LOCUS       NM_002595               4036 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cyclin dependent kinase 17 (CDK17), transcript variant
            1, mRNA.
ACCESSION   NM_002595
VERSION     NM_002595.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4036)
  AUTHORS   Qu,B., Sun,L., Xiao,P., Shen,H., Ren,Y. and Zhang,J.
  TITLE     CircCDK17 promotes the proliferation and metastasis of ovarian
            cancer cells by sponging miR-22-3p to regulate CD147 expression
  JOURNAL   Carcinogenesis 45 (1-2), 83-94 (2024)
   PUBMED   37952105
  REMARK    GeneRIF: CircCDK17 promotes the proliferation and metastasis of
            ovarian cancer cells by sponging miR-22-3p to regulate CD147
            expression.
REFERENCE   2  (bases 1 to 4036)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 4036)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 4036)
  AUTHORS   Chen,R., Liang,F., Yan,J. and Wang,Y.
  TITLE     CircCDK17 knockdown inhibits tumor progression and cell glycolysis
            by downregulaing YWHAZ expression through sponging miR-1294 in
            cervical cancer
  JOURNAL   J Ovarian Res 15 (1), 24 (2022)
   PUBMED   35168653
  REMARK    GeneRIF: CircCDK17 knockdown inhibits tumor progression and cell
            glycolysis by downregulaing YWHAZ expression through sponging
            miR-1294 in cervical cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4036)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 4036)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
REFERENCE   7  (bases 1 to 4036)
  AUTHORS   Yamochi,T., Nishimoto,I., Okuda,T. and Matsuoka,M.
  TITLE     ik3-1/Cables is associated with Trap and Pctaire2
  JOURNAL   Biochem Biophys Res Commun 286 (5), 1045-1050 (2001)
   PUBMED   11527406
REFERENCE   8  (bases 1 to 4036)
  AUTHORS   Hirose,T., Kawabuchi,M., Tamaru,T., Okumura,N., Nagai,K. and
            Okada,M.
  TITLE     Identification of tudor repeat associator with PCTAIRE 2 (Trap). A
            novel protein that interacts with the N-terminal domain of PCTAIRE
            2 in rat brain
  JOURNAL   Eur J Biochem 267 (7), 2113-2121 (2000)
   PUBMED   10727952
REFERENCE   9  (bases 1 to 4036)
  AUTHORS   Hirose,T., Tamaru,T., Okumura,N., Nagai,K. and Okada,M.
  TITLE     PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly
            expressed in terminally differentiated neurons
  JOURNAL   Eur J Biochem 249 (2), 481-488 (1997)
   PUBMED   9370357
REFERENCE   10 (bases 1 to 4036)
  AUTHORS   Meyerson,M., Enders,G.H., Wu,C.L., Su,L.K., Gorka,C., Nelson,C.,
            Harlow,E. and Tsai,L.H.
  TITLE     A family of human cdc2-related protein kinases
  JOURNAL   EMBO J 11 (8), 2909-2917 (1992)
   PUBMED   1639063
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC307775.1, BC033005.1 and
            AF086067.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002595.4.
