LOCUS       NM_001287135            5171 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens cyclin dependent kinase 14 (CDK14), transcript variant
            1, mRNA.
ACCESSION   NM_001287135 XM_005250434
VERSION     NM_001287135.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5171)
  AUTHORS   Zhao,Y., Chen,L., Xiang,Q., Lin,J., Jiang,S. and Li,W.
  TITLE     N6-methyladenosine-modified circCDK14 promotes ossification of the
            ligamentum flavum via epigenetic modulation by targeting AFF4
  JOURNAL   Cell Mol Life Sci 81 (1), 436 (2024)
   PUBMED   39414635
  REMARK    GeneRIF: N6-methyladenosine-modified circCDK14 promotes
            ossification of the ligamentum flavum via epigenetic modulation by
            targeting AFF4.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5171)
  AUTHORS   Parmasad,J.A., Ricke,K.M., Nguyen,B., Stykel,M.G., Buchner-Duby,B.,
            Bruce,A., Geertsma,H.M., Lian,E., Lengacher,N.A., Callaghan,S.M.,
            Joselin,A., Tomlinson,J.J., Schlossmacher,M.G., Stanford,W.L.,
            Ma,J., Brundin,P., Ryan,S.D. and Rousseaux,M.W.C.
  TITLE     Genetic and pharmacological reduction of CDK14 mitigates
            synucleinopathy
  JOURNAL   Cell Death Dis 15 (4), 246 (2024)
   PUBMED   38575601
  REMARK    GeneRIF: Genetic and pharmacological reduction of CDK14 mitigates
            synucleinopathy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5171)
  AUTHORS   Zhang,M., Kan,D., Zhang,B., Chen,X., Wang,C., Chen,S., Gao,W.,
            Yang,Z., Li,Y., Chen,Y., Zhu,S., Wen,S., Niu,Y. and Shang,Z.
  TITLE     P300/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA
            stability via internal m7G modification in CRPC
  JOURNAL   J Exp Clin Cancer Res 42 (1), 215 (2023)
   PUBMED   37599359
  REMARK    GeneRIF: P300/SP1 complex mediating elevated METTL1 regulates CDK14
            mRNA stability via internal m7G modification in CRPC.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5171)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   5  (bases 1 to 5171)
  AUTHORS   Chen,S., Zhang,Z., Zhang,B., Huang,Q., Liu,Y., Qiu,Y., Long,X.,
            Wu,M. and Zhang,Z.
  TITLE     CircCDK14 Promotes Tumor Progression and Resists Ferroptosis in
            Glioma by Regulating PDGFRA
  JOURNAL   Int J Biol Sci 18 (2), 841-857 (2022)
   PUBMED   35002529
  REMARK    GeneRIF: CircCDK14 Promotes Tumor Progression and Resists
            Ferroptosis in Glioma by Regulating PDGFRA.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5171)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 5171)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   8  (bases 1 to 5171)
  AUTHORS   Yang,T., Gao,Y.K. and Chen,J.Y.
  TITLE     KIAA0202, a human septin family member, interacting with hPFTAIRE1
  JOURNAL   Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 34 (4),
            520-525 (2002)
   PUBMED   12098780
REFERENCE   9  (bases 1 to 5171)
  AUTHORS   Yang,T. and Chen,J.Y.
  TITLE     Identification and cellular localization of human PFTAIRE1
  JOURNAL   Gene 267 (2), 165-172 (2001)
   PUBMED   11313143
REFERENCE   10 (bases 1 to 5171)
  AUTHORS   Lazzaro,M.A., Albert,P.R. and Julien,J.P.
