LOCUS       NM_176096               1834 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens CDK5 regulatory subunit associated protein 3
            (CDK5RAP3), transcript variant 3, mRNA.
ACCESSION   NM_176096
VERSION     NM_176096.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1834)
  AUTHORS   Zhuo,R., Zhang,Z., Chen,Y., Li,G., Du,S., Guo,X., Yang,R., Tao,Y.,
            Li,X., Fang,F., Xie,Y., Wu,D., Yang,Y., Yang,C., Yin,H., Qian,G.,
            Wang,H., Yu,J., Jia,S., Zhu,F., Feng,C., Wang,J., Xu,Y., Li,Z.,
            Shi,L., Wang,X., Pan,J. and Wang,J.
  TITLE     CDK5RAP3 is a novel super-enhancer-driven gene activated by master
            TFs and regulates ER-Phagy in neuroblastoma
  JOURNAL   Cancer Lett 591, 216882 (2024)
   PUBMED   38636893
  REMARK    GeneRIF: CDK5RAP3 is a novel super-enhancer-driven gene activated
            by master TFs and regulates ER-Phagy in neuroblastoma.
REFERENCE   2  (bases 1 to 1834)
  AUTHORS   Zhang,C., Du,F.H., Wang,R.X., Han,W.B., Lv,X., Zeng,L.H. and
            Chen,G.Q.
  TITLE     TSPAN6 reinforces the malignant progression of glioblastoma via
            interacting with CDK5RAP3 and regulating STAT3 signaling pathway
  JOURNAL   Int J Biol Sci 20 (7), 2440-2453 (2024)
   PUBMED   38725860
  REMARK    GeneRIF: TSPAN6 reinforces the malignant progression of
            glioblastoma via interacting with CDK5RAP3 and regulating STAT3
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1834)
  AUTHORS   Makhlouf,L., Peter,J.J., Magnussen,H.M., Thakur,R., Millrine,D.,
            Minshull,T.C., Harrison,G., Varghese,J., Lamoliatte,F.,
            Foglizzo,M., Macartney,T., Calabrese,A.N., Zeqiraj,E. and
            Kulathu,Y.
  TITLE     The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER
            translocons
  JOURNAL   Nature 627 (8003), 437-444 (2024)
   PUBMED   38383789
REFERENCE   4  (bases 1 to 1834)
  AUTHORS   DaRosa,P.A., Penchev,I., Gumbin,S.C., Scavone,F., Wachalska,M.,
            Paulo,J.A., Ordureau,A., Peter,J.J., Kulathu,Y., Harper,J.W.,
            Becker,T., Beckmann,R. and Kopito,R.R.
  TITLE     UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from
            the ER
  JOURNAL   Nature 627 (8003), 445-452 (2024)
   PUBMED   38383785
REFERENCE   5  (bases 1 to 1834)
  AUTHORS   Cen,H., Zheng,S., Fang,Y.M., Tang,X.P. and Dong,Q.
  TITLE     Induction of HSF1 expression is associated with sporadic colorectal
            cancer
  JOURNAL   World J Gastroenterol 10 (21), 3122-3126 (2004)
   PUBMED   15457556
REFERENCE   6  (bases 1 to 1834)
  AUTHORS   Xie,Y.H., He,X.H., Tang,Y.T., Li,J.J., Pan,Z.M., Qin,W.X., Wan,D.F.
            and Gu,J.R.
  TITLE     Cloning and characterization of human IC53-2, a novel CDK5
            activator binding protein
  JOURNAL   Cell Res 13 (2), 83-91 (2003)
   PUBMED   12737517
REFERENCE   7  (bases 1 to 1834)
  AUTHORS   Chen,J., Liu,B., Liu,Y., Han,Y., Yu,H., Zhang,Y., Lu,L., Zhen,Y.
            and Hui,R.
