LOCUS       NM_006201               3151 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens cyclin dependent kinase 16 (CDK16), transcript variant
            1, mRNA.
ACCESSION   NM_006201
VERSION     NM_006201.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3151)
  AUTHORS   Wang,X., Liu,R., Li,S., Xia,W., Guo,H., Yao,W., Liang,X., Lu,Y. and
            Zhang,H.
  TITLE     The roles, molecular interactions, and therapeutic value of CDK16
            in human cancers
  JOURNAL   Biomed Pharmacother 164, 114929 (2023)
   PUBMED   37236028
  REMARK    GeneRIF: The roles, molecular interactions, and therapeutic value
            of CDK16 in human cancers.
            Review article
REFERENCE   2  (bases 1 to 3151)
  AUTHORS   Wei,P.L., Huang,C.Y., Chang,T.C., Lin,J.C., Lee,C.C.,
            Prince,G.M.S.H., Makondi,P.T., Chui,A.W. and Chang,Y.J.
  TITLE     PCTAIRE Protein Kinase 1 (PCTK1) Suppresses Proliferation,
            Stemness, and Chemoresistance in Colorectal Cancer through the
            BMPR1B-Smad1/5/8 Signaling Pathway
  JOURNAL   Int J Mol Sci 24 (12), 10008 (2023)
   PUBMED   37373155
  REMARK    GeneRIF: PCTAIRE Protein Kinase 1 (PCTK1) Suppresses Proliferation,
            Stemness, and Chemoresistance in Colorectal Cancer through the
            BMPR1B-Smad1/5/8 Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3151)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 3151)
  AUTHORS   Li,X., Li,J., Xu,L., Wei,W., Cheng,A., Zhang,L., Zhang,M., Wu,G.
            and Cai,C.
  TITLE     CDK16 promotes the progression and metastasis of triple-negative
            breast cancer by phosphorylating PRC1
  JOURNAL   J Exp Clin Cancer Res 41 (1), 149 (2022)
   PUBMED   35449080
  REMARK    GeneRIF: CDK16 promotes the progression and metastasis of
            triple-negative breast cancer by phosphorylating PRC1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3151)
  AUTHORS   Esposito,T., Gianfrancesco,F., Ciccodicola,A., D'Esposito,M.,
            Nagaraja,R., Mazzarella,R., D'Urso,M. and Forabosco,A.
  TITLE     Escape from X inactivation of two new genes associated with
            DXS6974E and DXS7020E
  JOURNAL   Genomics 43 (2), 183-190 (1997)
   PUBMED   9244435
REFERENCE   6  (bases 1 to 3151)
  AUTHORS   Carrel,L., Clemson,C.M., Dunn,J.M., Miller,A.P., Hunt,P.A.,
            Lawrence,J.B. and Willard,H.F.
  TITLE     X inactivation analysis and DNA methylation studies of the
            ubiquitin activating enzyme E1 and PCTAIRE-1 genes in human and
            mouse
  JOURNAL   Hum Mol Genet 5 (3), 391-401 (1996)
   PUBMED   8852665
REFERENCE   7  (bases 1 to 3151)
  AUTHORS   Knight,J.C., Renwick,P.J., Downing,J.R. and Okuda,T.
  TITLE     Physical linkage of the cdc2-related gene (PCTK1) and the
            ubiquitin-activating enzyme E1 gene (UBE1) on human Xp11.3
  JOURNAL   Cytogenet Cell Genet 71 (2), 155-157 (1995)
   PUBMED   7656587
REFERENCE   8  (bases 1 to 3151)
  AUTHORS   Okuda,T., Valentine,V.A., Shapiro,D.N. and Downing,J.R.
  TITLE     Cloning of genomic loci and chromosomal localization of the human
            PCTAIRE-1 and -3 protein kinase genes
  JOURNAL   Genomics 21 (1), 217-221 (1994)
   PUBMED   8088790
REFERENCE   9  (bases 1 to 3151)
  AUTHORS   Okuda,T., Cleveland,J.L. and Downing,J.R.
  TITLE     PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related
            protein kinase gene family
  JOURNAL   Oncogene 7 (11), 2249-2258 (1992)
   PUBMED   1437147
REFERENCE   10 (bases 1 to 3151)
  AUTHORS   Meyerson,M., Enders,G.H., Wu,C.L., Su,L.K., Gorka,C., Nelson,C.,
            Harlow,E. and Tsai,L.H.
  TITLE     A family of human cdc2-related protein kinases
  JOURNAL   EMBO J 11 (8), 2909-2917 (1992)
   PUBMED   1639063
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA816614.1, AK096881.1,
            AK290145.1 and BC006190.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006201.4.
