LOCUS       NM_001145306           11663 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens cyclin dependent kinase 6 (CDK6), transcript variant
            2, mRNA.
ACCESSION   NM_001145306
VERSION     NM_001145306.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11663)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11663)
  AUTHORS   Mayer,I.M., Doma,E., Klampfl,T., Prchal-Murphy,M., Kollmann,S.,
            Schirripa,A., Scheiblecker,L., Zojer,M., Kunowska,N., Gebrail,L.,
            Shaw,L.E., Mann,U., Farr,A., Grausenburger,R., Heller,G.,
            Zebedin-Brandl,E., Farlik,M., Malumbres,M., Sexl,V. and Kollmann,K.
  TITLE     Kinase-inactivated CDK6 preserves the long-term functionality of
            adult hematopoietic stem cells
  JOURNAL   Blood 144 (2), 156-170 (2024)
   PUBMED   38684032
  REMARK    GeneRIF: Kinase-inactivated CDK6 preserves the long-term
            functionality of adult hematopoietic stem cells.
REFERENCE   3  (bases 1 to 11663)
  AUTHORS   Magrath,J.W., Sampath,S.S., Flinchum,D.A., Hartono,A.B.,
            Goldberg,I.N., Boehling,J.R., Savkovic,S.D. and Lee,S.B.
  TITLE     Comprehensive Transcriptomic Analysis of EWSR1::WT1 Targets
            Identifies CDK4/6 Inhibitors as an Effective Therapy for
            Desmoplastic Small Round Cell Tumors
  JOURNAL   Cancer Res 84 (9), 1426-1442 (2024)
   PUBMED   38588409
  REMARK    GeneRIF: Comprehensive Transcriptomic Analysis of EWSR1::WT1
            Targets Identifies CDK4/6 Inhibitors as an Effective Therapy for
            Desmoplastic Small Round Cell Tumors.
REFERENCE   4  (bases 1 to 11663)
  AUTHORS   Liu,Y., Jiang,H., Hu,K., Zou,H., Zhang,W., Liu,J. and Jian,X.
  TITLE     CircPRMT5 promotes progression of osteosarcoma by recruiting CNBP
            to regulate the translation and stability of CDK6 mRNA
  JOURNAL   PLoS One 19 (4), e0298947 (2024)
   PUBMED   38626179
  REMARK    GeneRIF: CircPRMT5 promotes progression of osteosarcoma by
            recruiting CNBP to regulate the translation and stability of CDK6
            mRNA.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11663)
  AUTHORS   Long,X., Jiang,H., Liu,Z., Liu,J. and Hu,R.
  TITLE     Long noncoding RNA LINC00675 drives malignancy in acute myeloid
            leukemia via the miR-6809 -CDK6 axis
  JOURNAL   Pathol Res Pract 255, 155221 (2024)
   PUBMED   38422911
  REMARK    GeneRIF: Long noncoding RNA LINC00675 drives malignancy in acute
            myeloid leukemia via the miR-6809 -CDK6 axis.
REFERENCE   6  (bases 1 to 11663)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   7  (bases 1 to 11663)
  AUTHORS   Lucas,J.J., Szepesi,A., Modiano,J.F., Domenico,J. and Gelfand,E.W.
  TITLE     Regulation of synthesis and activity of the PLSTIRE protein
            (cyclin-dependent kinase 6 (cdk6)), a major cyclin D-associated
            cdk4 homologue in normal human T lymphocytes
  JOURNAL   J Immunol 154 (12), 6275-6284 (1995)
   PUBMED   7759865
REFERENCE   8  (bases 1 to 11663)
  AUTHORS   Bullrich,F., MacLachlan,T.K., Sang,N., Druck,T., Veronese,M.L.,
            Allen,S.L., Chiorazzi,N., Koff,A., Heubner,K., Croce,C.M. et al.