  TITLE     A novel gene IC53 stimulates ECV304 cell proliferation and is
            upregulated in failing heart
  JOURNAL   Biochem Biophys Res Commun 294 (1), 161-166 (2002)
   PUBMED   12054757
  REMARK    GeneRIF: IC53 is a novel gene, mainly expressed in vascular
            endothelial cells and mediates cell proliferation
REFERENCE   8  (bases 1 to 1834)
  AUTHORS   Ching,Y.P., Pang,A.S., Lam,W.H., Qi,R.Z. and Wang,J.H.
  TITLE     Identification of a neuronal Cdk5 activator-binding protein as Cdk5
            inhibitor
  JOURNAL   J Biol Chem 277 (18), 15237-15240 (2002)
   PUBMED   11882646
REFERENCE   9  (bases 1 to 1834)
  AUTHORS   Wang,X., Ching,Y.P., Lam,W.H., Qi,Z., Zhang,M. and Wang,J.H.
  TITLE     Identification of a common protein association region in the
            neuronal Cdk5 activator
  JOURNAL   J Biol Chem 275 (41), 31763-31769 (2000)
   PUBMED   10915792
REFERENCE   10 (bases 1 to 1834)
  AUTHORS   Ching,Y.P., Qi,Z. and Wang,J.H.
  TITLE     Cloning of three novel neuronal Cdk5 activator binding proteins
  JOURNAL   Gene 242 (1-2), 285-294 (2000)
   PUBMED   10721722
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK023722.1 and AA427702.1.
            
            On Nov 23, 2018 this sequence version replaced NM_176096.2.
            
            Summary: This gene encodes a protein that has been reported to
            function in signaling pathways governing transcriptional regulation
            and cell cycle progression. It may play a role in tumorigenesis and
            metastasis. A pseudogene of this gene is located on the long arm of
            chromosome 20. Alternative splicing results in multiple transcript
            variants that encode different isoforms. [provided by RefSeq, May
            2013].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and has
            multiple coding region differences compared to variant 1. These
            differences cause translation initiation at an alternate AUG and
            result in an isoform (b) with a longer N-terminus, compared to
            isoform e.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.158098.1,
                                           SRR3476690.1032021.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338399.9/ ENSP00000344683.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1757              AK023722.1         24-1780
            1758-1834           AA427702.1         1-77                c
FEATURES             Location/Qualifiers
     source          1..1834
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..1834
                     /gene="CDK5RAP3"
                     /gene_synonym="C53; HSF-27; IC53; LZAP; MST016;
                     OK/SW-cl.114; PP1553"
                     /note="CDK5 regulatory subunit associated protein 3"
                     /db_xref="GeneID:80279"
                     /db_xref="HGNC:HGNC:18673"
                     /db_xref="MIM:608202"
     exon            1..40
                     /gene="CDK5RAP3"
                     /gene_synonym="C53; HSF-27; IC53; LZAP; MST016;
                     OK/SW-cl.114; PP1553"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1555
                     /gene="CDK5RAP3"
                     /gene_synonym="C53; HSF-27; IC53; LZAP; MST016;
                     OK/SW-cl.114; PP1553"
                     /note="isoform b is encoded by transcript variant 3;
                     ischemic heart CDK5 activator-binding protein C53;
