426)
  AUTHORS   Desai,D., Wessling,H.C., Fisher,R.P. and Morgan,D.O.
  TITLE     Effects of phosphorylation by CAK on cyclin binding by CDC2 and
            CDK2
  JOURNAL   Mol Cell Biol 15 (1), 345-350 (1995)
   PUBMED   7799941
REFERENCE   9  (bases 1 to 1426)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J Biol Chem 266 (33), 22537-22544 (1991)
   PUBMED   1939271
REFERENCE   10 (bases 1 to 1426)
  AUTHORS   Conaway,R.C. and Conaway,J.W.
  TITLE     ATP activates transcription initiation from promoters by RNA
            polymerase II in a reversible step prior to RNA synthesis
  JOURNAL   J Biol Chem 263 (6), 2962-2968 (1988)
   PUBMED   2449431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI520184.1, BC005298.1, BC000834.2 and CA437275.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001799.3.
            
            Summary: The protein encoded by this gene is a member of the
            cyclin-dependent protein kinase (CDK) family. CDK family members
            are highly similar to the gene products of Saccharomyces cerevisiae
            cdc28, and Schizosaccharomyces pombe cdc2, and are known to be
            important regulators of cell cycle progression. This protein forms
            a trimeric complex with cyclin H and MAT1, which functions as a
            Cdk-activating kinase (CAK). It is an essential component of the
            transcription factor TFIIH, that is involved in transcription
            initiation and DNA repair. This protein is thought to serve as a
            direct link between the regulation of transcription and the cell
            cycle. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.83086.1,
                                           SRR5189667.197822.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256443.8/ ENSP00000256443.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BI520184.1         92-93
            3-478               BC005298.1         1-476
            479-1301            BC000834.2         409-1231
            1302-1426           CA437275.1         18-142              c
FEATURES             Location/Qualifiers
     source          1..1426
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..1426
                     /gene="CDK7"
                     /gene_synonym="CAK; CAK1; CDKN7; HCAK; MO15; p39MO15;
                     STK1"
                     /note="cyclin dependent kinase 7"
                     /db_xref="GeneID:1022"
                     /db_xref="HGNC:HGNC:1778"
                     /db_xref="MIM:601955"
     exon            1..156
                     /gene="CDK7"
                     /gene_synonym="CAK; CAK1; CDKN7; HCAK; MO15; p39MO15;
                     STK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1131
                     /gene="CDK7"
                     /gene_synonym="CAK; CAK1; CDKN7; HCAK; MO15; p39MO15;
                     STK1"
                     /EC_number="2.7.11.23"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis,
                     cdk-activating kinase); serine/threonine kinase stk1;
                     serine/threonine protein kinase 1; serine/threonine
                     protein kinase MO15; homolog of Xenopus MO15
                     Cdk-activating kinase; kinase subunit of CAK; 39 KDa
                     protein kinase; cell division protein kinase 7; TFIIH
                     basal transcription factor complex kinase subunit;
                     CDK-activating kinase 1"
                     /codon_start=1
                     /product="cyclin-dependent kinase 7 isoform 1"
                     /protein_id="NP_001790.1"
                     /db_xref="CCDS:CCDS3999.1"
                     /db_xref="GeneID:1022"
                     /db_xref="HGNC:HGNC:1778"
                     /db_xref="MIM:601955"
                     /translation="MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIK
                     LGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVII
                     KDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAK
                     SFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSD
                     LDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLF
                     LFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEA
                     LEQGGLPKKLIF"
     exon            157..216
                     /gene="CDK7"
                     /gene_synonym="CAK; CAK1; CDKN7; HCAK; MO15; p39MO15;
                     STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            217..250
                     /gene="CDK7"
                     /gene_synonym="CAK; CAK1; CDKN7; HCAK; MO15; p39MO15;
                     STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            251..318