  TITLE     Chromosomal mapping of members of the cdc2 family of protein
            kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor,
            p27Kip1, to regions involved in human cancer
  JOURNAL   Cancer Res 55 (6), 1199-1205 (1995)
   PUBMED   7882308
REFERENCE   9  (bases 1 to 11663)
  AUTHORS   Verloes,A., Drunat,S., Gressens,P. and Passemard,S.
  TITLE     Primary Autosomal Recessive Microcephalies and Seckel Syndrome
            Spectrum Disorders - RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301772
REFERENCE   10 (bases 1 to 11663)
  AUTHORS   Meyerson,M., Enders,G.H., Wu,C.L., Su,L.K., Gorka,C., Nelson,C.,
            Harlow,E. and Tsai,L.H.
  TITLE     A family of human cdc2-related protein kinases
  JOURNAL   EMBO J 11 (8), 2909-2917 (1992)
   PUBMED   1639063
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AW665776.1, AK313491.1,
            BC052264.1, AC000065.1, AC005156.1, BC027989.1 and BQ773638.1.
            
            On Nov 30, 2019 this sequence version replaced NM_001145306.1.
            
            Summary: The protein encoded by this gene is a member of the CMGC
            family of serine/threonine protein kinases. This kinase is a
            catalytic subunit of the protein kinase complex that is important
            for cell cycle G1 phase progression and G1/S transition. The
            activity of this kinase first appears in mid-G1 phase, which is
            controlled by the regulatory subunits including D-type cyclins and
            members of INK4 family of CDK inhibitors. This kinase, as well as
            CDK4, has been shown to phosphorylate, and thus regulate the
            activity of, tumor suppressor protein Rb. Altered expression of
            this gene has been observed in multiple human cancers. A mutation
            in this gene resulting in reduced cell proliferation, and impaired
            cell motility and polarity, and has been identified in patients
            with primary microcephaly. [provided by RefSeq, Aug 2017].
            
            Transcript Variant: This variant (2) represents the longer
            transcript.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2287747.1,
                                           SRR11853564.24787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267764 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000424848.3/ ENSP00000397087.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AW665776.1         203-346             c
            145-1444            AK313491.1         137-1436
            1445-2122           BC052264.1         1375-2052
            2123-9634           AC000065.1         1-7512              c
            9635-9853           AC005156.1         73481-73699         c
            9854-11558          BC027989.1         12-1716
            11559-11663         BQ773638.1         17-121              c
FEATURES             Location/Qualifiers
     source          1..11663
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.2"