                     LXXLL/leucine-zipper-containing ARFbinding protein; CDK5
                     regulatory subunit associated protein IC53-2;
                     LXXLL/leucine-zipper-containing ARF-binding protein"
                     /codon_start=1
                     /product="CDK5 regulatory subunit-associated protein 3
                     isoform b"
                     /protein_id="NP_788276.1"
                     /db_xref="CCDS:CCDS42356.1"
                     /db_xref="GeneID:80279"
                     /db_xref="HGNC:HGNC:18673"
                     /db_xref="MIM:608202"
                     /translation="MEDHQHVPIDIQTSKLLDWLVDRRHCSLKWQSLVLTIREKINAA
                     IQDMPESEEIAQLLSGSYIHYFHCLRILDLLKGTEASTKNIFGRYSSQRMKDWQEIIA
                     LYEKDNTYLVELSSLLVRNVNYEIPSLKKQIAKCQQLQQEYSRKEEECQAGAAEMREQ
                     FYHSCKQYGITGENVRGELLALVKDLPSQLAEIGAAAQQSLGEAIDVYQASVGFVCES
                     PTEQVLPMLRFVQKRGNSTVYEWRTGTEPSVVERPHLEELPEQVAEDAIDWGDFGVEA
                     VSEGTDSGISAEAAGIDWGIFPESDSKDPGGDGIDWGDDAVALQITVLEAGTQAPEGV
                     ARGPDALTLLEYTETRNQFLDELMELEIFLAQRAVELSEEADVLSVSQFQLAPAILQG
                     QTKEKMVTMVSVLEDLIGKLTSLQLQHLFMILASPRYVDRVTEFLQQKLKQSQLLALK
                     KELMVQKQQEALEEQAALEPKLDLLLEKTKELQKLIEADISKRYSGRPVNLMGTSL"
     exon            41..86
                     /gene="CDK5RAP3"
                     /gene_synonym="C53; HSF-27; IC53; LZAP; MST016;
                     OK/SW-cl.114; PP1553"
                     /inference="alignment:Splign:2.1.0"
     exon            87..218
                     /gene="CDK5RAP3"
                     /gene_synonym="C53; HSF-27; IC53; LZAP; MST016;
                     OK/SW-cl.114; PP1553"
                     /inference="alignment:Splign:2.1.0"
     exon            219..319
                     /gene="CDK5RAP3"
                     /gene_synonym="C53; HSF-27; IC53; LZAP; MST016;
                     OK/SW-cl.114; PP1553"
                     /inference="alignment:Splign:2.1.0"
     exon            320..368
                     /gene="CDK5RAP3"
                     /gene_synonym="C53; HSF-27; IC53; LZAP; MST016;
                     OK/SW-cl.114; PP1553"
                     /inference="alignment:Splign:2.1.0"
     exon            369..547
                     /gene="CDK5RAP3"
                     /gene_synonym="C53; HSF-27; IC53; LZAP; MST016;
                     OK/SW-cl.114; PP1553"
                     /inference="alignment:Splign:2.1.0"
     exon            548..687
                     /gene="CDK5RAP3"
                     /gene_synonym="C53; HSF-27; IC53; LZAP; MST016;
                     OK/SW-cl.114; PP1553"
                     /inference="alignment:Splign:2.1.0"
     exon            688..832
                     /gene="CDK5RAP3"
                     /gene_synonym="C53; HSF-27; IC53; LZAP; MST016;
                     OK/SW-cl.114; PP1553"
                     /inference="alignment:Splign:2.1.0"
     exon            833..943
                     /gene="CDK5RAP3"
                     /gene_synonym="C53; HSF-27; IC53; LZAP; MST016;
                     OK/SW-cl.114; PP1553"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1022
                     /gene="CDK5RAP3"
                     /gene_synonym="C53; HSF-27; IC53; LZAP; MST016;
                     OK/SW-cl.114; PP1553"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1111
                     /gene="CDK5RAP3"
                     /gene_synonym="C53; HSF-27; IC53; LZAP; MST016;
