LOCUS       NM_001798               2240 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens cyclin dependent kinase 2 (CDK2), transcript variant
            1, mRNA.
ACCESSION   NM_001798
VERSION     NM_001798.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2240)
  AUTHORS   Zakaria,M.F., Kato,H., Sonoda,S., Kato,K., Uehara,N.,
            Kyumoto-Nakamura,Y., Sharifa,M.M., Yu,L., Dai,L., Yamaza,H.,
            Kajioka,S., Nishimura,F. and Yamaza,T.
  TITLE     NaV1.1 contributes to the cell cycle of human mesenchymal stem
            cells by regulating AKT and CDK2
  JOURNAL   J Cell Sci 137 (19) (2024)
   PUBMED   39258309
  REMARK    GeneRIF: NaV1.1 contributes to the cell cycle of human mesenchymal
            stem cells by regulating AKT and CDK2.
REFERENCE   2  (bases 1 to 2240)
  AUTHORS   Ji,Q., Ma,F., Zhang,X., Liu,Y., Wang,P. and Li,M.
  TITLE     Hsa_circ_0005320 affects cell proliferation and the cell cycle via
            the IGF2BP3/CDK2 axis in bladder cancer
  JOURNAL   Cell Signal 119, 111154 (2024)
   PUBMED   38565412
  REMARK    GeneRIF: Hsa_circ_0005320 affects cell proliferation and the cell
            cycle via the IGF2BP3/CDK2 axis in bladder cancer.
REFERENCE   3  (bases 1 to 2240)
  AUTHORS   Wang,K., Gong,Z., Chen,Y., Zhang,M., Wang,S., Yao,S., Liu,Z.,
            Huang,Z. and Fei,B.
  TITLE     KDM4C-mediated senescence defense is a targetable vulnerability in
            gastric cancer harboring TP53 mutations
  JOURNAL   Clin Epigenetics 15 (1), 163 (2023)
   PUBMED   37848946
  REMARK    GeneRIF: KDM4C-mediated senescence defense is a targetable
            vulnerability in gastric cancer harboring TP53 mutations.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2240)
  AUTHORS   Malumbres,M. and Barbacid,M.
  TITLE     Cell cycle, CDKs and cancer: a changing paradigm
  JOURNAL   Nat Rev Cancer 9 (3), 153-166 (2009)
   PUBMED   19238148
  REMARK    Review article
REFERENCE   5  (bases 1 to 2240)
  AUTHORS   Shiffman,D., Brooks,E.E., Brooks,A.R., Chan,C.S. and Milner,P.G.
  TITLE     Characterization of the human cyclin-dependent kinase 2 gene.
            Promoter analysis and gene structure
  JOURNAL   J Biol Chem 271 (21), 12199-12204 (1996)
   PUBMED   8647814
REFERENCE   6  (bases 1 to 2240)
  AUTHORS   Koff,A., Giordano,A., Desai,D., Yamashita,K., Harper,J.W.,
            Elledge,S., Nishimoto,T., Morgan,D.O., Franza,B.R. and Roberts,J.M.
  TITLE     Formation and activation of a cyclin E-cdk2 complex during the G1
            phase of the human cell cycle
  JOURNAL   Science 257 (5077), 1689-1694 (1992)
   PUBMED   1388288
REFERENCE   7  (bases 1 to 2240)
  AUTHORS   Pagano,M., Pepperkok,R., Verde,F., Ansorge,W. and Draetta,G.
  TITLE     Cyclin A is required at two points in the human cell cycle
  JOURNAL   EMBO J 11 (3), 961-971 (1992)
   PUBMED   1312467
REFERENCE   8  (bases 1 to 2240)
  AUTHORS   Ninomiya-Tsuji,J., Nomoto,S., Yasuda,H., Reed,S.I. and Matsumoto,K.
  TITLE     Cloning of a human cDNA encoding a CDC2-related kinase by
            complementation of a budding yeast cdc28 mutation
  JOURNAL   Proc Natl Acad Sci U S A 88 (20), 9006-9010 (1991)
   PUBMED   1717994
REFERENCE   9  (bases 1 to 2240)
  AUTHORS   Tsai,L.H., Harlow,E. and Meyerson,M.
