LOCUS       NM_024011               2984 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens cyclin dependent kinase 11A (CDK11A), transcript
            variant 1, mRNA.
ACCESSION   NM_024011 NM_033621 XM_001713742 XM_001713743 XM_001713744
            XM_001713745 XM_001713746 XM_001713747
VERSION     NM_024011.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2984)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2984)
  AUTHORS   Chen,Y., Su,L., Huang,C., Wu,S., Qiu,X., Zhao,X., Meng,Q.,
            Meng,Y.M., Kong,X., Wang,M., Liu,C. and Wong,P.P.
  TITLE     Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic
            ductal adenocarcinomas by upregulating N-linked glycosylation of
            CDK11p110
  JOURNAL   Cancer Lett 500, 228-243 (2021)
   PUBMED   33309857
  REMARK    GeneRIF: Galactosyltransferase B4GALT1 confers chemoresistance in
            pancreatic ductal adenocarcinomas by upregulating N-linked
            glycosylation of CDK11(p110).
REFERENCE   3  (bases 1 to 2984)
  AUTHORS   Du,Y., Yan,D., Yuan,Y., Xu,J., Wang,S., Yang,Z., Cheng,W., Tian,X.
            and Kan,Q.
  TITLE     CDK11p110 plays a critical role in the tumorigenicity of esophageal
            squamous cell carcinoma cells and is a potential drug target
  JOURNAL   Cell Cycle 18 (4), 452-466 (2019)
   PUBMED   30722725
  REMARK    GeneRIF: These results provided evidence that CDK11(p110) play a
            critical role in the tumorigenicity of esophageal squamous cell
            carcinoma cells, which suggests that CDK11(p110) may be a promising
            therapeutic target in esophageal squamous cell carcinoma.
            Erratum:[Cell Cycle. 2019 Jul;18(13):1523. doi:
            10.1080/15384101.2019.1625237.. PMID: 31142193]
REFERENCE   4  (bases 1 to 2984)
  AUTHORS   Zhou,Y., Shen,J.K., Hornicek,F.J., Kan,Q. and Duan,Z.
  TITLE     The emerging roles and therapeutic potential of cyclin-dependent
            kinase 11 (CDK11) in human cancer
  JOURNAL   Oncotarget 7 (26), 40846-40859 (2016)
   PUBMED   27049727
  REMARK    GeneRIF: CDK11 has a role in human cancers [review]
            Review article
REFERENCE   5  (bases 1 to 2984)
  AUTHORS   Rakkaa,T., Escude,C., Giet,R., Magnaghi-Jaulin,L. and Jaulin,C.
  TITLE     CDK11(p58) kinase activity is required to protect sister chromatid
            cohesion at centromeres in mitosis
  JOURNAL   Chromosome Res 22 (3), 267-276 (2014)
   PUBMED   24436071
REFERENCE   6  (bases 1 to 2984)
  AUTHORS   White,P.S., Maris,J.M., Beltinger,C., Sulman,E., Marshall,H.N.,
            Fujimori,M., Kaufman,B.A., Biegel,J.A., Allen,C., Hilliard,C.,
            Valentine,M.B., Look,A.T., Enomoto,H., Sakiyama,S. and Brodeur,G.M.
  TITLE     A region of consistent deletion in neuroblastoma maps within human
            chromosome 1p36.2-36.3
  JOURNAL   Proc Natl Acad Sci U S A 92 (12), 5520-5524 (1995)
   PUBMED   7777541
REFERENCE   7  (bases 1 to 2984)
  AUTHORS   Lahti,J.M., Valentine,M., Xiang,J., Jones,B., Amann,J., Grenet,J.,
            Richmond,G., Look,A.T. and Kidd,V.J.
  TITLE     Alterations in the PITSLRE protein kinase gene complex on
            chromosome 1p36 in childhood neuroblastoma
  JOURNAL   Nat Genet 7 (3), 370-375 (1994)
   PUBMED   7920654
REFERENCE   8  (bases 1 to 2984)
  AUTHORS   Eipers,P.G., Lahti,J.M. and Kidd,V.J.
  TITLE     Structure and expression of the human p58clk-1 protein kinase
            chromosomal gene
  JOURNAL   Genomics 13 (3), 613-621 (1992)
   PUBMED   1639388
REFERENCE   9  (bases 1 to 2984)
  AUTHORS   Eipers,P.G., Barnoski,B.L., Han,J., Carroll,A.J. and Kidd,V.J.
