LOCUS       NM_015076               6399 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cyclin dependent kinase 19 (CDK19), transcript variant
            1, mRNA.
ACCESSION   NM_015076
VERSION     NM_015076.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6399)
  AUTHORS   Chen,M., Li,J., Zhang,L., Wang,L., Cheng,C., Ji,H., Altilia,S.,
            Ding,X., Cai,G., Altomare,D., Shtutman,M., Byrum,S.D.,
            Mackintosh,S.G., Feoktistov,A., Soshnikova,N., Mogila,V.A.,
            Tatarskiy,V., Erokhin,M., Chetverina,D., Prawira,A., Ni,Y.,
            Urban,S., McInnes,C., Broude,E.V. and Roninson,I.B.
  TITLE     CDK8 and CDK19: positive regulators of signal-induced transcription
            and negative regulators of Mediator complex proteins
  JOURNAL   Nucleic Acids Res 51 (14), 7288-7313 (2023)
   PUBMED   37378433
  REMARK    GeneRIF: CDK8 and CDK19: positive regulators of signal-induced
            transcription and negative regulators of Mediator complex proteins.
REFERENCE   2  (bases 1 to 6399)
  AUTHORS   Dannappel,M.V., Zhu,D., Sun,X., Chua,H.K., Poppelaars,M.,
            Suehiro,M., Khadka,S., Lim Kam Sian,T.C., Sooraj,D., Loi,M.,
            Gao,H., Croagh,D., Daly,R.J., Faridi,P., Boyer,T.G. and
            Firestein,R.
  TITLE     CDK8 and CDK19 regulate intestinal differentiation and homeostasis
            via the chromatin remodeling complex SWI/SNF
  JOURNAL   J Clin Invest 132 (20), e158593 (2022)
   PUBMED   36006697
  REMARK    GeneRIF: CDK8 and CDK19 regulate intestinal differentiation and
            homeostasis via the chromatin remodeling complex SWI/SNF.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6399)
  AUTHORS   Offermann,A., Joerg,V., Becker,F., Roesch,M.C., Kang,D.,
            Lemster,A.L., Tharun,L., Behrends,J., Merseburger,A.S., Culig,Z.,
            Sailer,V., Bragelmann,J., Kirfel,J. and Perner,S.
  TITLE     Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19
            Suppresses Its Pro-Oncogenic Effects in Prostate Cancer
  JOURNAL   Am J Pathol 192 (5), 813-823 (2022)
   PUBMED   35181333
  REMARK    GeneRIF: Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent
            Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer.
REFERENCE   4  (bases 1 to 6399)
  AUTHORS   Fan,L., Lei,H., Lin,Y., Zhou,Z., Li,J., Wu,A., Shu,G., Roger,S. and
            Yin,G.
  TITLE     Hotair promotes the migration and proliferation in ovarian cancer
            by miR-222-3p/CDK19 axis
  JOURNAL   Cell Mol Life Sci 79 (5), 254 (2022)
   PUBMED   35451651
  REMARK    GeneRIF: Hotair promotes the migration and proliferation in ovarian
            cancer by miR-222-3p/CDK19 axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6399)
  AUTHORS   Zhang,Z., Lu,Y., Qi,Y., Xu,Y., Wang,S., Chen,F., Shen,M., Chen,M.,
            Chen,N., Yang,L., Chen,S., Wang,F., Su,Y., Hu,M. and Wang,J.
  TITLE     CDK19 regulates the proliferation of hematopoietic stem cells and
            acute myeloid leukemia cells by suppressing p53-mediated
            transcription of p21
  JOURNAL   Leukemia 36 (4), 956-969 (2022)
   PUBMED   35110726
  REMARK    GeneRIF: CDK19 regulates the proliferation of hematopoietic stem
            cells and acute myeloid leukemia cells by suppressing p53-mediated
            transcription of p21.
REFERENCE   6  (bases 1 to 6399)
  AUTHORS   Tsutsui,T., Fukasawa,R., Tanaka,A., Hirose,Y. and Ohkuma,Y.
  TITLE     Identification of target genes for the CDK subunits of the Mediator
            complex
  JOURNAL   Genes Cells 16 (12), 1208-1218 (2011)
   PUBMED   22117896
  REMARK    GeneRIF: Microarrays identified target genes for each CDK, and we
            selected six genes: two target genes of CDK8, two target genes of
            CDK19 and two genes that were targets for both.
REFERENCE   7  (bases 1 to 6399)
  AUTHORS   Tsutsui,T. and Ohkuma,Y.