  TITLE     A novel cdc2-related protein kinase expressed in the nervous system
  JOURNAL   J Neurochem 69 (1), 348-364 (1997)
   PUBMED   9202329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002456.2, HY179664.1, DC420282.1, AF119833.1, AK297974.1,
            BC136477.1, BP336072.1, DB476188.1, AB020641.1, BM740394.1 and
            BC152436.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001287135.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.197386.1,
                                           SRR1660809.234153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380050.8/ ENSP00000369390.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC002456.2         143102-143142
            42-79               HY179664.1         1-38
            80-176              DC420282.1         30-126
            177-778             AF119833.1         8-609
            779-1771            AK297974.1         694-1686
            1772-3882           BC136477.1         1510-3620
            3883-3958           BP336072.1         467-542
            3959-4018           DB476188.1         5-64
            4019-4134           AB020641.1         3804-3919
            4135-4439           DB476188.1         181-485
            4440-5029           BM740394.1         54-643
            5030-5171           BC152436.1         4817-4958
FEATURES             Location/Qualifiers
     source          1..5171
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.13"
     gene            1..5171
                     /gene="CDK14"
                     /gene_synonym="PFTAIRE1; PFTK1"
                     /note="cyclin dependent kinase 14"
                     /db_xref="GeneID:5218"
                     /db_xref="HGNC:HGNC:8883"
                     /db_xref="MIM:610679"
     exon            1..398
                     /gene="CDK14"
                     /gene_synonym="PFTAIRE1; PFTK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             308..1717
                     /gene="CDK14"
                     /gene_synonym="PFTAIRE1; PFTK1"
                     /EC_number="2.7.11.22"
                     /note="isoform a is encoded by transcript variant 1;
                     PFTAIRE protein kinase 1; cell division protein kinase 14;
                     serine/threonine-protein kinase PFTAIRE-1"
                     /codon_start=1
                     /product="cyclin-dependent kinase 14 isoform a"
                     /protein_id="NP_001274064.1"
                     /db_xref="CCDS:CCDS75626.1"
                     /db_xref="GeneID:5218"
                     /db_xref="HGNC:HGNC:8883"
                     /db_xref="MIM:610679"
                     /translation="MCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKDDTTFDEICV
                     TKMSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACIN
                     FKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKL
                     VALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLC
                     QYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFG
                     LARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPG
                     MKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHA
                     EDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGES
                     MRAFGKNNSYGKSLSNSKH"
     exon            399..430
                     /gene="CDK14"
                     /gene_synonym="PFTAIRE1; PFTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..676
                     /gene="CDK14"
                     /gene_synonym="PFTAIRE1; PFTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            677..771
                     /gene="CDK14"
                     /gene_synonym="PFTAIRE1; PFTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..851
                     /gene="CDK14"
                     /gene_synonym="PFTAIRE1; PFTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..946
                     /gene="CDK14"
                     /gene_synonym="PFTAIRE1; PFTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1009
