LOCUS       NM_016507               8287 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens cyclin dependent kinase 12 (CDK12), transcript variant
            1, mRNA.
ACCESSION   NM_016507
VERSION     NM_016507.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8287)
  AUTHORS   Ebara,S., Yoshida,M., Yamakawa,H., Shimokawa,K., Inoue,Y.,
            Tauchi,H. and Morishita,D.
  TITLE     Interaction of CDK12 with NXF1 is a new node for the linking
            mechanism between transcription and transportation of mRNA
  JOURNAL   Biochem Biophys Res Commun 735, 150608 (2024)
   PUBMED   39270556
  REMARK    GeneRIF: Interaction of CDK12 with NXF1 is a new node for the
            linking mechanism between transcription and transportation of mRNA.
REFERENCE   2  (bases 1 to 8287)
  AUTHORS   Li,Z., Li,X., Seebacher,N.A., Liu,X., Wu,W., Yu,S., Hornicek,F.J.,
            Huang,C. and Duan,Z.
  TITLE     CDK12 is a promising therapeutic target for the transcription cycle
            and DNA damage response in metastatic osteosarcoma
  JOURNAL   Carcinogenesis 45 (10), 786-798 (2024)
   PUBMED   39082894
  REMARK    GeneRIF: CDK12 is a promising therapeutic target for the
            transcription cycle and DNA damage response in metastatic
            osteosarcoma.
REFERENCE   3  (bases 1 to 8287)
  AUTHORS   Karolak,A., Urbaniak,K., Monastyrskyi,A., Duckett,D.R.,
            Branciamore,S. and Stewart,P.A.
  TITLE     Structure-independent machine-learning predictions of the CDK12
            interactome
  JOURNAL   Biophys J 123 (17), 2910-2920 (2024)
   PUBMED   38762754
  REMARK    GeneRIF: Structure-independent machine-learning predictions of the
            CDK12 interactome.
REFERENCE   4  (bases 1 to 8287)
  AUTHORS   Bhogal,T., Giannoudis,A., Sokol,E., Ali,S. and Palmieri,C.
  TITLE     Analysis of Breast Cancer Brain Metastases Reveals an Enrichment of
            Cyclin-Dependent Kinase 12 Structural Rearrangements in Human
            Epidermal Growth Factor Receptor 2-Positive Disease
  JOURNAL   JCO Precis Oncol 8, e2300639 (2024)
   PUBMED   38838276
  REMARK    GeneRIF: Analysis of Breast Cancer Brain Metastases Reveals an
            Enrichment of Cyclin-Dependent Kinase 12 Structural Rearrangements
            in Human Epidermal Growth Factor Receptor 2-Positive Disease.
REFERENCE   5  (bases 1 to 8287)
  AUTHORS   Zhang,H., Zhou,Y., Feng,Y., Hou,W., Chen,Y., Xing,Z., Zhang,Y.,
            Wei,Q., Yin,Y., Guo,J. and Hu,H.
  TITLE     Cyclin-dependent kinase 12 deficiency reprogrammes cellular
            metabolism to alleviate ferroptosis potential and promote the
            progression of castration-resistant prostate cancer
  JOURNAL   Clin Transl Med 14 (5), e1678 (2024)
   PUBMED   38736108
  REMARK    GeneRIF: Cyclin-dependent kinase 12 deficiency reprogrammes
            cellular metabolism to alleviate ferroptosis potential and promote
            the progression of castration-resistant prostate cancer.
REFERENCE   6  (bases 1 to 8287)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   7  (bases 1 to 8287)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   8  (bases 1 to 8287)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   9  (bases 1 to 8287)
  AUTHORS   Gan,Y., Taira,E., Irie,Y., Fujimoto,T. and Miki,N.
  TITLE     Arrest of cell cycle by amida which is phosphorylated by Cdc2
            kinase
  JOURNAL   Mol Cell Biochem 246 (1-2), 179-185 (2003)
   PUBMED   12841360
REFERENCE   10 (bases 1 to 8287)
  AUTHORS   Ko,T.K., Kelly,E. and Pines,J.