  TITLE     Localization of the expressed human p58 protein kinase chromosomal
            gene to chromosome 1p36 and a highly related sequence to chromosome
            15
  JOURNAL   Genomics 11 (3), 621-629 (1991)
   PUBMED   1774066
REFERENCE   10 (bases 1 to 2984)
  AUTHORS   Bunnell,B.A., Heath,L.S., Adams,D.E., Lahti,J.M. and Kidd,V.J.
  TITLE     Increased expression of a 58-kDa protein kinase leads to changes in
            the CHO cell cycle
  JOURNAL   Proc Natl Acad Sci U S A 87 (19), 7467-7471 (1990)
   PUBMED   2217177
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1991 Mar 15;88(6):2612]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031282.1, DC388505.1,
            AF067519.1, AL043340.1, BC094827.1 and BC073855.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_024011.3.
            
            Summary: This gene encodes a member of the serine/threonine protein
            kinase family. Members of this kinase family are known to be
            essential for eukaryotic cell cycle control. Due to a segmental
            duplication, this gene shares very high sequence identity with a
            neighboring gene. These two genes are frequently deleted or altered
            in neuroblastoma. The protein kinase encoded by this gene can be
            cleaved by caspases and may play a role in cell apoptosis.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) encodes isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF067519.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000404249.8/ ENSP00000384442.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AL031282.1         36137-36141         c
            6-438               DC388505.1         1-433
            439-957             AF067519.1         405-923
            958-1559            AL043340.1         93-694
            1560-2633           BC094827.1         532-1605
            2634-2980           BC073855.1         1767-2113
            2981-2984           AL031282.1         14163-14166         c
FEATURES             Location/Qualifiers
     source          1..2984
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..2984
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /note="cyclin dependent kinase 11A"
                     /db_xref="GeneID:728642"
                     /db_xref="HGNC:HGNC:1730"
                     /db_xref="MIM:116951"
     exon            1..100
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            101..224
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..2456
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     division cycle 2-like 2 (PITSLRE proteins); PITSLRE B;
                     galactosyltransferase-associated protein kinase p58/GTA;
                     cell division protein kinase 11A; PITSLRE
                     serine/threonine-protein kinase CDC2L2; cell division
                     cycle 2-like protein kinase 2"
                     /codon_start=1
                     /product="cyclin-dependent kinase 11A isoform 1"
                     /protein_id="NP_076916.2"
                     /db_xref="CCDS:CCDS44042.1"
                     /db_xref="GeneID:728642"
                     /db_xref="HGNC:HGNC:1730"
                     /db_xref="MIM:116951"
                     /translation="MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSK
                     RDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKD
                     EKRKEKCRHHSHSAEGGKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSR
                     RERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE
                     DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSS
                     AESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSA
                     EEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV
                     PDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVA
                     LKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDL
                     KSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDF
                     GLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFP
                     GNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGF
                     DLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRP
                     PEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF"
     exon            225..340
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            341..468
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            469..601
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            602..738
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            739..861
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            862..957