                     /gene="CDK14"
                     /gene_synonym="PFTAIRE1; PFTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1133
                     /gene="CDK14"
                     /gene_synonym="PFTAIRE1; PFTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1254
                     /gene="CDK14"
                     /gene_synonym="PFTAIRE1; PFTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1348
                     /gene="CDK14"
                     /gene_synonym="PFTAIRE1; PFTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1412
                     /gene="CDK14"
                     /gene_synonym="PFTAIRE1; PFTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1461
                     /gene="CDK14"
                     /gene_synonym="PFTAIRE1; PFTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1601
                     /gene="CDK14"
                     /gene_synonym="PFTAIRE1; PFTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1745
                     /gene="CDK14"
                     /gene_synonym="PFTAIRE1; PFTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..5171
                     /gene="CDK14"
                     /gene_synonym="PFTAIRE1; PFTK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5147..5152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK14"
                     /gene_synonym="PFTAIRE1; PFTK1"
                     /note="hexamer: AATAAA"
     polyA_site      5171
                     /gene="CDK14"
                     /gene_synonym="PFTAIRE1; PFTK1"
                     /note="major polyA site"
ORIGIN      
        1 acaaaggagg gaaaatgagc cgggcggcgg cggcgcggcg cggggccacc acggcggcgg
       61 cgagcgcggc cgcccccggc accacgtaaa ccgcccccgc ccgcccagct gcggcccagg
      121 ccggagcgga gcctgccgtc ctccgcctgc ctgctgctcg cctccctaga cctgcgcgtc
      181 gcttcccggc ccgccgagga ggtggtggag gaggaggcgc cgctttcccc gcggcgcgcg
      241 ccctcgccgt tgtctgagct gtgcctggac cagtttgggg aagttgtcgg ggctccgcgt
      301 cgcccagatg tgtgacctca ttgagccgca gccggccgag aagatcggca agatgaagaa
      361 gttgcggaga actttgtcgg agagtttcag tcgcattgct ttgaagaaag atgacaccac
      421 ctttgatgag atatgtgtca caaagatgtc tacacggaac tgccagggaa tggactcagt
      481 gatcaaaccc ctggacacaa ttcctgagga taaaaaagtc agagttcaga ggacacagag
      541 cacttttgac ccatttgaga aaccagctaa tcaagtaaag agggtgcatt ctgagaacaa
      601 tgcttgcatt aactttaaga cctcctccac tggcaaagag tcacctaaag ttaggcggca
      661 ctccagcccc agctcgccaa caagtcccaa atttggaaaa gctgactcat atgaaaagct
      721 ggaaaaacta ggggaaggat cttatgctac agtatacaaa gggaaaagca aggtaaatgg
      781 gaagttggta gctctgaagg tgatcaggct gcaggaagaa gaagggacac ctttcacagc
      841 tatcagggaa gcttctcttt taaaaggact aaaacatgct aacatagtgc tacttcatga
      901 catcatccat accaaggaga cgctgacact tgtgtttgaa tatgtgcaca ctgatttatg
      961 tcagtacatg gacaagcacc ctggggggct gcatccagat aatgtgaagt tgtttttatt
     1021 tcagttgctg cgaggtctgt cttacatcca ccagcgttat attttgcaca gagacctgaa
     1081 accacagaac cttctgatca gtgacacggg ggagttaaag ctggcagatt tcggtcttgc
     1141 aagagcaaaa tccgtcccta gccacacata ctccaacgaa gtggttacct tgtggtacag
     1201 acctccagat gtccttctag gctcaacaga atattccacc tgccttgaca tgtggggagt
     1261 aggttgcatc tttgttgaaa tgatccaagg agttgctgct tttccaggaa tgaaagacat
     1321 tcaggatcaa cttgaacgaa tatttctggt tcttggaaca ccaaatgagg acacatggcc
     1381 tggagttcat tctttaccac attttaagcc agaacgcttt accctgtaca gctctaaaaa
     1441 ccttagacaa gcatggaata agctcagcta tgtgaaccat gcagaggacc tggcctccaa
     1501 gctcctacaa tgttccccaa agaacagact gtcggcacag gctgccttga gccacgagta
     1561 ttttagtgac ctgccgccac ggctatggga actcaccgac atgtcttcta tttttactgt
     1621 cccaaatgtg agattgcaac cagaagctgg agaaagcatg cgggcctttg ggaaaaacaa
     1681 tagttatggc aaaagtctat caaacagcaa gcactgacaa gcagcacatt ctcaagagca
     1741 cacaggatta agttgtcatc attctgggaa gaaaaaaaaa acattaatga agaggccaat
     1801 aatatgaagg gaatcatgga tcagttttct ttcgctccct gtggtggatt tcacttacaa
     1861 gaaaattgaa gctggcaaga ccctgttttc tctgcaattt atttaaaacc ttgcacgcat
