LOCUS       NM_003885               3948 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cyclin dependent kinase 5 regulatory subunit 1
            (CDK5R1), mRNA.
ACCESSION   NM_003885
VERSION     NM_003885.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3948)
  AUTHORS   Kawano,M., Tanaka,K., Itonaga,I., Iwasaki,T., Kubota,Y. and
            Tsumura,H.
  TITLE     Tumor-suppressive microRNA-152 inhibits the proliferation of
            Ewing's sarcoma cells by targeting CDK5R1
  JOURNAL   Sci Rep 13 (1), 18546 (2023)
   PUBMED   37899376
  REMARK    GeneRIF: Tumor-suppressive microRNA-152 inhibits the proliferation
            of Ewing's sarcoma cells by targeting CDK5R1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3948)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3948)
  AUTHORS   Zeng,Z., Cao,Z., Zhang,E., Huang,H. and Tang,Y.
  TITLE     Elevated CDK5R1 predicts worse prognosis in hepatocellular
            carcinoma based on TCGA data
  JOURNAL   Biosci Rep 41 (1) (2021)
   PUBMED   33346796
  REMARK    GeneRIF: Elevated CDK5R1 predicts worse prognosis in hepatocellular
            carcinoma based on TCGA data.
REFERENCE   4  (bases 1 to 3948)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3948)
  AUTHORS   Man,A., Slevin,M., Petcu,E. and Fraefel,C.
  TITLE     The Cyclin-Dependent Kinase 5 Inhibitor Peptide Inhibits Herpes
            Simplex Virus Type 1 Replication
  JOURNAL   Sci Rep 9 (1), 1260 (2019)
   PUBMED   30718749
  REMARK    GeneRIF: The Cyclin-Dependent Kinase 5 Inhibitor Peptide Inhibits
            Herpes Simplex Virus Type 1 Replication.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3948)
  AUTHORS   Fletcher,A.I., Shuang,R., Giovannucci,D.R., Zhang,L., Bittner,M.A.
            and Stuenkel,E.L.
  TITLE     Regulation of exocytosis by cyclin-dependent kinase 5 via
            phosphorylation of Munc18
  JOURNAL   J Biol Chem 274 (7), 4027-4035 (1999)
   PUBMED   9933594
REFERENCE   7  (bases 1 to 3948)
  AUTHORS   Chae,T., Kwon,Y.T., Bronson,R., Dikkes,P., Li,E. and Tsai,L.H.
  TITLE     Mice lacking p35, a neuronal specific activator of Cdk5, display
            cortical lamination defects, seizures, and adult lethality
  JOURNAL   Neuron 18 (1), 29-42 (1997)
   PUBMED   9010203
  REMARK    GeneRIF: Performed functional studies in mouse.
REFERENCE   8  (bases 1 to 3948)
  AUTHORS   Tang,D., Yeung,J., Lee,K.Y., Matsushita,M., Matsui,H., Tomizawa,K.,
            Hatase,O. and Wang,J.H.
  TITLE     An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5)
            activator
  JOURNAL   J Biol Chem 270 (45), 26897-26903 (1995)
   PUBMED   7592934
REFERENCE   9  (bases 1 to 3948)
  AUTHORS   Takahashi,M., Tomizawa,K., Sato,K., Ohtake,A. and Omori,A.
  TITLE     A novel tau-tubulin kinase from bovine brain
  JOURNAL   FEBS Lett 372 (1), 59-64 (1995)
   PUBMED   7556643
REFERENCE   10 (bases 1 to 3948)
  AUTHORS   Tsai,L.H., Delalle,I., Caviness,V.S. Jr., Chae,T. and Harlow,E.
  TITLE     p35 is a neural-specific regulatory subunit of cyclin-dependent
            kinase 5
  JOURNAL   Nature 371 (6496), 419-423 (1994)
   PUBMED   8090221
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079336.5.
            
            On Nov 26, 2018 this sequence version replaced NM_003885.2.
