LOCUS       NM_052988               1767 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens cyclin dependent kinase 10 (CDK10), transcript variant
            a, mRNA.
ACCESSION   NM_052988
VERSION     NM_052988.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1767)
  AUTHORS   Zhu,J., Guo,L., Dai,H., Zheng,Z., Yan,J., Liu,J., Zhang,S., Li,X.,
            Sun,X., Zhao,Q. and Xu,C.
  TITLE     RNF115 aggravates tumor progression through regulation of CDK10
            degradation in thyroid carcinoma
  JOURNAL   Cell Biol Toxicol 40 (1), 14 (2024)
   PUBMED   38376606
  REMARK    GeneRIF: RNF115 aggravates tumor progression through regulation of
            CDK10 degradation in thyroid carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1767)
  AUTHORS   Zhang,X., Zhao,Y., Yiminniyaze,R., Zhu,N., Zhang,Y., Wumaier,G.,
            Xia,J., Dong,L., Zhou,D., Wang,J., Li,C., Zhang,Y. and Li,S.
  TITLE     CDK10 suppresses metastasis of lung adenocarcinoma through
            inhibition of the ETS2/c-Raf/p-MEK/p-ERK signaling loop
  JOURNAL   Mol Carcinog 63 (1), 61-74 (2024)
   PUBMED   37737453
  REMARK    GeneRIF: CDK10 suppresses metastasis of lung adenocarcinoma through
            inhibition of the ETS2/c-Raf/p-MEK/p-ERK signaling loop.
REFERENCE   3  (bases 1 to 1767)
  AUTHORS   Fredi,B.M., De Labio,R.W., Rasmussen,L.T., Chagas,E.F.B.,
            Chen,E.S., Turecki,G., Smith,M.A.C. and Payao,S.L.M.
  TITLE     CDK10, CDK11, FOXO1, and FOXO3 Gene Expression in Alzheimer's
            Disease Encephalic Samples
  JOURNAL   Cell Mol Neurobiol 43 (6), 2953-2962 (2023)
   PUBMED   36988771
  REMARK    GeneRIF: CDK10, CDK11, FOXO1, and FOXO3 Gene Expression in
            Alzheimer's Disease Encephalic Samples.
REFERENCE   4  (bases 1 to 1767)
  AUTHORS   Kasten,M. and Giordano,A.
  TITLE     Cdk10, a Cdc2-related kinase, associates with the Ets2
            transcription factor and modulates its transactivation activity
  JOURNAL   Oncogene 20 (15), 1832-1838 (2001)
   PUBMED   11313931
REFERENCE   5  (bases 1 to 1767)
  AUTHORS   Sergere,J.C., Thuret,J.Y., Le Roux,G., Carosella,E.D. and
            Leteurtre,F.
  TITLE     Human CDK10 gene isoforms
  JOURNAL   Biochem Biophys Res Commun 276 (1), 271-277 (2000)
   PUBMED   11006117
  REMARK    Erratum:[Biochem Biophys Res Commun 2000 Dec 20;279(2):738-9]
REFERENCE   6  (bases 1 to 1767)
  AUTHORS   Crawford,J., Ianzano,L., Savino,M., Whitmore,S.,
            Cleton-Jansen,A.M., Settasatian,C., d'apolito,M., Seshadri,R.,
            Pronk,J.C., Auerbach,A.D., Verlander,P.C., Mathew,C.G.,
            Tipping,A.J., Doggett,N.A., Zelante,L., Callen,D.F. and Savoia,A.
  TITLE     The PISSLRE gene: structure, exon skipping, and exclusion as tumor
            suppressor in breast cancer
  JOURNAL   Genomics 56 (1), 90-97 (1999)
   PUBMED   10036189
REFERENCE   7  (bases 1 to 1767)
  AUTHORS   Li,S., MacLachlan,T.K., De Luca,A., Claudio,P.P., Condorelli,G. and
            Giordano,A.
