LOCUS       NM_021924               3359 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens cadherin related family member 5 (CDHR5), transcript
            variant 1, mRNA.
ACCESSION   NM_021924
VERSION     NM_021924.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3359)
  AUTHORS   Gray,M.E., Johnson,Z.R., Modak,D., Tamilselvan,E., Tyska,M.J. and
            Sotomayor,M.
  TITLE     Heterophilic and homophilic cadherin interactions in intestinal
            intermicrovillar links are species dependent
  JOURNAL   PLoS Biol 19 (12), e3001463 (2021)
   PUBMED   34871294
  REMARK    GeneRIF: Heterophilic and homophilic cadherin interactions in
            intestinal intermicrovillar links are species dependent.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3359)
  AUTHORS   Beck,M., Baranger,M., Moufok-Sadoun,A., Bersuder,E., Hinkel,I.,
            Mellitzer,G., Martin,E., Marisa,L., Duluc,I., de Reynies,A.,
            Gaiddon,C., Freund,J.N. and Gross,I.
  TITLE     The atypical cadherin MUCDHL antagonizes colon cancer formation and
            inhibits oncogenic signaling through multiple mechanisms
  JOURNAL   Oncogene 40 (3), 522-535 (2021)
   PUBMED   33188295
  REMARK    GeneRIF: The atypical cadherin MUCDHL antagonizes colon cancer
            formation and inhibits oncogenic signaling through multiple
            mechanisms.
REFERENCE   3  (bases 1 to 3359)
  AUTHORS   Gao,J., Wang,M., Li,T., Liu,Q., You,L. and Liao,Q.
  TITLE     Up-regulation of CDHR5 expression promotes malignant phenotype of
            pancreatic ductal adenocarcinoma
  JOURNAL   J Cell Mol Med 24 (21), 12726-12735 (2020)
   PUBMED   33025744
  REMARK    GeneRIF: Up-regulation of CDHR5 expression promotes malignant
            phenotype of pancreatic ductal adenocarcinoma.
REFERENCE   4  (bases 1 to 3359)
  AUTHORS   Choi,M.S., Graves,M.J., Matoo,S., Storad,Z.A., El Sheikh
            Idris,R.A., Weck,M.L., Smith,Z.B., Tyska,M.J. and Crawley,S.W.
  TITLE     The small EF-hand protein CALML4 functions as a critical myosin
            light chain within the intermicrovillar adhesion complex
  JOURNAL   J Biol Chem 295 (28), 9281-9296 (2020)
   PUBMED   32209652
REFERENCE   5  (bases 1 to 3359)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 3359)
  AUTHORS   Goldberg,M., Wei,M., Yuan,L., Murty,V.V. and Tycko,B.
  TITLE     Biallelic expression of HRAS and MUCDHL in human and mouse
  JOURNAL   Hum Genet 112 (4), 334-342 (2003)
   PUBMED   12589428
  REMARK    GeneRIF: MUCDHL genes are biallelically expressed in multiple fetal
            and adult tissues both in humans and in mice
REFERENCE   7  (bases 1 to 3359)
  AUTHORS   Goldberg,M., Wei,M., Tycko,B., Falikovich,I. and Warburton,D.
  TITLE     Identification and expression analysis of the human
            mu-protocadherin gene in fetal and adult kidneys
  JOURNAL   Am J Physiol Renal Physiol 283 (3), F454-F463 (2002)
   PUBMED   12167596
  REMARK    GeneRIF: identifed the human mu-protocadherin ortholog and examined
            its expression in the developing kidney
REFERENCE   8  (bases 1 to 3359)
  AUTHORS   Paris,M.J. and Williams,B.R.
  TITLE     Characterization of a 500-kb contig spanning the region between
            c-Ha-Ras and MUC2 on chromosome 11p15.5
  JOURNAL   Genomics 69 (2), 196-202 (2000)
   PUBMED   11031102
REFERENCE   9  (bases 1 to 3359)
  AUTHORS   Goldberg,M., Peshkovsky,C., Shifteh,A. and Al-Awqati,Q.
  TITLE     mu-Protocadherin, a novel developmentally regulated protocadherin
            with mucin-like domains
  JOURNAL   J Biol Chem 275 (32), 24622-24629 (2000)
   PUBMED   10801787
REFERENCE   10 (bases 1 to 3359)
  AUTHORS   Yagi,T. and Takeichi,M.
  TITLE     Cadherin superfamily genes: functions, genomic organization, and
            neurologic diversity
  JOURNAL   Genes Dev 14 (10), 1169-1180 (2000)
   PUBMED   10817752
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA373160.1, AF301909.1,
            AK300991.1, AY358368.1, AP006284.2 and AA975851.1.
            
            On Jun 28, 2019 this sequence version replaced NM_021924.4.