            
            Summary: The protein encoded by this gene (p35) is a
            neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the
            activation of CDK5 is required for proper development of the
            central nervous system. The p35 form of this protein is
            proteolytically cleaved by calpain, generating a p25 form. The
            cleavage of p35 into p25 results in relocalization of the protein
            from the cell periphery to nuclear and perinuclear regions. P25
            deregulates CDK5 activity by prolonging its activation and changing
            its cellular location. The p25 form accumulates in the brain
            neurons of patients with Alzheimer's disease. This accumulation
            correlates with an increase in CDK5 kinase activity, and may lead
            to aberrantly phosphorylated forms of the microtubule-associated
            protein tau, which contributes to Alzheimer's disease. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030792.1, SRR1660805.215685.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145774, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313401.4/ ENSP00000318486.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               AC079336.5         65018-65187
            171-3948            AC079336.5         65501-69278
FEATURES             Location/Qualifiers
     source          1..3948
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..3948
                     /gene="CDK5R1"
                     /gene_synonym="CDK5P35; CDK5R; NCK5A; p23; p25; p35;
                     p35nck5a"
                     /note="cyclin dependent kinase 5 regulatory subunit 1"
                     /db_xref="GeneID:8851"
                     /db_xref="HGNC:HGNC:1775"
                     /db_xref="MIM:603460"
     exon            1..170
                     /gene="CDK5R1"
                     /gene_synonym="CDK5P35; CDK5R; NCK5A; p23; p25; p35;
                     p35nck5a"
                     /inference="alignment:Splign:2.1.0"
     exon            171..3948
                     /gene="CDK5R1"
                     /gene_synonym="CDK5P35; CDK5R; NCK5A; p23; p25; p35;
                     p35nck5a"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..1239
                     /gene="CDK5R1"
                     /gene_synonym="CDK5P35; CDK5R; NCK5A; p23; p25; p35;
                     p35nck5a"
                     /note="TPKII regulatory subunit; regulatory partner for
                     CDK5 kinase; CDK5 activator 1; tau protein kinase II 23kDa
                     subunit; neuronal CDK5 activator"
                     /codon_start=1
                     /product="cyclin-dependent kinase 5 activator 1"
                     /protein_id="NP_003876.1"
                     /db_xref="CCDS:CCDS11273.1"
                     /db_xref="GeneID:8851"
                     /db_xref="HGNC:HGNC:1775"
                     /db_xref="MIM:603460"
                     /translation="MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRH
                     SIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPP
                     PAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLC
                     RRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGS
                     DHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQIN
                     ADPHYFTQVFSDLKNESGQEDKKRLLLGLDR"
     regulatory      3927..3932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK5R1"
                     /gene_synonym="CDK5P35; CDK5R; NCK5A; p23; p25; p35;
                     p35nck5a"
                     /note="hexamer: AATAAA"
     polyA_site      3948
                     /gene="CDK5R1"
                     /gene_synonym="CDK5P35; CDK5R; NCK5A; p23; p25; p35;
                     p35nck5a"
                     /note="major polyA site"
ORIGIN      
        1 agaagctccc tagctgccgc cgccgccgcc gccgccgtcg ccgccgccga gcgcgagccc
       61 agccgatccc cgccgagcgc ccccgagcgc cgccgagcgc cgggaccgcg gcggcggggc
      121 cgcggcgcgc attgcggagg gcgcggagcg caggagctgc cgcctgccgg gcagatccaa
      181 gggggcagca cgcttcccgg gagcgccccc gcctcctctc cggggccgcc gcaggctcgg
      241 tgagcggttt tatccctccg gccggcaggc tgggcgcgca ggggcgcgag cccccgcccg
      301 gcgcgcagca gcaccatggg cacggtgctg tccctgtctc ccagctaccg gaaggccacg
      361 ctgtttgagg atggcgcggc caccgtgggc cactatacgg ccgtacagaa cagcaagaac
