LOCUS       NM_003936               2490 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens cyclin dependent kinase 5 regulatory subunit 2
            (CDK5R2), mRNA.
ACCESSION   NM_003936
VERSION     NM_003936.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2490)
  AUTHORS   Cheng,A., Wang,J., Li,J., Wang,J., Xu,M., Chen,H. and Zhang,P.
  TITLE     S-Nitrosylation of p39 promotes its degradation and contributes to
            synaptic dysfunction induced by beta-amyloid peptide
  JOURNAL   Commun Biol 7 (1), 1113 (2024)
   PUBMED   39256547
  REMARK    GeneRIF: S-Nitrosylation of p39 promotes its degradation and
            contributes to synaptic dysfunction induced by beta-amyloid
            peptide.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2490)
  AUTHORS   Perez-Morales,J., Mejias-Morales,D., Rivera-Rivera,S.,
            Gonzalez-Flores,J., Gonzalez-Loperena,M., Cordero-Baez,F.Y.,
            Pedreira-Garcia,W.M., Chardon-Colon,C., Caban-Rivera,J.,
            Cress,W.D., Gordian,E.R., Munoz-Antonia,T., Cabrera-Rios,M.,
            Isidro,A., Coppola,D., Rosa,M., Boyle,T.A., Izumi,V., Koomen,J.M.
            and Santiago-Cardona,P.G.
  TITLE     Hyper-phosphorylation of Rb S249 together with CDK5R2/p39
            overexpression are associated with impaired cell adhesion and
            epithelial-to-mesenchymal transition: Implications as a potential
            lung cancer grading and staging biomarker
  JOURNAL   PLoS One 13 (11), e0207483 (2018)
   PUBMED   30452490
  REMARK    GeneRIF: a biomarker consisting of the phosphorylation of the
            retinoblastoma protein (Rb) on serine 249 combined with elevated
            p39 expression. This biomarker correlates with
            epithelial-to-mesenchymal transition traits in non-small cell lung
            carcinoma (NSCLC) cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2490)
  AUTHORS   Tripathi,B.K., Lowy,D.R. and Zelenka,P.S.
  TITLE     The Cdk5 activator P39 specifically links muskelin to myosin II and
            regulates stress fiber formation and actin organization in lens
  JOURNAL   Exp Cell Res 330 (1), 186-198 (2015)
   PUBMED   25128817
  REMARK    GeneRIF: p39 is essential for recruiting scaffolding protein
            muskelin to stress fibers.
REFERENCE   4  (bases 1 to 2490)
  AUTHORS   Saito,T., Yano,M., Kawai,Y., Asada,A., Wada,M., Doi,H. and
            Hisanaga,S.I.
  TITLE     Structural basis for the different stability and activity between
            the Cdk5 complexes with p35 and p39 activators
  JOURNAL   J Biol Chem 288 (45), 32433-32439 (2013)
   PUBMED   24085300
  REMARK    GeneRIF: Structural basis for the different stability and activity
            between the Cdk5 complexes with p35 and p39 activators.
REFERENCE   5  (bases 1 to 2490)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   6  (bases 1 to 2490)
  AUTHORS   Agarwal-Mawal,A. and Paudel,H.K.
  TITLE     Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with
            protein phosphatase 1 and phosphorylates inhibitor-2
  JOURNAL   J Biol Chem 276 (26), 23712-23718 (2001)
   PUBMED   11320080
REFERENCE   7  (bases 1 to 2490)
  AUTHORS   Humbert,S., Lanier,L.M. and Tsai,L.H.
  TITLE     Synaptic localization of p39, a neuronal activator of cdk5
  JOURNAL   Neuroreport 11 (10), 2213-2216 (2000)
   PUBMED   10923673
REFERENCE   8  (bases 1 to 2490)
  AUTHORS   Humbert,S., Dhavan,R. and Tsai,L.
  TITLE     p39 activates cdk5 in neurons, and is associated with the actin
            cytoskeleton
  JOURNAL   J Cell Sci 113 (Pt 6), 975-983 (2000)
   PUBMED   10683146
REFERENCE   9  (bases 1 to 2490)
  AUTHORS   Muravenko,O.V., Gizatullin,R.Z., Protopopov,A.I., Kashuba,V.I.,
            Zabarovsky,E.R. and Zelenin,A.V.
