LOCUS       NM_018249               6232 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens CDK5 regulatory subunit associated protein 2
            (CDK5RAP2), transcript variant 1, mRNA.
ACCESSION   NM_018249
VERSION     NM_018249.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6232)
  AUTHORS   He,Y., Shao,Y., Zhou,Z., Li,T., Gao,Y., Liu,X., Yuan,G., Yang,G.,
            Zhang,L. and Li,F.
  TITLE     MORC2 regulates RBM39-mediated CDK5RAP2 alternative splicing to
            promote EMT and metastasis in colon cancer
  JOURNAL   Cell Death Dis 15 (7), 530 (2024)
   PUBMED   39048555
  REMARK    GeneRIF: MORC2 regulates RBM39-mediated CDK5RAP2 alternative
            splicing to promote EMT and metastasis in colon cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6232)
  AUTHORS   Rahimian,M., Askari,M., Salehi,N., Riccio,A., Jaafarinia,M.,
            Almadani,N. and Totonchi,M.
  TITLE     A novel missense variant in CDK5RAP2 associated with
            non-obstructive azoospermia
  JOURNAL   Taiwan J Obstet Gynecol 62 (6), 830-837 (2023)
   PUBMED   38008501
  REMARK    GeneRIF: A novel missense variant in CDK5RAP2 associated with
            non-obstructive azoospermia.
REFERENCE   3  (bases 1 to 6232)
  AUTHORS   Shen,Y., Chen,Y., Lin,Y., Li,Y., Liu,P., Zhang,B., Wang,Y.,
            Chan,K.C., Mak,N.K., Kahn,M., Qi,R.Z. and Yang,H.
  TITLE     CDK5RAP2 is a Wnt target gene and promotes stemness and progression
            of oral squamous cell carcinoma
  JOURNAL   Cell Death Dis 14 (2), 107 (2023)
   PUBMED   36774351
  REMARK    GeneRIF: CDK5RAP2 is a Wnt target gene and promotes stemness and
            progression of oral squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6232)
  AUTHORS   Batman,U., Deretic,J. and Firat-Karalar,E.N.
  TITLE     The ciliopathy protein CCDC66 controls mitotic progression and
            cytokinesis by promoting microtubule nucleation and organization
  JOURNAL   PLoS Biol 20 (7), e3001708 (2022)
   PUBMED   35849559
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6232)
  AUTHORS   O'Neill,A.C., Uzbas,F., Antognolli,G., Merino,F., Draganova,K.,
            Jack,A., Zhang,S., Pedini,G., Schessner,J.P., Cramer,K.,
            Schepers,A., Metzger,F., Esgleas,M., Smialowski,P., Guerrini,R.,
            Falk,S., Feederle,R., Freytag,S., Wang,Z., Bahlo,M., Jungmann,R.,
            Bagni,C., Borner,G.H.H., Robertson,S.P., Hauck,S.M. and Gotz,M.
  TITLE     Spatial centrosome proteome of human neural cells uncovers
            disease-relevant heterogeneity
  JOURNAL   Science 376 (6599), eabf9088 (2022)
   PUBMED   35709258
REFERENCE   6  (bases 1 to 6232)
  AUTHORS   Bond,J., Roberts,E., Springell,K., Lizarraga,S.B., Scott,S.,
            Higgins,J., Hampshire,D.J., Morrison,E.E., Leal,G.F., Silva,E.O.,
            Costa,S.M., Baralle,D., Raponi,M., Karbani,G., Rashid,Y., Jafri,H.,
            Bennett,C., Corry,P., Walsh,C.A. and Woods,C.G.
  TITLE     A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain
            size
  JOURNAL   Nat Genet 37 (4), 353-355 (2005)
   PUBMED   15793586
  REMARK    GeneRIF: Mutations in CDK5RAP2 gene is associated with autosomal
            recessive primary microcephaly
            Erratum:[Nat Genet. 2005 May;37(5):555. Lizarraga, Sophia
            [corrected to Lizarraga, Sofia B]]
REFERENCE   7  (bases 1 to 6232)
  AUTHORS   Andersen,J.S., Wilkinson,C.J., Mayor,T., Mortensen,P., Nigg,E.A.
            and Mann,M.