            
            Summary: The protein encoded by this gene belongs to the cdc2/cdkx
            subfamily of the ser/thr family of protein kinases. It may play a
            role in signal transduction cascades in terminally differentiated
            cells; in exocytosis; and in transport of secretory cargo from the
            endoplasmic reticulum. This gene is thought to escape X
            inactivation. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Dec
            2009].
            
            Transcript Variant: This variant (1) encodes the shortest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005637.1, SRR1803614.75673.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357227.9/ ENSP00000349762.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 DA816614.1         5-11
            8-1037              AK096881.1         1-1030
            1038-1819           AK290145.1         966-1747
            1820-2430           BC006190.2         1641-2251
            2431-3151           BC006190.2         2253-2973
FEATURES             Location/Qualifiers
     source          1..3151
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.3"
     gene            1..3151
                     /gene="CDK16"
                     /gene_synonym="PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1"
                     /note="cyclin dependent kinase 16"
                     /db_xref="GeneID:5127"
                     /db_xref="HGNC:HGNC:8749"
                     /db_xref="MIM:311550"
     exon            1..425
                     /gene="CDK16"
                     /gene_synonym="PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            426..633
                     /gene="CDK16"
                     /gene_synonym="PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             432..1922
                     /gene="CDK16"
                     /gene_synonym="PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     PCTAIRE-motif protein kinase 1; cell division protein
                     kinase 16; serine/threonine-protein kinase PCTAIRE-1;
                     testis secretory sperm-binding protein Li 224n"
                     /codon_start=1
                     /product="cyclin-dependent kinase 16 isoform 1"
                     /protein_id="NP_006192.1"
                     /db_xref="CCDS:CCDS14276.1"
                     /db_xref="GeneID:5127"
                     /db_xref="HGNC:HGNC:8749"
                     /db_xref="MIM:311550"
                     /translation="MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDP
                     GEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMR
                     NHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFG
                     KLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDL
                     KHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAY
                     CHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILL
                     GSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSN
                     EEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLG
                     ERIHKLPDTTSIFALKEIQLQKEASLRSSSMPDSGRPAFRVVDTEF"
     exon            634..767
                     /gene="CDK16"
                     /gene_synonym="PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..893
                     /gene="CDK16"
                     /gene_synonym="PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            894..950
                     /gene="CDK16"
                     /gene_synonym="PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1065
                     /gene="CDK16"
                     /gene_synonym="PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1160
                     /gene="CDK16"
                     /gene_synonym="PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1223
                     /gene="CDK16"
                     /gene_synonym="PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1347
                     /gene="CDK16"
                     /gene_synonym="PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1468
                     /gene="CDK16"
                     /gene_synonym="PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1566
                     /gene="CDK16"
                     /gene_synonym="PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1672
                     /gene="CDK16"
                     /gene_synonym="PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1715
                     /gene="CDK16"
                     /gene_synonym="PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1806
                     /gene="CDK16"
                     /gene_synonym="PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1884
                     /gene="CDK16"
                     /gene_synonym="PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..3151
