LOCUS       XM_047436286            6144 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens cyclin dependent kinase 12 (CDK12),
            transcript variant X39, mRNA.
ACCESSION   XM_047436286
VERSION     XM_047436286.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000017.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6144
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
     gene            1..6144
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /note="cyclin dependent kinase 12; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     mRNA, 24 ESTs, 758 long SRA reads, 2 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 93 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:51755"
                     /db_xref="HGNC:HGNC:24224"
                     /db_xref="MIM:615514"
     CDS             587..4738
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /codon_start=1
                     /product="cyclin-dependent kinase 12 isoform X6"
                     /protein_id="XP_047292242.1"
                     /db_xref="GeneID:51755"
                     /db_xref="HGNC:HGNC:24224"
                     /db_xref="MIM:615514"
                     /translation="MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKR
                     HKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGS
                     DRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDD
                     YGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKR
                     RSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVS
                     PPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSS
                     PFLSKRSLSRSPLPRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNS
                     SLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSV
                     KLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALK
                     EEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPPLP
                     PSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTS
                     TLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPP
                     DSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQV
                     YKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDA
                     LDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLH
                     RDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTP
                     AIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMK
                     PKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPP
                     DLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQP
                     APGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQ
                     QQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPAD
                     MQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPPEPPGP
                     PPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYST
                     RPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSS
                     YQGTG"
     polyA_site      6144
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 aagtgccgtt tcggtttaat ctagtgtgtg actgggtctg tgtgagggag agagtgtgtg
       61 tggtgtggag gtgaaacgga ggcaagaaag ggggctacct caggagcgag ggacaaaggg
      121 ggcgtgaggc acctaggccg cggcaccccg gcgacaggaa gccgtcctga accgggctac
      181 cgggtagggg aagggcccgc gtagtcctcg cagggcccca gagctggagt cggctccaca
      241 gccccgggcc gtcggcttct cacttcctgg acctccccgg cgcccgggcc tgaggactgg
      301 ctcggcggag ggagaagagg aaacagactt gagcagctcc ccgttgtctc gcaactccac
