LOCUS       NM_004935               1122 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens cyclin dependent kinase 5 (CDK5), transcript variant
            1, mRNA.
ACCESSION   NM_004935
VERSION     NM_004935.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1122)
  AUTHORS   Zheng,X.F., Sarkar,A., Lotana,H., Syed,A., Nguyen,H., Ivey,R.G.,
            Kennedy,J.J., Whiteaker,J.R., Tomasik,B., Huang,K., Li,F.,
            D'Andrea,A.D., Paulovich,A.G., Shah,K., Spektor,A. and Chowdhury,D.
  TITLE     CDK5-cyclin B1 regulates mitotic fidelity
  JOURNAL   Nature 633 (8031), 932-940 (2024)
   PUBMED   39232161
  REMARK    GeneRIF: CDK5-cyclin B1 regulates mitotic fidelity.
REFERENCE   2  (bases 1 to 1122)
  AUTHORS   Zhang,Y., Xia,S., Tian,X., Yuan,L., Gao,Y., Liu,D., Qi,H., Wang,S.,
            Liu,Z., Li,Y., Zhao,Z. and Liu,W.
  TITLE     miR-4645-3p attenuates podocyte injury and mitochondrial
            dysfunction in diabetic kidney disease by targeting Cdk5
  JOURNAL   FASEB J 38 (10), e23668 (2024)
   PUBMED   38742811
  REMARK    GeneRIF: miR-4645-3p attenuates podocyte injury and mitochondrial
            dysfunction in diabetic kidney disease by targeting Cdk5.
REFERENCE   3  (bases 1 to 1122)
  AUTHORS   Magen,D., Ofir,A., Berger,L., Goldsher,D., Eran,A., Katib,N.,
            Nijem,Y., Vlodavsky,E., Tzur,S., Behar,D.M., Fellig,Y. and
            Mandel,H.
  TITLE     Autosomal recessive lissencephaly with cerebellar hypoplasia is
            associated with a loss-of-function mutation in CDK5
  JOURNAL   Hum Genet 134 (3), 305-314 (2015)
   PUBMED   25560765
  REMARK    GeneRIF: A loss-of-function of the mutant CDK5 gene product is
            associated with lissencephaly with cerebellar hypoplasia.
            Erratum:[Hum Genet. 2015 Mar;134(3):315. doi:
            10.1007/s00439-015-1530-0.. Katib, Nassser [corrected to Katib,
            Nasser]; Zur, Shay [corrected to Tzur, Shay]. PMID: 25609191]
REFERENCE   4  (bases 1 to 1122)
  AUTHORS   Saito,T., Yano,M., Kawai,Y., Asada,A., Wada,M., Doi,H. and
            Hisanaga,S.I.
  TITLE     Structural basis for the different stability and activity between
            the Cdk5 complexes with p35 and p39 activators
  JOURNAL   J Biol Chem 288 (45), 32433-32439 (2013)
   PUBMED   24085300
  REMARK    GeneRIF: Structural basis for the different stability and activity
            between the Cdk5 complexes with p35 and p39 activators.
REFERENCE   5  (bases 1 to 1122)
  AUTHORS   Pozo,K., Castro-Rivera,E., Tan,C., Plattner,F., Schwach,G.,
            Siegl,V., Meyer,D., Guo,A., Gundara,J., Mettlach,G., Richer,E.,
            Guevara,J.A., Ning,L., Gupta,A., Hao,G., Tsai,L.H., Sun,X.,
            Antich,P., Sidhu,S., Robinson,B.G., Chen,H., Nwariaku,F.E.,
            Pfragner,R., Richardson,J.A. and Bibb,J.A.
  TITLE     The role of Cdk5 in neuroendocrine thyroid cancer
  JOURNAL   Cancer Cell 24 (4), 499-511 (2013)
   PUBMED   24135281
  REMARK    GeneRIF: Cdk5 signaling via Rb is critical to medullary thyroid
            carcinoma tumorigenesis and progression
REFERENCE   6  (bases 1 to 1122)
  AUTHORS   Li,Q., Liu,X., Zhang,M., Ye,G., Qiao,Q., Ling,Y., Wu,Y., Zhang,Y.
            and Yu,L.
