LOCUS       NM_001786               1889 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens cyclin dependent kinase 1 (CDK1), transcript variant
            1, mRNA.
ACCESSION   NM_001786
VERSION     NM_001786.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1889)
  AUTHORS   Van Matre,S., Huq,S., Akana,L., Eldridge,D.E., Zuniga,O.,
            Rodrigues,H. and Wolfe,A.R.
  TITLE     Enhanced radiosensitivity of pancreatic cancer achieved through
            inhibition of Cyclin-dependent kinase 1
  JOURNAL   Radiother Oncol 200, 110531 (2024)
   PUBMED   39270987
  REMARK    GeneRIF: Enhanced radiosensitivity of pancreatic cancer achieved
            through inhibition of Cyclin-dependent kinase 1.
REFERENCE   2  (bases 1 to 1889)
  AUTHORS   Vishwakarma,K.K., Kolthur,U.S. and Venkatramani,R.
  TITLE     Multiple Functional Protein-Protein Interaction Interfaces
            Allosterically Regulate ATP-Binding in Cyclin-Dependent Kinase-1
  JOURNAL   Proteins 92 (11), 1329-1342 (2024)
   PUBMED   39012208
  REMARK    GeneRIF: Multiple Functional Protein-Protein Interaction Interfaces
            Allosterically Regulate ATP-Binding in Cyclin-Dependent Kinase-1.
REFERENCE   3  (bases 1 to 1889)
  AUTHORS   Luo,C., He,J., Yang,Y., Wu,K., Fu,X., Cheng,J., Ming,Y., Liu,W. and
            Peng,Y.
  TITLE     SRSF9 promotes cell proliferation and migration of glioblastoma
            through enhancing CDK1 expression
  JOURNAL   J Cancer Res Clin Oncol 150 (6), 292 (2024)
   PUBMED   38842611
  REMARK    GeneRIF: SRSF9 promotes cell proliferation and migration of
            glioblastoma through enhancing CDK1 expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1889)
  AUTHORS   Du,X., Shi,L., Wang,B. and Zhang,G.
  TITLE     WTAP mediated m6A-modified circ_0056856 contributes to the
            proliferation, migration, and invasion of IL-22-stimulated human
            keratinocyte by miR-197-3p/CDK1 axis
  JOURNAL   Arch Dermatol Res 316 (6), 208 (2024)
   PUBMED   38787443
  REMARK    GeneRIF: WTAP mediated m6A-modified circ_0056856 contributes to the
            proliferation, migration, and invasion of IL-22-stimulated human
            keratinocyte by miR-197-3p/CDK1 axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1889)
  AUTHORS   Parker,L.L. and Piwnica-Worms,H.
  TITLE     Inactivation of the p34cdc2-cyclin B complex by the human WEE1
            tyrosine kinase
  JOURNAL   Science 257 (5078), 1955-1957 (1992)
   PUBMED   1384126
REFERENCE   6  (bases 1 to 1889)
  AUTHORS   Dutta,A. and Stillman,B.
  TITLE     cdc2 family kinases phosphorylate a human cell DNA replication
            factor, RPA, and activate DNA replication
  JOURNAL   EMBO J 11 (6), 2189-2199 (1992)
   PUBMED   1318195
REFERENCE   7  (bases 1 to 1889)
  AUTHORS   Pagano,M., Pepperkok,R., Verde,F., Ansorge,W. and Draetta,G.
  TITLE     Cyclin A is required at two points in the human cell cycle
  JOURNAL   EMBO J 11 (3), 961-971 (1992)
   PUBMED   1312467
REFERENCE   8  (bases 1 to 1889)
  AUTHORS   Azzi,L., Meijer,L., Reed,S.I., Pidikiti,R. and Tung,H.Y.
  TITLE     Interaction between the cell-cycle-control proteins p34cdc2 and
            p9CKShs2. Evidence for two cooperative binding domains in p9CKShs2
  JOURNAL   Eur J Biochem 203 (3), 353-360 (1992)
   PUBMED   1310466
REFERENCE   9  (bases 1 to 1889)
  AUTHORS   Nazarenko,S.A., Ostroverhova,N.V. and Spurr,N.K.
  TITLE     Regional assignment of the human cell cycle control gene CDC2 to
            chromosome 10q21 by in situ hybridization
  JOURNAL   Hum Genet 87 (5), 621-622 (1991)
   PUBMED   1916766
REFERENCE   10 (bases 1 to 1889)
  AUTHORS   Lee,M.G. and Nurse,P.
  TITLE     Complementation used to clone a human homologue of the fission
            yeast cell cycle control gene cdc2
  JOURNAL   Nature 327 (6117), 31-35 (1987)
   PUBMED   3553962
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG723076.1, X05360.1,
            AC022390.9 and BC107750.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001786.4.
            
            Summary: The protein encoded by this gene is a member of the
            Ser/Thr protein kinase family. This protein is a catalytic subunit
            of the highly conserved protein kinase complex known as M-phase
            promoting factor (MPF), which is essential for G2/M phase
            transitions of eukaryotic cell cycle. Mitotic cyclins stably
            associate with this protein and function as regulatory subunits.