                     OK/SW-cl.114; PP1553"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1317
                     /gene="CDK5RAP3"
                     /gene_synonym="C53; HSF-27; IC53; LZAP; MST016;
                     OK/SW-cl.114; PP1553"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1489
                     /gene="CDK5RAP3"
                     /gene_synonym="C53; HSF-27; IC53; LZAP; MST016;
                     OK/SW-cl.114; PP1553"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1834
                     /gene="CDK5RAP3"
                     /gene_synonym="C53; HSF-27; IC53; LZAP; MST016;
                     OK/SW-cl.114; PP1553"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1804..1809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK5RAP3"
                     /gene_synonym="C53; HSF-27; IC53; LZAP; MST016;
                     OK/SW-cl.114; PP1553"
                     /note="hexamer: AATAAA"
     polyA_site      1834
                     /gene="CDK5RAP3"
                     /gene_synonym="C53; HSF-27; IC53; LZAP; MST016;
                     OK/SW-cl.114; PP1553"
                     /note="major polyA site"
ORIGIN      
        1 acagtctcca gcctgaagcg gaagtggagg aaagatggag gaccatcagc acgtgcccat
       61 cgacatccag accagcaagc tgctcgattg gctggtggac agaaggcact gcagcctgaa
      121 atggcagagt ctggtgctga cgatccgcga gaagatcaat gctgccatcc aggacatgcc
      181 agagagcgaa gagatcgccc agctgctgtc tgggtcctac attcactact ttcactgcct
      241 aagaatcctg gaccttctca aaggcacaga ggcctccacg aagaatattt ttggccgata
      301 ctcttcacag cggatgaagg attggcagga gattatagct ctgtatgaga aggacaacac
      361 ctacttagtg gaactctcta gcctcctggt tcggaatgtc aactatgaga tcccctcact
      421 gaagaagcag attgccaagt gccagcagct gcagcaagaa tacagccgca aggaggagga
      481 gtgccaggca ggggctgccg agatgcggga gcagttctac cactcctgca agcagtatgg
      541 catcacgggc gaaaatgtcc gaggagaact gctggccctg gtgaaggacc tgccgagtca
      601 gctggctgag attggggcag cggctcagca gtccctgggg gaagccattg acgtgtacca
      661 ggcgtctgtg gggtttgtgt gtgagagccc cacagagcag gtgttgccaa tgctgcggtt
      721 cgtgcagaag cggggaaact caacggtgta cgagtggagg acagggacag agccctctgt
      781 ggtggaacga ccccacctcg aggagcttcc tgagcaggtg gcagaagatg cgattgactg
      841 gggcgacttt ggggtagagg cagtgtctga ggggactgac tctggcatct ctgccgaggc
      901 tgctggaatc gactggggca tcttcccgga atcagattca aaggatcctg gaggtgatgg
      961 gatagactgg ggagacgatg ctgttgcttt gcagatcaca gtgctggaag caggaaccca
     1021 ggctccagaa ggtgttgcca ggggcccaga tgccctgaca ctgcttgaat acactgagac
     1081 ccggaatcag ttccttgatg agctcatgga gcttgagatc ttcttagccc agagagcagt
     1141 ggagttgagt gaggaggcag atgtcctgtc tgtgagccag ttccagctgg ctccagccat
     1201 cctgcagggc cagaccaaag agaagatggt taccatggtg tcagtgctgg aggatctgat
     1261 tggcaagctt accagtcttc agctgcaaca cctgtttatg atcctggcct caccaaggta
     1321 tgtggaccga gtgactgaat tcctccagca aaagctgaag cagtcccagc tgctggcttt
     1381 gaagaaagag ctgatggtgc agaagcagca ggaggcactt gaggagcagg cggctctgga
     1441 gcctaagctg gacctgctac tggagaagac caaggagctg cagaagctga ttgaagctga
     1501 catctccaag aggtacagcg ggcgccctgt gaacctgatg ggaacctctc tgtgacaccc
     1561 tccgtgttct tgcctgccca tcttctccgc ttttgggatg aagatgatag ccagggctgt
     1621 tgttttgggg cccttcaagg caaaagacca ggctgactgg aagatggaaa gccacaggaa
     1681 ggaagcggca cctgatggtg atcttggcac tctccatgtt ctctacaaga agctgtggtg
     1741 attggccctg tggtctatca ggcgaaaacc acagattctc cttctagtta gtatagcgga
     1801 cttaataaaa gaggaaaaaa ctcttgcttc agta
//