  TITLE     Assignment of CDK5R2 coding for the cyclin-dependent kinase 5,
            regulatory subunit 2 (NCK5AI protein) to human chromosome band 2q35
            by fluorescent in situ hybridization
  JOURNAL   Cytogenet Cell Genet 89 (3-4), 160-161 (2000)
   PUBMED   10965112
REFERENCE   10 (bases 1 to 2490)
  AUTHORS   Tang,D., Yeung,J., Lee,K.Y., Matsushita,M., Matsui,H., Tomizawa,K.,
            Hatase,O. and Wang,J.H.
  TITLE     An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5)
            activator
  JOURNAL   J Biol Chem 270 (45), 26897-26903 (1995)
   PUBMED   7592934
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097468.3.
            
            On May 17, 2019 this sequence version replaced NM_003936.4.
            
            Summary: The protein encoded by this gene is a neuron-specific
            activator of CDK5 kinase. It associates with CDK5 to form an active
            kinase. This protein and neuron-specific CDK5 activator
            CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus
            may define a distinct family of cyclin-dependent kinase activating
            proteins. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC041771.1, U34051.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302625.6/ ENSP00000304250.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2490              AC097468.3         39304-41793
FEATURES             Location/Qualifiers
     source          1..2490
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..2490
                     /gene="CDK5R2"
                     /gene_synonym="NCK5AI; P39; p39nck5ai"
                     /note="cyclin dependent kinase 5 regulatory subunit 2"
                     /db_xref="GeneID:8941"
                     /db_xref="HGNC:HGNC:1776"
                     /db_xref="MIM:603764"
     exon            1..2490
                     /gene="CDK5R2"
                     /gene_synonym="NCK5AI; P39; p39nck5ai"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1259
                     /gene="CDK5R2"
                     /gene_synonym="NCK5AI; P39; p39nck5ai"
                     /note="CDK5 activator 2; p39I"
                     /codon_start=1
                     /product="cyclin-dependent kinase 5 activator 2"
                     /protein_id="NP_003927.1"
                     /db_xref="CCDS:CCDS2427.1"
                     /db_xref="GeneID:8941"
                     /db_xref="HGNC:HGNC:1776"
                     /db_xref="MIM:603764"
                     /translation="MGTVLSLSPASSAKGRRPGGLPEEKKKAPPAGDEALGGYGAPPV
                     GKGGKGESRLKRPSVLISALTWKRLVAASAKKKKGSKKVTPKPASTGPDPLVQQRNRE
                     NLLRKGRDPPDGGGTAKPLAVPVPTVPAAAATCEPPSGGSAAAQPPGSGGGKPPPPPP
                     PAPQVAPPVPGGSPRRVIVQASTGELLRCLGDFVCRRCYRLKELSPGELVGWFRGVDR
                     SLLLQGWQDQAFITPANLVFVYLLCRESLRGDELASAAELQAAFLTCLYLAYSYMGNE
                     ISYPLKPFLVEPDKERFWQRCLRLIQRLSPQMLRLNADPHFFTQVFQDLKNEGEAAAS
                     GGGPPSGGAPAASSAARDSCAAGTKHWTMNLDR"
     regulatory      2467..2472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK5R2"
                     /gene_synonym="NCK5AI; P39; p39nck5ai"
                     /note="hexamer: TATAAA"
     polyA_site      2490
                     /gene="CDK5R2"