  TITLE     CrkRS: a novel conserved Cdc2-related protein kinase that
            colocalises with SC35 speckles
  JOURNAL   J Cell Sci 114 (Pt 14), 2591-2603 (2001)
   PUBMED   11683387
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009283.6, AK302645.1,
            BC150265.1, BM557102.1, AF227198.1 and BE003756.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 29, 2019 this sequence version replaced NM_016507.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF227198.1, SRR7346977.2502340.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000447079.6/ ENSP00000398880.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AC009283.6         67412-67436
            26-276              AK302645.1         1-251
            277-4169            BC150265.1         8-3900
            4170-4170           BM557102.1         387-387
            4171-5225           AF227198.1         3618-4672
            5226-7956           AC009283.6         137409-140139
            7957-8287           BE003756.1         37-367              c
FEATURES             Location/Qualifiers
     source          1..8287
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..8287
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /note="cyclin dependent kinase 12"
                     /db_xref="GeneID:51755"
                     /db_xref="HGNC:HGNC:24224"
                     /db_xref="MIM:615514"
     exon            1..1632
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /inference="alignment:Splign:2.1.0"
     CDS             587..5059
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /EC_number="2.7.11.23"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Cdc2-related kinase, arginine/serine-rich; CDC2-related
                     protein kinase 7; cell division protein kinase 12; cell
                     division cycle 2-related protein kinase 7"
                     /codon_start=1
                     /product="cyclin-dependent kinase 12 isoform 1"
                     /protein_id="NP_057591.2"
                     /db_xref="CCDS:CCDS11337.1"
                     /db_xref="GeneID:51755"
                     /db_xref="HGNC:HGNC:24224"
                     /db_xref="MIM:615514"
                     /translation="MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKR
                     HKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGS
                     DRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDD
                     YGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKR
                     RSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVS
                     PPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSS
                     PFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLN
                     SSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRS
                     VKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIAL
                     KEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPPL
                     PPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKT
                     STLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSP
                     PDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQ
                     VYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQD
                     ALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFL
                     HRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYT
                     PAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTM
                     KPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAP
                     PDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQ
                     PAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEM
                     QQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPA
                     DMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPP
                     EKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH
                     QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSG
                     SLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETK
                     LQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRGVPY"
     exon            1633..2517
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2694
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2834
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..3005
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3195
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3252
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3354
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /inference="alignment:Splign:2.1.0"
     exon            3355..3432
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /inference="alignment:Splign:2.1.0"
     exon            3433..3549
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /inference="alignment:Splign:2.1.0"
     exon            3550..3681
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /inference="alignment:Splign:2.1.0"
     exon            3682..3893
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /inference="alignment:Splign:2.1.0"
     exon            3894..4346
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /inference="alignment:Splign:2.1.0"
     exon            4347..8287
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5990..5995
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /note="hexamer: AATAAA"
     polyA_site      6017
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /note="major polyA site"
     regulatory      7266..7271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /note="hexamer: AATAAA"
     polyA_site      7293
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /note="major polyA site"
     regulatory      7749..7754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /note="hexamer: ATTAAA"
     polyA_site      7772
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
     regulatory      8265..8270
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
                     /note="hexamer: ATTAAA"
     polyA_site      8287
                     /gene="CDK12"
                     /gene_synonym="CRK7; CRKR; CRKRS"
ORIGIN      
        1 aagtgccgtt tcggtttaat ctagtgtgtg actgggtctg tgtgagggag agagtgtgtg
       61 tggtgtggag gtgaaacgga ggcaagaaag ggggctacct caggagcgag ggacaaaggg
      121 ggcgtgaggc acctaggccg cggcaccccg gcgacaggaa gccgtcctga accgggctac
      181 cgggtagggg aagggcccgc gtagtcctcg cagggcccca gagctggagt cggctccaca
      241 gccccgggcc gtcggcttct cacttcctgg acctccccgg cgcccgggcc tgaggactgg
      301 ctcggcggag ggagaagagg aaacagactt gagcagctcc ccgttgtctc gcaactccac
      361 tgccgaggaa ctctcatttc ttccctcgct ccttcacccc ccacctcatg tagaagggtg
      421 ctgaggcgtc gggagggagg aggagcctgg gctaccgtcc ctgccctccc cacccccttc
      481 ccggggcgct ttggtgggcg tggagttggg gttggggggg tgggtggggg ttgctttttg
      541 gagtgctggg gaactttttt cccttcttca ggtcagggga aagggaatgc ccaattcaga
      601 gagacatggg ggcaagaagg acgggagtgg aggagcttct ggaactttgc agccgtcatc
      661 gggaggcggc agctctaaca gcagagagcg tcaccgcttg gtatcgaagc acaagcggca
      721 taagtccaaa cactccaaag acatggggtt ggtgaccccc gaagcagcat ccctgggcac
      781 agttatcaaa cctttggtgg agtatgatga tatcagctct gattccgaca ccttctccga
      841 tgacatggcc ttcaaactag accgaaggga gaacgacgaa cgtcgtggat cagatcggag
      901 cgaccgcctg cacaaacatc gtcaccacca gcacaggcgt tcccgggact tactaaaagc
      961 taaacagacc gaaaaagaaa aaagccaaga agtctccagc aagtcgggat cgatgaagga
     1021 ccggatatcg ggaagttcaa agcgttcgaa tgaggagact gatgactatg ggaaggcgca
     1081 ggtagccaaa agcagcagca aggaatccag gtcatccaag ctccacaagg agaagaccag
     1141 gaaagaacgg gagctgaagt ctgggcacaa agaccggagt aaaagtcatc gaaaaaggga
     1201 aacacccaaa agttacaaaa cagtggacag cccaaaacgg agatccagga gcccccacag
     1261 gaagtggtct gacagctcca aacaagatga tagcccctcg ggagcttctt atggccaaga
     1321 ttatgacctt agtccctcac gatctcatac ctcgagcaat tatgactcct acaagaaaag
     1381 tcctggaagt acctcgagaa ggcagtcggt cagtccccct tacaaggagc cttcggccta
     1441 ccagtccagc acccggtcac cgagccccta cagtaggcga cagagatctg tcagtcccta
     1501 tagcaggaga cggtcgtcca gctacgaaag aagtggctct tacagcgggc gatcgcccag
     1561 tccctatggt cgaaggcggt ccagcagccc tttcctgagc aagcggtctc tgagtcggag
     1621 tccactcccc agtaggaaat ccatgaagtc cagaagtaga agtcctgcat attcaagaca