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1116
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1182
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1358
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1449
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1571
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1677
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1799
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1907
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2024
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2173
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2363
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2984
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2959..2964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /note="hexamer: ATTAAA"
     polyA_site      2984
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /note="major polyA site"
ORIGIN      
        1 atatcatcat taggcgtcaa cacaggaagt gaggatactt ctggcgagcg ccggttgctg
       61 tttcttctca ggctcaggga ccggccgcgg ccccgtaggg tgttttaact caaatgggtg
      121 atgaaaagga ctcttggaaa gtgaaaactt tagatgaaat tcttcaggaa aagaaacgaa
      181 ggaaggaaca agaggagaaa gcagagataa aacgcttaaa aaattctgat gaccgggatt
      241 ccaagcggga ttcccttgag gagggggagc tgagagatca ctgcatggag atcacaataa
      301 ggaactcccc gtatagaaga gaagactcaa tggaagacag aggagaagaa gatgattctt
      361 tggccatcaa accaccccag caaatgtctc ggaaagaaaa agttcatcac agaaaagatg
      421 aaaagagaaa agaaaaatgt aggcatcata gccattcagc agaagggggg aagcatgcta
      481 gagtgaaaga aagagagcac gaacgtcgga aacgacatcg agaagaacag gataaagctc
      541 gccgggaatg ggaaagacag aagagaaggg aaatggcaag ggagcattcc aggagagaaa
      601 gggaccgctt ggagcagtta gaaaggaagc gggagcggga gcgcaagatg cgggagcagc
      661 agaaggagca gcgggagcag aaggagcgcg agcggcgggc ggaggagcgg cgcaaggagc
      721 gggaggcccg cagggaagtg tctgcacatc accgaacgat gagagaggac tacagcgaca
      781 aagtgaaagc cagccactgg agtcgcagcc cgcctcggcc gccgcgggag cggttcgagt
      841 tgggagacgg ccggaagcca gtaaaagaag agaaaatgga agaaagggac ctgctgtccg
      901 acttacagga catcagcgac agcgagagga agaccagctc ggccgagtcc tcgtcagcgg
      961 aatcaggctc aggttctgag gaagaagagg aggaggagga agaggaggag gaggaaggga
     1021 gcaccagtga agaatcagag gaggaggagg aggaagagga agaggaggag gaggagaccg
     1081 gcagcaactc tgaggaggca tcagagcagt ctgccgaaga agtaagtgag gaagaaatga
     1141 gtgaagatga agaacgagaa aatgaaaacc acctcttggt tgttccagag tcacggttcg
     1201 accgagattc cggggagagt gaagaagcag aggaagaagt gggtgaggga acgccgcaga
     1261 gcagcgccct gacagagggc gactatgtgc ccgactcccc tgccctgttg cccatcgagc
     1321 tcaagcagga gctgcccaag tacctgccgg ccctgcaggg ctgccggagc gtcgaggagt
     1381 tccagtgcct gaacaggatc gaggagggca cctatggagt ggtctacaga gcaaaagaca
     1441 agaaaacaga tgaaattgtg gctctaaagc ggctgaagat ggagaaggag aaggagggct
     1501 tcccgatcac gtccctgagg gagatcaaca ccatcctcaa ggcccagcat cccaacattg
     1561 tcaccgttag agagattgtg gtgggcagca acatggacaa gatctacatc gtgatgaact
     1621 acgtggagca cgacctcaag agcctgatgg agaccatgaa acagcccttc ctgccagggg
     1681 aggtgaagac cctgatgatc cagctgctgc ggggggtgaa acacctgcac gacaactgga
     1741 tcctgcaccg tgacctcaag acgtccaacc tgctgctgag ccacgccggc atcctcaagg
     1801 tgggtgattt tgggctggcg cgggagtacg gatcccctct gaaggcctac accccggtcg
     1861 tggtgaccca gtggtaccgc gccccagagc tgctgcttgg tgccaaggaa tactccacgg
     1921 ccgtggacat gtggtcagtg ggctgcatct tcggggagct gctgactcag aagcctctgt
     1981 tccccgggaa ttcggaaatc gatcagatca acaaagtgtt caaggagctg gggaccccca
     2041 gtgagaaaat ctggcccggc tacagtgagc tcccagtagt caaaaagatg accttcagcg
     2101 agcaccccta caacaacctc cgcaagcgct tcggggctct gctctcagac cagggcttcg
     2161 acctcatgaa caagttcctg acctacttcc ccgggaggag gatcagcgct gaggacggcc
     2221 tcaagcatga gtatttccgc gagacccccc tccccatcga cccctccatg ttccccacgt
     2281 ggcccgccaa gagcgagcag cagcgtgtga agcggggcac cagcccgagg ccccctgagg
     2341 gaggcctggg ctacagccag ctgggtgacg acgacctgaa ggagacgggc ttccacctta
     2401 ccaccacgaa ccagggggcc tctgccgcgg gccccggctt cagcctcaag ttctgaaggt
     2461 cagagtggac cccgtcatgg ggagaactca gccgggacca caggcgtggc tactgcggct
     2521 ggagctgcga tgagactcgg aactcctcgt cttactttgt gctccatgtt ttgtttttgt
     2581 attttggttt gtaaatttgt agaattaaat cattttcctt gttgtggagg aaagagctgt
     2641 gttttctccg tgacttgcca gggcatcttc gggtgcccac gtggggcagc acaaacctcc
     2701 acacaccctc tcccactctc gacacgcacg gggctggctg ggccgtgatt tggaaaggaa
     2761 ctggtgggag ccgggtggat tgtttaatct tcggagctgg agacctgttt ctgtgttggg
     2821 atgagcgatg ccctcttgcc ccaacccact cgtccagacc agccctgtcc acacaggccc
     2881 ccggccccca acccccagcc ccagctgtgc cagcagactc gacaggtttt tatacaaggt
     2941 tgttgagttt taaaatgtat taaaatattc ttcgaggaaa gctc
//