      421 gccaaggaca agaacctgaa gcgccactcc atcatctccg tgctgccttg gaagagaatc
      481 gtggccgtgt cggccaagaa gaagaactcc aagaaggtgc agcccaacag cagctaccag
      541 aacaacatca cgcacctcaa caatgagaac ctgaagaagt cgctgtcgtg cgccaacctg
      601 tccacattcg cccagccccc accggcccag ccgcctgcac ccccggccag ccagctctcg
      661 ggttcccaga ccgggggctc ctcctcagtc aagaaagccc ctcaccctgc cgtcacctcc
      721 gcagggacgc ccaaacgggt catcgtccag gcgtccacca gtgagctgct tcgctgcctg
      781 ggtgagtttc tctgccgccg gtgctaccgc ctgaagcacc tgtcccccac ggaccccgtg
      841 ctctggctgc gcagcgtgga ccgctcgctg cttctgcagg gctggcagga ccagggcttc
      901 atcacgccgg ccaacgtggt cttcctctac atgctctgca gggatgttat ctcctccgag
      961 gtgggctcgg atcacgagct ccaggccgtc ctgctgacat gcctgtacct ctcctactcc
     1021 tacatgggca acgagatctc ctacccgctc aagcccttcc tggtggagag ctgcaaggag
     1081 gccttttggg accgttgcct ctctgtcatc aacctcatga gctcaaagat gctgcagata
     1141 aatgccgacc cacactactt cacacaggtc ttctccgacc tgaagaacga gagcggccag
     1201 gaggacaaga agcggctcct cctaggcctg gatcggtgag cactgtagcc tgcgtcatgg
     1261 ctcaaggatt caatgcattt ttaagaattt attattaaat cagttttgtg tacagtatgt
     1321 gtctagcaaa gccaccaagg gcctcacctt tcccacagtc tctccctggg gtttttttca
     1381 tccctgccaa gaactctggg cacttttgaa ctcacgagcc ttgcgcaaaa cccagaagat
     1441 gtattcagag ccacccaggc cactgacctc ccactttggg gaactcaaag gactgacctg
     1501 cccctgccgc ctgtgccctt gctgggtcca gggtaggcaa ggctgccggc tgcaccctgt
     1561 atggagctag agaggggcct ctggctgcct ggcccaggga ggaattgggg tttctggttg
     1621 gaggcccttt tctggctcct gtgtggagtt attcactctc ccagaggctc ctggagccag
     1681 ccaccctaac tgagctgcca gtggggtcgt gaggcaagat ccccgccacc cggggacatc
     1741 ttcaatctag gcgaggcgaa gctgagcggg tctagtggaa agattgtgtc tggtcgtttg
     1801 accacacacc gccctgattt gctgttttct ttttttaggg agaagggctt ttctttagtg
     1861 gagaaatgga actcgccccc ctaccccctt gtctgctgct cccagccacg ttggtggtat
     1921 tggccgatga gctggtttga ctcattaatt tctctcaatt tgggtcccag ctaaagaggt
     1981 ggggtgaagc tggggacagc tttcctgggt gagtttttct tttgaataat gtagtgcagt
     2041 caccctgtgg caaatgccag gacagctgca ggtgcccatt agcaacgcct gccttctggg
     2101 caaggtgagg gatgccatac cttgagacca agccggtgcc cacctaaggg ctaaggcctc
     2161 ttgctggtgc acatgacatt tgtcctgcag agctgggggg aaggcgatgt ggtgacccca
     2221 cccccacccg ttaatttaaa gctgtttcta aacagttgag tttcttctaa agaggaagcc
     2281 ttgcccagca aggaccagtg agacagccgg atcttggaga caattacaag acggggagtg
     2341 agactcctga ttgctctgga agcctgctga tttctacaac tgatcatttg cagctgctgg
     2401 ttttggtttc caccttaccc tactggctgt aaaaacacaa atgtgtactt tattgatttt
     2461 ctttctaatt ctcccgcatt ggtggcttgg gacttgggag agggagcaag ccttcctcca
     2521 tggcccatca ctcggctgtg gagaacaaag accaatgtga agacactaca gaggattctg
     2581 tcttccaggc ccagtccact ggggagtgct ggaatgggga cctggggtgg ggaggcagag
     2641 ggtcacttta cataggatta agttcgaggt ggctaccgat ttcagcacat gcactactga
     2701 aatttacaca aaaagaaagc tgtgaaattg aagtcccaat ttaagagtcc tgaggcagaa
     2761 cctggtggct ggaggcattc ccagaggtgg ggaagagagc ctgcccggcc ggagaacatc
     2821 tgccttgctg cacctgaggc ccagcagagc cgttcctggg actgtcagat aatcggtgca
     2881 gcggtggaag gagcctgcgg ctgctggcac agacttcaca cagcacctcc tctctgctgg
     2941 gtttccacac agcctgtctt cagatcctgc tgccgcgtgc gaccagaggt gggaggcccc
     3001 tggtggcatg gaagagggag ggtcagtgcc aagtctcagg aggagggcgc atgtgtgtat
     3061 caccctcagc tggcggaacc tggctgcgaa ctgtgcagtt acgttgcatc cacaggattc
     3121 cagttgcgtg tctgtttcct tctctttctc cgtatttatt tttttattct tcggaggagg
     3181 tggacatttc ggaagtggtg gggactaagg gaagaactct ctagttccct cagtgtgaag
     3241 cctgtcgtgt tctctcccct tgcactggtc atcagtattg tgtaaaggaa caactgatat
     3301 acttgagtgt gcaagcaaag aacccatttg ccatgctgct atgaagacta cttttagatc
     3361 aacaataaaa aaaaacctac aaaaaaacct ttattcttta attgttgctt ttacggtgat
     3421 attgtgcatg caaaccagga gcattttgtg tcttaagaaa aataatctta gaacagatgg
     3481 ctgtgaaaat tacacccatg cacagaacaa gccacaggaa taatagttca ggatttggtt
     3541 tttctctttt tcttgtaaac ctggagggtt gatatattct ttccatgcag ttattagaac
     3601 ttagttttgt tccaacagtt aaacttgcaa tgaaaagaaa atgtgccatt tttttcactc
     3661 agaattattc atagctgtat atttgaaact gctaattaca cacgtgtgat gtatgttggt
     3721 tttttagtgc aatttcttct gtagctattc tttgaccaaa ctgtgggtat tgttaatatt
     3781 aatttatatt tgtctcattt tgtatgtatg tgtagtgtgt ttgtgagtat gtgtggttta
     3841 taatctgaca aagtcatgaa gctcagtttg gctgtaattt aattcccctt cccttatttt
     3901 tatttatttt tgtactgtgc tgattcaata aaatgcactg accatcca
//