                     /gene_synonym="NCK5AI; P39; p39nck5ai"
                     /note="major polyA site"
ORIGIN      
        1 agagcagcgg agccgcctag cagccacctt cccccgccag tccgcgcgcc cgggccgggg
       61 ctaggccccc caccgccggg tcccccgggg ctgcagtagc agcggcgccg cccgcggctc
      121 ccgctggggc ctgggcgccg gccccgctct gcaggatggg cacagtgctg tctctttcgc
      181 ctgcctcctc ggccaagggc cggaggcccg gcgggctgcc cgaggagaag aagaaggcgc
      241 cgcccgcggg ggacgaggcg ctggggggct acggggcgcc gccagtgggc aagggcggca
      301 aaggcgagag ccgactcaag cggccgtccg tgctcatctc ggcgctcacc tggaagcgcc
      361 tggtggccgc gtccgccaag aagaagaaag gcagcaagaa ggtgacaccc aagccggcat
      421 ccacgggccc cgaccccctg gtccagcaac gcaaccgcga gaaccttctc cgcaagggcc
      481 gggatccccc cgacggcggc ggcaccgcca agcccctggc ggtgccagtg cccaccgtgc
      541 ccgcggctgc cgccacctgc gagccaccgt cggggggcag cgcggccgct cagccgccgg
      601 gctcgggcgg gggaaagcct ccgccgccgc ctcccccagc cccgcaggtg gcgccgccgg
      661 tgcctggcgg ctcgccgcgg cgggtcatcg tgcaggcgtc caccggcgag ctgctgcgct
      721 gtctgggcga cttcgtgtgc cgacgctgct atcgcctcaa ggagctgagc ccgggcgagc
      781 tggtgggctg gttccgcggt gtggaccgct cgctgctgct gcagggctgg caagaccagg
      841 ccttcattac gcctgcaaac ctggtgttcg tgtacctgct gtgccgcgag tcgctgcgtg
      901 gggacgagct ggcgtcggcc gccgagctgc aggccgcctt cctcacctgc ctctacctcg
      961 cctactccta catgggcaac gagatctcct acccactcaa gcccttcctc gtggagcccg
     1021 acaaggagcg cttctggcag cgctgcctgc gcctcatcca gcggctcagc ccgcagatgc
     1081 tgcggctcaa cgccgacccc cacttcttca cgcaggtctt tcaagacctc aagaacgagg
     1141 gcgaggccgc cgccagcggc gggggcccac cgagcggggg cgcgcccgcc gcctcctcgg
     1201 ccgccaggga cagctgcgcg gccggaacca agcactggac tatgaacctg gaccgctagg
     1261 gatacccagg ggccgcgccc atcccccgcc ccagcccctg acacacactc ggaccccccg
     1321 ggaccacaaa gccaccgccg ctgttaccgc cgctcagcgc cccggctggg cggaggagga
     1381 gacgcccatg cccctcaggg gaaagtggag accgggacac cagaggccgc ggtgtttgga
     1441 tttgctgggc gtggagtggg gacggaagat gagcgcggga aaggcactcc aacctcactc
     1501 ttcccgtctg tctgcgcccc catttctcca tttctgccgg ggtctccccc ttcccttcag
     1561 cccattcccc ctcggtttta tccatttcct tgcctccttt ttgtgtcttc atttttcctc
     1621 ctgtctgcat tcctctctct ctctctccct ctctctcctg ttcctctctt tcttcctccc
     1681 tctccctgcc tttccatttt ccgttccttg ggtttgtgtg tctgcatctc catcttaccc
     1741 cttgcctgac tgtaccccgt agacccctgt ttctcctcct gcacctgtgt ccccatctgc
     1801 ccttcttgtt gctcctgtca tgtgtcacca tcttccctcc tgtctgcctt cttcctccac
     1861 ttgtgtcagc ttgcattttt ttattcctga ctgagtcacc acacccctct cccctgatca
     1921 aagggaatat tagtttttaa tttggatcga ctgaggtgcc aggagaaact gcagtcccag
     1981 gtatccagac agccaccagg atggtccctc gccccacccc caccgcctct ccccaccttt
     2041 tccaacgtgt tgcatgctgg gagctggggg gtgtggggga aggggctgcc ggcttctttc
     2101 aggaggctga ggtttggagg caaaatcaac ctgggagacc accccggccg cggcgcctca
     2161 gtggacaggt gggaggaaaa gaaaacttct taccttggag gagggacatc ccgcttcctt
     2221 atccttagct tttttgttgc tcctccccac tgcccctttt aatttatttg gttgtttgcg
     2281 gagggagggg ggaggggggt aggctgggcc gggaactgtc cgaggtgctg agctggggcg
     2341 ggaccggaat cctcccggta gggtaccagg gactgagttg ggcctggggc cgtgtccaag
     2401 gtgccaatga tgcgggccga cagagcgggc cgcactgtct gtctgtccgt ctgtcccgga
     2461 aagaactata aagcgctgga agcgcctgca
//