      361 tgccgaggaa ctctcatttc ttccctcgct ccttcacccc ccacctcatg tagaagggtg
      421 ctgaggcgtc gggagggagg aggagcctgg gctaccgtcc ctgccctccc cacccccttc
      481 ccggggcgct ttggtgggcg tggagttggg gttggggggg tgggtggggg ttgctttttg
      541 gagtgctggg gaactttttt cccttcttca ggtcagggga aagggaatgc ccaattcaga
      601 gagacatggg ggcaagaagg acgggagtgg aggagcttct ggaactttgc agccgtcatc
      661 gggaggcggc agctctaaca gcagagagcg tcaccgcttg gtatcgaagc acaagcggca
      721 taagtccaaa cactccaaag acatggggtt ggtgaccccc gaagcagcat ccctgggcac
      781 agttatcaaa cctttggtgg agtatgatga tatcagctct gattccgaca ccttctccga
      841 tgacatggcc ttcaaactag accgaaggga gaacgacgaa cgtcgtggat cagatcggag
      901 cgaccgcctg cacaaacatc gtcaccacca gcacaggcgt tcccgggact tactaaaagc
      961 taaacagacc gaaaaagaaa aaagccaaga agtctccagc aagtcgggat cgatgaagga
     1021 ccggatatcg ggaagttcaa agcgttcgaa tgaggagact gatgactatg ggaaggcgca
     1081 ggtagccaaa agcagcagca aggaatccag gtcatccaag ctccacaagg agaagaccag
     1141 gaaagaacgg gagctgaagt ctgggcacaa agaccggagt aaaagtcatc gaaaaaggga
     1201 aacacccaaa agttacaaaa cagtggacag cccaaaacgg agatccagga gcccccacag
     1261 gaagtggtct gacagctcca aacaagatga tagcccctcg ggagcttctt atggccaaga
     1321 ttatgacctt agtccctcac gatctcatac ctcgagcaat tatgactcct acaagaaaag
     1381 tcctggaagt acctcgagaa ggcagtcggt cagtccccct tacaaggagc cttcggccta
     1441 ccagtccagc acccggtcac cgagccccta cagtaggcga cagagatctg tcagtcccta
     1501 tagcaggaga cggtcgtcca gctacgaaag aagtggctct tacagcgggc gatcgcccag
     1561 tccctatggt cgaaggcggt ccagcagccc tttcctgagc aagcggtctc tgagtcggag
     1621 tccactcccc aggaaatcca tgaagtccag aagtagaagt cctgcatatt caagacattc
     1681 atcttctcat agtaaaaaga agagatccag ttcacgcagt cgtcattcca gtatctcacc
     1741 tgtcaggctt ccacttaatt ccagtctggg agctgaactc agtaggaaaa agaaggaaag
     1801 agcagctgct gctgctgcag caaagatgga tggaaaggag tccaagggtt cacctgtatt
     1861 tttgcctaga aaagagaaca gttcagtaga ggctaaggat tcaggtttgg agtctaaaaa
     1921 gttacccaga agtgtaaaat tggaaaaatc tgccccagat actgaactgg tgaatgtaac
     1981 acatctaaac acagaggtaa aaaattcttc agatacaggg aaagtaaagt tggatgagaa
     2041 ctccgagaag catcttgtta aagatttgaa agcacaggga acaagagact ctaaacccat
     2101 agcactgaaa gaggagattg ttactccaaa ggagacagaa acatcagaaa aggagacccc
     2161 tccacctctt cccacaattg cttctccccc accccctcta ccaactacta cccctccacc
     2221 tcagacaccc cctttgccac ctttgcctcc aataccagct cttccacagc aaccacctct
     2281 gcctccttct cagccagcat ttagtcaggt tcctgcttcc agtacttcaa ctttgccccc
     2341 ttctactcac tcaaagacat ctgctgtgtc ctctcaggca aattctcagc cccctgtaca
     2401 ggtttctgtg aagactcaag tatctgtaac agctgctatt ccacacctga aaacttcaac
     2461 gttgcctcct ttgcccctcc cacccttatt acctggagat gatgacatgg atagtccaaa
     2521 agaaactctt ccttcaaaac ctgtgaagaa agagaaggaa cagaggacac gtcacttact
     2581 cacagacctt cctctccctc cagagctccc tggtggagat ctgtctcccc cagactctcc
     2641 agaaccaaag gcaatcacac cacctcagca accatataaa aagagaccaa aaatttgttg
     2701 tcctcgttat ggagaaagaa gacaaacaga aagcgactgg gggaaacgct gtgtggacaa
     2761 gtttgacatt attgggatta ttggagaagg aacctatggc caagtatata aagccaagga
     2821 caaagacaca ggagaactag tggctctgaa gaaggtgaga ctagacaatg agaaagaggg
     2881 cttcccaatc acagccattc gtgaaatcaa aatccttcgt cagttaatcc accgaagtgt
     2941 tgttaacatg aaggaaattg tcacagataa acaagatgca ctggatttca agaaggacaa
     3001 aggtgccttt taccttgtat ttgagtatat ggaccatgac ttaatgggac tgctagaatc
     3061 tggtttggtg cacttttctg aggaccatat caagtcgttc atgaaacagc taatggaagg
     3121 attggaatac tgtcacaaaa agaatttcct gcatcgggat attaagtgtt ctaacatttt
     3181 gctgaataac agtgggcaaa tcaaactagc agattttgga cttgctcggc tctataactc