  TITLE     Proteomic characterization of the human centrosome by protein
            correlation profiling
  JOURNAL   Nature 426 (6966), 570-574 (2003)
   PUBMED   14654843
REFERENCE   8  (bases 1 to 6232)
  AUTHORS   Mayor,T., Stierhof,Y.D., Tanaka,K., Fry,A.M. and Nigg,E.A.
  TITLE     The centrosomal protein C-Nap1 is required for cell cycle-regulated
            centrosome cohesion
  JOURNAL   J Cell Biol 151 (4), 837-846 (2000)
   PUBMED   11076968
REFERENCE   9  (bases 1 to 6232)
  AUTHORS   Moynihan,L., Jackson,A.P., Roberts,E., Karbani,G., Lewis,I.,
            Corry,P., Turner,G., Mueller,R.F., Lench,N.J. and Woods,C.G.
  TITLE     A third novel locus for primary autosomal recessive microcephaly
            maps to chromosome 9q34
  JOURNAL   Am J Hum Genet 66 (2), 724-727 (2000)
   PUBMED   10677332
REFERENCE   10 (bases 1 to 6232)
  AUTHORS   Verloes,A., Drunat,S., Gressens,P. and Passemard,S.
  TITLE     Primary Autosomal Recessive Microcephalies and Seckel Syndrome
            Spectrum Disorders - RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301772
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX495012.1, AK122913.1 and
            AF448860.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_018249.5.
            
            Summary: This gene encodes a regulator of CDK5 (cyclin-dependent
            kinase 5) activity. The protein encoded by this gene is localized
            to the centrosome and Golgi complex, interacts with CDK5R1 and
            pericentrin (PCNT), plays a role in centriole engagement and
            microtubule nucleation, and has been linked to primary microcephaly
            and Alzheimer's disease. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833481.1, KP294527.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000349780.9/ ENSP00000343818.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BX495012.1         6-13
            9-170               AK122913.1         1-162
            171-315             AF448860.1         124-268
            316-1053            AK122913.1         308-1045
            1054-6232           AF448860.1         1007-6185
FEATURES             Location/Qualifiers
     source          1..6232
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.2"
     gene            1..6232
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /note="CDK5 regulatory subunit associated protein 2"
                     /db_xref="GeneID:55755"
                     /db_xref="HGNC:HGNC:18672"
                     /db_xref="MIM:608201"
     exon            1..248
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..5871
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /note="isoform a is encoded by transcript variant 1;
                     centrosomal protein 215 kDa; CDK5 activator-binding
                     protein C48; centrosomin"
                     /codon_start=1
                     /product="CDK5 regulatory subunit-associated protein 2
                     isoform a"
                     /protein_id="NP_060719.4"
                     /db_xref="CCDS:CCDS6823.1"
                     /db_xref="GeneID:55755"
                     /db_xref="HGNC:HGNC:18672"
                     /db_xref="MIM:608201"
                     /translation="MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLL
                     PNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKT
                     NIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLL
                     TKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDE
                     KDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEA
                     AQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKV
                     EELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKST
                     ENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV
                     NEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNC
                     YLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTH
                     LVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFS
