LOCUS       NM_001007540            2528 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cadherin related family member 4 (CDHR4), mRNA.
ACCESSION   NM_001007540 XM_371639
VERSION     NM_001007540.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2528)
  AUTHORS   Morgan,A.R., Han,D.Y., Lam,W.J., Fraser,A.G. and Ferguson,L.R.
  TITLE     Association analysis of 3p21 with Crohn's disease in a New Zealand
            population
  JOURNAL   Hum Immunol 71 (6), 602-609 (2010)
   PUBMED   20307617
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   2  (bases 1 to 2528)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139451.7, AY358221.1, BC146674.1 and DR008129.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001007540.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146674.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000412678.7/ ENSP00000391409.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AC139451.7         69370-69407
            39-52               AY358221.1         1-14
            53-1482             BC146674.1         1-1430
            1483-1483           DR008129.1         372-372
            1484-2528           BC146674.1         1432-2476
FEATURES             Location/Qualifiers
     source          1..2528
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..2528
                     /gene="CDHR4"
                     /gene_synonym="CDH29; PRO34300"
                     /note="cadherin related family member 4"
                     /db_xref="GeneID:389118"
                     /db_xref="HGNC:HGNC:34527"
     exon            1..110
                     /gene="CDHR4"
                     /gene_synonym="CDH29; PRO34300"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2428
                     /gene="CDHR4"
                     /gene_synonym="CDH29; PRO34300"
                     /note="cadherin-like 29; cadherin-like protein 29;
                     Cadherin-like protein UNQ9392/PRO34300; VLLR9392"
                     /codon_start=1
                     /product="cadherin-related family member 4 precursor"
                     /protein_id="NP_001007541.2"
                     /db_xref="CCDS:CCDS46829.1"
                     /db_xref="GeneID:389118"
                     /db_xref="HGNC:HGNC:34527"
                     /translation="MVLLRLLVFLFAPVVSDLCSLPCFINVSESQGPGTVLQFLSFNC
                     SSYTPTPTLELLNVQPPTTFFNPPSLARWQGTYVGKLTLSSSAQLDALMVNHYKVQLK
                     FTCGNHVMEGSLSVDVQRDLSHIQCAGQFASPAGEMIQVPETVTPGARLYTLLLPGLE
                     LHGAQMSIISAQDLPHFPGPFSINEQGWLQAPSQGLLGQAQKVFQLQISVSFGQRQSC
                     QGMVIVKVLPVPSSQVSFLEQAQNITIPENLAPGSEVVQVQARGVDLRYEILSPVPSP
                     LFSIGRADGVVRTTTPLELARTSGTAVSRLQVKAFEQGQLWASAKLNLTMNVQLVNLW
                     PPRCLPALLVSQIPETAPVGTVLNTLTCEDPDSVGATLDYKLWFRSSSNPASLCLYDR
                     VLEVNATLDCDTPGACFQHAASILVLDGGQPQMTTEVPVLVMVTPINEFSPACAPRTF
                     RVQEDAAPHTLLGSVVGTDMDYPHDNIEYYTSGGPTTFAVDRLSGEVHLLGPLDYEQQ
                     RLYRLTVLVIDHGQDQNPNHHLSGSCTITIEVEDVNDHAPECEPPFQELTIYAPLGRS
                     VEVTKMSCQIPQEPQRLIYSYSIVGGNSQNRFILQGAILVHSDLVLGPFWPEQPRTYE
                     LLICVADAGPSTPHLSTTATIIVHLVPRRASTVATSTHRTTVPSTMTPMLVTDTEAFW
                     QPQPWFVVVLTATGALLLLALGWLLGRLLQGLAQLLQAPSKPAQALLLNSIQGTEGSI
                     EGFLEAPKMEMSQAPSSVMSLHFDGRAQDSRTGRDYLFNTHTGARRWL"
     exon            111..301
                     /gene="CDHR4"
                     /gene_synonym="CDH29; PRO34300"
                     /inference="alignment:Splign:2.1.0"
     exon            302..464
                     /gene="CDHR4"
                     /gene_synonym="CDH29; PRO34300"
                     /inference="alignment:Splign:2.1.0"
     exon            465..556
                     /gene="CDHR4"
                     /gene_synonym="CDH29; PRO34300"
                     /inference="alignment:Splign:2.1.0"
     exon            557..667
                     /gene="CDHR4"
                     /gene_synonym="CDH29; PRO34300"
                     /inference="alignment:Splign:2.1.0"
     exon            668..771
                     /gene="CDHR4"
                     /gene_synonym="CDH29; PRO34300"
                     /inference="alignment:Splign:2.1.0"
     exon            772..908
                     /gene="CDHR4"
                     /gene_synonym="CDH29; PRO34300"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1092
                     /gene="CDHR4"
                     /gene_synonym="CDH29; PRO34300"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1246
                     /gene="CDHR4"
                     /gene_synonym="CDH29; PRO34300"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1340
                     /gene="CDHR4"
                     /gene_synonym="CDH29; PRO34300"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1544