  TITLE     [Mechanisms of transcriptional regulation upon protein
            phosphorylation by mediator complexes]
  JOURNAL   Seikagaku 82 (3), 191-199 (2010)
   PUBMED   20408451
  REMARK    GeneRIF: plays a role in mechanisms of transcriptional regulation
            upon protein phosphorylation. (review)
            Review article
REFERENCE   8  (bases 1 to 6399)
  AUTHORS   Malumbres,M., Harlow,E., Hunt,T., Hunter,T., Lahti,J.M.,
            Manning,G., Morgan,D.O., Tsai,L.H. and Wolgemuth,D.J.
  TITLE     Cyclin-dependent kinases: a family portrait
  JOURNAL   Nat Cell Biol 11 (11), 1275-1276 (2009)
   PUBMED   19884882
REFERENCE   9  (bases 1 to 6399)
  AUTHORS   Sato,S., Tomomori-Sato,C., Parmely,T.J., Florens,L., Zybailov,B.,
            Swanson,S.K., Banks,C.A., Jin,J., Cai,Y., Washburn,M.P.,
            Conaway,J.W. and Conaway,R.C.
  TITLE     A set of consensus mammalian mediator subunits identified by
            multidimensional protein identification technology
  JOURNAL   Mol Cell 14 (5), 685-691 (2004)
   PUBMED   15175163
REFERENCE   10 (bases 1 to 6399)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z84480.1, AY028424.1 and
            AB028951.2.
            
            On Nov 23, 2018 this sequence version replaced NM_015076.4.
            
            Summary: This gene encodes a protein that is one of the components
            of the Mediator co-activator complex. The Mediator complex is a
            multi-protein complex required for transcriptional activation by
            DNA binding transcription factors of genes transcribed by RNA
            polymerase II. The protein encoded by this gene is similar to
            cyclin-dependent kinase 8 which can also be a component of the
            Mediator complex. Alternative splicing results in multiple
            transcript variants encoding distinct isoforms. [provided by
            RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB028951.2, SRR14038191.1823295.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368911.8/ ENSP00000357907.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               Z84480.1           71073-71225         c
            154-2133            AY028424.1         1-1980
            2134-6399           AB028951.2         1798-6063
FEATURES             Location/Qualifiers
     source          1..6399
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..6399
                     /gene="CDK19"
                     /gene_synonym="bA346C16.3; CDC2L6; CDK11; DEE87; EIEE87"
                     /note="cyclin dependent kinase 19"
                     /db_xref="GeneID:23097"
                     /db_xref="HGNC:HGNC:19338"
                     /db_xref="MIM:614720"
     exon            1..461
                     /gene="CDK19"
                     /gene_synonym="bA346C16.3; CDC2L6; CDK11; DEE87; EIEE87"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..1842
                     /gene="CDK19"
                     /gene_synonym="bA346C16.3; CDC2L6; CDK11; DEE87; EIEE87"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cyclin-dependent kinase (CDC2-like) 11; cell division
                     cycle 2-like 6 (CDK8-like); CDK8-like cyclin-dependent
                     kinase; cell division protein kinase 19; death-preventing
                     kinase; cell division cycle 2-like protein kinase 6;
                     cyclin-dependent kinase 11; CDC2-related protein kinase 6"
                     /codon_start=1
                     /product="cyclin-dependent kinase 19 isoform 1"
                     /protein_id="NP_055891.1"
                     /db_xref="CCDS:CCDS5085.1"
                     /db_xref="GeneID:23097"
                     /db_xref="HGNC:HGNC:19338"
                     /db_xref="MIM:614720"
