LOCUS       NM_001366386            3719 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens cyclin dependent kinase 15 (CDK15), transcript variant
            4, mRNA.
ACCESSION   NM_001366386 XM_005246781
VERSION     NM_001366386.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3719)
  AUTHORS   Huang,C., Du,R., Jia,X., Liu,K., Qiao,Y., Wu,Q., Yao,N., Yang,L.,
            Zhou,L., Liu,X., Xiang,P., Xin,M., Wang,Y., Chen,X., Kim,D.J.,
            Dong,Z. and Li,X.
  TITLE     CDK15 promotes colorectal cancer progression via phosphorylating
            PAK4 and regulating beta-catenin/ MEK-ERK signaling pathway
  JOURNAL   Cell Death Differ 29 (1), 14-27 (2022)
   PUBMED   34262144
  REMARK    GeneRIF: CDK15 promotes colorectal cancer progression via
            phosphorylating PAK4 and regulating beta-catenin/ MEK-ERK signaling
            pathway.
REFERENCE   2  (bases 1 to 3719)
  AUTHORS   Zhang,X., Wang,Q., Luo,Y., Song,M., Zhou,Z., Zeng,L., Hu,M. and
            Yang,C.
  TITLE     Cyclin-dependent kinase 15 upregulation is correlated with poor
            prognosis for patients with breast cancer
  JOURNAL   J Int Med Res 49 (6), 300060521999552 (2021)
   PUBMED   34162268
  REMARK    GeneRIF: Cyclin-dependent kinase 15 upregulation is correlated with
            poor prognosis for patients with breast cancer.
REFERENCE   3  (bases 1 to 3719)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3719)
  AUTHORS   Park,M.H., Kim,S.Y., Kim,Y.J. and Chung,Y.H.
  TITLE     ALS2CR7 (CDK15) attenuates TRAIL induced apoptosis by inducing
            phosphorylation of survivin Thr34
  JOURNAL   Biochem Biophys Res Commun 450 (1), 129-134 (2014)
   PUBMED   24866247
  REMARK    GeneRIF: In summary, our results suggest that ALS2CR7 confers TRAIL
            resistance to cancer cells via phosphorylation of survivin.
REFERENCE   5  (bases 1 to 3719)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   6  (bases 1 to 3719)
  AUTHORS   Taipale,M., Krykbaeva,I., Koeva,M., Kayatekin,C., Westover,K.D.,
            Karras,G.I. and Lindquist,S.
  TITLE     Quantitative analysis of HSP90-client interactions reveals
            principles of substrate recognition
  JOURNAL   Cell 150 (5), 987-1001 (2012)
   PUBMED   22939624
REFERENCE   7  (bases 1 to 3719)
  AUTHORS   Malumbres,M., Harlow,E., Hunt,T., Hunter,T., Lahti,J.M.,
            Manning,G., Morgan,D.O., Tsai,L.H. and Wolgemuth,D.J.
  TITLE     Cyclin-dependent kinases: a family portrait
  JOURNAL   Nat Cell Biol 11 (11), 1275-1276 (2009)
   PUBMED   19884882
REFERENCE   8  (bases 1 to 3719)
  AUTHORS   Malumbres,M. and Barbacid,M.
  TITLE     Mammalian cyclin-dependent kinases
  JOURNAL   Trends Biochem Sci 30 (11), 630-641 (2005)
   PUBMED   16236519
  REMARK    Review article
REFERENCE   9  (bases 1 to 3719)
  AUTHORS   Manning,G., Whyte,D.B., Martinez,R., Hunter,T. and Sudarsanam,S.
  TITLE     The protein kinase complement of the human genome
  JOURNAL   Science 298 (5600), 1912-1934 (2002)
   PUBMED   12471243
  REMARK    Review article
REFERENCE   10 (bases 1 to 3719)
  AUTHORS   Hadano,S., Hand,C.K., Osuga,H., Yanagisawa,Y., Otomo,A.,
            Devon,R.S., Miyamoto,N., Showguchi-Miyata,J., Okada,Y.,
            Singaraja,R., Figlewicz,D.A., Kwiatkowski,T., Hosler,B.A.,
            Sagie,T., Skaug,J., Nasir,J., Brown,R.H. Jr., Scherer,S.W.,
            Rouleau,G.A., Hayden,M.R. and Ikeda,J.E.
