LOCUS       NM_013399               2706 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens cell death inducing p53 target 1 (CDIP1), transcript
            variant 2, mRNA.
ACCESSION   NM_013399
VERSION     NM_013399.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2706)
  AUTHORS   Inukai,R., Mori,K., Maki,M., Takahara,T. and Shibata,H.
  TITLE     Cytoprotective Role of Autophagy in CDIP1 Expression-Induced
            Apoptosis in MCF-7 Breast Cancer Cells
  JOURNAL   Int J Mol Sci 25 (12), 6520 (2024)
   PUBMED   38928226
  REMARK    GeneRIF: Cytoprotective Role of Autophagy in CDIP1
            Expression-Induced Apoptosis in MCF-7 Breast Cancer Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2706)
  AUTHORS   Yan,G. and Lei,W.
  TITLE     Role of ELK1 in regulating colorectal cancer progression:
            miR-31-5p/CDIP1 axis in CRC pathogenesis
  JOURNAL   PeerJ 11, e15602 (2023)
   PUBMED   37547727
  REMARK    GeneRIF: Role of ELK1 in regulating colorectal cancer progression:
            miR-31-5p/CDIP1 axis in CRC pathogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2706)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 2706)
  AUTHORS   Inukai,R., Mori,K., Kuwata,K., Suzuki,C., Maki,M., Takahara,T. and
            Shibata,H.
  TITLE     The Novel ALG-2 Target Protein CDIP1 Promotes Cell Death by
            Interacting with ESCRT-I and VAPA/B
  JOURNAL   Int J Mol Sci 22 (3), 1175 (2021)
   PUBMED   33503978
  REMARK    GeneRIF: The Novel ALG-2 Target Protein CDIP1 Promotes Cell Death
            by Interacting with ESCRT-I and VAPA/B.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2706)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2706)
  AUTHORS   Brown-Endres,L., Schoenfeld,D., Tian,F., Kim,H.G., Namba,T.,
            Munoz-Fontela,C., Mandinova,A., Aaronson,S.A. and Lee,S.W.
  TITLE     Expression of the p53 target CDIP correlates with sensitivity to
            TNFalpha-induced apoptosis in cancer cells
  JOURNAL   Cancer Res 72 (9), 2373-2382 (2012)
   PUBMED   22549949
  REMARK    GeneRIF: CDIP expression correlates with sensitivity of cancer
            cells with TNFalpha, and CDIP seems to be a regulator of the
            p53-mediated death versus survival response of cells to TNFalpha.
REFERENCE   7  (bases 1 to 2706)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   8  (bases 1 to 2706)
  AUTHORS   Brown,L., Ongusaha,P.P., Kim,H.G., Nuti,S., Mandinova,A., Lee,J.W.,
            Khosravi-Far,R., Aaronson,S.A. and Lee,S.W.
  TITLE     CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated
            apoptosis in a p53-dependent manner
  JOURNAL   EMBO J 26 (14), 3410-3422 (2007)
   PUBMED   17599062
  REMARK    GeneRIF: These findings support a novel p53 --> CDIP --> TNF-alpha
            apoptotic pathway that directs apoptosis after exposure of cells to
            genotoxic stress.
REFERENCE   9  (bases 1 to 2706)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   10 (bases 1 to 2706)
  AUTHORS   Bhalla,K., Eyre,H.J., Whitmore,S.A., Sutherland,G.R. and
            Callen,D.F.
  TITLE     C16orf5, a novel proline-rich gene at 16p13.3, is highly expressed
            in the brain
  JOURNAL   J Hum Genet 44 (6), 383-387 (1999)
   PUBMED   10570909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA055704.1, BC002882.2 and AC007606.8.
