LOCUS       NP_001274064             469 aa            linear   PRI 28-APR-2025
DEFINITION  cyclin-dependent kinase 14 isoform a [Homo sapiens].
ACCESSION   NP_001274064 XP_005250491
VERSION     NP_001274064.1
DBSOURCE    REFSEQ: accession NM_001287135.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 469)
  AUTHORS   Zhao,Y., Chen,L., Xiang,Q., Lin,J., Jiang,S. and Li,W.
  TITLE     N6-methyladenosine-modified circCDK14 promotes ossification of the
            ligamentum flavum via epigenetic modulation by targeting AFF4
  JOURNAL   Cell Mol Life Sci 81 (1), 436 (2024)
   PUBMED   39414635
  REMARK    GeneRIF: N6-methyladenosine-modified circCDK14 promotes
            ossification of the ligamentum flavum via epigenetic modulation by
            targeting AFF4.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 469)
  AUTHORS   Parmasad,J.A., Ricke,K.M., Nguyen,B., Stykel,M.G., Buchner-Duby,B.,
            Bruce,A., Geertsma,H.M., Lian,E., Lengacher,N.A., Callaghan,S.M.,
            Joselin,A., Tomlinson,J.J., Schlossmacher,M.G., Stanford,W.L.,
            Ma,J., Brundin,P., Ryan,S.D. and Rousseaux,M.W.C.
  TITLE     Genetic and pharmacological reduction of CDK14 mitigates
            synucleinopathy
  JOURNAL   Cell Death Dis 15 (4), 246 (2024)
   PUBMED   38575601
  REMARK    GeneRIF: Genetic and pharmacological reduction of CDK14 mitigates
            synucleinopathy.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 469)
  AUTHORS   Zhang,M., Kan,D., Zhang,B., Chen,X., Wang,C., Chen,S., Gao,W.,
            Yang,Z., Li,Y., Chen,Y., Zhu,S., Wen,S., Niu,Y. and Shang,Z.
  TITLE     P300/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA
            stability via internal m7G modification in CRPC
  JOURNAL   J Exp Clin Cancer Res 42 (1), 215 (2023)
   PUBMED   37599359
  REMARK    GeneRIF: P300/SP1 complex mediating elevated METTL1 regulates CDK14
            mRNA stability via internal m7G modification in CRPC.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 469)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   5  (residues 1 to 469)
  AUTHORS   Chen,S., Zhang,Z., Zhang,B., Huang,Q., Liu,Y., Qiu,Y., Long,X.,
            Wu,M. and Zhang,Z.
  TITLE     CircCDK14 Promotes Tumor Progression and Resists Ferroptosis in
            Glioma by Regulating PDGFRA
  JOURNAL   Int J Biol Sci 18 (2), 841-857 (2022)
   PUBMED   35002529
  REMARK    GeneRIF: CircCDK14 Promotes Tumor Progression and Resists
            Ferroptosis in Glioma by Regulating PDGFRA.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 469)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (residues 1 to 469)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   8  (residues 1 to 469)
  AUTHORS   Yang,T., Gao,Y.K. and Chen,J.Y.
  TITLE     KIAA0202, a human septin family member, interacting with hPFTAIRE1
  JOURNAL   Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 34 (4),
            520-525 (2002)
   PUBMED   12098780
REFERENCE   9  (residues 1 to 469)
  AUTHORS   Yang,T. and Chen,J.Y.
  TITLE     Identification and cellular localization of human PFTAIRE1
  JOURNAL   Gene 267 (2), 165-172 (2001)
   PUBMED   11313143
REFERENCE   10 (residues 1 to 469)
  AUTHORS   Lazzaro,M.A., Albert,P.R. and Julien,J.P.
  TITLE     A novel cdc2-related protein kinase expressed in the nervous system
  JOURNAL   J Neurochem 69 (1), 348-364 (1997)
   PUBMED   9202329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002456.2, HY179664.1, DC420282.1, AF119833.1, AK297974.1,
            BC136477.1, BP336072.1, DB476188.1, AB020641.1, BM740394.1 and
            BC152436.1.
            
            On Nov 27, 2013 this sequence version replaced XP_005250491.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.197386.1,
                                           SRR1660809.234153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380050.8/ ENSP00000369390.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.13"
     Protein         1..469
                     /product="cyclin-dependent kinase 14 isoform a"
                     /EC_number="2.7.11.22"
                     /note="PFTAIRE protein kinase 1; cell division protein
                     kinase 14; serine/threonine-protein kinase PFTAIRE-1"
                     /calculated_mol_wt=52926
     Site            24
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O94921.3)"
     Site            78
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O94921.3)"
     Site            95
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18691976,
                     ECO:0007744|PubMed:19369195; propagated from
                     UniProtKB/Swiss-Prot (O94921.3)"
     Region          103..133
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O94921.3)"
     Region          129..431
                     /region_name="STKc_PFTAIRE1"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     PFTAIRE-1 kinase; cd07869"
                     /db_xref="CDD:143374"
     Site            134
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O94921.3)"
     Site            order(141..144,149,162,164,180,194,210..213,216,218..219,
                     256,258,260..261,263,274,277,289,291..294,296,334..335)
                     /site_type="active"
                     /db_xref="CDD:143374"
     Site            order(141..144,149,162,164,194,210..213,216,219,260..261,
                     263,274)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:143374"
     Site            order(172..174,176,179..180,182..183,186..187,199,201,206,
                     245,248..251,279,281..284,288..289,405,409..411)
                     /site_type="other"
                     /note="putative CDK/cyclin interface [polypeptide
                     binding]"
                     /db_xref="CDD:143374"
     Site            order(180,218,256,258,277,289,291..294,296,334..335)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:143374"
     Site            273..296
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:143374"
     Region          449..469
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O94921.3)"
     CDS             1..469
                     /gene="CDK14"
                     /gene_synonym="PFTAIRE1; PFTK1"
                     /coded_by="NM_001287135.2:308..1717"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS75626.1"
                     /db_xref="GeneID:5218"
                     /db_xref="HGNC:HGNC:8883"
                     /db_xref="MIM:610679"
ORIGIN      
        1 mcdliepqpa ekigkmkklr rtlsesfsri alkkddttfd eicvtkmstr ncqgmdsvik
       61 pldtipedkk vrvqrtqstf dpfekpanqv krvhsennac infktsstgk espkvrrhss
      121 pssptspkfg kadsyeklek lgegsyatvy kgkskvngkl valkvirlqe eegtpftair
      181 easllkglkh anivllhdii htketltlvf eyvhtdlcqy mdkhpgglhp dnvklflfql
      241 lrglsyihqr yilhrdlkpq nllisdtgel kladfglara ksvpshtysn evvtlwyrpp
      301 dvllgsteys tcldmwgvgc ifvemiqgva afpgmkdiqd qleriflvlg tpnedtwpgv
      361 hslphfkper ftlyssknlr qawnklsyvn haedlaskll qcspknrlsa qaalsheyfs
      421 dlpprlwelt dmssiftvpn vrlqpeages mrafgknnsy gkslsnskh
//
