LOCUS       NM_033486               2992 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens cyclin dependent kinase 11B (CDK11B), transcript
            variant 2, mRNA.
ACCESSION   NM_033486
VERSION     NM_033486.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2992)
  AUTHORS   Zhang,Q., Chen,Y., Teng,Z., Lin,Z. and Liu,H.
  TITLE     CDK11 facilitates centromeric transcription to maintain centromeric
            cohesion during mitosis
  JOURNAL   Mol Biol Cell 35 (2), ar18 (2024)
   PUBMED   38019613
  REMARK    GeneRIF: CDK11 facilitates centromeric transcription to maintain
            centromeric cohesion during mitosis.
REFERENCE   2  (bases 1 to 2992)
  AUTHORS   Fredi,B.M., De Labio,R.W., Rasmussen,L.T., Chagas,E.F.B.,
            Chen,E.S., Turecki,G., Smith,M.A.C. and Payao,S.L.M.
  TITLE     CDK10, CDK11, FOXO1, and FOXO3 Gene Expression in Alzheimer's
            Disease Encephalic Samples
  JOURNAL   Cell Mol Neurobiol 43 (6), 2953-2962 (2023)
   PUBMED   36988771
  REMARK    GeneRIF: CDK10, CDK11, FOXO1, and FOXO3 Gene Expression in
            Alzheimer's Disease Encephalic Samples.
REFERENCE   3  (bases 1 to 2992)
  AUTHORS   Blazek,D.
  TITLE     Therapeutic potential of CDK11 in cancer
  JOURNAL   Clin Transl Med 13 (3), e1201 (2023)
   PUBMED   36855776
  REMARK    GeneRIF: Therapeutic potential of CDK11 in cancer.
REFERENCE   4  (bases 1 to 2992)
  AUTHORS   Ou,D., Chen,L., He,J., Rong,Z., Gao,J., Li,Z., Liu,L., Tang,F.,
            Li,J., Deng,Y. and Sun,L.
  TITLE     CDK11 negatively regulates Wnt/beta-catenin signaling in the
            endosomal compartment by affecting microtubule stability
  JOURNAL   Cancer Biol Med 17 (2), 328-342 (2020)
   PUBMED   32587772
  REMARK    GeneRIF: CDK11 negatively regulates Wnt/beta-catenin signaling in
            the endosomal compartment by affecting microtubule stability.
REFERENCE   5  (bases 1 to 2992)
  AUTHORS   Gajduskova,P., Ruiz de Los Mozos,I., Rajecky,M., Hluchy,M., Ule,J.
            and Blazek,D.
  TITLE     CDK11 is required for transcription of replication-dependent
            histone genes
  JOURNAL   Nat Struct Mol Biol 27 (5), 500-510 (2020)
   PUBMED   32367068
  REMARK    GeneRIF: CDK11 is required for transcription of
            replication-dependent histone genes.
REFERENCE   6  (bases 1 to 2992)
  AUTHORS   White,P.S., Maris,J.M., Beltinger,C., Sulman,E., Marshall,H.N.,
            Fujimori,M., Kaufman,B.A., Biegel,J.A., Allen,C., Hilliard,C.,
            Valentine,M.B., Look,A.T., Enomoto,H., Sakiyama,S. and Brodeur,G.M.
  TITLE     A region of consistent deletion in neuroblastoma maps within human
            chromosome 1p36.2-36.3
  JOURNAL   Proc Natl Acad Sci U S A 92 (12), 5520-5524 (1995)
   PUBMED   7777541
REFERENCE   7  (bases 1 to 2992)
  AUTHORS   Lahti,J.M., Valentine,M., Xiang,J., Jones,B., Amann,J., Grenet,J.,
            Richmond,G., Look,A.T. and Kidd,V.J.
  TITLE     Alterations in the PITSLRE protein kinase gene complex on
            chromosome 1p36 in childhood neuroblastoma
  JOURNAL   Nat Genet 7 (3), 370-375 (1994)
   PUBMED   7920654
REFERENCE   8  (bases 1 to 2992)
  AUTHORS   Eipers,P.G., Lahti,J.M. and Kidd,V.J.
  TITLE     Structure and expression of the human p58clk-1 protein kinase
            chromosomal gene
  JOURNAL   Genomics 13 (3), 613-621 (1992)
   PUBMED   1639388
REFERENCE   9  (bases 1 to 2992)
  AUTHORS   Eipers,P.G., Barnoski,B.L., Han,J., Carroll,A.J. and Kidd,V.J.
  TITLE     Localization of the expressed human p58 protein kinase chromosomal
            gene to chromosome 1p36 and a highly related sequence to chromosome
            15
  JOURNAL   Genomics 11 (3), 621-629 (1991)
   PUBMED   1774066
REFERENCE   10 (bases 1 to 2992)
  AUTHORS   Bunnell,B.A., Heath,L.S., Adams,D.E., Lahti,J.M. and Kidd,V.J.