            
            On Nov 22, 2018 this sequence version replaced NM_013399.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136698.1, SRR3476690.144279.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2153946
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000567695.6/ ENSP00000457877.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DA055704.1         56-67
            13-2051             BC002882.2         1-2039
            2052-2700           AC007606.8         59240-59888         c
            2701-2706           AC007606.8         59234-59239         c
FEATURES             Location/Qualifiers
     source          1..2706
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..2706
                     /gene="CDIP1"
                     /gene_synonym="C16orf5; CDIP; I1; LITAFL"
                     /note="cell death inducing p53 target 1"
                     /db_xref="GeneID:29965"
                     /db_xref="HGNC:HGNC:13234"
                     /db_xref="MIM:610503"
     exon            1..72
                     /gene="CDIP1"
                     /gene_synonym="C16orf5; CDIP; I1; LITAFL"
                     /inference="alignment:Splign:2.1.0"
     exon            73..162
                     /gene="CDIP1"
                     /gene_synonym="C16orf5; CDIP; I1; LITAFL"
                     /inference="alignment:Splign:2.1.0"
     exon            163..261
                     /gene="CDIP1"
                     /gene_synonym="C16orf5; CDIP; I1; LITAFL"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..803
                     /gene="CDIP1"
                     /gene_synonym="C16orf5; CDIP; I1; LITAFL"
                     /note="isoform a is encoded by transcript variant 2;
                     LITAF-like protein; cell death inducing protein;
                     transmembrane protein I1; cell death involved p53-target;
                     lipopolysaccharide-induced tumor necrosis
                     factor-alpha-like protein; cell death-inducing p53-target
                     protein 1"
                     /codon_start=1
                     /product="cell death-inducing p53-target protein 1 isoform
                     a"
                     /protein_id="NP_037531.2"
                     /db_xref="CCDS:CCDS42114.1"
                     /db_xref="GeneID:29965"
                     /db_xref="HGNC:HGNC:13234"
                     /db_xref="MIM:610503"
                     /translation="MSSEPPPPYPGGPTAPLLEEKSGAPPTPGRSSPAVMQPPPGMPL
                     PPADIGPPPYEPPGHPMPQPGFIPPHMSADGTYMPPGFYPPPGPHPPMGYYPPGPYTP
                     GPYPGPGGHTATVLVPSGAATTVTVLQGEIFEGAPVQTVCPHCQQAITTKISYEIGLM
                     NFVLGFFCCFMGCDLGCCLIPCLINDFKDVTHTCPSCKAYIYTYKRLC"
     exon            262..417
                     /gene="CDIP1"
                     /gene_synonym="C16orf5; CDIP; I1; LITAFL"
                     /inference="alignment:Splign:2.1.0"
     exon            418..691
                     /gene="CDIP1"
                     /gene_synonym="C16orf5; CDIP; I1; LITAFL"
                     /inference="alignment:Splign:2.1.0"
     exon            692..2706
                     /gene="CDIP1"
                     /gene_synonym="C16orf5; CDIP; I1; LITAFL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2025..2030
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDIP1"
                     /gene_synonym="C16orf5; CDIP; I1; LITAFL"
                     /note="hexamer: ATTAAA"
     polyA_site      2049
                     /gene="CDIP1"
                     /gene_synonym="C16orf5; CDIP; I1; LITAFL"
                     /note="major polyA site"
     regulatory      2650..2655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDIP1"
                     /gene_synonym="C16orf5; CDIP; I1; LITAFL"
                     /note="hexamer: AATAAA"
     polyA_site      2669
