LOCUS       NM_001313896            2993 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens cyclin dependent kinase 11A (CDK11A), transcript
            variant 5, mRNA.
ACCESSION   NM_001313896
VERSION     NM_001313896.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2993)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2993)
  AUTHORS   Chen,Y., Su,L., Huang,C., Wu,S., Qiu,X., Zhao,X., Meng,Q.,
            Meng,Y.M., Kong,X., Wang,M., Liu,C. and Wong,P.P.
  TITLE     Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic
            ductal adenocarcinomas by upregulating N-linked glycosylation of
            CDK11p110
  JOURNAL   Cancer Lett 500, 228-243 (2021)
   PUBMED   33309857
  REMARK    GeneRIF: Galactosyltransferase B4GALT1 confers chemoresistance in
            pancreatic ductal adenocarcinomas by upregulating N-linked
            glycosylation of CDK11(p110).
REFERENCE   3  (bases 1 to 2993)
  AUTHORS   Du,Y., Yan,D., Yuan,Y., Xu,J., Wang,S., Yang,Z., Cheng,W., Tian,X.
            and Kan,Q.
  TITLE     CDK11p110 plays a critical role in the tumorigenicity of esophageal
            squamous cell carcinoma cells and is a potential drug target
  JOURNAL   Cell Cycle 18 (4), 452-466 (2019)
   PUBMED   30722725
  REMARK    GeneRIF: These results provided evidence that CDK11(p110) play a
            critical role in the tumorigenicity of esophageal squamous cell
            carcinoma cells, which suggests that CDK11(p110) may be a promising
            therapeutic target in esophageal squamous cell carcinoma.
            Erratum:[Cell Cycle. 2019 Jul;18(13):1523. doi:
            10.1080/15384101.2019.1625237.. PMID: 31142193]
REFERENCE   4  (bases 1 to 2993)
  AUTHORS   Zhou,Y., Shen,J.K., Hornicek,F.J., Kan,Q. and Duan,Z.
  TITLE     The emerging roles and therapeutic potential of cyclin-dependent
            kinase 11 (CDK11) in human cancer
  JOURNAL   Oncotarget 7 (26), 40846-40859 (2016)
   PUBMED   27049727
  REMARK    GeneRIF: CDK11 has a role in human cancers [review]
            Review article
REFERENCE   5  (bases 1 to 2993)
  AUTHORS   Rakkaa,T., Escude,C., Giet,R., Magnaghi-Jaulin,L. and Jaulin,C.
  TITLE     CDK11(p58) kinase activity is required to protect sister chromatid
            cohesion at centromeres in mitosis
  JOURNAL   Chromosome Res 22 (3), 267-276 (2014)
   PUBMED   24436071
REFERENCE   6  (bases 1 to 2993)
  AUTHORS   White,P.S., Maris,J.M., Beltinger,C., Sulman,E., Marshall,H.N.,
            Fujimori,M., Kaufman,B.A., Biegel,J.A., Allen,C., Hilliard,C.,
            Valentine,M.B., Look,A.T., Enomoto,H., Sakiyama,S. and Brodeur,G.M.
  TITLE     A region of consistent deletion in neuroblastoma maps within human
            chromosome 1p36.2-36.3
  JOURNAL   Proc Natl Acad Sci U S A 92 (12), 5520-5524 (1995)
   PUBMED   7777541
REFERENCE   7  (bases 1 to 2993)
  AUTHORS   Lahti,J.M., Valentine,M., Xiang,J., Jones,B., Amann,J., Grenet,J.,
            Richmond,G., Look,A.T. and Kidd,V.J.
  TITLE     Alterations in the PITSLRE protein kinase gene complex on
            chromosome 1p36 in childhood neuroblastoma
  JOURNAL   Nat Genet 7 (3), 370-375 (1994)
   PUBMED   7920654
REFERENCE   8  (bases 1 to 2993)
  AUTHORS   Eipers,P.G., Lahti,J.M. and Kidd,V.J.
  TITLE     Structure and expression of the human p58clk-1 protein kinase
            chromosomal gene
  JOURNAL   Genomics 13 (3), 613-621 (1992)
   PUBMED   1639388
REFERENCE   9  (bases 1 to 2993)
  AUTHORS   Eipers,P.G., Barnoski,B.L., Han,J., Carroll,A.J. and Kidd,V.J.
  TITLE     Localization of the expressed human p58 protein kinase chromosomal
            gene to chromosome 1p36 and a highly related sequence to chromosome
            15
  JOURNAL   Genomics 11 (3), 621-629 (1991)
   PUBMED   1774066
REFERENCE   10 (bases 1 to 2993)
  AUTHORS   Bunnell,B.A., Heath,L.S., Adams,D.E., Lahti,J.M. and Kidd,V.J.