     gene            1..11663
                     /gene="CDK6"
                     /gene_synonym="MCPH12; PLSTIRE"
                     /note="cyclin dependent kinase 6"
                     /db_xref="GeneID:1021"
                     /db_xref="HGNC:HGNC:1777"
                     /db_xref="MIM:603368"
     exon            1..96
                     /gene="CDK6"
                     /gene_synonym="MCPH12; PLSTIRE"
                     /inference="alignment:Splign:2.1.0"
     exon            97..696
                     /gene="CDK6"
                     /gene_synonym="MCPH12; PLSTIRE"
                     /inference="alignment:Splign:2.1.0"
     CDS             464..1444
                     /gene="CDK6"
                     /gene_synonym="MCPH12; PLSTIRE"
                     /EC_number="2.7.11.22"
                     /note="cell division protein kinase 6;
                     serine/threonine-protein kinase PLSTIRE"
                     /codon_start=1
                     /product="cyclin-dependent kinase 6"
                     /protein_id="NP_001138778.1"
                     /db_xref="CCDS:CCDS5628.1"
                     /db_xref="GeneID:1021"
                     /db_xref="HGNC:HGNC:1777"
                     /db_xref="MIM:603368"
                     /translation="MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKR
                     VRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD
                     QDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIK
                     LADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPL
                     FRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDL
                     LLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA"
     exon            697..832
                     /gene="CDK6"
                     /gene_synonym="MCPH12; PLSTIRE"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1000
                     /gene="CDK6"
                     /gene_synonym="MCPH12; PLSTIRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1110
                     /gene="CDK6"
                     /gene_synonym="MCPH12; PLSTIRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1161
                     /gene="CDK6"
                     /gene_synonym="MCPH12; PLSTIRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1297
                     /gene="CDK6"
                     /gene_synonym="MCPH12; PLSTIRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..11663
                     /gene="CDK6"
                     /gene_synonym="MCPH12; PLSTIRE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11534..11539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK6"
                     /gene_synonym="MCPH12; PLSTIRE"
                     /note="hexamer: AATAAA"
     polyA_site      11558
                     /gene="CDK6"
                     /gene_synonym="MCPH12; PLSTIRE"
                     /note="major polyA site"