  TITLE     Isolation of the human cdk2 gene that encodes the cyclin A- and
            adenovirus E1A-associated p33 kinase
  JOURNAL   Nature 353 (6340), 174-177 (1991)
   PUBMED   1653904
REFERENCE   10 (bases 1 to 2240)
  AUTHORS   Elledge,S.J. and Spottswood,M.R.
  TITLE     A new human p34 protein kinase, CDK2, identified by complementation
            of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of
            Xenopus Eg1
  JOURNAL   EMBO J 10 (9), 2653-2659 (1991)
   PUBMED   1714386
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA814453.1, AK291941.1,
            BC003065.2 and AA789250.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001798.4.
            
            Summary: This gene encodes a member of a family of serine/threonine
            protein kinases that participate in cell cycle regulation. The
            encoded protein is the catalytic subunit of the cyclin-dependent
            protein kinase complex, which regulates progression through the
            cell cycle. Activity of this protein is especially critical during
            the G1 to S phase transition. This protein associates with and
            regulated by other subunits of the complex including cyclin A or E,
            CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Mar 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.367753.1,
                                           SRR1163658.467306.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266970.9/ ENSP00000266970.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DA814453.1         62-62
            2-1468              AK291941.1         2-1468
            1469-2054           BC003065.2         1450-2035
            2055-2240           AA789250.1         3-188               c
FEATURES             Location/Qualifiers
     source          1..2240
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.2"
     gene            1..2240
                     /gene="CDK2"
                     /gene_synonym="CDKN2; p33(CDK2)"
                     /note="cyclin dependent kinase 2"
                     /db_xref="GeneID:1017"
                     /db_xref="HGNC:HGNC:1771"
                     /db_xref="MIM:116953"
     exon            1..295
                     /gene="CDK2"
                     /gene_synonym="CDKN2; p33(CDK2)"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1076
                     /gene="CDK2"
                     /gene_synonym="CDKN2; p33(CDK2)"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cdc2-related protein kinase; p33 protein kinase; cell
                     division protein kinase 2"
                     /codon_start=1
                     /product="cyclin-dependent kinase 2 isoform 1"
                     /protein_id="NP_001789.2"
                     /db_xref="CCDS:CCDS8898.1"
                     /db_xref="GeneID:1017"
                     /db_xref="HGNC:HGNC:1771"
                     /db_xref="MIM:116953"
                     /translation="MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGV
                     PSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLP
                     LIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT
                     HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRT
                     LGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS
                     AKAALAHPFFQDVTKPVPHLRL"
     exon            296..373
                     /gene="CDK2"
                     /gene_synonym="CDKN2; p33(CDK2)"
                     /inference="alignment:Splign:2.1.0"
     exon            374..494
                     /gene="CDK2"
                     /gene_synonym="CDKN2; p33(CDK2)"
                     /inference="alignment:Splign:2.1.0"
     exon            495..665
                     /gene="CDK2"