     3241 tgaagagagt cgcccttaca caaacaaagt cattactttg tggtaccgac ctccagaact
     3301 actgctagga gaggaacgtt acacaccagc catagatgtt tggagctgtg gatgtattct
     3361 tggggaacta ttcacaaaga agcctatttt tcaagccaat ctggaactgg ctcagctaga
     3421 actgatcagc cgactttgtg gtagcccttg tccagctgtg tggcctgatg ttatcaaact
     3481 gccctacttc aacaccatga aaccgaagaa gcaatatcga aggcgtctac gagaagaatt
     3541 ctctttcatt ccttctgcag cacttgattt attggaccac atgctgacac tagatcctag
     3601 taagcggtgc acagctgaac agaccctaca gagcgacttc cttaaagatg tcgaactcag
     3661 caaaatggct cctccagacc tcccccactg gcaggattgc catgagttgt ggagtaagaa
     3721 acggcgacgt cagcgacaaa gtggtgttgt agtcgaagag ccacctccat ccaaaacttc
     3781 tcgaaaagaa actacctcag ggacaagtac tgagcctgtg aagaacagca gcccagcacc
     3841 acctcagcct gctcctggca aggtggagtc tggggctggg gatgcaatag gccttgctga
     3901 catcacacaa cagctgaatc aaagtgaatt ggcagtgtta ttaaacctgc tgcagagcca
     3961 aaccgacctg agcatccctc aaatggcaca gctgcttaac atccactcca acccagagat
     4021 gcagcagcag ctggaagccc tgaaccaatc catcagtgcc ctgacggaag ctacttccca
     4081 gcagcaggac tcagagacca tggccccaga ggagtctttg aaggaagcac cctctgcccc
     4141 agtgatcctg ccttcagcag aacagacgac ccttgaagct tcaagcacac cagctgacat
     4201 gcagaatata ttggcagttc tcttgagtca gctgatgaaa acccaagagc cagcaggcag
     4261 tctggaggaa aacaacagtg acaagaacag tgggccacag gggccccgaa gaactcccac
     4321 aatgccacag gaggaggcag cagagaagag gccccctgag ccccccggac ctccaccgcc
     4381 gccacctcca ccccctctgg ttgaaggcga tctttccagc gccccccagg agttgaaccc
     4441 agccgtgaca gccgccttgc tgcaactttt atcccagcct gaagcagagc ctcctggcca
     4501 cctgccacat gagcaccagg ccttgagacc aatggagtac tccacccgac cccgtccaaa
     4561 caggacttat ggaaacactg atgggcctga aacagggttc agtgccattg acactgatga
     4621 acgaaactct ggtccagcct tgacagaatc cttggtccag accctggtga agaacaggac
     4681 cttctcaggc tctctgagcc accttgggga gtccagcagt taccagggca cagggtagga
     4741 gcaacggtgg gaatgccctc tgaggaatgc agtgatgtcc atcagtcacc tctcacccag
     4801 agcctggcaa attcagtctc tttcacagaa cctaaagcca agccaggttc agtgggaaat
     4861 cccacctgtc caaacactgt gtgagacacc agaattagag gcctgcaagc ctgcttcctt
     4921 catccccaat gcccagatgg gacaggtcac cagcctcctg tgtctacccc cacctttctt
     4981 gcttgctgtg cctctctcat ccctgcaatc cagacagcac atgcagcagc tcaaatgtga
     5041 aaaacaagac ccagagaggg gaaatcattt gaatcctgtc ctggtattgc tttgtgttcc
     5101 tggatttgga gaatttctgg gaacacagga aaaggaaagt gaatgccacc aggatctgaa
     5161 cccaagattc cagcctcggt caccaccctg accctgagaa tgccactggg atggggagaa
     5221 cttgtcagtc ttcatccttc cccacaagta tactgaagcc aggacagcac ctgccttaga
     5281 gagctcttag agggattatc cgcagcctga agaaagaagg ttacaactga ggaagaactt
     5341 ctgaacaggg aagagtggaa gaaaagactg cagctcagct ccagaagcag acccagaatg
     5401 gcatccttct ctgagaccca gaccccagcc ccttttcatg gaagaccagc acaaaggagg
     5461 aagtaggtta gggaatggta aggctccatg tgatgggact aatgtggaga ggcctggggc
     5521 ctttccctga ggactggatg gctggagttt gggagcctga gttgacagag gaggctaagc
     5581 ccgggcagct actttgttcc agaaatctaa ggtccctgga gggaggctct gctttgggag
     5641 ggggaaggga gctaacattg cagagcacca actgtgaacc aggtacaatg gcagagcctt
     5701 tccatacctg tactcacaac tagcgggtga ggagtcaagg caaataggtg tctcatagct
     5761 ccccatatct cggcagtcga ccacctcctc ctttgattct ctgatgtcac tgccagttct
     5821 cctcctattg ctctgacctg tctttctctg tgtcctttgc aaactcattc tcaactcctt
     5881 agactcagtc aagtccccca gttacacact tccatggtac tatatatcat tccttcagag
     5941 cacttaacac agttatttcc tatgtatttg tccagtcatt tgaataatga tcctagtttc
     6001 attggatgga aagttccaca aggtcagtga ccatttctat ctgtgttcac caatgtgttc
     6061 ccagtgccca gaaacaatgc ctagcataaa gcagctgttt tgtaaatact tgttcaatga
     6121 atgaataaat gacaaaagaa catc
//