                     /translation="MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGK
                     DEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEH
                     DLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVM
                     GEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIW
                     AIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEY
                     PTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPY
                     FQEDPLPTLDVFAGCQIPYPKREFLNEDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAP
                     PQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSG
                     GPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY"
     exon            462..537
                     /gene="CDK19"
                     /gene_synonym="bA346C16.3; CDC2L6; CDK11; DEE87; EIEE87"
                     /inference="alignment:Splign:2.1.0"
     exon            538..648
                     /gene="CDK19"
                     /gene_synonym="bA346C16.3; CDC2L6; CDK11; DEE87; EIEE87"
                     /inference="alignment:Splign:2.1.0"
     exon            649..789
                     /gene="CDK19"
                     /gene_synonym="bA346C16.3; CDC2L6; CDK11; DEE87; EIEE87"
                     /inference="alignment:Splign:2.1.0"
     exon            790..847
                     /gene="CDK19"
                     /gene_synonym="bA346C16.3; CDC2L6; CDK11; DEE87; EIEE87"
                     /inference="alignment:Splign:2.1.0"
     exon            848..979
                     /gene="CDK19"
                     /gene_synonym="bA346C16.3; CDC2L6; CDK11; DEE87; EIEE87"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1123
                     /gene="CDK19"
                     /gene_synonym="bA346C16.3; CDC2L6; CDK11; DEE87; EIEE87"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1193
                     /gene="CDK19"
                     /gene_synonym="bA346C16.3; CDC2L6; CDK11; DEE87; EIEE87"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1266
                     /gene="CDK19"
                     /gene_synonym="bA346C16.3; CDC2L6; CDK11; DEE87; EIEE87"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1364
                     /gene="CDK19"
                     /gene_synonym="bA346C16.3; CDC2L6; CDK11; DEE87; EIEE87"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1443
                     /gene="CDK19"
                     /gene_synonym="bA346C16.3; CDC2L6; CDK11; DEE87; EIEE87"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1710
                     /gene="CDK19"
                     /gene_synonym="bA346C16.3; CDC2L6; CDK11; DEE87; EIEE87"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..6399
                     /gene="CDK19"
                     /gene_synonym="bA346C16.3; CDC2L6; CDK11; DEE87; EIEE87"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6379..6384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK19"
                     /gene_synonym="bA346C16.3; CDC2L6; CDK11; DEE87; EIEE87"
                     /note="hexamer: AATAAA"
     polyA_site      6399
                     /gene="CDK19"
                     /gene_synonym="bA346C16.3; CDC2L6; CDK11; DEE87; EIEE87"
                     /note="major polyA site"
ORIGIN      
        1 agtgagttcg ctaatgagct cgaggaagcc acggcgcggc ccaccaggtt ccaaaacaag
       61 gaaatgaagg agggaggcgg gactgggggt gcctgcggga gccgccgccg ccgtcgcgga
      121 ggaggaggag gaagaggtgg aggaggtggc tgctgtggcc gccgaggagt cccttgctga
      181 aggcggaccg cggagcggcg ggcggcgggc ggcgcgcgcg cgcgcgcgag aggcggctgt
      241 tggagaagtg gagcggcggt cgcgggggga ggaggaggag ggactgagcg gcggcggccc
      301 ccgcgtcccg tgcctctatg ggggaagcag acaatggatt atgatttcaa ggcgaagctg
      361 gcggcggagc gggagcgggt ggaggatttg tttgagtacg aagggtgcaa agtgggacgc