  TITLE     The cdc-2-related kinase, PISSLRE, is essential for cell growth and
            acts in G2 phase of the cell cycle
  JOURNAL   Cancer Res 55 (18), 3992-3995 (1995)
   PUBMED   7664269
REFERENCE   8  (bases 1 to 1767)
  AUTHORS   Bullrich,F., MacLachlan,T.K., Sang,N., Druck,T., Veronese,M.L.,
            Allen,S.L., Chiorazzi,N., Koff,A., Heubner,K., Croce,C.M. et al.
  TITLE     Chromosomal mapping of members of the cdc2 family of protein
            kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor,
            p27Kip1, to regions involved in human cancer
  JOURNAL   Cancer Res 55 (6), 1199-1205 (1995)
   PUBMED   7882308
REFERENCE   9  (bases 1 to 1767)
  AUTHORS   Brambilla,R. and Draetta,G.
  TITLE     Molecular cloning of PISSLRE, a novel putative member of the cdk
            family of protein serine/threonine kinases
  JOURNAL   Oncogene 9 (10), 3037-3041 (1994)
   PUBMED   8084611
REFERENCE   10 (bases 1 to 1767)
  AUTHORS   Grana,X., Claudio,P.P., De Luca,A., Sang,N. and Giordano,A.
  TITLE     PISSLRE, a human novel CDC2-related protein kinase
  JOURNAL   Oncogene 9 (7), 2097-2103 (1994)
   PUBMED   8208557
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK298386.1 and BC017342.2.
            
            On Nov 23, 2018 this sequence version replaced NM_052988.4.
            
            Summary: The protein encoded by this gene belongs to the CDK
            subfamily of the Ser/Thr protein kinase family. The CDK subfamily
            members are highly similar to the gene products of S. cerevisiae
            cdc28, and S. pombe cdc2, and are known to be essential for cell
            cycle progression. This kinase has been shown to play a role in
            cellular proliferation and its function is limited to cell cycle
            G2-M phase. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, May
            2009].
            
            Transcript Variant: This variant (a) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.36649.1,
                                           SRR1660807.224093.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000353379.12/ ENSP00000338673.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1069              AK298386.1         22-1090
            1070-1767           BC017342.2         1015-1712
FEATURES             Location/Qualifiers
     source          1..1767
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.3"
     gene            1..1767
                     /gene="CDK10"
                     /gene_synonym="ALSAS; PISSLRE"
                     /note="cyclin dependent kinase 10"
                     /db_xref="GeneID:8558"
                     /db_xref="HGNC:HGNC:1770"
                     /db_xref="MIM:603464"
     exon            1..109
                     /gene="CDK10"
                     /gene_synonym="ALSAS; PISSLRE"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1105
                     /gene="CDK10"
                     /gene_synonym="ALSAS; PISSLRE"
                     /EC_number="2.7.11.22"
                     /note="isoform a is encoded by transcript variant a;
                     cyclin-dependent kinase (CDC2-like) 10; serine/threonine
                     protein kinase PISSLRE; CDC2-related protein kinase; cell
                     division protein kinase 10; cyclin-dependent kinase
                     related protein"
                     /codon_start=1
                     /product="cyclin-dependent kinase 10 isoform a"
                     /protein_id="NP_443714.3"
                     /db_xref="CCDS:CCDS10984.2"
                     /db_xref="GeneID:8558"
                     /db_xref="HGNC:HGNC:1770"
                     /db_xref="MIM:603464"
                     /translation="MAEPDLECEQIRLKCIRKEGFFTVPPEHRLGRCRSVKEFEKLNR
                     IGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELK
                     EVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFII
                     HRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTT
                     SIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYS
                     LRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKEKPLPCEPEL
                     MPTFPHHRNKRAAPATSEGQSKRCKP"
     exon            110..182
                     /gene="CDK10"