     1681 ttcatcttct catagtaaaa agaagagatc cagttcacgc agtcgtcatt ccagtatctc
     1741 acctgtcagg cttccactta attccagtct gggagctgaa ctcagtagga aaaagaagga
     1801 aagagcagct gctgctgctg cagcaaagat ggatggaaag gagtccaagg gttcacctgt
     1861 atttttgcct agaaaagaga acagttcagt agaggctaag gattcaggtt tggagtctaa
     1921 aaagttaccc agaagtgtaa aattggaaaa atctgcccca gatactgaac tggtgaatgt
     1981 aacacatcta aacacagagg taaaaaattc ttcagataca gggaaagtaa agttggatga
     2041 gaactccgag aagcatcttg ttaaagattt gaaagcacag ggaacaagag actctaaacc
     2101 catagcactg aaagaggaga ttgttactcc aaaggagaca gaaacatcag aaaaggagac
     2161 ccctccacct cttcccacaa ttgcttctcc cccaccccct ctaccaacta ctacccctcc
     2221 acctcagaca ccccctttgc cacctttgcc tccaatacca gctcttccac agcaaccacc
     2281 tctgcctcct tctcagccag catttagtca ggttcctgct tccagtactt caactttgcc
     2341 cccttctact cactcaaaga catctgctgt gtcctctcag gcaaattctc agccccctgt
     2401 acaggtttct gtgaagactc aagtatctgt aacagctgct attccacacc tgaaaacttc
     2461 aacgttgcct cctttgcccc tcccaccctt attacctgga gatgatgaca tggatagtcc
     2521 aaaagaaact cttccttcaa aacctgtgaa gaaagagaag gaacagagga cacgtcactt
     2581 actcacagac cttcctctcc ctccagagct ccctggtgga gatctgtctc ccccagactc
     2641 tccagaacca aaggcaatca caccacctca gcaaccatat aaaaagagac caaaaatttg
     2701 ttgtcctcgt tatggagaaa gaagacaaac agaaagcgac tgggggaaac gctgtgtgga
     2761 caagtttgac attattggga ttattggaga aggaacctat ggccaagtat ataaagccaa
     2821 ggacaaagac acaggagaac tagtggctct gaagaaggtg agactagaca atgagaaaga
     2881 gggcttccca atcacagcca ttcgtgaaat caaaatcctt cgtcagttaa tccaccgaag
     2941 tgttgttaac atgaaggaaa ttgtcacaga taaacaagat gcactggatt tcaagaagga
     3001 caaaggtgcc ttttaccttg tatttgagta tatggaccat gacttaatgg gactgctaga
     3061 atctggtttg gtgcactttt ctgaggacca tatcaagtcg ttcatgaaac agctaatgga
     3121 aggattggaa tactgtcaca aaaagaattt cctgcatcgg gatattaagt gttctaacat
     3181 tttgctgaat aacagtgggc aaatcaaact agcagatttt ggacttgctc ggctctataa
     3241 ctctgaagag agtcgccctt acacaaacaa agtcattact ttgtggtacc gacctccaga
     3301 actactgcta ggagaggaac gttacacacc agccatagat gtttggagct gtggatgtat
     3361 tcttggggaa ctattcacaa agaagcctat ttttcaagcc aatctggaac tggctcagct
     3421 agaactgatc agccgacttt gtggtagccc ttgtccagct gtgtggcctg atgttatcaa
     3481 actgccctac ttcaacacca tgaaaccgaa gaagcaatat cgaaggcgtc tacgagaaga
     3541 attctctttc attccttctg cagcacttga tttattggac cacatgctga cactagatcc
     3601 tagtaagcgg tgcacagctg aacagaccct acagagcgac ttccttaaag atgtcgaact
     3661 cagcaaaatg gctcctccag acctccccca ctggcaggat tgccatgagt tgtggagtaa
     3721 gaaacggcga cgtcagcgac aaagtggtgt tgtagtcgaa gagccacctc catccaaaac
     3781 ttctcgaaaa gaaactacct cagggacaag tactgagcct gtgaagaaca gcagcccagc
     3841 accacctcag cctgctcctg gcaaggtgga gtctggggct ggggatgcaa taggccttgc
     3901 tgacatcaca caacagctga atcaaagtga attggcagtg ttattaaacc tgctgcagag
     3961 ccaaaccgac ctgagcatcc ctcaaatggc acagctgctt aacatccact ccaacccaga
     4021 gatgcagcag cagctggaag ccctgaacca atccatcagt gccctgacgg aagctacttc
     4081 ccagcagcag gactcagaga ccatggcccc agaggagtct ttgaaggaag caccctctgc
     4141 cccagtgatc ctgccttcag cagaacagac gacccttgaa gcttcaagca caccagctga
     4201 catgcagaat atattggcag ttctcttgag tcagctgatg aaaacccaag agccagcagg
     4261 cagtctggag gaaaacaaca gtgacaagaa cagtgggcca caggggcccc gaagaactcc
     4321 cacaatgcca caggaggagg cagcagcatg tcctcctcac attcttccac cagagaagag
     4381 gccccctgag ccccccggac ctccaccgcc gccacctcca ccccctctgg ttgaaggcga
     4441 tctttccagc gccccccagg agttgaaccc agccgtgaca gccgccttgc tgcaactttt
     4501 atcccagcct gaagcagagc ctcctggcca cctgccacat gagcaccagg ccttgagacc
     4561 aatggagtac tccacccgac cccgtccaaa caggacttat ggaaacactg atgggcctga
     4621 aacagggttc agtgccattg acactgatga acgaaactct ggtccagcct tgacagaatc
     4681 cttggtccag accctggtga agaacaggac cttctcaggc tctctgagcc accttgggga
     4741 gtccagcagt taccagggca cagggtcagt gcagtttcca ggggaccagg acctccgttt
     4801 tgccagggtc cccttagcgt tacacccggt ggtcgggcaa ccattcctga aggctgaggg
     4861 aagcagcaat tctgtggtac atgcagagac caaattgcaa aactatgggg agctggggcc
     4921 aggaaccact ggggccagca gctcaggagc aggccttcac tgggggggcc caactcagtc