  TITLE     Characterization of a novel human CDK5 splicing variant that
            inhibits Wnt/beta-catenin signaling
  JOURNAL   Mol Biol Rep 37 (5), 2415-2421 (2010)
   PUBMED   19693690
  REMARK    GeneRIF: CDK5-splicing variant might also be a negative regulator
            of Wnt/beta-catenin signaling pathway.
REFERENCE   7  (bases 1 to 1122)
  AUTHORS   Tarricone,C., Dhavan,R., Peng,J., Areces,L.B., Tsai,L.H. and
            Musacchio,A.
  TITLE     Structure and regulation of the CDK5-p25(nck5a) complex
  JOURNAL   Mol Cell 8 (3), 657-669 (2001)
   PUBMED   11583627
REFERENCE   8  (bases 1 to 1122)
  AUTHORS   Patrick,G.N., Zukerberg,L., Nikolic,M., de la Monte,S., Dikkes,P.
            and Tsai,L.H.
  TITLE     Conversion of p35 to p25 deregulates Cdk5 activity and promotes
            neurodegeneration
  JOURNAL   Nature 402 (6762), 615-622 (1999)
   PUBMED   10604467
REFERENCE   9  (bases 1 to 1122)
  AUTHORS   Goedert,M., Cohen,E.S., Jakes,R. and Cohen,P.
  TITLE     p42 MAP kinase phosphorylation sites in microtubule-associated
            protein tau are dephosphorylated by protein phosphatase 2A1.
            Implications for Alzheimer's disease [corrected]
  JOURNAL   FEBS Lett 312 (1), 95-99 (1992)
   PUBMED   1330687
  REMARK    Erratum:[FEBS Lett 1992 Nov 23;313(2):203]
REFERENCE   10 (bases 1 to 1122)
  AUTHORS   Meyerson,M., Enders,G.H., Wu,C.L., Su,L.K., Gorka,C., Nelson,C.,
            Harlow,E. and Tsai,L.H.
  TITLE     A family of human cdc2-related protein kinases
  JOURNAL   EMBO J 11 (8), 2909-2917 (1992)
   PUBMED   1639063
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP309068.1, BC005115.1,
            AK026533.1 and CA429180.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004935.3.
            
            Summary: This gene encodes a proline-directed serine/threonine
            kinase that is a member of the cyclin-dependent kinase family of
            proteins. Unlike other members of the family, the protein encoded
            by this gene does not directly control cell cycle regulation.
            Instead the protein, which is predominantly expressed at high
            levels in mammalian postmitotic central nervous system neurons,
            functions in diverse processes such as synaptic plasticity and
            neuronal migration through phosphorylation of proteins required for
            cytoskeletal organization, endocytosis and exocytosis, and
            apoptosis. In humans, an allelic variant of the gene that results
            in undetectable levels of the protein has been associated with
            lethal autosomal recessive lissencephaly-7. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, May
            2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026533.1, GQ900934.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000485972.6/ ENSP00000419782.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BP309068.1         49-72
            25-1043             BC005115.1         1-1019
            1044-1044           AK026533.1         1033-1033
            1045-1122           CA429180.1         22-99               c
FEATURES             Location/Qualifiers
     source          1..1122
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..1122
                     /gene="CDK5"
                     /gene_synonym="LIS7; PSSALRE"
                     /note="cyclin dependent kinase 5"
                     /db_xref="GeneID:1020"
                     /db_xref="HGNC:HGNC:1774"
                     /db_xref="MIM:123831"
     exon            1..86
                     /gene="CDK5"
                     /gene_synonym="LIS7; PSSALRE"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..928
                     /gene="CDK5"
                     /gene_synonym="LIS7; PSSALRE"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     division protein kinase 5; protein kinase CDK5 splicing;
                     cyclin-dependent-like kinase 5; TPKII catalytic subunit;
                     serine/threonine-protein kinase PSSALRE; tau protein
                     kinase II catalytic subunit; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="cyclin-dependent kinase 5 isoform 1"
                     /protein_id="NP_004926.1"
