LOCUS       NM_152750               6448 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens cadherin related family member 3 (CDHR3), transcript
            variant 1, mRNA.
ACCESSION   NM_152750 XR_108861 XR_110727 XR_114075
VERSION     NM_152750.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6448)
  AUTHORS   Eliasen,A.U., Pedersen,C.E.T., Rasmussen,M.A., Wang,N.,
            Soverini,M., Fritz,A., Stokholm,J., Chawes,B.L., Morin,A.,
            Bork-Jensen,J., Grarup,N., Pedersen,O., Hansen,T., Linneberg,A.,
            Mortensen,P.B., Hougaard,D.M., Bybjerg-Grauholm,J.,
            Baekvad-Hansen,M., Mors,O., Nordentoft,M., Borglum,A.D., Werge,T.,
            Agerbo,E., Soderhall,C., Altman,M.C., Thysen,A.H., McKennan,C.G.,
            Brix,S., Gern,J.E., Ober,C., Ahluwalia,T.S., Bisgaard,H.,
            Pedersen,A.G. and Bonnelykke,K.
  TITLE     Genome-wide study of early and severe childhood asthma identifies
            interaction between CDHR3 and GSDMB
  JOURNAL   J Allergy Clin Immunol 150 (3), 622-630 (2022)
   PUBMED   35381269
  REMARK    GeneRIF: Genome-wide study of early and severe childhood asthma
            identifies interaction between CDHR3 and GSDMB.
REFERENCE   2  (bases 1 to 6448)
  AUTHORS   Hirsch,S.D., Elling,C.L., Bootpetch,T.C., Scholes,M.A., Hafren,L.,
            Streubel,S.O., Pine,H.S., Wine,T.M., Szeremeta,W., Prager,J.D.,
            Einarsdottir,E., Yousaf,A., Baschal,E.E., Rehman,S., Bamshad,M.J.,
            Nickerson,D.A., Riazuddin,S., Leal,S.M., Ahmed,Z.M., Yoon,P.J.,
            Kere,J., Chan,K.H., Mattila,P.S., Friedman,N.R., Chonmaitree,T.,
            Frank,D.N., Ryan,A.F. and Santos-Cortez,R.L.P.
  TITLE     The role of CDHR3 in susceptibility to otitis media
  JOURNAL   J Mol Med (Berl) 99 (11), 1571-1583 (2021)
   PUBMED   34322716
  REMARK    GeneRIF: The role of CDHR3 in susceptibility to otitis media.
REFERENCE   3  (bases 1 to 6448)
  AUTHORS   Zhang,M., Chen,G., Wang,Y., Wu,S.Q., Sandford,A.J. and He,J.Q.
  TITLE     Polymorphisms in the airway epithelium related genes CDHR3 and EMSY
            are associated with asthma susceptibility
  JOURNAL   BMC Pulm Med 20 (1), 305 (2020)
   PUBMED   33213402
  REMARK    GeneRIF: Polymorphisms in the airway epithelium related genes CDHR3
            and EMSY are associated with asthma susceptibility.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6448)
  AUTHORS   Shigemasa,R., Masuko,H., Hyodo,K., Kitazawa,H., Kanazawa,J.,
            Yatagai,Y., Iijima,H., Naito,T., Saito,T., Hirota,T., Tamari,M.,
            Sakamoto,T. and Hizawa,N.
  TITLE     Genetic impact of CDHR3 on the adult onset of asthma and COPD
  JOURNAL   Clin Exp Allergy 50 (11), 1223-1229 (2020)
   PUBMED   32615023
  REMARK    GeneRIF: Genetic impact of CDHR3 on the adult onset of asthma and
            COPD.
REFERENCE   5  (bases 1 to 6448)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 6448)
  AUTHORS   Jamieson,K.C., Warner,S.M., Leigh,R. and Proud,D.
  TITLE     Rhinovirus in the Pathogenesis and Clinical Course of Asthma
  JOURNAL   Chest 148 (6), 1508-1516 (2015)
   PUBMED   26270739
  REMARK    GeneRIF: CDHR3 is a susceptibility locus for early childhood Asthma
            with severe exacerbations.
            Review article
REFERENCE   7  (bases 1 to 6448)
  AUTHORS   Bochkov,Y.A., Watters,K., Ashraf,S., Griggs,T.F., Devries,M.K.,
            Jackson,D.J., Palmenberg,A.C. and Gern,J.E.