  TITLE     Increased expression of a 58-kDa protein kinase leads to changes in
            the CHO cell cycle
  JOURNAL   Proc Natl Acad Sci U S A 87 (19), 7467-7471 (1990)
   PUBMED   2217177
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1991 Mar 15;88(6):2612]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031282.1, AF067522.1 and
            BC073855.1.
            
            On May 31, 2019 this sequence version replaced NM_001313896.1.
            
            Summary: This gene encodes a member of the serine/threonine protein
            kinase family. Members of this kinase family are known to be
            essential for eukaryotic cell cycle control. Due to a segmental
            duplication, this gene shares very high sequence identity with a
            neighboring gene. These two genes are frequently deleted or altered
            in neuroblastoma. The protein kinase encoded by this gene can be
            cleaved by caspases and may play a role in cell apoptosis.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (5) uses an alternate splice site
            in the central coding region compared to variant 1. The encoded
            isoform (5) is longer than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF067522.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AL031282.1         36090-36141         c
            53-389              AF067522.1         19-355
            390-428             AL031282.1         31152-31190         c
            429-849             AF067522.1         395-815
            850-850             AL031282.1         21283-21283         c
            851-967             AF067522.1         817-933
            968-1065            AL031282.1         20638-20735         c
            1066-1630           AF067522.1         1023-1587
            1631-1631           AL031282.1         16389-16389         c
            1632-1720           AF067522.1         1589-1677
            1721-1721           AL031282.1         16094-16094         c
            1722-2092           AF067522.1         1679-2049
            2093-2093           AL031282.1         15349-15349         c
            2094-2491           AF067522.1         2051-2448
            2492-2989           BC073855.1         1616-2113
            2990-2993           AL031282.1         14163-14166         c
FEATURES             Location/Qualifiers
     source          1..2993
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..2993
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /note="cyclin dependent kinase 11A"
                     /db_xref="GeneID:728642"
                     /db_xref="HGNC:HGNC:1730"
                     /db_xref="MIM:116951"
     exon            1..100
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            101..224
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..2465
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /EC_number="2.7.11.22"
                     /note="isoform 5 is encoded by transcript variant 5; cell
                     division cycle 2-like 2 (PITSLRE proteins); PITSLRE B;
                     galactosyltransferase-associated protein kinase p58/GTA;
                     cell division protein kinase 11A; PITSLRE
                     serine/threonine-protein kinase CDC2L2; cell division
                     cycle 2-like protein kinase 2"
                     /codon_start=1
                     /product="cyclin-dependent kinase 11A isoform 5"
                     /protein_id="NP_001300825.1"
                     /db_xref="CCDS:CCDS81253.1"
                     /db_xref="GeneID:728642"
                     /db_xref="HGNC:HGNC:1730"
                     /db_xref="MIM:116951"
                     /translation="MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSK
                     RDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKD
                     EKRKEKWKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLE
                     RKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASH
                     WSRSPPRPPRERFELGDGRKPGEARPAPAQKPAQLKEEKMEERDLLSDLQDISDSERK
                     TSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASE
                     QSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEG
                     DYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDE
                     IVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVE
                     HDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKV
                     GDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKP
                     LFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSD
                     QGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTS
                     PRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF"
     exon            225..340
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            341..438
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            439..571
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            572..708