            
            Summary: This gene is a novel mucin-like gene that is a member of
            the cadherin superfamily. While encoding nonpolymorphic tandem
            repeats rich in proline, serine and threonine similar to mucin
            proteins, the gene also contains sequence encoding calcium-binding
            motifs found in all cadherins. The role of the hybrid extracellular
            region and the specific function of this protein have not yet been
            determined. Alternatively spliced transcript variants encoding
            different isoforms have been described. [provided by RefSeq, Jan
            2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1, also known as
            MUCDHLFL).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF301909.1, SRR14372080.2924826.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153932, SAMEA2153946
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397542.7/ ENSP00000380676.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                DA373160.1         55-107
            54-1123             AF301909.1         1-1070
            1124-1124           AK300991.1         1088-1088
            1125-1478           AF301909.1         1072-1425
            1479-1765           AY358368.1         1430-1716
            1766-2157           AF301909.1         1713-2104
            2158-2158           AP006284.2         76684-76684         c
            2159-2404           AF301909.1         2106-2351
            2405-2683           AK300991.1         1787-2065
            2684-2972           AP006284.2         75687-75975         c
            2973-3269           AY358368.1         2924-3220
            3270-3359           AA975851.1         19-108              c
FEATURES             Location/Qualifiers
     source          1..3359
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..3359
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /note="cadherin related family member 5"
                     /db_xref="GeneID:53841"
                     /db_xref="HGNC:HGNC:7521"
                     /db_xref="MIM:606839"
     exon            1..138
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..2591
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; mucin and cadherin-like protein;
                     mu-protocadherin; differentiation-associated catenin
                     regulator"
                     /codon_start=1
                     /product="cadherin-related family member 5 isoform 1
                     precursor"
                     /protein_id="NP_068743.3"
                     /db_xref="CCDS:CCDS7707.1"
                     /db_xref="GeneID:53841"
                     /db_xref="HGNC:HGNC:7521"
                     /db_xref="MIM:606839"
                     /translation="MGSWALLWPPLLFTGLLVRPPGTMAQAQYCSVNKDIFEVEENTN
                     VTEPLVDIHVPEGQEVTLGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQSGG
                     TLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDIL
                     FYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHT
                     ATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYA
                     EDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMTFLLLVKGQQADLAR
                     YSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEF
                     SDLNSAITYRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHNTVTSGTATTVIEIQ
                     VSEQEPPSTDVPPSPEAGGTTGPWTSTTSEVPRPPEPSQGPSTTSSGGGTGPHPPSGT
                     TLRPPTSSTPGGPPGAENSTSHQPATPGGDTAQTPKPGTSQPMPPGVGTSTSHQPATP
                     SGGTAQTPEPGTSQPMPPSMGTSTSHQPATPGGGTAQTPEAGTSQPMPPGMGTSTSHQ
                     PTTPGGGTAQTPEPGTSQPMPLSKSTPSSGGGPSEDKRFSVVDMAALGGVLGALLLLA
                     LLGLAVLVHKHYGPRLKCCCGKAPEPQPQGFDNQAFLPDHKANWAPVPSPTHDPKPAE
                     APMPAEPAPPGPASPGGAPEPPAAARAGGSPTAVRSILTKERRPEGGYKAVWFGEDIG
                     TEADVVVLNAPTLDVDGASDSGSGDEGEGAGRGGGPYDAPGGDDSYI"
     exon            139..314
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /inference="alignment:Splign:2.1.0"
     exon            315..365
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /inference="alignment:Splign:2.1.0"
     exon            366..458
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /inference="alignment:Splign:2.1.0"
     exon            459..560
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /inference="alignment:Splign:2.1.0"
     exon            561..671
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /inference="alignment:Splign:2.1.0"
     exon            672..842
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /inference="alignment:Splign:2.1.0"
     exon            843..933
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1031
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1232
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1346