     regulatory      11640..11645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK6"
                     /gene_synonym="MCPH12; PLSTIRE"
                     /note="hexamer: ATTAAA"
     polyA_site      11663
                     /gene="CDK6"
                     /gene_synonym="MCPH12; PLSTIRE"
                     /note="major polyA site"
ORIGIN      
        1 gtctgattac ctgctccgcg aggccgcgga cacgtgcgga gagccgactg acactcgcag
       61 ccccctcggg aggcccgacg cgactgggcc cctcaggtgc aatgattctg gactgagacg
      121 cgcttgggca gaggctatgt aatcgtgtct gtgttgagga cttcgcttcg aggagggaag
      181 aggagggatc ggctcgctcc tccggcggcg gcggcggcgg cgactctgca ggcggagttt
      241 cgcggcggcg gcaccagggt tacgccagcc ccgcggggag gtctctccat ccagcttctg
      301 cagcggcgaa agccccagcg cccgagcgcc tgagccggcg gggagcaagt aaagctagac
      361 cgatctccgg ggagccccgg agtaggcgag cggcggccgc cagctagttg agcgcacccc
      421 ccgcccgccc cagcggcgcc gcggcgggcg gcgtccaggc ggcatggaga aggacggcct
      481 gtgccgcgct gaccagcagt acgaatgcgt ggcggagatc ggggagggcg cctatgggaa
      541 ggtgttcaag gcccgcgact tgaagaacgg aggccgtttc gtggcgttga agcgcgtgcg
      601 ggtgcagacc ggcgaggagg gcatgccgct ctccaccatc cgcgaggtgg cggtgctgag
      661 gcacctggag accttcgagc accccaacgt ggtcaggttg tttgatgtgt gcacagtgtc
      721 acgaacagac agagaaacca aactaacttt agtgtttgaa catgtcgatc aagacttgac
      781 cacttacttg gataaagttc cagagcctgg agtgcccact gaaaccataa aggatatgat
      841 gtttcagctt ctccgaggtc tggactttct tcattcacac cgagtagtgc atcgcgatct
      901 aaaaccacag aacattctgg tgaccagcag cggacaaata aaactcgctg acttcggcct
      961 tgcccgcatc tatagtttcc agatggctct aacctcagtg gtcgtcacgc tgtggtacag
     1021 agcacccgaa gtcttgctcc agtccagcta cgccaccccc gtggatctct ggagtgttgg
     1081 ctgcatattt gcagaaatgt ttcgtagaaa gcctcttttt cgtggaagtt cagatgttga
     1141 tcaactagga aaaatcttgg acgtgattgg actcccagga gaagaagact ggcctagaga
     1201 tgttgccctt cccaggcagg cttttcattc aaaatctgcc caaccaattg agaagtttgt
     1261 aacagatatc gatgaactag gcaaagacct acttctgaag tgtttgacat ttaacccagc
     1321 caaaagaata tctgcctaca gtgccctgtc tcacccatac ttccaggacc tggaaaggtg
     1381 caaagaaaac ctggattccc acctgccgcc cagccagaac acctcggagc tgaatacagc
     1441 ctgaggcctc agcagccgcc ttaagctgat cctgcggaga acacccttgg tggcttatgg
     1501 gtccccctca gcaagcccta cagagctgtg gaggattgct atctggaggc cttccagctg
     1561 ctgtcttctg gacaggctct gcttctccaa ggaaaccgcc tagtttactg ttttgaaatc
     1621 aatgcaagag tgattgcagc tttatgttca tttgtttgtt tgtttgtctg tttgtttcaa
     1681 gaacctggaa aaattccaga agaagagaag ctgctgacca attgtgctgc catttgattt
     1741 ttctaacctt gaatgctgcc agtgtggagt gggtaatcca ggcacagctg agttatgatg
     1801 taatctctct gcagctgccg ggcctgattt ggtacttttg agtgtgtgtg tgcatgtgtg
     1861 tgtgtgtgtg tgtgtgtgtg tgtgtgtatg tgagagattc tgtgatcttt taaagtgtta
     1921 ctttttgtaa acgacaagaa taattcaatt ttaaagactc aaggtggtca gtaaataaca
     1981 ggcatttgtt cactgaaggt gattcaccaa aatagtcttc tcaaattaga aagttaaccc
     2041 catgtcctca gcatttcttt tctggccaaa agcagtaaat ttgctagcag taaaagatga
     2101 agttttatac acacagcaaa aaggagaaaa aattctagta tattttaaga gatgtgcatg