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            709..870
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            871..966
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1125
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1191
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1367
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1458
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1580
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1686
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1808
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1916
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2033
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2182
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2372
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2993
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2968..2973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /note="hexamer: ATTAAA"
     polyA_site      2993
                     /gene="CDK11A"
                     /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
                     CDK11-p58; p58GTA; PITSLRE"
                     /note="major polyA site"
ORIGIN      
        1 atatcatcat taggcgtcaa cacaggaagt gaggatactt ctggcgagcg ccggttgctg
       61 tttcttctca ggctcaggga ccggccgcgg ccccgtaggg tgttttaact caaatgggtg
      121 atgaaaagga ctcttggaaa gtgaaaactt tagatgaaat tcttcaggaa aagaaacgaa
      181 ggaaggaaca agaggagaaa gcagagataa aacgcttaaa aaattctgat gaccgggatt
      241 ccaagcggga ttcccttgag gagggggagc tgagagatca ctgcatggag atcacaataa
      301 ggaactcccc gtatagaaga gaagactcaa tggaagacag aggagaagaa gatgattctt
      361 tggccatcaa accaccccag caaatgtctc ggaaagaaaa agttcatcac agaaaagatg
      421 aaaagagaaa agaaaaatgg aagcatgcta gagtgaaaga aagagagcac gaacgtcgga
      481 aacgacatcg agaagaacag gataaagctc gccgggaatg ggaaagacag aagagaaggg
      541 aaatggcaag ggagcattcc aggagagaaa gggaccgctt ggagcagtta gaaaggaagc
      601 gggagcggga gcgcaagatg cgggagcagc agaaggagca gcgggagcag aaggagcgcg
      661 agcggcgggc ggaggagcgg cgcaaggagc gggaggcccg cagggaagtg tctgcacatc
      721 accgaacgat gagagaggac tacagcgaca aagtgaaagc cagccactgg agtcgcagcc
      781 cgcctcggcc gccgcgggag cggttcgagt tgggagacgg ccggaagcca ggtgaggcca
      841 ggccggcgcc tgcgcagaag ccagcacagt taaaagaaga gaaaatggaa gaaagggacc
      901 tgctgtccga cttacaggac atcagcgaca gcgagaggaa gaccagctcg gccgagtcct
      961 cgtcagcgga atcaggctca ggttctgagg aagaagagga ggaggaggaa gaggaggagg
     1021 aggaagggag caccagtgaa gaatcagagg aggaggagga ggaagaggaa gaggaggagg
     1081 aggagaccgg cagcaactct gaggaggcat cagagcagtc tgccgaagaa gtaagtgagg
     1141 aagaaatgag tgaagatgaa gaacgagaaa atgaaaacca cctcttggtt gttccagagt
     1201 cacggttcga ccgagattcc ggggagagtg aagaagcaga ggaagaagtg ggtgagggaa
     1261 cgccgcagag cagcgccctg acagagggcg actatgtgcc cgactcccct gccctgttgc
     1321 ccatcgagct caagcaggag ctgcccaagt acctgccggc cctgcagggc tgccggagcg
     1381 tcgaggagtt ccagtgcctg aacaggatcg aggagggcac ctatggagtg gtctacagag
     1441 caaaagacaa gaaaacagat gaaattgtgg ctctaaagcg gctgaagatg gagaaggaga
     1501 aggagggctt cccgatcacg tccctgaggg agatcaacac catcctcaag gcccagcatc
     1561 ccaacattgt caccgttaga gagattgtgg tgggcagcaa catggacaag atctacatcg
     1621 tgatgaacta cgtggagcac gacctcaaga gcctgatgga gaccatgaaa cagcccttcc
     1681 tgccagggga ggtgaagacc ctgatgatcc agctgctgcg gggggtgaaa cacctgcacg
     1741 acaactggat cctgcaccgt gacctcaaga cgtccaacct gctgctgagc cacgccggca
     1801 tcctcaaggt gggtgatttt gggctggcgc gggagtacgg atcccctctg aaggcctaca
     1861 ccccggtcgt ggtgacccag tggtaccgcg ccccagagct gctgcttggt gccaaggaat
     1921 actccacggc cgtggacatg tggtcagtgg gctgcatctt cggggagctg ctgactcaga
     1981 agcctctgtt ccccgggaat tcggaaatcg atcagatcaa caaagtgttc aaggagctgg
     2041 ggacccccag tgagaaaatc tggcccggct acagtgagct cccagtagtc aaaaagatga
     2101 ccttcagcga gcacccctac aacaacctcc gcaagcgctt cggggctctg ctctcagacc
     2161 agggcttcga cctcatgaac aagttcctga cctacttccc cgggaggagg atcagcgctg
     2221 aggacggcct caagcatgag tatttccgcg agacccccct ccccatcgac ccctccatgt
     2281 tccccacgtg gcccgccaag agcgagcagc agcgtgtgaa gcggggcacc agcccgaggc
     2341 cccctgaggg aggcctgggc tacagccagc tgggtgacga cgacctgaag gagacgggct
     2401 tccaccttac caccacgaac cagggggcct ctgccgcggg ccccggcttc agcctcaagt
     2461 tctgaaggtc agagtggacc ccgtcatggg gagaactcag ccgggaccac aggcgtggct
     2521 actgcggctg gagctgcgat gagactcgga actcctcgtc ttactttgtg ctccatgttt
     2581 tgtttttgta ttttggtttg taaatttgta gaattaaatc attttccttg ttgtggagga
     2641 aagagctgtg ttttctccgt gacttgccag ggcatcttcg ggtgcccacg tggggcagca
     2701 caaacctcca cacaccctct cccactctcg acacgcacgg ggctggctgg gccgtgattt
     2761 ggaaaggaac tggtgggagc cgggtggatt gtttaatctt cggagctgga gacctgtttc
     2821 tgtgttggga tgagcgatgc cctcttgccc caacccactc gtccagacca gccctgtcca
     2881 cacaggcccc cggcccccaa cccccagccc cagctgtgcc agcagactcg acaggttttt
     2941 atacaaggtt gttgagtttt aaaatgtatt aaaatattct tcgaggaaag ctc
//