     1921 ttggatacct tgtgatttcc aagaactacg tgaagattaa gctttgctta ctgatacatg
     1981 gcatgtattc ttttcagtct tttgtgtttg attttgtttg atttccctct gcagcacagc
     2041 gtctctgtaa aggtttttat gctttcacca gccatgtctt aaatacatta agacaacaca
     2101 tttggtgttc acacttcttc agtaatgtct gaacttgaaa gccacagagt ggcataaaac
     2161 aatgtgtgtt ttctttgaga gcagtgcaca ttttgcaacc actaggaagg aaattttctg
     2221 ctaaagcaaa cccctgttct ctgacttgac aacttggccc cggactgtgg ggccccacct
     2281 gttgcttacc ttttgaggta attttgcaaa tgtggttttt ttacttggaa ataactgcac
     2341 atttatatat aggatattgg actctgctta gcattttcaa gccacatagc atgactgttt
     2401 tttgaatagg ttggaattga aaaaacaatt atcaaacgtt aagaacaaag acagggataa
     2461 attgcttaca tttcaacctc tggagattga ggtaactttt tgtgtctggg tcttgtcaac
     2521 atctaatttt tttccatcca ttctgttaca ctttgtattt tctaactgga gaaaagagtg
     2581 aggaacagaa tgttttaaat ctggtgcaaa agaactatat ctgctggatg agccttgaaa
     2641 gcagtcttgg cctgttaggg cttacaaagt aaattacaaa gtgatccagt tcaaagtttg
     2701 cttagttaca acaaagcacc tttaaaaaaa atacatttta aaaaaacatt ccaagccaat
     2761 tggaagacat cattgggttc ttactttaag acatctcctg gaataactgt tcaaatgcag
     2821 gttttagaaa caatgcagga atcttgcttt aaagatgaaa aagggaatgg gccagcttcc
     2881 cttactcaag gagttgaggg accttggagg atgaaggcga gtatgtgaca ctggagaaaa
     2941 gtggaccagg catgtctttt gctttgatct ggagggaggg ctgcctgatg caggccggct
     3001 cccagtgggg caggcctcgc tgcagaatgc ccagtagtac tgcggccaag gggacagtta
     3061 ggagacttca tctaaagcat gaaacctagc tcctctacac acaaattcct atggaaatac
     3121 ctttgtgtac agtgtcttac attttcctat tagtcagaaa gaaggagaga atgagtgagt
     3181 gcttgaaatg tgtcatactg ttttaggatc aagactagga attaggagcc aggttgacaa
     3241 ggactttttc tgagagttgg gtgagggtaa agcttttcta taatcaagct caatacacca
     3301 aggaaactgg atccagaatt cctaaacttt aaaatggtac tgtctgcgga gtggagtatg
     3361 gatggttatg tcaaagtcat agttcatcct atccagatgt agcattcatg gtaaactttt
     3421 aagtgctaag caaggaatta tttactgatt ggttttaaag agagcagaaa acacccaagt
     3481 gtagaatgtc tactgtttgc tacctagaaa tcttttccat tcctctttca tacattccaa
     3541 cccactggaa gtctttagag gtattttgat ttaaagtata cttaaattag gatttcttaa
     3601 agaaaacata gggagaaaac tttacatgca attaaaaatg gactttcctg tgatttgttt
     3661 ttaatcattc atttggagaa gaggcatgac ctttgtattt cactaagttt aaagcaagag
     3721 caactgatga ttaaatgttg ctttttaata aggtttttaa cttgaaaatt tgaaaatatt
     3781 taatgttgaa agacttcaat tagggctatt agagttatat ctccctgtcg taggcagctt
     3841 cttcggagaa gtgaaatata acattactca gtggacggag aaatctgttt tgttacagag
     3901 acatgcctct cagaaggtca ggaggttttg agtacctatc cttgccaccc atacaggaaa
     3961 tccaaagttt ggtgtctctc tctctctgtc tctttctttc tctttctccc cccaaacccc
     4021 tctcactccc tccctccctc tctccttccc ctatttgcaa tcatattctc cctctgcttc
     4081 ttttctcttc tgccctcctt gtgggcagtc atgaaaatca attcagactg tgttgattag
     4141 cagatttatt attctattga gaaagcactg gaatgttttg tgagattatt tttatatgaa
     4201 ggaatagcct gaactcaaac agatggtaag aatagtacaa acaccttagc acatcactgc
     4261 acacacagta ttctgaaagg agatttgaca cttaattccc attttcttaa aataacagtt
     4321 ttgttgactt aaaaatatga gatacatagg atgtgaaaaa aaatgtttgc agtactcagc
     4381 aaaaaatagg gtacataaag cagggtggct gtccatccac tgattctggg gtgagaagcg
     4441 atttctacct cgcaagagtg actagaaagt ttctaggagc acctccaggc ttgcaaagaa
     4501 agtgaggcct cttggtatcc tttcctcagt gtgtatatga cagccagtat aatcaatacc
     4561 ctaggttatg cgtctatatg atactcatct gtgaatatta ttggttttgt aatctttgtt
     4621 atataagagg atgtttaggc tgtatatact ggggtagatt attgcctgcc ccttatacat
     4681 aggaatatgc tgcataattg cgcataactt ccatctccct tactggcttg taggcagagg
     4741 aaactgtata tgttactgcc ttgtactttt ctcatacacc aaaaacacac caaaaaaatc
     4801 aataaaataa gcaatcttct attctcattc cttttcccac agcagcatat tttagaggca
     4861 catacaaaac ctacattctc tagttgggag tggattttta aagttttcct tttatctttt
     4921 attttttttt gtatgatgca ctgagatgtg tactttctaa caggggattg gtacctaaga
     4981 aatgtggtag cattattcag aaaactatta tactttcaaa tgacacatag taaggagaat
     5041 ggaataatac atgttgcata tttgttacca gttgtaattt gtctgtatta tgaaagatgt
     5101 aatggtttgt cagctgtcac tgttgttttc ttgtaacatg atatggaata aagtatagca
     5161 gaatctccgt a
//