     2161 cattctattt agtcttcaga atgctgaatt tacttgttgt aagtctattt taaccttctg
     2221 tatgacatca tgctttatca tttcttttgg aaaatagcct gtaagctttt tattacttgc
     2281 tataggttta gggagtgtac ctcagataga ttttaaaaaa aagaatagaa agcctttatt
     2341 tcctggtttg aaattccttt cttccctttt tttgttgttg ttattgttgt ttgttgttgt
     2401 tattttgttt ttgtttttag gaatttgtca gaaactcttt cctgttttgg tttggagagt
     2461 agttctctct aactagagac aggagtggcc ttgaaatttt cctcatctat tacactgtac
     2521 tttctgccac acactgcctt gttggcaaag tatccatctt gtctatctcc cggcacttct
     2581 gaaatatatt gctaccattg tataactaat aacagattgc ttaagctgtt cccatgcacc
     2641 acctgtttgc ttgctttcaa tgaacctttc ataaattcgc agtctcagct tatggtttat
     2701 ggcctcgatt ctgcaaacct aacagggtca catatgttct ctaatgcagt ccttctacct
     2761 ggtgtttact tttgttacct aaataatgag taggatcttg ttttgtttta tcaccagcac
     2821 acagattgct ataaactgtt actttgtgaa ttacattttt atagaagata ttttcagtgt
     2881 ctttacctga gggtatgtct ttagctatgt tttagggcca tacatttact ctatcaaatg
     2941 atcttttctc catcccccag gctgtgctta tttctagtgc cttgtgctca ctcctgctct
     3001 ctacagagcc agcctggcct gggcattgta aacagctttt cctttttctc ttactgtttt
     3061 ctctacagtc ctttatattt cataccatct ctgccttata agtggtttag tgctcagttg
     3121 gctctagtaa ccagaggaca cagaaagtat cttttggaaa gtttagccac ctgtgctttc
     3181 tgactcagag tgcatgcaac agttagatca tgcaacagtt agattatgtt tagggttagg
     3241 attttcaaag aatggaggtt gctgcactca gaaaataatt cagatcatgt ttatgcatta
     3301 ttaagttgta ctgaattctt tgcagcttaa tgtgatatat gactatcttg aacaagagaa
     3361 aaaactagga gatgtttctc ctgaagagct tttggggttg ggaactattc ttttttaatt
     3421 gctgtactac ttaacattgt tctaattcag tagcttgagg aacaggaaca ttgttttcta
     3481 gagcaagata ataaaggaga tgggccatac aaatgttttc tactttcgtt gtgacaacat
     3541 tgattaggtg ttgtcagtac tataaatgct tgagatataa tgaatccaca gcattcaagg
     3601 tcaggtctac tcaaagtctc acatggaaaa gtgagttctg cctttccttt gatcgagggt
     3661 caaaatacaa agacattttt gctagggcct acaaattgaa tttaaaaact cactgcactg
     3721 attcatctga gctttttggt tagtattcat ggctagagtg aacatagctt tagtttttgc
     3781 tgttgtaaaa gtgttttcat aagttcactc aagaaaaatg cagctgttct gaactggaat
     3841 ttttcagcat tctttagaat tttaaatgag tagagagctc aacttttatt cctagcatct
     3901 gcttttgact catttctagg cagtgcttat gaagaaaaat taaagcacaa acattctggc
     3961 attcaatcgt tggcagatta tcttctgatg acacagaatg aaagggcatc tcagcctctc
     4021 tgaactttgt aaaaatctgt ccccagttct tccatcggtg tagttgttgc atttgagtga
     4081 atactctctt gatttatgta ttttatgtcc agattcgcca tttctgaaat ccagatccaa
     4141 cacaagcagt cttgccgtta gggcattttg aagcagatag tagagtaaga acttagtgac
     4201 tacagcttat tcttctgtaa catatggttt caaacatctt tgccaaaagc taagcagtgg
     4261 tgaactgaaa agggcatatt gccccaaggt tacactgaag cagctcatag caagttaaaa
     4321 tattgtgaca gatttgaaat catgtttgaa tttcatagta ggaccagtac aagaatgtcc
     4381 ctgctagttt ctgtttgatg tttggttctg gcggctcagg cattttggga actgttgcac
     4441 agggtggagt caaaacaacc tacatataaa aagagaaaaa gagaaacttg tccatttagc