                     /gene="CDK7"
                     /gene_synonym="CAK; CAK1; CDKN7; HCAK; MO15; p39MO15;
                     STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            319..387
                     /gene="CDK7"
                     /gene_synonym="CAK; CAK1; CDKN7; HCAK; MO15; p39MO15;
                     STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            388..498
                     /gene="CDK7"
                     /gene_synonym="CAK; CAK1; CDKN7; HCAK; MO15; p39MO15;
                     STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..617
                     /gene="CDK7"
                     /gene_synonym="CAK; CAK1; CDKN7; HCAK; MO15; p39MO15;
                     STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            618..717
                     /gene="CDK7"
                     /gene_synonym="CAK; CAK1; CDKN7; HCAK; MO15; p39MO15;
                     STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..804
                     /gene="CDK7"
                     /gene_synonym="CAK; CAK1; CDKN7; HCAK; MO15; p39MO15;
                     STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..954
                     /gene="CDK7"
                     /gene_synonym="CAK; CAK1; CDKN7; HCAK; MO15; p39MO15;
                     STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1102
                     /gene="CDK7"
                     /gene_synonym="CAK; CAK1; CDKN7; HCAK; MO15; p39MO15;
                     STK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1426
                     /gene="CDK7"
                     /gene_synonym="CAK; CAK1; CDKN7; HCAK; MO15; p39MO15;
                     STK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1278..1283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK7"
                     /gene_synonym="CAK; CAK1; CDKN7; HCAK; MO15; p39MO15;
                     STK1"
                     /note="hexamer: ATTAAA"
     regulatory      1294..1299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK7"
                     /gene_synonym="CAK; CAK1; CDKN7; HCAK; MO15; p39MO15;
                     STK1"
                     /note="hexamer: AATAAA"
     polyA_site      1301
                     /gene="CDK7"
                     /gene_synonym="CAK; CAK1; CDKN7; HCAK; MO15; p39MO15;
                     STK1"
                     /note="major polyA site"
     polyA_site      1334
                     /gene="CDK7"
                     /gene_synonym="CAK; CAK1; CDKN7; HCAK; MO15; p39MO15;
                     STK1"
     regulatory      1392..1397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK7"
                     /gene_synonym="CAK; CAK1; CDKN7; HCAK; MO15; p39MO15;
                     STK1"
                     /note="hexamer: AATAAA"
     polyA_site      1426
                     /gene="CDK7"
                     /gene_synonym="CAK; CAK1; CDKN7; HCAK; MO15; p39MO15;
                     STK1"
ORIGIN      
        1 agtgggtgtt ggaggcttta aggtagcttt aaattcgtgt tgtcctggga gctcgccctt
       61 ttcggctgga gtcgggcttt acggcgccgg atggctctgg acgtgaagtc tcgggcaaag
      121 cgttatgaga agctggactt ccttggggag ggacagtttg ccaccgttta caaggccaga
      181 gataagaaca ccaaccaaat tgtcgccatt aagaaaatca aacttggaca tagatcagaa
      241 gctaaagatg gtataaatag aaccgcctta agagagataa aattattaca ggagctaagt
      301 catccaaata taattggtct ccttgatgct tttggacata aatctaatat tagccttgtc
      361 tttgatttta tggaaactga tctagaggtt ataataaagg ataatagtct tgtgctgaca
      421 ccatcacaca tcaaagccta catgttgatg actcttcaag gattagaata tttacatcaa
      481 cattggatcc tacataggga tctgaaacca aacaacttgt tgctagatga aaatggagtt
      541 ctaaaactgg cagattttgg cctggccaaa tcttttggga gccccaatag agcttataca
      601 catcaggttg taaccaggtg gtatcgggcc cccgagttac tatttggagc taggatgtat
      661 ggtgtaggtg tggacatgtg ggctgttggc tgtatattag cagagttact tctaagggtt
      721 ccttttttgc caggagattc agaccttgat cagctaacaa gaatatttga aactttgggc
      781 acaccaactg aggaacagtg gccggacatg tgtagtcttc cagattatgt gacatttaag
      841 agtttccctg gaataccttt gcatcacatc ttcagtgcag caggagacga cttactagat
      901 ctcatacaag gcttattctt atttaatcca tgtgctcgaa ttacggccac acaggcactg
      961 aaaatgaagt atttcagtaa tcggccaggg ccaacacctg gatgtcagct gccaagacca
     1021 aactgtccag tggaaacctt aaaggagcaa tcaaatccag ctttggcaat aaaaaggaaa
     1081 agaacagagg ccttagaaca aggaggattg cccaagaaac taatttttta aagagaacac
     1141 tggacaacat tttactactg agggaaatag ccaaaaaggc aaataatgga aaaatagtaa
     1201 acattaagta aatgctgtag aagtgagttt gtaaatattc tacacatgta aaatatgtaa
     1261 aactatgggt tatttttatt aaatgtattt taaaataaaa atttaattct ggtttttctg
     1321 attagagtgc aaaagtgaga aaagttcaat actcttgaaa tgtagaattg aaaatgcatt
     1381 agggaaaact taataaaaat tattaccagt tatttggaag atctga
//