  TITLE     A gene encoding a putative GTPase regulator is mutated in familial
            amyotrophic lateral sclerosis 2
  JOURNAL   Nat Genet 29 (2), 166-173 (2001)
   PUBMED   11586298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007242.3 and AC007358.2.
            
            On Nov 21, 2019 this sequence version replaced NM_001366386.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.38727.1,
                                           SRR14038192.2067572.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000652192.3/ ENSP00000498608.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               AC007242.3         71342-71592         c
            252-401             AC007242.3         70486-70635         c
            402-496             AC007242.3         70177-70271         c
            497-576             AC007242.3         65567-65646         c
            577-671             AC007242.3         55226-55320         c
            672-734             AC007242.3         54402-54464         c
            735-858             AC007242.3         44158-44281         c
            859-979             AC007242.3         42366-42486         c
            980-1073            AC007242.3         30655-30748         c
            1074-1137           AC007242.3         23192-23255         c
            1138-1186           AC007242.3         5803-5851           c
            1187-1326           AC007358.2         153373-153512       c
            1327-1469           AC007358.2         142613-142755       c
            1470-3719           AC007358.2         137990-140239       c
FEATURES             Location/Qualifiers
     source          1..3719
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     gene            1..3719
                     /gene="CDK15"
                     /gene_synonym="ALS2CR7; PFTAIRE2; PFTK2"
                     /note="cyclin dependent kinase 15"
                     /db_xref="GeneID:65061"
                     /db_xref="HGNC:HGNC:14434"
                     /db_xref="MIM:616147"
     exon            1..251
                     /gene="CDK15"
                     /gene_synonym="ALS2CR7; PFTAIRE2; PFTK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1436
                     /gene="CDK15"
                     /gene_synonym="ALS2CR7; PFTAIRE2; PFTK2"
                     /EC_number="2.7.11.22"
                     /note="isoform 4 is encoded by transcript variant 4;
                     amyotrophic lateral sclerosis 2 (juvenile) chromosome
                     region, candidate 7; PFTAIRE protein kinase 2; cell
                     division protein kinase 15; serine/threonine protein
                     kinase; serine/threonine-protein kinase ALS2CR7;
                     serine/threonine-protein kinase PFTAIRE-2; amyotrophic
                     lateral sclerosis 2 chromosomal region candidate gene 7
                     protein"
                     /codon_start=1
                     /product="cyclin-dependent kinase 15 isoform 4"
                     /protein_id="NP_001353315.1"
                     /db_xref="CCDS:CCDS92927.1"
                     /db_xref="GeneID:65061"
                     /db_xref="HGNC:HGNC:14434"
                     /db_xref="MIM:616147"
                     /translation="MGQELCAKTVQPGCSCYHCSEGGEAHSCRRSQPETTEAAFKLTD
                     LKEASCSMTSFHPRGLQAARAQKFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASS
                     YLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHAN
                     IVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQ
                     HVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATE
                     YSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNY
                     NPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPS
                     QLYQLPDEESLFTVSGVRLKPEMCDLLASYQKGHHPAQFSKCW"
     exon            252..401
                     /gene="CDK15"
                     /gene_synonym="ALS2CR7; PFTAIRE2; PFTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            402..496
                     /gene="CDK15"
                     /gene_synonym="ALS2CR7; PFTAIRE2; PFTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            497..576
                     /gene="CDK15"
                     /gene_synonym="ALS2CR7; PFTAIRE2; PFTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..671
                     /gene="CDK15"
                     /gene_synonym="ALS2CR7; PFTAIRE2; PFTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            672..734
                     /gene="CDK15"
                     /gene_synonym="ALS2CR7; PFTAIRE2; PFTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            735..858
                     /gene="CDK15"
                     /gene_synonym="ALS2CR7; PFTAIRE2; PFTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            859..979
                     /gene="CDK15"
                     /gene_synonym="ALS2CR7; PFTAIRE2; PFTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1073
                     /gene="CDK15"
                     /gene_synonym="ALS2CR7; PFTAIRE2; PFTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1137
                     /gene="CDK15"
                     /gene_synonym="ALS2CR7; PFTAIRE2; PFTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1186
                     /gene="CDK15"
                     /gene_synonym="ALS2CR7; PFTAIRE2; PFTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1326
                     /gene="CDK15"
                     /gene_synonym="ALS2CR7; PFTAIRE2; PFTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1469
                     /gene="CDK15"
                     /gene_synonym="ALS2CR7; PFTAIRE2; PFTK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..3719
                     /gene="CDK15"
                     /gene_synonym="ALS2CR7; PFTAIRE2; PFTK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3638..3643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK15"
                     /gene_synonym="ALS2CR7; PFTAIRE2; PFTK2"
                     /note="hexamer: AATAAA"
     polyA_site      3663
                     /gene="CDK15"
                     /gene_synonym="ALS2CR7; PFTAIRE2; PFTK2"
                     /note="major polyA site"
     regulatory      3693..3698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK15"
                     /gene_synonym="ALS2CR7; PFTAIRE2; PFTK2"
                     /note="hexamer: AATAAA"
     polyA_site      3719
                     /gene="CDK15"
                     /gene_synonym="ALS2CR7; PFTAIRE2; PFTK2"
                     /note="major polyA site"
ORIGIN      
        1 agagccatca tgtgagtcat atgaaagctc cacgctgctg acctctggca aaaagggaga
       61 gaacaaggat aggagaggca gtgggggaaa ggttcaagtg cgggttttct ccttgaacct
      121 acaagattat gggtcaagag ctgtgtgcaa agactgtaca gcctggatgc agctgctacc
      181 attgttcaga gggaggcgag gcacacagct gtcggaggag tcagcctgag accacggagg
      241 ctgcgttcaa gctaacagac ctaaaagaag catcatgttc catgacttca tttcacccca
      301 ggggacttca agctgcccgt gcccagaagt tcaagagtaa aaggccacgg agtaacagtg
      361 attgttttca ggaagaggat ctgaggcagg gttttcagtg gaggaagagc ctcccttttg
      421 gggcagcctc atcttacttg aacttggaga agctgggtga aggctcttat gcgacagttt
      481 acaaggggat tagcagaata aatggacaac tagtggcttt aaaagtcatc agcatgaatg
      541 cagaggaagg agtcccattt acagctatcc gagaagcttc tctcctgaag ggtttgaaac
      601 atgccaatat tgtgctcctg catgacataa tccacaccaa agagacactg acattcgttt
      661 ttgaatacat gcacacagac ctggcccagt atatgtctca gcatccagga gggcttcatc