     4501 tttcataaga aatcccatgg caaagggtaa taaaaaggac ctaatcttaa aaatacaatt
     4561 tctaagcact tgtaagaacc cagtgggttg gagcctccca ctttgtccct cctttgaagt
     4621 ggatgggaac tcaaggtgca aagaacctgt tttggaagaa agcttggggc catttcagcc
     4681 ccctgtattc tcatgatttt ctctcaggaa gcacacactg tgaatggcag acttttcatt
     4741 tagccccagg tgacttacta aaaatagttg aaaattattc acctaagaat agaatctcag
     4801 cattgtgtta aataaaaatg aaagctttag aaggcatgag atgttcctat cttaaataaa
     4861 gcatgtttct tttctataga gaaatgtata gtttgactct ccagaatgta ctatccatct
     4921 tgatgagaaa actcttaaat agtaccaaac attttgaact ttaaattatg tatttaaagt
     4981 gagtgtttaa gaaactgtag ctgcttcttt tacaagtggt gcctattaaa gtcagtaatg
     5041 gccattattg ttccattgtg gaaattaaat tatgtaagct tcctaatatc ataaacatat
     5101 taaaattctt ctaaaatatt gcttttcttt taagtgacaa tttgactatt cttatgataa
     5161 gcacatgaga gtgtcttaca ttttccaaaa gcaggcttta attgcatagt tgagtctagg
     5221 aaaaaataat gttaaaagtg aatatgccac cataattact taattatgtt agtatagaaa
     5281 ctacagaata tttaccctgg aaagaaaata ttggaatgtt attataaact cttagatatt
     5341 tatataattc aaaagaatgc atgtttcaca ttgtgacaga taaagatgta tgatttctaa
     5401 ggctttaaaa attattcata aaacagtggg caatagataa aggaaattct ggagaaaatg
     5461 aaggtattta aagggtagtt tcaaagctat atatattttg aaggatatat tctttatgaa
     5521 caaatatatt gtaaaaattt atactaaggt catctggtaa ctgtgggatt aatatggtcg
     5581 aaaacaaatg ttatggagaa gctgtcccaa gcaaactaaa ttacctgtac ttttttccca
     5641 tttcaaggga agaggcaacc acatgaagca atacttctta cacatgccta agaacgttca
     5701 ttgaaaaaat aaatttttaa aaggcatgtg tttcctatgc caccaatact tttgaaaaat
     5761 tgtgaacctt acccaaaacc atttatcatg tccattaagt atatttgggt atataattag
     5821 gaagatattt acatgttcca tctccacagt ggaaaaactt attgaggcta ccaaagtgtg
     5881 ccaagaaatg taagtcctta gagtaattag aaatgctgtt ttcctcaaaa gcatgagaaa
     5941 ctagcatttt catttcttat ttactccctt tctatatcaa tgcaattcac aacccaattt
     6001 taatacatcc ctatatctca agcatttcta tcttgtactt tttcagaaaa taaaccaaaa
     6061 ataatccttt ggtctctcta tcttctgacc tttgtaagca acagaaatgt aaaaacagaa
     6121 ggggtccaat ttttacacgt ttttttctca agtagccttt ctggggattt ttattttctt
     6181 aatgaagtgc caatcagctt ttcaaaatgt tttctatttc tcagcatttc caggaagtga
     6241 taacgtttag ctaaatgagt agaagtggac ttccttcaac atattgttac cttgtctagc
     6301 cttaggaaga aaacaagagc cacctgaaaa taaatacagg ctcttttcga gcatctgctg
     6361 aaatactgtt acagcaattt gaagttgatg tggtaggaaa ggaaggtgac ttttcttgca
     6421 aaagtctttc taaacattca cactgtccta agagatgagc tttcttgttt tattccggta
     6481 tattccacaa ggtggcactt ttagagaaaa acaaatctga tgaagactaa agaggtactt
     6541 ctaaaagaga tttcattcta actttatttt tctgcgcata tttaactctt tcctagcact
     6601 tgttttttgg gatgattaat agtctctata atgttctgta acttcaatat tttacttgtt
     6661 acctaggttc tgaacaattg tctgcaaata aattgttctt aaggatggat aatacaccca
     6721 ttttgatcat ttaagtaaag aaagcctagt cattcattca gtcaagaaaa aatttttgaa
     6781 gtacccagtt accttacttt tctagattaa aacaggctta gttactaaaa aggcagtcct
     6841 catctgtgaa caggatagtt tcgttagaag tataaaactc ctttagtggc cccagttaaa