                     /gene="CDHR4"
                     /gene_synonym="CDH29; PRO34300"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1684
                     /gene="CDHR4"
                     /gene_synonym="CDH29; PRO34300"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1835
                     /gene="CDHR4"
                     /gene_synonym="CDH29; PRO34300"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..2056
                     /gene="CDHR4"
                     /gene_synonym="CDH29; PRO34300"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2199
                     /gene="CDHR4"
                     /gene_synonym="CDH29; PRO34300"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2256
                     /gene="CDHR4"
                     /gene_synonym="CDH29; PRO34300"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2344
                     /gene="CDHR4"
                     /gene_synonym="CDH29; PRO34300"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2372
                     /gene="CDHR4"
                     /gene_synonym="CDH29; PRO34300"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2528
                     /gene="CDHR4"
                     /gene_synonym="CDH29; PRO34300"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2508..2513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDHR4"
                     /gene_synonym="CDH29; PRO34300"
                     /note="hexamer: AACAAA"
     polyA_site      2528
                     /gene="CDHR4"
                     /gene_synonym="CDH29; PRO34300"
                     /note="major polyA site"
ORIGIN      
        1 gagtcagaca aacagcctag ctttctgaag cctcctctgc tgtctgtgtc ttcaggtcat
       61 catggtgctg ctcaggctcc tcgtgttcct ctttgctccg gtggtctctg acctctgcag
      121 cctgccctgc tttataaatg tctctgagag ccagggccct ggcacagtcc ttcagttttt
      181 atccttcaac tgctcctcct acacgcccac acccaccctg gagttgctca atgtccagcc
      241 acccaccacc ttcttcaacc cacccagctt ggccaggtgg caagggacct atgtgggcaa
      301 gttgaccttg agcagctctg ctcagttgga tgccctgatg gtgaaccact acaaggtgca
      361 gctgaagttc acatgtggca accatgtgat ggagggctca ctctctgtgg atgtgcagcg
      421 ggaccttagc catatccagt gtgctggtca atttgccagc ccagctgggg aaatgattca
      481 ggtgccagag acagtcacac ctggggctcg gctgtacact ctgctcctcc caggcctaga
      541 actccacgga gcgcagatga gcattatcag tgcccaggac ctgccacact tccctggacc
      601 tttctccatc aatgagcaag gttggctgca ggcaccatcc cagggcctcc taggccaggc
      661 tcaaaaggtc ttccagctgc aaatctcagt gtcctttgga caaaggcaaa gctgccaagg
      721 gatggtgata gtgaaggttt tgcctgttcc ctccagccag gtctccttcc tcgagcaggc
      781 tcagaatatc accatccctg agaatctggc ccccggtagt gaggtggttc aggtccaggc
      841 ccggggtgtc gacctgcgct atgaaatcct gtctccggtg cccagcccac tcttctccat
      901 tggtcgtgca gacggtgtgg tccggaccac cacgccccta gagttagctc gcacctcagg
      961 caccgcggtc tccaggctgc aggtgaaggc ctttgagcag ggccagctgt gggccagtgc
     1021 caagctcaat ctcaccatga atgtgcagct ggtcaacctc tggcctccac gctgcctccc
     1081 agcgcttctg gtgtcccaaa tcccggagac tgcacccgtg ggcaccgtgc tgaatactct
     1141 cacttgcgaa gatccggact ctgttggtgc caccctggac tacaagctgt ggttccgcag
     1201 ctcttccaac cctgccagcc tctgccttta tgacagagtc cttgaggtga atgccacact
     1261 ggactgtgac actcctggag cctgcttcca gcatgcagcc tccatcctgg tgctcgatgg
     1321 tggccagccc cagatgacca ctgaggtgcc ggtactggtg atggtgacac ccatcaacga
     1381 gttctcccca gcctgtgccc ctcgcacgtt ccgggttcag gaggatgcgg cgccccacac
     1441 tctactgggc tccgtggtgg gcacggatat ggattaccct catgacaaca ttgagtacta
     1501 cacctctggt ggtcctacca cctttgctgt ggaccgtctc agcggggaag ttcacctcct
     1561 gggacctttg gactatgagc agcagaggct gtacaggctc actgtccttg tgattgacca
     1621 tggccaagac cagaacccca accatcacct ctcaggctcc tgtaccatta ccatcgaggt
     1681 tgaggatgtg aatgaccatg cccccgagtg tgagccccca tttcaggaac tcaccatcta
     1741 tgctcctctg ggccgtagcg tggaggtgac caagatgtca tgccagatcc ctcaggagcc
     1801 acagcgcctg atctactcct atagcatcgt gggagggaat agccagaacc gattcatcct
     1861 gcaaggggcc atcctggtgc acagtgacct tgtgttgggg ccgttctggc cagagcagcc
     1921 ccgtacctat gagctactga tctgtgtggc cgatgcaggc ccctccaccc cccacctcag
     1981 caccacagcc accattattg tgcatctagt tccccggagg gccagcacag tggccaccag
     2041 cacccacaga accacagtgc cctcaacgat gacacccatg ctcgtgacag acacagaggc
     2101 tttctggcag ccacagccct ggtttgtggt ggtgttgaca gcaactggtg ctcttctcct
     2161 cttggcccta ggctggcttc ttggcaggct cctccagggg ttggcccagc tgctgcaagc
     2221 acccagcaaa ccagcccagg ctttgctgct aaacagcatc cagggaactg agggatccat
     2281 cgagggtttc ctggaggcac cgaagatgga gatgtcccag gcacccagca gtgtcatgag
     2341 tctgcatttt gatggcagag cacaggactc ccgtaccgga agagactacc tgtttaacac
     2401 acacacagga gcccggcgct ggctctgagg ccaagtagct gtcttactat gtgtggaatt
     2461 tctttttcac accatcatgg gctgtatttt caagttgatt cataataaac aaaattacaa
     2521 aaagaaaa
//