            
            Summary: The protein encoded by this gene belongs to the cdc2/cdkx
            subfamily of the ser/thr family of protein kinases. It has
            similarity to a rat protein that is thought to play a role in
            terminally differentiated neurons. Alternatively spliced transcript
            variants encoding different isoforms have been found. [provided by
            RefSeq, Jul 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033005.1, SRR14038195.2829935.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261211.8/ ENSP00000261211.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-367               DC307775.1         150-516
            368-3744            BC033005.1         6-3382
            3745-4036           AF086067.1         175-466
FEATURES             Location/Qualifiers
     source          1..4036
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.1"
     gene            1..4036
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
                     /note="cyclin dependent kinase 17"
                     /db_xref="GeneID:5128"
                     /db_xref="HGNC:HGNC:8750"
                     /db_xref="MIM:603440"
     exon            1..454
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            455..601
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             484..2055
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein kinase PCTAIRE-2; protein kinase
                     cdc2-related PCTAIRE-2; cell division protein kinase 17;
                     PCTAIRE-motif protein kinase 2"
                     /codon_start=1
                     /product="cyclin-dependent kinase 17 isoform 1"
                     /protein_id="NP_002586.2"
                     /db_xref="CCDS:CCDS9061.1"
                     /db_xref="GeneID:5128"
                     /db_xref="HGNC:HGNC:8750"
                     /db_xref="MIM:603440"
                     /translation="MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVK
                     NGRPPTSHSMHSFLHQYTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLK
                     MGSDGESDQASGTSSDEVQSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEK
                     LQINSPPFDQPMSRRSRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLV
                     ALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQ
                     YMDDCGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGL
                     ARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGS
                     TVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYKPQPLINHAPRLDSEGIELI
                     TKFLQYESKKRVSAEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPGFRNSSY
                     PETGHGKNRRQSMLF"
     exon            602..766
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            767..900
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1026
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1083
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1198
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1293
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1356
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1480
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1601
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1699
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1805
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1848
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1939
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2017
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..4036
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3721..3726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
                     /note="hexamer: AACAAA"
     polyA_site      3744
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
                     /note="major polyA site"
     regulatory      3928..3933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
                     /note="hexamer: TATAAA"
     polyA_site      3953
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
     regulatory      4018..4023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
                     /note="hexamer: TATAAA"
     polyA_site      4036
                     /gene="CDK17"
                     /gene_synonym="PCTAIRE2; PCTK2"
ORIGIN      
        1 aatccgcagc cgccgagtgt gaaagcgacg cacacgcaag gagcgaacgc ggccgcccgc
       61 agtctcctga gctccccgcg ggccgccgca gagccgcgga gaaggagcca gcgcccggcc
      121 agacagtctc agcccgccgt cggcgcccgc cgcgctcgcg cccggctgct ccgaggggat
      181 tagtgggccg tccgcgcggc tcgtcggcgc gggagccatg ttgaccgagg gacttggcaa
      241 cgcgtgagac acccgcggcc cctcccgagg ctccggaccc gcggcgagag ccggaaggcg