      421 ggcacctacg gtcacgtcta caaggcgagg cggaaagatg gaaaagatga aaaggaatat
      481 gcattgaagc aaattgaagg cacaggaata tccatgtcgg cttgtagaga gattgcactt
      541 ttgcgagaat tgaagcaccc taatgtgatt gcattgcaga aggtgttcct ttctcacagt
      601 gacaggaagg tatggctgct gtttgattat gcagagcatg acttgtggca tattattaag
      661 tttcaccgtg catcaaaagc aaataaaaag cccatgcagt tgccaagatc tatggttaaa
      721 tccttacttt accagattct tgatggtatc cattacctcc atgcaaattg ggtgcttcac
      781 agagacttga aaccagcaaa tatcctagta atgggagaag gtcctgagag ggggagagtc
      841 aaaatagctg acatgggttt tgccagatta ttcaattctc ctctaaagcc actagcagat
      901 ttggatccag tagttgtgac attttggtat cgggctccag aacttttgct tggtgcaagg
      961 cattatacaa aggccattga tatatgggca ataggttgta tatttgctga attgttgact
     1021 tcggaaccta tttttcactg tcgtcaggaa gatataaaaa caagcaatcc ctttcatcat
     1081 gatcaactgg atcggatatt tagtgtcatg gggtttcctg cagataaaga ctgggaagat
     1141 attagaaaga tgccagaata tcccacactt caaaaagact ttagaagaac aacgtatgcc
     1201 aacagtagcc tcataaagta catggagaaa cacaaggtca agcctgacag caaagtgttc
     1261 ctcttgcttc agaaactcct gaccatggat ccaaccaaga gaattacctc ggagcaagct
     1321 ctgcaggatc cctattttca ggaggaccct ttgccaacat tagatgtatt tgccggctgc
     1381 cagattccat accccaaacg agaattcctt aatgaagatg atcctgaaga aaaaggtgac
     1441 aagaatcagc aacagcagca gaaccagcat cagcagccca cagcccctcc acagcaggca
     1501 gcagcccctc cacaggcgcc cccaccacag cagaacagca cccagaccaa cgggaccgca
     1561 ggtggggctg gggccggggt cgggggcacc ggagcagggt tgcagcacag ccaggactcc
     1621 agcctgaacc aggtgcctcc aaacaagaag ccacggctag ggccttcagg cgcaaactca
     1681 ggtggacctg tgatgccctc ggattatcag cactccagtt ctcgcctgaa ttaccaaagc
     1741 agcgttcagg gatcctctca gtcccagagc acacttggct actcttcctc gtctcagcag
     1801 agctcacagt accacccatc tcaccaggcc caccggtact gaccagctcc cgttgggcca
     1861 ggccagccca gcccagagca caggctccag caatatgtct gcattgaaaa gaaccaaaaa
     1921 aatgcaaact atgatgccat ttaaaactca tacacatggg aggaaaacct tatatactga
     1981 gcattgtgca ggactgatag ctcttcttta ttgacttaaa gaagattctt gtgaagtttc
     2041 cccagcaccc cttccctgca tgtgttccat tgtgacttct ctgataaagc gtctgatcta
     2101 atcccagcac ttctgtaacc ttcagcattt ctttgaagga tttcctggtg cacctttctc
     2161 atgctgtagc aatcactatg gtttatcttt tcaaagctct tttaatagga ttttaatgtt
     2221 ttagaaacag gattccagtg gtgtatagtt ttatacttca tgaactgatt tagcaacaca
     2281 ggtaaaaatg caccttttaa agcactacgt tttcacagac aataactgtt ctgctcatgg
     2341 aagtcttaaa cagaaactgt tactgtccca aagtacttta ctattacgtt cgtatttatc
     2401 tagtttcagg gaaggtctaa taaaaagaca agcggtggga cagagggaac ctacaaccaa
     2461 aaactgccta gatctttgca gttatgtgct ttatgccacg aagaactgaa gtatgtggta
     2521 atttttatag aatcattcat atggaactga gttcccagca tcatcttatt ctgaatagca
     2581 ttcagtaatt aagaattaca attttaacct tcatgtagct aagtctacct taaaaagggt
     2641 ttcaagagct ttgtacagtc tcgatggccc acaccaaaac gctgaagaga gtaacaactg
     2701 cactaggatt tctgtaagga gtaattttga tcaaaagacg tgttacttcc ctttgaagga
     2761 aaagttttta gtgtgtattg tacataaagt cggcttctct aaagaaccat tggtttcttc
     2821 acatctgggt ctgcgtgagt aactttcttg cataatcaag gttactcaag tagaagcctg
     2881 aaaattaatc tgcttttaaa ataaagagca gtgttctcca ttcgtatttg tattagatat
     2941 agagtgacta tttttaaagc atgttaaaaa tttaggtttt attcatgttt aaagtatgta
     3001 ttatgtatgc ataattttgc tgttgttact gaaacttaat tctatcaaga atctttttca
     3061 ttgcactgaa tgatttcttt tgcccctagg agaaaactta ataattgtgc ctaaaaacta
     3121 tgggcggata gtataagact atactagaca aagtgaatat ttgcatttcc attatctatg
     3181 aattagtggc tgagttcttt cttagctgct ttaaggagcc cctcactccc cagagtcaaa
     3241 aggaaatgta aaaacttaga gctcccattg taatgtaagg ggcaagaaat ttgtgttctt
     3301 ctgaatgcta ctagcagcac cagccttgtt ttaaatgttt tcttgagcta gaagaaatag
     3361 ctgattattg tatatgcaaa ttacatgcat ttttaaaaac tattctttct gaacttatct