      721 ctcataatgt cagacttttc atgtttcaac ttttgcgggg cctggcgtac atccaccacc
      781 aacacgttct tcacagggac ctgaaacctc agaacttact catcagtcac ctgggagagc
      841 tcaaactggc tgattttggt cttgcccggg ccaagtccat tcccagccag acatactctt
      901 cagaagtcgt gaccctctgg taccggcccc ctgatgcttt gctgggagcc actgaatatt
      961 cctctgagct ggacatatgg ggtgcaggct gcatctttat tgaaatgttc cagggtcaac
     1021 ctttgtttcc tggggtttcc aacatccttg aacagctgga gaaaatctgg gaggtgctgg
     1081 gagtccctac agaggatact tggccgggag tctccaagct acctaactac aatccagaat
     1141 ggttcccact gcctacgcct cgaagccttc atgttgtctg gaacaggctg ggcagggttc
     1201 ctgaagctga agacctggcc tcccagatgc taaaaggctt tcccagagac cgcgtctccg
     1261 cccaggaagc acttgttcat gattatttca gcgccctgcc atctcagctg taccagcttc
     1321 ctgatgagga gtctttgttt acagtttcag gagtgaggct aaagccagaa atgtgtgacc
     1381 ttttggcctc ctaccagaaa ggtcaccacc cagcccagtt tagcaaatgc tggtgaaaag
     1441 aaagggcgag atcaccaagg ttcttccagg gctgtatttc tgcagtttcg gttttcattt
     1501 gcttcagctt actaagaagc ttcaaatcta actccatact gaacaagggg ctttatgtcc
     1561 tcacctatga cctggaatag tttaaatatg gtgttcaagg caatagtaca taatagtgga
     1621 agaaaattca gtggaaggtt attgctattg tcatttgcat agaatttaag tgattgattt
     1681 aaaaaaactg gacataaact aagtctaaga agagggcttc tgaataactt cattcatttt
     1741 ggcatttgtt aagagattcc tgggctagaa ggttgatttc ccaaaaagac agataagaga
     1801 ctgacaattt aaaagaatct ggagacagag ctggtgctta cagagacctg ccactcctgt
     1861 gttcacttac aatttctccc aacaaaagga tttctgtggc aaggagaaaa ctagcctaaa
     1921 gtttagaaaa agatggtttc ttggataaca ttgttaacaa aaggacttcc tgaggactat
     1981 ttattattat tttgtagggg gcacttcctc cttcactaaa ctggattatc agaacgtatt
     2041 accacccaac ccatatttta gaagtttgga tttggctgct gattagaaat gaatttcagg
     2101 ctatctcctc ctactgaatc ttaattgtct gtgatgatgg caacagtgat ggggaatcta
     2161 agcgctggtt tgatggtgga gatattgaat aagtagttgg gagcagagtt ccaaagatgt
     2221 aatttaagcc ctgttgcacc accacacaca cacacacaca cacacacaca cacacacaca
     2281 cacccctcaa gtaaaatgag agatctgtct tagctaacac gtgtgccgtt ttatacaatg
     2341 actccttcta aaagcagcca gggaaactca aatcgcttct gtccagggat catctcagga
     2401 aatgtagcag cctagaaacc agagacctct gtatatcctt tggaagagca aggaggaact
     2461 aattaagaga taattaaaaa atagtaacta tcccccaatg tctgagatgg aaaaaggaaa
     2521 aagacacatg ggtagcccaa atcaacctgc ctgagtaagt atctgatttt agtaaggcat
     2581 ttgacaaaga ctgtccagct atacctgaaa gatgaaacag tgtaggctgg gtgatggagc
     2641 agatatatgt actcaaatca tggtgtttat ttaacccaga gaaaggccag ccgtggtgtg
     2701 ctacaaggtt cagtcttgag tcctattctg gtcaaatatt tttattaatt actcgaataa
     2761 atcagagtac atggacaact ttatacaact ccttgaagta agtactatta ttattaattt
     2821 atgacttcca tttcacaaaa gaggagactg aggctcagtg aagttaggta actccttcat
     2881 agtagcatgc cagagtgaag atgcaaacct cagacctggt tctccaatgt tcctgacacc
     2941 tatcgaattt agagaataca caactcttgc agaggcagct gctatttagt attggatcat
     3001 gattcaaaag acaccttgct agaagccaat gaacagcagg ccaaaacaac acttacttgc
     3061 atcaaatttc atctgactta aattcttaca ctttgggcta caacttaaaa aaggctatga
     3121 cttagtggaa attggcactt ttaagtacaa tatgaattaa tagtataatt tcgctgtccc
     3181 ccagagataa tgctagtacc aatcgaaagc tcagggatgc tactgttgac gcatcagcaa
     3241 gagttcttga gcagttttac ctgtccatca atacaaagag ttcccacaac agtagtggga
     3301 ttcctctgcc tctctgaaga tatgagagct ataggaggga ttcccatgtt ggaggttaga
     3361 agagctgacc tccaatgtcc cgtctaattc caagattctc caataatgac tttggaacag
     3421 ctgtgtacag attatacttg gaattatgct tagatactat tgctgcagga atgaatagac
     3481 aaattttgtt attaaaaaat tgattttatt aagtggaagt tgacagaatt atcctcttta
     3541 taatggagga acattatgct tatgcatatg catatacctt atgcatatga ttatgcttgt
     3601 gcttccttct ttaatggatt tacctattca aaagcttaat aaatgttata agactctaaa
     3661 acatttaaat ctttcatttc tcaattttat caaataaaca ttcctggaat ttgtgcata
//