     6901 acacacatac cctctctgct gctttcaaat tccctagcat ggtggccttt caacattgat
     6961 taaattttaa aatcctaatt taaagatcag gtgagcaaaa tgagtagcac atcagtaatt
     7021 cagtagacaa aacttttgtc tgaaaaattg ctgtattgaa acagagccct aaaataccaa
     7081 aagaccaggt aattttaaca tttgtggaat cacaaatgta aattcataag aagctctaat
     7141 taaaaaaaaa aagtctgaag tatatgagca taacaactta ggagtgtgtc tacatactta
     7201 acttttgaag ttttttggca actttatata ctttttttaa atttacaagt ctacttaaag
     7261 acttcttata ccccaaatga ttaagttaat tttagaggtc acctttctca cagcagtgtc
     7321 acttgaaatt tagtagggaa ggatattgca gtatttttca gtttccttag cacagcacca
     7381 cagaaagcag cttattcctt ttgagtggca gacactcgac ggtgcctgcc caactttcct
     7441 cctgagtggc aagcagatga gtctcagtaa ttcatactga accaaaatgc cacatacact
     7501 aggggcagtc agaaactggc tgagaaatcc cccgcctcat tcgcccctct gctcccagga
     7561 actagagtcc agttaaagcc cctatgcgaa aggccgaatt ccaccccagg gtttgttata
     7621 acagtggcca gtctgaaccc catttgctcg tgctcaaaac ttgattccca cttgaaagcc
     7681 ttccgggcgc gctgcctcgt tgccccgccc ctttggcagg agagaggcag tgggcgaggc
     7741 cgggctgggg ccccgcctcc cactcacctg ccggtgcctg aaattatgtg cggccccgcg
     7801 ggctgctttc cgaggtcaga gtgccctgct gctgtctcag aggcatctgt tctgcaaatc
     7861 ttaggaagaa aaatgtccct agtagcaaac gggtgtcttc tgtgcataaa taagtacaac
     7921 acaattctcc gaaagttcgg gtaaaaagag atgcggtagc agctgccctg tgtgaagctg
     7981 tctaccccgc atctctcagg cgctaagctc agtttttgtt tttgtttttg tttttttaaa
     8041 gaaaagatgt ataattgcag gaattttttt ttattttttt attttccatc attctatata
     8101 tgtgatggtg aaagatatgc ctggaaaagt tttgttttga aaagtttatt ttctgcttcg
     8161 tcttcagttg gcaaaagctc tcaattcttt agcttccagt ttcttttctc tctttttctt
     8221 tgttaggtaa ttaaaggtat gtaaacaaat tatctcatgt agcaggggat tttcatgttg
     8281 agaggaatct tccgtgtgag ttgtttggtc acacaaataa ccctttctca attttaggag
     8341 tttggattgt caaatgtagg tttttctcaa agggggcata taactacata ttgactgcca
     8401 agaactatga ctgtagcact aatcagcaca catagagcca cacaattatt taatttctaa
     8461 ctctctgtgg tccctagaaa aattccgttg atgtgcttag gttaaagttc tgaagatacc
     8521 cgttgtaccc ttacttgaaa gtttctaatc ttaagtttta tgaaatgcaa taatatgtat
     8581 cagctagcaa tatttctgtg atcaccaaca actctcagtt tgatcttaaa gtctgaataa
     8641 taaaacaaat cccagcagta atacatttct taaacctcac agtgcatgat atatcttttc
     8701 attctgatcc tgtgtttgca aaaatataca catgtatatc atagttcctc actttttatt
     8761 catttgtttt cctattacct gtagtaaata tattagttag tacatggaat ttatagcatc
     8821 agctaccccc aggaacagca cctgacaggc gggggatttt ttttcaagtt gttctacatt
     8881 tgcataaatt atttctatta ttattcatgt atgttattta tttctgaatc acactagtcc
     8941 tgtgaaagta caactgaagg cagaaagtgt taggattttg catctaatgt tcattatcat
     9001 ggtattgatg gacctaagaa aataaaaatt agactaagcc cccaaataag ctgcatgcat
     9061 ttgtaacatg attagtagat ttgaatatat agatgtagta ttttgggtat ctaggtgttt
     9121 tatcattatg taaaggaatt aaagtaaagg actttgtagt tgtttttatt aaatatgcat
     9181 atagtagagt gcaaaaatat agcaaaaata aaaactaaag gtagaaaagc attttagata
     9241 tgccttaatt tagaaactgt gccaggtggc cctcggaata gatgccaggc agagaccagt