     3421 acctggttat gatactgtgg gtccatacac aagtaaaata agattagaca gaagccagta
     3481 tacattttgc actattgatg tgatactgta gccagccagg accttactga tctcagcata
     3541 ataatgctca ctaataatga agtctgcata gtgacactca tcaagactga agatgaagca
     3601 ggttacgtgc tccattggaa ggagtttctg atagtctcct gctgttttac cccttccatt
     3661 ttttaaaata agaaattagc agccctctgc ataatgtagc tgcctatatg cagttttatc
     3721 ctgtgcccta aagcctcact gtccagagct gttggtcatc agatgcttat tgcaccctca
     3781 ccatgtgcct ggtgccctgc tgggtagaga acacagagga cagggcatac ttcttgtcct
     3841 taaggagctt gtgatctgtg acagtaagcc ctcctgggat gtctgtgcca tgtgattgac
     3901 ttacaagtga aactgtctta taatatgaag gtctttttgt ttacttctaa acccacttgg
     3961 gtagttacta tccccaaatc tgttctgtaa ataatattat ggaagggttt ctatgtcagt
     4021 ctaccttaga gaaagccagt gattcaatat cacaaaaggc attgacgtat ctttgaaatg
     4081 ttcacagcag ccttttaaca acaactgggt ggtccttgta ggcagaacat actctcctaa
     4141 gtggttgtag gaaattgcaa ggaaaataga aggtctgttc ttgctctcaa ggaggttacc
     4201 tttaataaaa gaagacaaac ccagatagat atgtaaacca aaatactatg ccccttaata
     4261 ctttataagc agcattgtta aatagttctt acgcttatac attcacagaa ctaccctgtt
     4321 ttccttgtat ataatgactt ttgctggcag aactgaaata taaactgtaa ggggatttcg
     4381 tcagttgctc ccagtataca atatcctcca ggacatagcc agaaatctcc attccacaca
     4441 tgactgagtt cctatccctg cactggtact ggctcttttc tcctctttcc ttgcctcagg
     4501 gttcgtgcta cccactgatt ccctttaccc ttagtaataa ttttggatca ttttctttcc
     4561 tttaaagggg aacaaagcct tttttttttt tgagacggag tgttgctctg tcacccaagc
     4621 tggagtgcag tggcacgatc ttggctcact ccaacctcca ccttccaggt tcaagtgatt
     4681 ctcctgcctc agcctcccga gtagctggga ctacgggcac gcaccaccac gtctggctaa
     4741 tttttgtatt tttagtagag atggggtttc accctattgg tcaggctggt cttgaattcc
     4801 tcacctcagg tcatccgcct gtctcggcct cccgaagtgc tgggattata ggtgtgagcc
     4861 accgcaccca gttgggaaca aagccttttt aacacacgta agggccctca aaccgtggga
     4921 cctctaagga gacctttgaa gctttttgag ggcaaacttt acctttgtgg tccccaaatg
     4981 atggcatttc tctttgaaat ttattagata ctgttatgtc ccccaagggt acaggagggg
     5041 catccctcag cctatgggaa cacccaaact aggaggggtt attgacagga aggaatgaat
     5101 ccaagtgaag gctttctgct cttcgtgtta caaaccagtt tcagagttag ctttctgggg
     5161 aggtgtgtgt ttgtgaaagg aattcaagtg ttgcaggaca gatgagctca aggtaaggta
     5221 gctttggcag cagggctgat actatgaggc tgaaacaatc cttgtgatga agtagatcat
     5281 gcagtgacat acaaagacca aggattatgt atatttttat atctctgtgg ttttgaaact
     5341 ttagtactta gaattttggc cttctgcact actcttttgc tcttacgaac ataatggact
     5401 cttaagaatg gaaagggatg acatttacct atgtgtgctg cctcattcct ggtgaagcaa
     5461 ctgctacttg ttctctatgc ctctaaaatg atgctgtttt ctctgctaaa ggtaaaagaa
     5521 aagaaaaaaa tagttggaaa ataagacatg caacttgatg tgcttttgag taaatttatg
     5581 cagcagaaac tatacaatga aggaagaatt ctatggaaat tacaaatcca aaactctatg
     5641 atgatgtctt cctagggagt agagaaaggc agtgaaatgg cagttagacc aacagaggct
     5701 tgaaggattc aagtacaagt aatattttgt ataaaacata gcagtttagg tccccataat
     5761 cctcaaaaat agtcacaaat ataacaaagt tcattgtttt agggttttta aaaaacgtgt
     5821 tgtacctaag gccatactta ctcttctatg ctatcactgc aaaggggtga tatgtatgta
     5881 ttatataaaa aaaaaaaccc ttaatgcact gttatctcct aaatatttag taaattaata
     5941 ctatttaatt tttttaaaga tttgtctgtg tagacactaa aagtattaca caaaatctgg
     6001 actgaaggtg tcctttttaa caacaattta aagtactttt tatatatgtt atgtagtata
     6061 tcctttctaa actgcctagt ttgtatattc ctataattcc tatttgtgaa gtgtacctgt
     6121 tcttgtctct tttttcagtc attttctgca cgcatccccc tttatatggt tatagagatg
     6181 actgtagctt ttcgtgctcc actgcgaggt ttgtgctcag agccgctgca ccccagcgag
     6241 gcctgctcca tggagtgcag gacgagctac tgctttggag cgagggtttc ctgcttttga
     6301 gttgacctga cttccttctt gaaatgactg ttaaaactaa aataaattac attgcattta
     6361 ttttatattc ttggttgaaa taaaatttaa ttgactttg
//