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1431
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..2013
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2171
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..3359
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2666..2671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /note="hexamer: AATAAA"
     polyA_site      2690
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
     regulatory      3335..3340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /note="hexamer: AATACA"
     polyA_site      3359
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /note="major polyA site"
ORIGIN      
        1 agtcctagac gccagacccg ctcagaccct cctgccaggt gacagccgcc aagatggggt
       61 cttgggccct gctgtggcct cccctgctgt tcaccgggct gctcgtccga cccccgggga
      121 ccatggccca ggcccagtac tgctctgtga acaaggacat ctttgaagta gaggagaaca
      181 caaatgtcac cgagccgctg gtggacatcc acgtcccgga gggccaggag gtgaccctcg
      241 gagccttgtc cacccccttt gcatttcgga tccagggaaa ccagctgttt ctcaacgtga
      301 ctcctgatta cgaggagaag tcactgcttg aggctcagct gctgtgtcag agcggaggca
      361 cattggtgac ccagctaagg gtgttcgtgt cagtgctgga cgtcaatgac aatgcccccg
      421 aattcccctt taagaccaag gagataaggg tggaggagga cacgaaagtg aactccaccg
      481 tcatccccga gacgcaactg caggctgagg accgcgacaa ggacgacatt ctgttctaca
      541 ccctccagga aatgacagca ggtgccagtg actacttctc cctggtgagt gtaaaccgtc
      601 ccgccctgag gctggaccgg cccctggact tctacgagcg gccgaacatg accttctggc
      661 tgctggtgcg ggacactccg ggggagaatg tggaacccag ccacactgcc accgccacac
      721 tagtgctgaa cgtggtgccc gccgacctgc ggcccccgtg gttcctgccc tgcaccttct
      781 cagatggcta cgtctgcatt caagctcagt accacggggc tgtccccacg gggcacatac
      841 tgccatctcc cctcgtcctg cgtcccggac ccatctacgc tgaggacgga gaccgcggca
      901 tcaaccagcc catcatctac agcatcttta ggggaaacgt gaatggtaca ttcatcatcc
      961 acccagactc gggcaacctc accgtggcca ggagtgtccc cagccccatg accttccttc
     1021 tgctggtgaa gggccaacag gccgaccttg cccgctactc agtgacccag gtcaccgtgg
     1081 aggctgtggc tgcggccggg agcccgcccc gcttccccca gagactgtat cgtggcaccg
     1141 tggcgcgtgg cgctggagcg ggcgttgtgg tcaaggatgc agctgcccct tctcagcctc
     1201 tgaggatcca ggctcaggac ccggagttct cggacctcaa ctcggccatc acatatcgaa
     1261 ttaccaacca ctcacacttc cggatggagg gagaggttgt gctgaccacc accacactgg
     1321 cacaggcggg agccttctac gcagaggttg aggcccacaa cacggtgacc tctggcaccg
     1381 caaccacagt cattgagata caagtttccg aacaggagcc cccctccaca gatgtccccc
     1441 catccccaga ggctggagga acaactgggc cctggaccag caccacttcc gaggtcccca
     1501 gaccccctga gccctcccag ggaccctcca cgaccagctc tgggggaggc acaggccctc
     1561 atccaccctc tggcacaact ctgaggccac caacctcgtc cacacccggg gggcccccgg
     1621 gtgcagaaaa cagcacctcc caccaaccag ccactcccgg tggggacaca gcacagaccc
     1681 caaagccagg aacctctcag ccgatgcccc ccggtgtggg aaccagcacc tcccaccaac
     1741 cagccacacc cagtgggggc acagcacaga ccccagagcc aggaacctct cagccgatgc
     1801 cccccagtat gggaaccagc acctcccacc aaccagccac acccggtggg ggcacagcac
     1861 agaccccaga ggcaggaacc tctcagccga tgccccccgg tatgggaacc agcacctccc
     1921 accaaccaac cacacccggt gggggcacag cacagacccc agagccagga acctctcagc
     1981 cgatgcccct cagcaagagc accccatctt caggtggcgg cccctcggag gacaagcgct
     2041 tctcggtggt ggatatggcg gccctgggcg gggtgctggg tgcgctgctg ctgctggctc
     2101 tccttggcct cgccgtcctt gtccacaagc actatggccc ccggctcaag tgctgctgtg
     2161 gcaaagctcc ggagccccag ccccaaggct ttgacaacca ggcgttcctc cctgaccaca
     2221 aggccaactg ggcgcccgtc cccagcccca cgcacgaccc caagcccgcg gaggcaccga
     2281 tgcccgcaga gcccgcaccc cccggccctg cctccccagg cggtgcccct gagccccccg
     2341 cagcggcccg agctggcgga agccccacgg cggtgaggtc catcctgacc aaggagcggc
     2401 ggccggaggg cgggtacaag gctgtctggt ttggcgagga catcgggacg gaggcagacg
     2461 tggtcgttct caacgcgccc accctggacg tggatggcgc cagtgactcc ggcagcggcg
     2521 atgagggcga gggcgcgggg aggggtgggg gtccctacga tgcgcccggt ggtgatgact
     2581 cctacatcta agtggcccct ccaccctctc ccccagccgc acgggcactg gaggtctcgc
     2641 tcccccagcc tccgacccga ggcagaataa agcaaggctc ccgaaaccca ggccatggcg
     2701 tggggcaggc gcgcgggtcc atgggggtcc cattcactca gtcccctgtc gtcattagcg
     2761 cttgagccca ggtgtgcaga tgaggcggtg ggtctggcca cgctgtcccc accccaaggc
     2821 tgcagcactt cccgtaaacc acctgcagtg cccgccgcct tcccgaggct ctgtgccagc
     2881 tagtctggga agttcctctc ccgctctaac cacagcccga ggggggctcc cctcccccga
     2941 cctgcaccgg agatctcagg cacccggctc atctcagacc tcccgctccc gaccctacac
     3001 agagattgcc tggggaggct gaggagccga tgcaaacccc caaggcgacg cacttgggag
     3061 ccggtggtct caaacacctg ccgggggtcc tagtcccctt ctgaaatcta catgcttggg
     3121 ttggagcgca gcagtaaaca ccctgcccag tgacctggac tgaggcgcgc tgggggtggg
     3181 tgcgccgtgt ggcctgagca ggagccagac caggaggcct aggggtgaga gacacattcc
     3241 cctcgctgct cccaaagcca gagcccaggc tgggcgccca tgcccagaac catcaaggga
     3301 tcccttgcgg cttgtcagca ctttccctaa tggaaataca ccattaattc ctttccaaa
//