                     /gene_synonym="CDKN2; p33(CDK2)"
                     /inference="alignment:Splign:2.1.0"
     exon            666..767
                     /gene="CDK2"
                     /gene_synonym="CDKN2; p33(CDK2)"
                     /inference="alignment:Splign:2.1.0"
     exon            768..971
                     /gene="CDK2"
                     /gene_synonym="CDKN2; p33(CDK2)"
                     /inference="alignment:Splign:2.1.0"
     exon            972..2240
                     /gene="CDK2"
                     /gene_synonym="CDKN2; p33(CDK2)"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2210..2215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK2"
                     /gene_synonym="CDKN2; p33(CDK2)"
                     /note="hexamer: ATTAAA"
     polyA_site      2240
                     /gene="CDK2"
                     /gene_synonym="CDKN2; p33(CDK2)"
                     /note="major polyA site"
ORIGIN      
        1 attgtttcaa gttggccaaa ttgacaagag cgagaggtat actgcgttcc atcccgaccc
       61 ggggccacgg tactgggccc tgtttccccc tcctcggccc ccgagagcca gggtccgcct
      121 tctgcagggt tcccaggccc ccgctccagg gccgggctga cccgactcgc tggcgcttca
      181 tggagaactt ccaaaaggtg gaaaagatcg gagagggcac gtacggagtt gtgtacaaag
      241 ccagaaacaa gttgacggga gaggtggtgg cgcttaagaa aatccgcctg gacactgaga
      301 ctgagggtgt gcccagtact gccatccgag agatctctct gcttaaggag cttaaccatc
      361 ctaatattgt caagctgctg gatgtcattc acacagaaaa taaactctac ctggtttttg
      421 aatttctgca ccaagatctc aagaaattca tggatgcctc tgctctcact ggcattcctc
      481 ttcccctcat caagagctat ctgttccagc tgctccaggg cctagctttc tgccattctc
      541 atcgggtcct ccaccgagac cttaaacctc agaatctgct tattaacaca gagggggcca
      601 tcaagctagc agactttgga ctagccagag cttttggagt ccctgttcgt acttacaccc
      661 atgaggtggt gaccctgtgg taccgagctc ctgaaatcct cctgggctgc aaatattatt
      721 ccacagctgt ggacatctgg agcctgggct gcatctttgc tgagatggtg actcgccggg
      781 ccctattccc tggagattct gagattgacc agctcttccg gatctttcgg actctgggga
      841 ccccagatga ggtggtgtgg ccaggagtta cttctatgcc tgattacaag ccaagtttcc
      901 ccaagtgggc ccggcaagat tttagtaaag ttgtacctcc cctggatgaa gatggacgga
      961 gcttgttatc gcaaatgctg cactacgacc ctaacaagcg gatttcggcc aaggcagccc
     1021 tggctcaccc tttcttccag gatgtgacca agccagtacc ccatcttcga ctctgatagc
     1081 cttcttgaag cccccagccc taatctcacc ctctcctcca gtgtgggctt gaccaggctt
     1141 ggccttgggc tatttggact caggtgggcc ctctgaactt gccttaaaca ctcaccttct
     1201 agtcttggcc agccaactct gggaatacag gggtgaaagg ggggaaccag tgaaaatgaa
     1261 aggaagtttc agtattagat gcacttaagt tagcctccac caccctttcc cccttctctt
     1321 agttattgct gaagagggtt ggtataaaaa taattttaaa aaagccttcc tacacgttag
     1381 atttgccgta ccaatctctg aatgccccat aattattatt tccagtgttt gggatgacca
     1441 ggatcccaag cctcctgctg ccacaatgtt tataaaggcc aaatgatagc gggggctaag
     1501 ttggtgcttt tgagaaccaa gtaaaacaaa accactggga ggagtctatt ttaaagaatt
     1561 cggttgaaaa aatagatcca atcagtttat accctagtta gtgttttgcc tcacctaata
     1621 ggctgggaga ctgaagactc agcccgggtg gggctgcaga aaaatgattg gccccagtcc
     1681 ccttgtttgt cccttctaca ggcatgagga atctgggagg ccctgagaca gggattgtgc
     1741 ttcattccaa tctattgctt caccatggcc ttatgaggca ggtgagagat gtttgaattt
     1801 ttctcttcct tttagtattc ttagttgttc agttgccaag gatccctgat cccattttcc
     1861 tctgacgtcc acctcctacc ccataggagt tagaagttag ggtttaggca tcattttgag
     1921 aatgctgaca ctttttcagg gctgtgattg agtgagggca tgggtaaaaa tatttcttta
     1981 aaagaaggat gaacaattat atttatattt caggttatat ccaatagtag agttggcttt
     2041 tttttttttt ttttggtcat agtgggtgga tttgttgcca tgtgcacctt ggggttttgt
     2101 aatgacagtg ctaaaaaaaa aaagcatttt ttttttatga tttgtctctg tcacccttgt
     2161 ccttgagtgc tcttgctatt aacgttattt gtaatttagt ttgtagctca ttaaaaaaat
     2221 gtgcctagtt ttatagttca
//