                     /gene="CDIP1"
                     /gene_synonym="C16orf5; CDIP; I1; LITAFL"
     regulatory      2686..2691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDIP1"
                     /gene_synonym="C16orf5; CDIP; I1; LITAFL"
                     /note="hexamer: AATGAA"
     polyA_site      2706
                     /gene="CDIP1"
                     /gene_synonym="C16orf5; CDIP; I1; LITAFL"
ORIGIN      
        1 agaagtgcga ctgccagctg ccgaggcgtt cggtcctgct gttgcggccg ctgccccagg
       61 gctgcgggga cgctcccgga gccctgcctg ttccctgtcc atccaggcca gcagctgaag
      121 gagcctcacc tgcctccctt ctctgagtag cacggatttg aggagaagca gcgaagatgt
      181 ccagcgagcc tccccctcct tatcctgggg gccccacagc cccacttctg gaagagaaaa
      241 gtggagcccc gcccacccca ggccgttcct ccccagctgt gatgcagccc cctccaggca
      301 tgccactgcc ccctgcggac attggccccc caccctatga gccgccgggt cacccaatgc
      361 cccagcctgg cttcatccca ccacacatga gtgcagatgg cacctacatg cctccgggtt
      421 tctaccctcc tccaggcccc cacccaccca tgggctacta ccccccaggg ccctacacgc
      481 cagggcccta ccctggccct gggggccaca cagccacagt cctggtccct tcaggagctg
      541 ccaccacggt gacagtgctg cagggagaga tctttgaggg agcgcctgtg cagacggtgt
      601 gtccccactg ccagcaggcc atcaccacca agatctccta cgagattggc ttgatgaatt
      661 tcgtgctggg tttcttctgt tgcttcatgg gatgtgatct gggctgctgc ctgatcccct
      721 gcctcatcaa tgacttcaag gatgtgacgc acacatgccc cagctgcaaa gcctacatct
      781 acacgtacaa gcgcctgtgc taacggagct gggactcggg actcccccgc ctgtcagtct
      841 ggccccctgt gctttgctcc ctgtgctcag tggtcacttt cccgctccca cttggggctg
      901 ggagccgtgc caccatcccc tagaagtcct gtcctcttca ccctgcccta cctgagccgc
      961 tgactcttct ggcaaaaatt ctgttgggat ttaaggccaa gggtcagtgg gtggcagggg
     1021 gctgacaatg agcttgtgtg ttgttggtct gcttggtgtg tgtgatcggg aagataagct
     1081 gggaggggtc tcctgctggg gtcctgatgc ctctgtttcc aaacaaggta caggttcagt
     1141 ccagactctt tccccctggg accaacagca gccagagcag ttagccagtt agtccccagg
     1201 cctgtggcca caggcgtttc tgacctgctg ggccgagaat gggtaagttg tctggagtca
     1261 ggtgggccca cgtaggacag ggtcacaaag cctgggtttg tttctgggta ctttgcgcct
     1321 ctggggtgct agaggtgggg catggtggct ggaagtaaaa ctgccaactc tggccctcag
     1381 aactctcagg tatagaagcc caggatgtct aataccctgt cccagtgccc gagagctgcc
     1441 tggtgtcagg tagagaggac actgtacctg ggtgaatgat cagaccctgg tagctaagaa
     1501 ggaacttgtc cctttgagtc agtgtgcaga ccccctttca ggccatgcct ctgtgaaccc
     1561 tgtattgctg gggccggaag gagcccctga gcctagcccc ttcccgtctg ccctgtgtcc
     1621 tcactgcgtg tgggtatgac ctctgcctgg tggctggtgt atcccaactg ggcaagagat
     1681 ggcagagggt cccccttgtg ggtgcgcttg gatgtgcaga gccttctcca tggattttct
     1741 tccctgtaag tgccgggccc ctcaccccag ctgacaggct gttgctgtgc ctgctcacac
     1801 ctgctcctgc aggcacactg ggctagggac gaggaaggag cagccacaag tggtagaact
     1861 gccttggtgg acaccagcct cgccctgtct ttatttcctg aatggtttgt gaacttgctc
     1921 acctggacca ctgtatcctg ccactgtcct tcctggtctc gcactgccac tgcatggcct
     1981 cctgtcactg tgaatcgtgg cccagtctca gtttgtagtt tctcattaaa ttggcccttt
     2041 cactcccccg ccctgggcct ctgctctctt gcctggcttc cttctttttt gagggaaaga
     2101 gggtggggct gcaggcagtc tactggcagg acgggaggct gagtcctcag ggtctcacac
     2161 cctcagtgct gatgccatgc caactgcctg ggacaacacc aacacgtaag gacctaatta
     2221 aaccaaacca gagtcgggtg tagaccagcc ctgggatttc cagctgtgac tgggccaggg
     2281 cacacgttgg tctcggcagt ggctgtaagg tcaccttcct tcctctgatg ctggtttcaa
     2341 ccatctatat atggcatcca cgcatgggat ctgcaagctg gagccctcct acccgcaggc
     2401 ttgagcacag catcatccag ccctggggag gcgcaccctt aagcaacaca gactgggctg
     2461 aggctgacag gcagaagact aacagagcgc agtctgcaca cgcaggttct gggcgacctc
     2521 tggccctggc catctctgca ctaactcatc tgaattatga aggtggcagt cttggtcagt
     2581 agtttaaaga gtttccctac tttttaaccc tttttgaaat aaaactttta caggtagtag
     2641 attcctatta ataaaattat ttaagttcat gtttctcttt tagagaatga attgtttaaa
     2701 tacaaa
//