     4981 ttctgcttat ggaaaactct atcgggggcc tacaagagtc ccaccaagag ggggaagagg
     5041 gagaggagtt ccttactaac ccagagactt cagtgtcctg aaagattcct ttcctatcca
     5101 tccttccatc cagttctctg aatctttaat gaaatcattt gccagagcga ggtaatcatc
     5161 tgcatttggc tactgcaaag ctgtccgttg tattccttgc tcacttgcta ctagcaggcg
     5221 acttacgaaa taatgatgtt ggcaccagtt ccccctggat gggctatagc cagaacattt
     5281 acttcaactc taccttagta gatacaagta gagaatatgg agaggatcat tacattgaaa
     5341 agtaaatgtt ttattagttc attgcctgca cttactgatc ggaagagaga aagaacagtt
     5401 tcagtattga gatggctcag gagaggctct ttgattttta aagttttggg gtgggggatt
     5461 gtgtgtggtt tctttctttt gaattttaat ttaggtgttt tgggtttttt tcctttaaag
     5521 agaatagtgt tcacaaaatt tgagctgctc tttggctttt gctataaggg aaacagagtg
     5581 gcctggctga tttgaataaa tgtttctttc ctctccacca tctcacattt tgcttttaag
     5641 tgaacacttt ttccccattg agcatcttga acatactttt tttccaaata aattactcat
     5701 ccttaaagtt tactccactt tgacaaaaga tacgcccttc tccctgcaca taaagcaggt
     5761 tgtagaacgt ggcattcttg ggcaagtagg tagactttac ccagtctctt tccttttttg
     5821 ctgatgtgtg ctctctctct ctctttctct ctctctctct ctctctctct ctctctctct
     5881 ctctctgtct cgcttgctcg ctctcgctgt ttctctctct ttgaggcatt tgtttggaaa
     5941 aaatcgttga gatgcccaag aacctgggat aattctttac tttttttgaa ataaaggaaa
     6001 ggaaattcag actcttacat tgttctctgt aactcttcaa ttctaaaatg ttttgttttt
     6061 taaaccatgt tctgatgggg aagttgattt gtaagtgtgg acagcttgga cattgctgct
     6121 gagctgtggt tagagatgat gcctccattc ctagagggct aataacagca tttagcatat
     6181 tgtttacaca tatattttta tgtcaaaaaa aaaacaaaaa cctttcaaac agagcattgt
     6241 gatattgtca aagagaaaaa caaatcctga agatacatgg aaatgtaacc tagtttaggg
     6301 tgggtatttt tctgaagata catcaatacc tgaccttttt taaaaaaata attttaaaac
     6361 agcatactgt gaggaagaac agtattgaca tacccacatc ccagcatgtg taccctgcca
     6421 gttcttttag ggatttttcc tccaaagaga tttggatttg gttttggtaa aaggggttaa
     6481 attgtgcttc caggcaagaa ctttgcctta tcataaacag gaaatgaaaa agggaagggc
     6541 tgtcaggatg ggataatttg ggaggcttct cattctggct tctatttcta tgtgagtacc
     6601 agcatataga gtgttttaaa aacagataca tgtcatataa tttatctgca cagacttaga
     6661 ccttcaggaa acataggtta agcccccttt tacaaagaaa aagtaaacat acttcagcat
     6721 cttggagggt agttttcaaa actcaagttt catgtttcaa tgccaagttc ttattttaaa
     6781 aaataaaatc tacttataag agaaaggtgc attacttaaa aaaaaaaaac tttaaagaaa
     6841 tgaaagaaga accctcttca gatacttact tgaagactgt tttcccctgt taatgagata
     6901 tagctagata tcggtgtgtg tatttcttta ttattctctg gtttttgatc tggccttgcc
     6961 tccagggcca aacactgatt tagaaagaga gccttctagc tattttggca ttgatggctt
     7021 tttataccag tgtgtccagt tagatttact aggcttactg acatgctatt ggtaaatcgc
     7081 attaaagttc atctgaacct tctgtctgtt gacttcttag tcctcagaca tgggcctttg
     7141 tgttttagaa tatttgaatt tgagttattg ggccccactc cctgtttttt attaaagaac
     7201 gtgagcctgg gatactttca gaagtatctg ttcaatgaaa aaaagttggt ttcccatcaa
     7261 atatgaataa aattctctat atatttcatt gtattttggt tatcagcagt catcaataat
     7321 gtttttccct cccctctccc acctcttatt tttaattatg ccaaatatcc taaataatat
     7381 acttaagcct ccattccctc atccctacta gggaaggggg tgagtgtatg tgtgagtgta
     7441 tgtgtatgta tgatcccatc tcacccccac ccccattttg ggagtctttt aaaatgaaaa
     7501 caaagtttgg tagttttgac tatttctaaa agcagaggag aaaaaaaaac ttatttaaat
     7561 atcctggaat ctgtatggag gaagaaaagg tatttgttaa tttttcagtt acgttatcta
     7621 taaacatgat ggaagtaaag gtttggcaga atttcacctt gactatttga aaattacaga
     7681 cccaattaat tccattcaaa agtggttttc gttttgtttt aattattgta caatgagaga
     7741 tattgtctat taaatacatt attttgaaca gatgagaaat ctgattctgt tcatgagtgg
     7801 gaggcaaaac tggtttgacc gtgatcattt ttgtggtttt gaaaacaaat atacttgacc
     7861 cagtttcctt agttttttct tcaactgtcc ataggaacga taagtatttg aaagcaacat
     7921 caaatctata cgtttaaagc agggcagtta gcacaaattt gcaagtagaa cttctattag
     7981 cttatgccat agacatcacc caaccacttg tatgtgtgtg tgtatatata atatgcatat
     8041 atagttaccg tgctaaaatg gttaccagca ggttttgaga gagaatgctg catcagaaaa
     8101 gtgtcagttg ccacctcatt ctccctgatt taggttcctg acactgattc ctttctctct
     8161 cgtttttgac ccccattggg tgtatcttgt ctatgtacag atattttgta atatattaaa
     8221 tttttttctt tcagtttata aaaatggaaa gtggagattg gaaaattaaa tatttcctgt
     8281 tactata
//