                     /db_xref="CCDS:CCDS47748.1"
                     /db_xref="GeneID:1020"
                     /db_xref="HGNC:HGNC:1774"
                     /db_xref="MIM:123831"
                     /translation="MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGV
                     PSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEI
                     VKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSA
                     EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRL
                     LGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS
                     AEEALQHPYFSDFCPP"
     exon            87..175
                     /gene="CDK5"
                     /gene_synonym="LIS7; PSSALRE"
                     /inference="alignment:Splign:2.1.0"
     exon            176..243
                     /gene="CDK5"
                     /gene_synonym="LIS7; PSSALRE"
                     /inference="alignment:Splign:2.1.0"
     exon            244..304
                     /gene="CDK5"
                     /gene_synonym="LIS7; PSSALRE"
                     /inference="alignment:Splign:2.1.0"
     exon            305..361
                     /gene="CDK5"
                     /gene_synonym="LIS7; PSSALRE"
                     /inference="alignment:Splign:2.1.0"
     exon            362..457
                     /gene="CDK5"
                     /gene_synonym="LIS7; PSSALRE"
                     /inference="alignment:Splign:2.1.0"
     exon            458..532
                     /gene="CDK5"
                     /gene_synonym="LIS7; PSSALRE"
                     /inference="alignment:Splign:2.1.0"
     exon            533..629
                     /gene="CDK5"
                     /gene_synonym="LIS7; PSSALRE"
                     /inference="alignment:Splign:2.1.0"
     exon            630..699
                     /gene="CDK5"
                     /gene_synonym="LIS7; PSSALRE"
                     /inference="alignment:Splign:2.1.0"
     exon            700..760
                     /gene="CDK5"
                     /gene_synonym="LIS7; PSSALRE"
                     /inference="alignment:Splign:2.1.0"
     exon            761..841
                     /gene="CDK5"
                     /gene_synonym="LIS7; PSSALRE"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1122
                     /gene="CDK5"
                     /gene_synonym="LIS7; PSSALRE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1100..1105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK5"
                     /gene_synonym="LIS7; PSSALRE"
                     /note="hexamer: CATAAA"
     polyA_site      1122
                     /gene="CDK5"
                     /gene_synonym="LIS7; PSSALRE"
                     /note="major polyA site"
ORIGIN      
        1 gccagagtct taaaaccgag ggcccgcagg ggtccccgcg gccgccgcga tgcagaaata
       61 cgagaaactg gaaaagattg gggaaggcac ctacggaact gtgttcaagg ccaaaaaccg
      121 ggagactcat gagatcgtgg ctctgaaacg ggtgaggctg gatgacgatg atgagggtgt
      181 gccgagttcc gccctccggg agatctgcct actcaaggag ctgaagcaca agaacatcgt
      241 caggcttcat gacgtcctgc acagcgacaa gaagctgact ttggtttttg aattctgtga
      301 ccaggacctg aagaagtatt ttgacagttg caatggtgac ctcgatcctg agattgtaaa
      361 gtcattcctc ttccagctac taaaagggct gggattctgt catagccgca atgtgctaca
      421 cagggacctg aagccccaga acctgctaat aaacaggaat ggggagctga aattggctga
      481 ttttggcctg gctcgagcct ttgggattcc cgtccgctgt tactcagctg aggtggtcac
      541 actgtggtac cgcccaccgg atgtcctctt tggggccaag ctgtactcca cgtccatcga
      601 catgtggtca gccggctgca tctttgcaga gctggccaat gctgggcggc ctctttttcc
      661 cggcaatgat gtcgatgacc agttgaagag gatcttccga ctgctgggga cgcccaccga
      721 ggagcagtgg ccctctatga ccaagctgcc agactataag ccctatccga tgtacccggc
      781 cacaacatcc ctggtgaacg tcgtgcccaa actcaatgcc acagggaggg atctgctgca
      841 gaaccttctg aagtgtaacc ctgtccagcg tatctcagca gaagaggccc tgcagcaccc
      901 ctacttctcc gacttctgtc cgccctaggc cccgggaccc ccggcctcca ggctggggcc
      961 tggcctattt aagccccctc ttgagagggg tgagacagtg ggggtgcctg gtgcgctgtg
     1021 ctccagcagt gctgggccca gccggggtgg ggtgcctgag cccgaatttc tcactccctt
     1081 tgtggacttt atttaatttc ataaattggc tcctttccca ca
//