  TITLE     Cadherin-related family member 3, a childhood asthma susceptibility
            gene product, mediates rhinovirus C binding and replication
  JOURNAL   Proc Natl Acad Sci U S A 112 (17), 5485-5490 (2015)
   PUBMED   25848009
  REMARK    GeneRIF: the asthma susceptibility gene product CDHR3 mediates RV-C
            entry into host cells, and suggest that rs6967330 mutation could be
            a risk factor for RV-C wheezing illnesses.
REFERENCE   8  (bases 1 to 6448)
  AUTHORS   Bonnelykke,K., Sleiman,P., Nielsen,K., Kreiner-Moller,E.,
            Mercader,J.M., Belgrave,D., den Dekker,H.T., Husby,A.,
            Sevelsted,A., Faura-Tellez,G., Mortensen,L.J., Paternoster,L.,
            Flaaten,R., Molgaard,A., Smart,D.E., Thomsen,P.F., Rasmussen,M.A.,
            Bonas-Guarch,S., Holst,C., Nohr,E.A., Yadav,R., March,M.E.,
            Blicher,T., Lackie,P.M., Jaddoe,V.W., Simpson,A., Holloway,J.W.,
            Duijts,L., Custovic,A., Davies,D.E., Torrents,D., Gupta,R.,
            Hollegaard,M.V., Hougaard,D.M., Hakonarson,H. and Bisgaard,H.
  TITLE     A genome-wide association study identifies CDHR3 as a
            susceptibility locus for early childhood asthma with severe
            exacerbations
  JOURNAL   Nat Genet 46 (1), 51-55 (2014)
   PUBMED   24241537
  REMARK    GeneRIF: the role of CDHR3 variants in the development of asthma
            with severe exacerbations based on genome-wide association study in
            Denmark
REFERENCE   9  (bases 1 to 6448)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   10 (bases 1 to 6448)
  AUTHORS   Cha,P.C., Mushiroda,T., Takahashi,A., Kubo,M., Minami,S.,
            Kamatani,N. and Nakamura,Y.
  TITLE     Genome-wide association study identifies genetic determinants of
            warfarin responsiveness for Japanese
  JOURNAL   Hum Mol Genet 19 (23), 4735-4744 (2010)
   PUBMED   20833655
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK126338.1, BC111738.1 and AC004836.2.
            
            On Nov 23, 2018 this sequence version replaced NM_152750.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK126338.1, SRR1660809.206702.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317716.14/ ENSP00000325954.9
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1943              AK126338.1         25-1967
            1944-1953           BC111738.1         1936-1945
            1954-3437           AK126338.1         1978-3461
            3438-6447           AC004836.2         62309-65318
            6448-6448           AC004836.2         65319-65319
FEATURES             Location/Qualifiers
     source          1..6448
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.3"
     gene            1..6448
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /note="cadherin related family member 3"
                     /db_xref="GeneID:222256"
                     /db_xref="HGNC:HGNC:26308"
                     /db_xref="MIM:615610"
     exon            1..101
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..2713
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cadherin-like protein 28"
                     /codon_start=1
                     /product="cadherin-related family member 3 isoform 1
                     precursor"
                     /protein_id="NP_689963.2"
                     /db_xref="CCDS:CCDS47684.1"
                     /db_xref="GeneID:222256"
                     /db_xref="HGNC:HGNC:26308"
                     /db_xref="MIM:615610"
                     /translation="MQEAIILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKF
                     SVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFD
                     LQIYVKDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFD
                     PEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKA
                     STELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSI
                     TTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFI
                     VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVG
                     SGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYIL
                     TSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQY
                     PNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSSVTVTVNILEENDEKPIC
                     TPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSN
                     VTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVIPH
                     PTTIITTTPRPRVTYQVLRKNVYSPSAWYVPFVITLGSILLLGLLVYLVVLLAKAIHR
                     HCPCKTGKNKEPLTKKGETKTAERDVVVETIQMNTIFDGEAIDPVTGETYEFNSKTGA
                     RKWKDPLTQMPKWKESSHQGAAPRRVTAGEGMGSLRSANWEEDELSGKAWAEDAGLGS
                     RNEGGKLGNPKNRNPAFMNRAYPKPHPGK"
     exon            102..304
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /inference="alignment:Splign:2.1.0"
     exon            305..470
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /inference="alignment:Splign:2.1.0"
     exon            471..568
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /inference="alignment:Splign:2.1.0"
     exon            569..663
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /inference="alignment:Splign:2.1.0"
     exon            664..768
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /inference="alignment:Splign:2.1.0"
     exon            769..917
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1107
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1279
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1382
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1481
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1708
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1880
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2131
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2313
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2327
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2359
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2408
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..6448
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3065..3070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /note="hexamer: CATAAA"
     polyA_site      3088
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
     regulatory      3767..3772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /note="hexamer: AATAAA"
     polyA_site      3793
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /note="major polyA site"
     regulatory      6425..6430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
                     /note="hexamer: AATAAA"
     polyA_site      6448
                     /gene="CDHR3"
                     /gene_synonym="CDH28"
ORIGIN      
        1 gggattcagg ctgtggctaa tgtgctggaa gcacgcacag ttgtgaccat caagtatgca
       61 ggaagcaatc attctcctgg ctctcctggg tgccatgtca gggggagaag cactacacct
      121 aatcctctta cctgctacag gcaatgtggc agagaattct ccacctggga cttcagtgca
      181 caagttttct gtgaagttat cagcatcatt gtcacctgtg atcccaggat ttccccagat
      241 agtcaactca aatcccctca ctgaagcttt tagggtgaat tggctgtcag gcacctactt
      301 tgaggttgtc accactggga tggaacaact agattttgaa acaggaccaa acatatttga
      361 tttgcagatt tatgtgaagg atgaggttgg tgtcacagac ctgcaagtcc tgactgtcca
      421 ggtaacagat gtgaacgagc cacctcagtt tcaaggcaac ttggcagaag gtctacacct
      481 ctacatagta gaaagagcaa accctggatt catttaccag gttgaggcct tcgatccaga
      541 agacacaagc cgaaacattc ccctcagtta tttcctgatt tctcccccaa agagcttcag
      601 aatgtctgct aatggcaccc tcttctccac aacagaattg gactttgaag caggacacag
      661 aagtttccat ctcatcgtgg aggtgaggga cagtggaggc ctcaaagcct ccacagagct
      721 ccaggtgaac atcgtgaacc tcaacgacga agtccctcgc tttaccagcc cgacacgagt
      781 gtacacagtc ctggaggaac tgagtccagg aaccatcgtg gccaatatca cagcggagga
      841 tcctgatgat gaaggttttc ccagccacct cctctacagc attaccactg ttagcaaata
      901 tttcatgata aatcagttga ctggtacaat ccaagtggcc caaaggatag accgagatgc
      961 aggtgaattg agacaaaatc ccaccatttc cctggaagtt ctagtgaagg acagaccata
     1021 tgggggtcag gagaatcgca tccagataac cttcattgtg gaagacgtca acgacaatcc
     1081 tgccacatgc caaaagttca ccttcagcat tatggtgccg gaaagaacag ccaaggggac
     1141 gttgcttctt gacctaaaca agttctgctt tgatgatgac agtgaggcac caaacaacag
     1201 attcaacttc accatgccat ctggagtggg gagcggcagc agatttttac aggatccagc
     1261 tggctctggg aagattgtgc tgattggtga tctagactac gaaaatccaa gtaacctagc