  TITLE     Increased expression of a 58-kDa protein kinase leads to changes in
            the CHO cell cycle
  JOURNAL   Proc Natl Acad Sci U S A 87 (19), 7467-7471 (1990)
   PUBMED   2217177
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1991 Mar 15;88(6):2612]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC362247.1, BC140714.1,
            AK000081.1, DB516340.1, AA778148.1 and FO704657.2.
            
            On Jun 2, 2019 this sequence version replaced NM_033486.2.
            
            Summary: This gene encodes a member of the serine/threonine protein
            kinase family. Members of this kinase family are known to be
            essential for eukaryotic cell cycle control. Due to a segmental
            duplication, this gene shares very high sequence identity with a
            neighboring gene. These two genes are frequently deleted or altered
            in neuroblastoma. The protein kinase encoded by this gene can be
            cleaved by caspases and may play a role in cell apoptosis.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Apr 2014].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the central coding region, compared to variant 1. The encoded
            isoform (2) is shorter, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC140714.1, AF067512.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341832.11/ ENSP00000463048.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                DC362247.1         92-125
            35-697              BC140714.1         1-663
            698-698             AK000081.1         550-550
            699-2473            BC140714.1         665-2439
            2474-2630           AK000081.1         2365-2521
            2631-2988           DB516340.1         118-475
            2989-2991           AA778148.1         25-27               c
            2992-2992           FO704657.2         7247-7247           c
FEATURES             Location/Qualifiers
     source          1..2992
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..2992
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /note="cyclin dependent kinase 11B"
                     /db_xref="GeneID:984"
                     /db_xref="HGNC:HGNC:1729"
                     /db_xref="MIM:176873"
     exon            1..91
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /inference="alignment:Splign:2.1.0"
     exon            92..215
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2453
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /EC_number="2.7.11.22"
                     /note="isoform 2 is encoded by transcript variant 2; cell
                     division cycle 2-like 1 (PITSLRE proteins); CDC-related
                     protein kinase p58; PITSLRE serine/threonine-protein
                     kinase CDC2L1; cell division protein kinase 11B;
                     galactosyltransferase-associated protein kinase p58/GTA;
                     p58 CLK-1"
                     /codon_start=1
                     /product="cyclin-dependent kinase 11B isoform 2"
                     /protein_id="NP_277021.2"
                     /db_xref="CCDS:CCDS72684.1"
                     /db_xref="GeneID:984"
                     /db_xref="HGNC:HGNC:1729"
                     /db_xref="MIM:176873"
                     /translation="MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSK
                     RDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKD
                     EKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREH
                     SRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTM
                     REDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKT
                     SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ
                     SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD
                     YVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEI
                     VALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEH
                     DLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVG
                     DFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPL
                     FPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQ
                     GFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSP
                     RPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF"
     exon            216..331
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /inference="alignment:Splign:2.1.0"
     exon            332..459
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /inference="alignment:Splign:2.1.0"
     exon            460..598
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /inference="alignment:Splign:2.1.0"
     exon            599..735
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /inference="alignment:Splign:2.1.0"
     exon            736..858
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /inference="alignment:Splign:2.1.0"