                     LYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLS
                     CMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLS
                     KGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKV
                     VRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQ
                     LVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHG
                     VPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILELQ
                     GELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTT
                     SSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQP
                     SAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITV
                     LCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQ
                     QLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKD
                     GHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK
                     SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDN
                     ETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTS
                     IFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHL
                     QREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDK
                     LLQSLRVELKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIE
                     TSSTLQSRLKEQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFD
                     LFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRH
                     VLGLIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVS
                     TAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNT
                     MKLLQLSKRQEKVIFDQLVVTHKILRKARGNLELRPGGAHPGTCSPSRPGS"
     exon            249..316
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            317..384
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            385..495
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            496..572
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            573..696
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            697..851
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1014
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1068
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1188
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1281
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1500
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1671
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1815
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1916
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2047
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2157
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2295
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2391
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2564
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2982
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            2983..3214
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3337
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3911
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            3912..4144
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            4145..4193
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            4194..4366
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            4367..4486
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            4487..4603
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            4604..4793
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            4794..4915
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            4916..5152
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            5153..5230
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            5231..5496
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            5497..5640
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            5641..5767
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            5768..5814
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            5815..6232
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6210..6215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /note="hexamer: ATTAAA"
     polyA_site      6232
                     /gene="CDK5RAP2"
                     /gene_synonym="C48; Cep215; MCPH3"
                     /note="major polyA site"
ORIGIN      
        1 gtttccgtag gaagaagcgc cgggaaagat ggcggcgtct gtggtttgaa ttccagcggc
       61 gccgccagag tctgaacaag agctggggtg gagggggcgg ggacctgggg agcccggcgg
      121 gtcgctatcg cggggggtac tagtggcgcc gccgccacag acaccaacgc tgtcgccacc
      181 tctgtagcca tgatggactt ggtgttggaa gaggacgtca ccgtccctgg gacgctcagc
      241 ggctgcagtg gccttgttcc cagtgtacca gatgacctgg atggcatcaa ccccaatgct
      301 gggttgggaa atggtctgct cccaaatgtg tcagaagaaa cagtgtctcc caccagagca
      361 cggaacatga aggactttga aaatcaaatc actgaattga agaaagaaaa ctttaaccta
      421 aagctccgca tctatttcct tgaggaaaga atgcaacagg aatttcatgg ccccactgaa
      481 catatctaca aaactaacat tgagctcaag gtggaagtag aaagtctgaa gcgggaactc
      541 caggagagag agcagctgct catcaaagcc tccaaagcag ttgagagctt agctgaagca
      601 ggtggctctg aaatccagcg ggtgaaagaa gatgctcgaa agaaggtgca gcaggtggaa
      661 gatctcctaa ctaaaagaat actccttttg gaaaaggatg tgacagccgc ccaggcagaa
      721 ctggaaaagg cctttgcagg gacagagacg gagaaggctc ttcggttgcg tttggaaagc
      781 aagctttcag agatgaagaa gatgcacgag ggggacttgg cgatggctct ggtcctggat
      841 gagaaagaca gactgattga ggagttgaag ctgtctttga agagcaaaga agctttaatt
      901 cagtgcctta aagaggagaa atctcagatg gcatgtcctg atgagaatgt gtcatctgga
      961 gagctccgag gactttgtgc tgctccaagg gaagaaaagg agagagaaac tgaggctgca
     1021 caaatggagc atcagaagga gagaaacagc tttgaagaga ggatccaggc acttgaagag
     1081 gacctgagag agaaggaaag agaaattgct acagagaaga aaaatagtct aaagagggat
     1141 aaagccattc agggtttaac catggcatta aaatcaaagg aaaaaaaggt tgaagaactt
     1201 aactctgaaa ttgaaaagct cagtgctgcc tttgctaaag ccagagaggc cctacagaaa
     1261 gcacagaccc aggaatttca ggggtctgaa gactatgaga ctgctctatc aggaaaggaa
     1321 gccctttcgg ctgcgctgcg ctcacaaaac ctcaccaaga gtacagagaa ccacagactg
     1381 cgtagaagca ttaagaagat cacccaggag ctgagtgact tgcagcagga gagggagaga
     1441 ctggagaagg acctggagga agcccatcga gagaagagca aaggagactg caccatccgt
     1501 gatcttagaa atgaagttga aaaattacgc aatgaagtga atgaaagaga gaaagcaatg
     1561 gaaaatcgtt acaagagtct tctgagtgaa agcaataaaa aattgcacaa tcaagagcaa
     1621 gtgatcaaac atctaacaga aagtaccaat cagaaggacg tgttgcttca gaaattcaat
     1681 gaaaaagatt tggaagtaat acagcagaac tgctatttaa tggctgcaga ggatcttgag
     1741 ctcaggagtg aaggcttaat aacagaaaag tgctcttctc aacagccacc aggcagcaaa
     1801 accatcttct ctaaggaaaa gaaacaatca tcagactatg aagagctgat tcaggtctta
     1861 aagaaagagc aggacatcta tacccatctg gtcaaatctc tgcaggaatc agacagtatc
     1921 aacaacctgc aggctgagtt aaacaagatt tttgccctgc ggaagcaact ggagcaggat
     1981 gtgctttcat atcagaattt gcggaagacc ttggaggagc agatcagcga aattcggagg
     2041 cgggaagaag aatcattttc actttatagt gatcaaacat cttatctaag tatttgcctt
     2101 gaagaaaaca atcggtttca agtggaacat ttttctcaag aagaacttaa gaaaaaggtc
     2161 agtgacctta tacagctagt gaaggagctg tatacagaca accagcacct gaagaaaacc
     2221 atttttgatc tctcctgcat gggtttccag ggaaatgggt ttccagatag acttgcgtct
     2281 acagaacaaa cagagcttct ggctagcaag gaggacgagg acacgatcaa aattggggag
     2341 gatgacgaga ttaatttcct gagtgaccag catttgcagc agagtaatga gattatgaaa
     2401 gacctttcca aaggaggctg caaaaatgga tacttaaggc acacggagtc taagatttca
     2461 gattgtgatg gggcccacgc acctggctgc ctagaagaag gtgcattcat aaacctgctt
     2521 gcccctttgt tcaatgagaa ggccacatta ttactggaat ccaggccaga ccttctgaaa
     2581 gtggtacggg aactgcttct gggacaacta ttcttgacag agcaggaagt ttctggagaa
     2641 caccttgatg gtaaaactga gaagacacct aagcaaaaag gtgaacttgt acattttgtc
     2701 caaaccaact cattttccaa gccacatgat gaactgaagt tgtcttgtga ggcccagcta
     2761 gtaaaggcag gcgaagtgcc caaggtagga ctgaaagatg cctcagtgca gactgtggcc
     2821 acggagggcg acctgctgag attcaagcat gaagcaacaa gagaggcttg ggaagagaaa
     2881 ccgatcaaca ctgcactcag cgcagagcat cggccagaga acctgcacgg ggtgcctggg