            The kinase activity of this protein is controlled by cyclin
            accumulation and destruction through the cell cycle. The
            phosphorylation and dephosphorylation of this protein also play
            important regulatory roles in cell cycle control. Alternatively
            spliced transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, May 2023].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.192414.1,
                                           SRR5189658.204446.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395284.8/ ENSP00000378699.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               BG723076.1         30-136
            108-1041            X05360.1           116-1049
            1042-1753           AC022390.9         127006-127717
            1754-1889           BC107750.1         1764-1899
FEATURES             Location/Qualifiers
     source          1..1889
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.2"
     gene            1..1889
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /note="cyclin dependent kinase 1"
                     /db_xref="GeneID:983"
                     /db_xref="HGNC:HGNC:1722"
                     /db_xref="MIM:116940"
     exon            1..93
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            94..155
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1012
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /EC_number="2.7.11.23"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     division cycle 2, G1 to S and G2 to M; cell division
                     control protein 2 homolog; p34 protein kinase; cell cycle
                     controller CDC2; cell division protein kinase 1"
                     /codon_start=1
                     /product="cyclin-dependent kinase 1 isoform 1"
                     /protein_id="NP_001777.1"
                     /db_xref="CCDS:CCDS44408.1"
                     /db_xref="GeneID:983"
                     /db_xref="HGNC:HGNC:1722"
                     /db_xref="MIM:116940"
                     /translation="MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGV
                     PSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDS
                     SLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY
                     THEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR
                     ALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI
                     SGKMALNHPYFNDLDNQIKKM"
     exon            156..312
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            313..436
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            437..607
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            608..771
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..913
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1889
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1238..1243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /note="hexamer: AATAAA"
     polyA_site      1276
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /note="major polyA site"
     regulatory      1869..1874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /note="hexamer: ATTAAA"
     polyA_site      1889
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /note="major polyA site"
ORIGIN      
        1 gcacttggct tcaaagctgg ctcttggaaa ttgagcggag agcgacgcgg ttgttgtagc
       61 tgccgctgcg gccgccgcgg aataataagc cgggatctac catacccatt gactaactat
      121 ggaagattat accaaaatag agaaaattgg agaaggtacc tatggagttg tgtataaggg
      181 tagacacaaa actacaggtc aagtggtagc catgaaaaaa atcagactag aaagtgaaga
      241 ggaaggggtt cctagtactg caattcggga aatttctcta ttaaaggaac ttcgtcatcc
      301 aaatatagtc agtcttcagg atgtgcttat gcaggattcc aggttatatc tcatctttga
      361 gtttctttcc atggatctga agaaatactt ggattctatc cctcctggtc agtacatgga
      421 ttcttcactt gttaagagtt atttatacca aatcctacag gggattgtgt tttgtcactc
      481 tagaagagtt cttcacagag acttaaaacc tcaaaatctc ttgattgatg acaaaggaac
      541 aattaaactg gctgattttg gccttgccag agcttttgga atacctatca gagtatatac
      601 acatgaggta gtaacactct ggtacagatc tccagaagta ttgctggggt cagctcgtta
      661 ctcaactcca gttgacattt ggagtatagg caccatattt gctgaactag caactaagaa
      721 accacttttc catggggatt cagaaattga tcaactcttc aggattttca gagctttggg
      781 cactcccaat aatgaagtgt ggccagaagt ggaatcttta caggactata agaatacatt
      841 tcccaaatgg aaaccaggaa gcctagcatc ccatgtcaaa aacttggatg aaaatggctt
      901 ggatttgctc tcgaaaatgt taatctatga tccagccaaa cgaatttctg gcaaaatggc
      961 actgaatcat ccatatttta atgatttgga caatcagatt aagaagatgt agctttctga
     1021 caaaaagttt ccatatgtta tatcaacaga tagttgtgtt tttattgtta actcttgtct
     1081 atttttgtct tatatatatt tctttgttat caaacttcag ctgtacttcg tcttctaatt
     1141 tcaaaaatat aacttaaaaa tgtaaatatt ctatatgaat ttaaatataa ttctgtaaat
     1201 gtgtgtaggt ctcactgtaa caactatttg ttactataat aaaactataa tattgatgtc
     1261 aggaatcagg aaaaaatttg agttggctta aatcatctca gtccttatgg cagttttatt
     1321 ttcctgtagt tggaactact aaaatttagg aaaatgctaa gttcaagttt cgtaatgctt
     1381 tgaagtattt ttatgctctg aatgtttaaa tgttctcatc agtttcttgc catgttgtta
     1441 actatacaac ctggctaaag atgaatattt ttctactggt attttaattt ttgacctaaa
     1501 tgtttaagca ttcggaatga gaaaactata cagatttgag aaatgatgct aaatttatag
     1561 gagttttcag taacttaaaa agctaacatg agagcatgcc aaaatttgct aagtcttaca
     1621 aagatcaagg gctgtccgca acagggaaga acagttttga aaatttatga actatcttat
     1681 ttttaggtag gttttgaaag ctttttgtct aagtgaattc ttatgccttg gtcagagtaa
     1741 taactgaagg agttgcttat cttggctttc gagtctgagt ttaaaactac acattttgac
     1801 atagtgttta ttagcagcca tctaaaaagg ctctaatgta tatttaacta aaattactag
     1861 ctttgggaat taaactgttt aacaaataa
//