      301 gctgtggcgg cggaggcctg cgctcggaag cgcctcacgt ctgccggccg ctgagacccg
      361 gacttgcatc cggtcgccgc gggcgtccgc ggagcagctt ccccccgcgc ctctcttcgc
      421 ctcgcctcgg gacccgcggt ccccgctctt gctggatttt tcaagccaca ttcaattgat
      481 aggatgaaaa aatttaagag aaggctatcc ctcacactcc gaggaagtca gactattgat
      541 gaatcattgt ctgaattggc tgaacaaatg actattgaag aaaacagcag caaggataat
      601 gagcctattg tgaagaatgg caggcctcca acgtctcaca gtatgcattc cttcctccac
      661 cagtacacag gatctttcaa gaagccccca ttgcggagac cacacagtgt tattggaggg
      721 agccttggct ccttcatggc aatgcccaga aatggaagca gattagatat tgttcatgaa
      781 aatctaaaaa tgggatcaga tggtgagagt gaccaagctt ctgggacatc atctgatgaa
      841 gtccagtcac ctacaggtgt ttgtctcaga aatcgtatac atagacggat ctcaatggag
      901 gatttaaata agcggttatc actgcctgca gacatcagaa tacctgatgg atatcttgaa
      961 aagttgcaga taaacagtcc accatttgac caaccaatga gtcgaaggtc tcgtagagct
     1021 tccttatcag aaattggctt tggaaaaatg gaaacctaca tcaaattgga aaagcttgga
     1081 gagggtacat atgcaacagt atataaagga agaagtaaat tgacagagaa tttggtggca
     1141 ttaaaagaga tccgattgga acatgaagaa ggtgcaccct gcacagctat aagagaagtt
     1201 tcactattaa aggatttaaa acatgcaaat atagtaacct tacatgacat tgttcacaca
     1261 gataaatcct tgactttggt gtttgagtat ctggataaag acctgaaaca gtacatggat
     1321 gactgtggaa acatcatgag tatgcacaac gtaaagctgt ttctgtacca aattctacgt
     1381 ggtttggcat attgccatag aagaaaggta ttgcatcgag acttgaaacc acagaacctc
     1441 ctcattaatg agaaaggaga attaaagcta gcagattttg gactagcccg agccaagtca
     1501 gttcccacaa agacctactc aaatgaagtt gtcacactat ggtaccggcc acctgatgtg
     1561 cttcttggtt cctcggagta ctcaacacag attgacatgt ggggtgttgg ttgcattttc
     1621 tttgaaatgg cttctggaag acctttattt ccaggatcaa ccgtggaaga tgaactgcac
     1681 ttaattttcc gactgctagg aactccatct caggaaactt ggccaggtat ttcttcaaat
     1741 gaggagttca agaactacaa ctttccaaaa tataaaccac agcctctaat taaccacgca
     1801 cccaggttag actctgaagg aattgagttg ataacaaaat ttcttcagta tgaatctaag
     1861 aaaagggttt cagctgaaga ggccatgaaa catgtgtact ttcgaagtct gggaccaaga
     1921 atacatgctt taccagaaag tgtatcaata ttcagtttga aagagattca gttgcaaaag
     1981 gacccgggtt ttcgaaattc ttcttatcca gagacaggac atgggaagaa cagaagacag
     2041 agcatgctct tttaagtctg ataacatggt ttcaagccca gcccccagcc tttcttacca
     2101 atcaaggact cagaactgaa ggcaattatt tcttttggtg gacttggaat ctccgtttgt
     2161 ctacactgtc ctcttcacag tggagtcttt ttatttcaga cctacagatt gtttttatat
     2221 ttgttgtcac agtgtgacaa ttttttgtac agtcggtttt aaggtcttct ctgccattag
     2281 agccagtagg ttacagctat tgatgtaact atagctgcaa tttttgtgca ggactgagaa
     2341 acacagtgca ttatttattg cggaatcatt gctgctaaat aactactgtc tgtttattta
     2401 acacaacaat tgaatgcctg aagaagttgc agtggcttta ttatatgtga atgcatctgt
     2461 ttctcctcac gaattgtttt actgctgcat tttttgtttt taaaattaaa ctgcagtgtt
     2521 tcctggaatg taaatttagc tttgcttaat agtaaaataa gtgagccatc ttgaacactt
     2581 taagtttata ctatataatt tcttaatgaa cattggcaaa tagagtagct aagagattga
     2641 caagcacatt acgtttagat aagcatgtga tgcagaagtt gattcaagca agtgaatccc
     2701 tgacattttg aggatctcac attagacacc aacaaattaa agctccaaaa ttatttattt
     2761 tttatgtgtt cctcacttta gaaacgtcta ctgcatatta ctggatattt gtatactaat
     2821 acacttacct attttacatt gtgttttaaa tttagttaaa acttaaccgt agaagtctgt
     2881 tcaaacgcga aaggtcttgc tttgtttgtt ttaaatacat ttattttatt agaaaggatg
     2941 atatttcatt ggggaatagt ttctttcatt tgggggctat gtgtttcaat aacattcact
     3001 tggaatcagc tgaaagctgt aatatgtctt tgaaatgagc catgataaat tacaaacaag
     3061 agaaatgaga acttacagga ttgcttgaaa ttattgtggg tattatctgt ttaccagaga
     3121 tactaaatat tagttttaat tatgcatctc tttgaacatc ataaacacac tttggtgttg
     3181 gtaacagtat tttaagcatt tttgttcact tttaaggact atttgtttag tgcatcttac
     3241 aaactataaa tcttaattgg tatattttga aatggtcgtg taaatttttg ccttatatat
     3301 catgaaaata gtcataactt aatttctttt cctgaaattc actgtaaaac attcaggggt
     3361 cctaccattt ctgttcagga aatcttgtag tttattgttg ttatttaaca gtattaagtg
     3421 gatttttgta tatttcattt taactttatt tgtgaatagt gattgtggca tgtttggggt
     3481 gttattttaa tatttcacga tactaaaatt ttaattttaa aaaattctgg aagaaacaga
     3541 ttcatgtgta atggtgaata ttggaccact actgcttttc acatttgtaa attggtttta
     3601 tgttaaacct tgtagcctaa caaactgctg ttctttctaa ctgacagaca tgtattaata
     3661 ttgtactttg aaggttataa atatgtggaa attccttcat tttgttttga aatttataat
     3721 aacaaaatct ccatgttgtt aaaatgtggt tttattgagt cacagttctt tcttggggat
     3781 gaaggctgtg ccgagtgggg tccttttctt ttatgggtcg ttcttaagat aatgaagtct
     3841 cactgtgcta gaggtgttat tgttttctgt ttgtgccaat catttgctta gtaatttctg
     3901 ctgggttttt tttatagcac tctcaattat aaagtatcaa atttgtcact tcatagaatg
     3961 tatatttgat ttgttgcaaa tttgacatta tagcttttca taggcttaat tcttgcgtat
     4021 aaaagatgaa aatata
//