     2941 tggcaggctg ccctcctttc cctccctggt attaccaaca gagaggctaa gaagtcccgc
     3001 ttgccaatcc taataaaacc atcccggtca ttaggaaata tgtatcgtct ccctgccacc
     3061 caggaggtgg tgacgcagct gcagagccag atcttggagc tgcaggggga gctgaaggag
     3121 tttaaaactt gtaataagca acttcaccaa aagttaattc tggctgaagc agtgatggag
     3181 gggaggccaa cgcccgacaa aacgttgctg aatgctcagc cccctgtggg agcagcctac
     3241 caggacagcc caggagagca gaaaggaatt aaaaccacat cttctgtctg gagagacaag
     3301 gaaatggaca gtgatcagca aagaagctac gagattgact ctgagatttg cccacctgat
     3361 gaccttgcca gcttgccatc atgcaaagaa aatcctgaag atgttctgag cccaacttca
     3421 gtagctactt acctgagttc caagagtcag ccttctgcta aagtcagtgt gatggggact
     3481 gatcagtcag agagcattaa tacctcaaat gagacagaat acttaaaaca gaaaatccat
     3541 gacttggaaa ctgagctgga aggctaccag aatttcatat ttcagcttca aaagcactcc
     3601 cagtgcagtg aggccataat tacagttttg tgtgggacag aaggggccca ggatggcttg
     3661 agcaagccca agaatggttc tgatggggaa gaaatgacct tttcaagttt gcaccaagtg
     3721 cgatacgtga aacacgtgaa aatcctcggt ccgctggccc cagagatgat tgacagcagg
     3781 gtgctggaga acctcaaaca gcagctggag gaacaggaat acaagctgca gaaggagcag
     3841 aatttgaaca tgcaactttt cagtgagatc cataatctgc agaataagtt cagagatctc
     3901 tcacctccca gatacgattc attagttcag tcccaagcca gggagctctc ccttcaacgg
     3961 cagcagatta aggatggcca tggcatctgt gtcatctccc gtcaacacat gaacaccatg
     4021 attaaggcat ttgaggagtt gctgcaggcc agtgatgtgg attactgtgt ggccgagggt
     4081 ttccaggaac agctgaatca atgtgctgag ctgctggaga aattggaaaa gctatttctc
     4141 aacggaaaat cagttggagt ggaaatgaac acccagaatg aactgatgga gaggattgag
     4201 gaagacaact taacctacca acatcttctg cctgaatctc ctgagccttc agcctctcat
     4261 gcgctctctg attatgaaac atctgaaaag tccttcttct cacgagacca gaagcaagat
     4321 aatgagacag agaagacttc agttatggtg aacagttttt ctcaagactt actaatggaa
     4381 cacatacagg aaattcgaac tttgagaaag cgtttagaag aatctattaa aacaaatgag
     4441 aagctacgga aacagttgga acggcaagga tctgaatttg ttcaaggttc tacaagcatt
     4501 tttgcttctg gttcagagct tcatagttct ctaacatcag aaattcattt cttgaggaag
     4561 cagaaccagg ccctcaatgc aatgctcatt aaaggatcca gagataaaca gaaggagaat
     4621 gacaaattac gagagtccct ctccaggaag accgtgagcc tggagcacct tcagcgggag
     4681 tatgccagcg tgaaggaaga aaatgaaagg ctgcagaaag aaggcagcga gaaggagaga
     4741 cacaaccagc agctgatcca ggaggtccgc tgcagcggcc aggagctgag cagggtgcag
     4801 gaggaggtga agttgaggca gcagctgctc tcacagaatg acaagctatt gcagtctctc
     4861 cgagtggagc tgaaggcgta tgagaagctg gatgaagagc acaggagact gagagaggcg
     4921 tcgggagaag gctggaaggg gcaggatcct ttcagggacc tgcacagcct cctgatggag
     4981 atccaggctc tgcgcttgca actagaaagg agcatcgaaa ccagcagcac tctgcagagc
     5041 aggctcaagg aacagctggc aaggggggca gagaaggcac aggaaggagc cctcactctg
     5101 gctgtccaag ccgtgtccat ccctgaggtg ccccttcagc ctgacaaaca cgatggtgac
     5161 aaatatccca tggaaagtga taattcattt gatctgtttg attcctccca ggcagtgaca
     5221 ccaaaatcag tttcagagac tcctccactc tctgggaatg acacggactc cctctcctgc
     5281 gacagtggca gttcggcaac tagcactccg tgtgtgtccc gcctggtcac tggccaccac
     5341 ctgtgggcca gcaagaatgg ccgccatgtc ctgggcctga ttgaggacta tgaggccctg
     5401 ctcaaacaga tcagccaggg acagaggctc cttgctgaaa tggacattca aacccaagag
     5461 gctcccagct ccacaagtca agagctggga acaaagggtc cacacccagc accactgagc
     5521 aagtttgtga gcagtgtgag cacggccaag ctgaccctgg aagaggccta caggcggctg
     5581 aagcttctct ggagagtctc actccccgag gatggccagt gcccccttca ctgtgagcag
     5641 attggagaaa tgaaggcaga ggtcaccaaa ctacataaaa aattgtttga acaagaaaag
     5701 aagttgcaaa acaccatgaa gcttttgcag ctgagcaagc gccaggaaaa agtcatcttt
     5761 gatcaattgg tcgtaaccca caaaatcctt cggaaggcca gaggaaacct ggagcttagg
     5821 cctgggggag cccatccagg aacatgcagt cccagcagac caggctcctg agaagaactt
     5881 tcagccaata aagcttgtgc ttcccccacc gagctcacgc tgtctctttg ttccaagtgt
     5941 ggttcctatt tattgaggaa gaaagagctg tctggccaaa ggaaatctat tttttccctt
     6001 catgttttct ctctgaaagt tggcttgaga gttgttgtca gaaaggtgca ggtgctccac
     6061 aaacgggtgg taaaaaggcc tcgagctctt ggatgttgta tttcagatca ggggcaggca
     6121 ccggagttga ggctgtgcgc cttggtgggc ttcacgtctt cccctggatt tgcttagtac
     6181 tcagccagtg ccacagtttg aagattctca ttaaatgatt catttcattt ca
//