                     /gene_synonym="ALSAS; PISSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            183..254
                     /gene="CDK10"
                     /gene_synonym="ALSAS; PISSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            255..357
                     /gene="CDK10"
                     /gene_synonym="ALSAS; PISSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            358..439
                     /gene="CDK10"
                     /gene_synonym="ALSAS; PISSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            440..507
                     /gene="CDK10"
                     /gene_synonym="ALSAS; PISSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            508..560
                     /gene="CDK10"
                     /gene_synonym="ALSAS; PISSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            561..630
                     /gene="CDK10"
                     /gene_synonym="ALSAS; PISSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            631..690
                     /gene="CDK10"
                     /gene_synonym="ALSAS; PISSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            691..814
                     /gene="CDK10"
                     /gene_synonym="ALSAS; PISSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            815..954
                     /gene="CDK10"
                     /gene_synonym="ALSAS; PISSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1007
                     /gene="CDK10"
                     /gene_synonym="ALSAS; PISSLRE"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1767
                     /gene="CDK10"
                     /gene_synonym="ALSAS; PISSLRE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1747..1752
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK10"
                     /gene_synonym="ALSAS; PISSLRE"
                     /note="hexamer: GATAAA"
     polyA_site      1767
                     /gene="CDK10"
                     /gene_synonym="ALSAS; PISSLRE"
                     /note="major polyA site"
ORIGIN      
        1 agaggcgggg ccagcgctcg gcatggcgga gccagatctg gagtgcgagc agatccgtct
       61 gaagtgtatt cgtaaggagg gcttcttcac ggtgcctccg gaacacaggc tgggacgatg
      121 ccggagtgtg aaggagtttg agaagctgaa ccgcattgga gagggtacct acggcattgt
      181 gtatcgggcc cgggacaccc agacagatga gattgtcgca ctgaagaagg tgcggatgga
      241 caaggagaag gatggcatcc ccatcagcag cttgcgggag atcacgctgc tgctccgcct
      301 gcgtcatccg aacatcgtgg agctgaagga ggtggttgtg gggaaccacc tggagagcat
      361 cttcctggtg atgggttact gtgagcagga cctggccagc ctcctggaga atatgccaac
      421 acccttctcg gaggctcagg tcaagtgcat cgtgctgcag gtgctccggg gcctccagta
      481 tctgcacagg aacttcatta tccacaggga cctgaaggtt tccaacttgc tcatgaccga
      541 caagggttgt gtgaagacag cggatttcgg cctggcccgg gcctatggtg tcccagtaaa
      601 gccaatgacc cccaaggtgg tcactctctg gtaccgagcc cctgaactgc tgttgggaac
      661 caccacgcag accaccagca tcgacatgtg ggctgtgggc tgcatactgg ccgagctgct
      721 ggcgcacagg cctcttctcc ccggcacttc cgagatccac cagatcgact tgatcgtgca
      781 gctgctgggc acgcccagtg agaacatctg gccgggcttt tccaagctgc cactggtcgg
      841 ccagtacagc ctccggaagc agccctacaa caacctgaag cacaagttcc catggctgtc
      901 ggaggccggg ctgcgcctgc tgcacttcct gttcatgtac gaccctaaga aaagggcgac
      961 ggccggggac tgcctggaga gctcctattt caaggagaag cccctaccct gtgagccgga
     1021 gctcatgccg acctttcccc accaccgcaa caagcgggcc gccccagcca cctccgaggg
     1081 ccagagcaag cgctgtaaac cctgacggtg ggcctggcac acgcctgtat tcccacacca
     1141 ggtcttccga tcagtggtgt ctgtgaaggg tgccgcgagc caggctgacc aggcgcccgg
     1201 gatccagctc atccccttgg ctgggaacat cctccactga cttcctccca ctgtctgccc
     1261 tgaacccact gctgccccca gaaaaaggcc gggtgacacc ggggggctcc cagcccgtgc
     1321 accctggaag ggcaggtctg gcggctccat ccgtggctgc aggggtctca tgtggtcctc
     1381 ctcgctatgt tggaaatgtg caaccactgc ttcttgggag gagtggtggg tgcagtcccc
     1441 ccgctgtctt tgagttgtgg tggacgctgg cctgggatga gagggcccag aagaccttcg
     1501 tatcccctct cagtcgcccg gggctgtccc gtgcatgggt tggctgtggg gaccccaggt
     1561 gggcctggca ggactccaga tgaggacaag agggacaagg tatggggtgg gagccacaat
     1621 tgaggatacc ccgagactac caggagagcc ctgggctgga ggctgagctg catccctgct
     1681 ccccacatgg aggacccaac aggaggccgt ggctctgatg ctgagcgaag ctataggctc
     1741 ttgttggata aaagcttttt taacaga
//