     9301 gcctgggtgg tgcctcctct tgtctgccct catgaagaag cttccctcac gtgatgtagt
     9361 gccctcgtag gtgtcatgtg gagtagtggg aacaggcagt actgttgaga ggagagcagt
     9421 gtgagagttt ttctgtagaa gcagaactgt cagcttgtgc cttgaggctt ccagaacgtg
     9481 tcagatggag aagtccaagt ttccatgctt caggcaactt agctgtgtac agaagcaatc
     9541 cagtgtggta ataaaaagca aggattgcct gtataattta ttataaaata aaagggattt
     9601 taacaaccaa caattcccaa cacctcaaaa gcttgttgca ttttttggta tttgaggttt
     9661 ttatctgaag gttaaagggc aagtgtttgg tatagaagag cagtatgtgt taagaaaaga
     9721 aaaatattgg ttcacgtaga gtgcaaatta gaactagaaa gttttatacg attatcattt
     9781 tgagatgtgt taaagtaggt tttcactgta aaatgtatta gtgtttctgc attgccatag
     9841 ggcctggtta aaactttctc ttaggtttca ggaagactgt cacatacagt aagctttttt
     9901 ccttctgact tataatagaa aatgttttga aagtaaaaaa aaaaaatcta atttggaaat
     9961 ttgacttgtt agtttctgtg tttgaaatca tggttctaga aatgtagaaa ttgtgtatat
    10021 cagatactca tctaggctgt gtgaaccagc ccaagatgac caacatcccc acacctctac
    10081 atctctgtcc cctgtatctc ttcctttcta ccactaaagt gttccctgct accatcctgg
    10141 cttgtccaca tggtgctctc catcttcctc cacatcatgg accacaggtg tgcctgtcta
    10201 ggcctggcca ccactcccaa cttgacctag ccacattcat ctagagatgg ttcctgatgc
    10261 tgggcacaga ctgtgctcat ggcacccatt agaaatgcct ctagcatctt tgtatgcatc
    10321 ttgattttta aaccaagtca ttgtacagag cattcagttt tggctgtggt accaagagaa
    10381 aaactaatca agaatataaa ccacattcca ggctgctgtt ttctctccat ctacaggcca
    10441 cacttttact gtatttcttc atacttgaaa ttcattctgc tattttcata tcagggtaca
    10501 gacttataag ggtgcatgtt ccttaaaggt gcataattat tcttattccg tttgcttata
    10561 ttgctacaga atgctctgtt ttggtgcttt gagttctgca gacccaagaa gcagtgtgga
    10621 aattcactgc ctgggacaca gtcttataag aatgttggca ggtgactttg tatcagatgt
    10681 tgcttctctt ttctctgtac acagattgag agttaccaca gtggcctgtc gggtccaccc
    10741 tgtgggtgca gcacagctct ctgaaagcaa gaaccttcct acctattcta acgtttttgc
    10801 cctctaagaa aaatggcctc aggtatggta tagacatagc aagaggggaa gggctgtctc
    10861 actctagcaa ccatccctcc attacacaca gaaagccctc ttgaagcaaa agaagaagaa
    10921 agaaagaaag cttatctcta aggctactgt cttcagaatg ctctgagctg aatgctcttg
    10981 ctcctttccc aagaggcaga tgaaaatata gccagtttat ctataccctt cctatctgag
    11041 gaggagaata gaaaagtagg gtaaatatgt aacgtaaaat atgtcattca aggaccacca
    11101 aaactttaag taccctatca ttaaaaatct ggttttaaaa gtagctcaag taagggatgc
    11161 tttgtgaccc agggtttctg aagtcagata gccattctta cctgcccctt actctgactt
    11221 attgggaaag ggagaactgc agtggtgttt ctgttgcagt ggcaaaggta acatgtcaga
    11281 aaattcagag ggttgcatac caataatcct ttggaaactg gatgtcttac tgggtgctag
    11341 aatgaaaatg taggtattta ttgtcagatg atgaagttca ttgttttttt caaaattggt
    11401 gttgaaatat cactgtccaa tgtgttcact tatgtgaaag ctaaattgaa tgaggcaaaa
    11461 agagcaaata gtttgtatat ttgtaatacc ttttgtattt cttacaataa aaatattggt
    11521 agcaaataaa aataataaaa acaataactt taaactgctt tctggagatg aattactctc
    11581 ctggctattt tcttttttac tttaatgtaa aatgagtata actgtagtga gtaaaattca
    11641 ttaaattcca agttttagca gaa
//