     exon            859..954
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1113
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1179
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1355
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1446
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1568
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1674
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1796
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1904
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2021
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2170
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2360
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2992
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2970..2975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /note="hexamer: ATTAAA"
     polyA_site      2992
                     /gene="CDK11B"
                     /gene_synonym="CDC2L1; CDK11; CDK11-p110; CDK11-p46;
                     CDK11-p58; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA;
                     PK58"
                     /note="major polyA site"
ORIGIN      
        1 agtgacgata cttttggcgc gcgccggttg ctgtttcttc tctggctccg ggaccggcgg
       61 cggcggcggc ggcagcggcg gcggcgtagg gtgttttaac tcaaatgggt gatgaaaagg
      121 actcttggaa agtgaaaact ttagatgaaa ttcttcagga aaagaaacga aggaaggaac
      181 aagaggagaa agcagagata aaacgcttaa aaaattctga tgaccgggat tccaagcggg
      241 attcccttga ggagggggag ctgagagatc accgcatgga gatcacaata aggaactccc
      301 cgtatagaag agaagactct atggaagaca gaggagaaga agatgattct ttggccatca
      361 aaccacccca gcaaatgtct cggaaagaaa aagctcatca cagaaaagat gaaaagagaa
      421 aagagaaacg taggcatcgt agccattcag cagaaggggg gaagcatgct agagtgaaag
      481 aaaaagaaag agagcacgaa cgtcggaaac ggcatcgaga agaacaggat aaagctcgcc
      541 gggaatggga aagacagaag agaagggaga tggcaaggga gcattccagg agagaaaggg
      601 accgcttgga gcagttagaa aggaagcggg agcgggagcg caagatgcgg gagcagcaga
      661 aggagcagcg ggagcagaag gagcgcgagc ggcgggcaga ggagcggcgc aaggagcggg
      721 aggcccgcag ggaagtgtct gcacatcacc gaacgatgag agaggactac agcgacaaag
      781 tgaaagccag ccactggagt cgcagcccgc ctcggccgcc gcgggagcgg ttcgagttgg
      841 gagacggccg gaagccagta aaagaagaga aaatggaaga aagggacctg ctgtccgact
      901 tacaggacat cagcgacagc gagaggaaga ccagctcggc cgagtcctcg tcagcggaat
      961 caggctcagg ttctgaggaa gaagaggagg aggaggaaga ggaggaggag gaagggagca
     1021 ccagtgaaga atcagaggag gaggaggagg aagaggaaga ggaggaggag gagaccggca
     1081 gcaactctga ggaggcatca gagcagtctg ccgaagaagt aagtgaggaa gaaatgagtg
     1141 aagatgaaga acgagaaaat gaaaaccacc tcttggttgt tccagagtca cggttcgacc
     1201 gagattccgg ggagagtgaa gaagcagagg aagaagtggg tgagggaacg ccgcagagca
     1261 gcgccctgac agagggcgac tatgtgcccg actcccctgc cctgtcgccc atcgagctca
     1321 agcaggagct gcccaagtac ctgccggccc tgcagggctg ccggagcgtc gaggagttcc
     1381 agtgcctgaa caggatcgag gagggcacct atggagtggt ctacagagca aaagacaaga
     1441 aaacagatga aattgtggct ctaaagcggc tgaagatgga gaaggagaag gagggcttcc
     1501 cgatcacgtc gctgagggag atcaacacca tcctcaaggc ccagcatccc aacatcgtca
     1561 ccgttagaga gattgtggtg ggcagcaaca tggacaagat ctacatcgtg atgaactatg
     1621 tggagcacga cctcaagagc ctgatggaga ccatgaaaca gcccttcctg ccaggggagg
     1681 tgaagaccct gatgatccag ctgctgcgtg gggtgaaaca cctgcacgac aactggatcc
     1741 tgcaccgtga cctcaagacg tccaacctgc tgctgagcca cgccggcatc ctcaaggtgg
     1801 gtgacttcgg gctggcgcgg gagtacggat cccctctgaa ggcctacacc ccggtcgtgg
     1861 tgaccctgtg gtaccgcgcc ccagagctgc tgcttggtgc caaggaatac tccacggccg
     1921 tggacatgtg gtcagtgggt tgcatcttcg gggagctgct gactcagaag cctctgttcc
     1981 ccgggaagtc agaaatcgat cagatcaaca aggtgttcaa ggatctgggg acccctagtg
     2041 agaaaatctg gcccggctac agcgagctcc cagcagtcaa gaagatgacc ttcagcgagc
     2101 acccctacaa caacctccgc aagcgcttcg gggctctgct ctcagaccag ggcttcgacc
     2161 tcatgaacaa gttcctgacc tacttccccg ggaggaggat cagcgctgag gacggcctca
     2221 agcatgagta tttccgcgag acccccctcc ccatcgaccc ctccatgttc cccacgtggc
     2281 ccgccaagag cgagcagcag cgtgtgaagc ggggcaccag cccgaggccc cctgagggag
     2341 gcctgggcta cagccagctg ggtgacgacg acctgaagga gacgggcttc caccttacca
     2401 ccacgaacca gggggcctct gccgcgggcc ccggcttcag cctcaagttc tgaaggtcag
     2461 agtggacccc gtcatgggga gaactcagcc gggaccacag gcgtggctac tgcggctgga
     2521 gctgcgatga gactcggaac tcctcgtctt actttgtgct ccatgttttg tttttgtatt
     2581 ttggtttgta aatttgtaga attaaatcat tttccttgtt gtggaggaaa gagctgtgtt
     2641 ttctccgtga cttgcccagg gcggagaggg tggacatctt cgggtgccca cgtggggcag
     2701 cacaaacctc cacacaccct ctcccactct cgacacgcac ggggctggct gggccgtgat
     2761 ttggaaagga actggtggga gccgggtgga ttgtttaatc ttcggagctg gagacctgtt
     2821 tctgtgttgg gatgagcgat gccctcttgc cccaacccac tcgtccagac cagccctgtc
     2881 cacacaggcc cccggccccc aacccccagc cccagctgtg ccagcagact cgacaggttt
     2941 ttatacaagg ttgttgagtt ttaaaatgta ttaaaatatt cttcgaggaa ag
//