                     /gene="CDK16"
                     /gene_synonym="PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2122..2127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK16"
                     /gene_synonym="PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1"
                     /note="hexamer: AACAAA"
     polyA_site      2145
                     /gene="CDK16"
                     /gene_synonym="PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1"
                     /note="major polyA site"
     regulatory      3130..3135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK16"
                     /gene_synonym="PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1"
                     /note="hexamer: ATTAAA"
     polyA_site      3151
                     /gene="CDK16"
                     /gene_synonym="PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1"
ORIGIN      
        1 ccacttcacc cttccgagcg cctgcgtgcg catgcgcgga gcgcggcgcg cgcggcggtt
       61 gggccgttgg ctgttcggcc ctgggatccg ccgccactcc gcgatcagac cgctctgtgc
      121 cgcgagccgc cgtgagcact cggattcaag ccggcgccaa cgagtccggg ggcatcgccc
      181 gcagcggcca agctcatggc cggctgagcg ggacgccgcc tccgcctcag ccaccgccgc
      241 cgccgccgcc tcctcctcct cagccggcgg cggcccgggc ccagcaacca tggctgaaga
      301 ctactgggac gggcgcctgc ggcgaacagg aggagaagga ggtcgcgcgg cctcatcccg
      361 ggccgccgcc ccaggcgccg ccgcgccggc cccgcggctc tgaggttgct cgcgcgcccc
      421 cgccgatcgc catggatcgg atgaagaaga tcaaacggca gctgtcaatg acactccgag
      481 gtggccgagg catagacaag accaatggtg cccctgagca gataggcctg gatgagagtg
      541 gtggtggtgg cggcagtgac cctggagagg cccccacacg tgctgctcct ggggaacttc
      601 gttctgcacg gggcccactc agctctgcac cagagattgt gcacgaggac ttgaagatgg
      661 ggtctgatgg ggagagtgac caggcttcag ccacgtcctc ggatgaggtg cagtctccag
      721 tgagagtgcg tatgcgcaac catcccccac gcaagatctc cactgaggac atcaacaagc
      781 gcctatcact accagctgac atccggctgc ctgagggcta cctggagaag ctgaccctca
      841 atagccccat ctttgacaag cccctcagcc gccgcctccg tcgtgtcagc ctatctgaga
      901 ttggctttgg gaaactggag acctacatta agctggacaa actgggcgag ggtacctatg
      961 ccaccgtcta caaaggcaaa agcaagctca cagacaacct tgtggcactc aaggagatca
     1021 gactggaaca tgaagagggg gcaccctgca ccgccatccg ggaagtgtcc ctgctcaagg
     1081 acctcaaaca cgccaacatc gttacgctac atgacattat ccacacggag aagtccctca
     1141 cccttgtctt tgagtacctg gacaaggacc tgaagcagta cctggatgac tgtgggaaca
     1201 tcatcaacat gcacaacgtg aaactgttcc tgttccagct gctccgtggc ctggcctact
     1261 gccaccggca gaaggtgcta caccgagacc tcaagcccca gaacctgctc atcaacgaga
     1321 ggggagagct caagctggct gactttggcc tggcccgagc caagtcaatc ccaacaaaga
     1381 catactccaa tgaggtggtg acactgtggt accggccccc tgacatcctg cttgggtcca
     1441 cggactactc cactcagatt gacatgtggg gtgtgggctg catcttctat gagatggcca
     1501 caggccgtcc cctctttccg ggctccacgg tggaggaaca gctacacttc atcttccgta
     1561 tcttaggaac cccaactgag gagacgtggc caggcatcct gtccaacgag gagttcaaga
     1621 catacaacta ccccaagtac cgagccgagg cccttttgag ccacgcaccc cgacttgata
     1681 gcgacggggc cgacctcctc accaagctgt tgcagtttga gggtcgaaat cggatctccg
     1741 cagaggatgc catgaaacat ccattcttcc tcagtctggg ggagcggatc cacaaacttc
     1801 ctgacactac ttccatattt gcactaaagg agattcagct acaaaaggag gccagccttc
     1861 ggtcttcgtc gatgcctgac tcaggcaggc cagctttccg cgtggtggac accgagttct
     1921 aagccacaga ccgaggcccc agcaggcagc ggctggaggg atgccacacc cctcacaggg
     1981 cagcccccaa ctacatcttc cctgcttact ctctgcctac ctgcctgagc catgttcacc
     2041 tgcccacttg tcccctgctg cctgcccaaa caccccacca ttggcctgtc aacccaccca
     2101 ttggcctgtc tgctgggtgc taacaaagct ctcatcactc cttcacttgg tctgtctgtc
     2161 tctgtcttgg tagttgccgg tggacagcat ggccgtgcca gcctcccaca ctgaggccag
     2221 gtctaccccc catcatacca gcccccagga ccactacccc acggccagcc aggggtccag
     2281 agctagccca ggctggggat ctcgactcag acaagatggt gacaatgcct tgagtctgag
     2341 gcatcctctg cctgctttcc tgcctgcccc acctgcctca tattgtgtgg gccttttttt
     2401 gtttgtttca ttcattgttt tttttttttt aattatttta aatgagattt ttgttttttt
     2461 taaatgcaat atctctgtat acagactggc tgggccccac cccctgcgtg tggccctccc
     2521 acagtatttt gtgcaatgaa gccctgctcc cagcctttca gagacaggga cacagcccct
     2581 atttggaacc ctgatcatca ccagaccctg ggattggcta tgggaaagca tgccacagcc
     2641 actcgccttc ctacccccgc ccgccatccc cagttgcagg gggatctggg gactaccaga
     2701 gactctggga aatggacaag gtggggggcc ccactctttc tctcctgcag tcccgtagct
     2761 ggggcctcct tccttctcag ggtctcccca gcccagtccc cttgctccca tcccactcgg
     2821 tgctgttggg taggggccct gccaggaact gaccagctca gcgaggagcc ataatgtgca
     2881 tatgtgcaca agcagggttg ggggaggggg gtgtgagggg ttgtgcccag gtgttgcccc
     2941 ctatctcctg gggagggtga ggcagggcag ggacagtctc cagggtcagt ccctggatgg
     3001 gtggttacct ccccttcctc caccctaagc cctggggccc tgaaatgggg tgggagggca
     3061 ggggtgggag ccctcctagt gggtttgggg ggttgggttc ctgaatgcac cataatcgct
     3121 gtatgaaata ttaaaaagtc taaagtgaaa a
//