     1321 agccggcaat aaatatacgg tgataatcca ggtgcaggat gtggcccccc cttactataa
     1381 aaataacgtc tacgtttata tcctaacaag cccagaaaat gagtttcctc tcatttttga
     1441 taggccatcc tatgtatttg atgtgtcaga aagaaggccc gccagaaccc gagtgggaca
     1501 ggtgcgagcc actgataaag acctccccca gagcagcctc ctgtactcca tctccactgg
     1561 aggggccagc ctccagtatc caaatgtatt ttggattaat cccaagacag gagaactcca
     1621 gctggtaact aaagtggact gtgaaacaac ccccatctat attctcagaa tccaggccac
     1681 caacaacgaa gacacaagct ctgtcactgt tactgtgaac atccttgaag aaaatgatga
     1741 aaagccaatt tgtactccaa actcttattt cctggccctc ccagtggatc tgaaagttgg
     1801 cacaaatatt cagaatttca agctgacatg taccgacctt gattccagcc ccagatcttt
     1861 ccgttattcc attggcccag gtaacgtcaa caatcatttc accttctctc ccaatgctgg
     1921 ttccaatgtc acacgcctgc tgcttacatc tcgctttgac tatgctggtg ggtttgataa
     1981 gatctgggac tacaagctac ttgtctacgt aactgatgac aacttgatgt ctgacaggaa
     2041 gaaagcggag gctcttgttg agacaggaac agtgacactg agtattaaag tcattcccca
     2101 cccaaccact atcatcacca cgacccccag gcccagggtc acctatcagg tcctgaggaa
     2161 aaacgtttac tctccatctg catggtacgt gccgtttgtc atcactttgg gctccatatt
     2221 gcttctgggt ctcctcgtgt acctggtcgt cctattggcc aaagccatcc acagacactg
     2281 cccctgcaag actgggaaga acaaggaacc tctgacaaag aaaggagaaa cgaagactgc
     2341 agagagagac gtcgtggtgg aaactatcca gatgaacact atctttgatg gagaagccat
     2401 agatccagtg accggggaaa catatgaatt caactcaaaa actggagcca gaaagtggaa
     2461 agatccacta acccaaatgc caaaatggaa agagtccagc caccagggag ctgccccacg
     2521 cagagtcact gctggggaag ggatggggtc actgagaagt gccaactggg aagaagatga
     2581 gctgagtggc aaagcgtggg ctgaggatgc tggtctgggt tccagaaatg agggtggcaa
     2641 gctgggcaac ccaaagaaca gaaatccagc cttcatgaac agggcttacc ccaaaccaca
     2701 cccaggaaag taaacggggt ctaaggaggg gcctgtcaat cactgagatg ctgcctcacc
     2761 ctaaattcta tggggatggt gtgggcatgg tgtagggggg aaaatgtggg ctgaggggat
     2821 tcagacatcc agggtcaaac atgggatgtt tgacaaattt ttaaacaaat agaaaggggt
     2881 ttgatcacat agttgcgtgt tctgaaatga tacaggaaca ttttctatca gatttcagaa
     2941 ctacctgtgc ttctgataag caagactgtt aactttgggg tgtggaattg ttgtgtttct
     3001 tctttgcatt gactgctagg aagctctatt ctgttcacca tagaaagttt gtaggaattc
     3061 ctgacataaa tagtgaagac tatccttaca tctggtttcc accttatttt cctgccctcg
     3121 ttttaacatc acccagattt cttcagttat aaatatgcca tacacctttg taagtcacct
     3181 caaatcttct tcaaaagaag cagaacagtg aaaaaaacag atgagtaagt taagagttgg
     3241 tcatctggaa agaagaaaac tcagtaggca ccttcttttg ttttttcttg tggtgtccgg
     3301 atcagcatcc tgcatgtgag attcatccac gttgtcctgt ctagcagtag ttcagttctc
     3361 ttcatggtta tgtctggttt cattctatga ttatatcaca atttatctat tctacacttg
     3421 ggtggcagct gcttcagatt ttttactttt aaaaaatata cttaaaagtg aactacaggc
     3481 agggcatgat ggctcatgcc tgtaatgcca gcactttgcc aaggtgggca gatcacctaa
     3541 ggtcaggagt tcaagatcag cctggcctag atggcaaaac cctgtctcta ctaaaaaata
     3601 caaaaattag cttggtgtgg tggtgggcac atgtaatccc agctacttgg gaggctgagg
     3661 tagggagaac tgcttaaacc tgagaggtgg aggttacagt gagttgagat tgtgccactg
     3721 cactctagcc tgggtgacaa agcaagactc catctcagaa aaaaaaaata aaagtgaatt
     3781 acaacactat gaactttctt gtacatgtct tttggtgaac ataaacactc acttttttgc
     3841 tcatatatct aagagtggga ttgctggagc aattgctgga tctgccaaag agttccaaag
     3901 tggtggctct gattcacatt ccagcagcaa acactgagag ttgcaattgc tctctatcct
     3961 tgccaacact tgggattgtc aatcctttta actttagcca ttctggttaa aattactatt
     4021 gaagtgaaat cactttttcc tcaaagctga aacaccatca gccttacaac ctacctgcct
     4081 tgctccttcc cacttcctat gattggaagg aactgcagga ctctgagtgg ggacatactg
     4141 gaagccccat ctagacataa aactcagact tccacctgta ggcatgagca atgaactggg
     4201 aataaatggt attatgatgg aataggaaat gtaactttcc aatgtgtgcc tagcagagcc
     4261 tgagcaagct tcactcgagc tctatgccct gctgcccagc tgctgcgacc ctagtccagt
     4321 aaccctaaga aaggtccagg tgagtgttca ttagggaagc actcccttcc caactgggga
     4381 gtcaggtgag agcctaccag gtccacaagg tcctgtggga gacagactgg atccagcaaa
     4441 tgtagagctt cagagagagc agcagcttgt ttactgtgtg cctagtgcca gtgtcacttc
     4501 tcaagcaaaa gaagcatttg caaaatgcct gtcctggcct agattgagcg tgatttatta
     4561 ataagggttg gttgccaggg aactcccttg aatggattta aactttgcaa aagaaggcag
     4621 aactgttcat ttatgcaggt taaagtgagt gaagtggctg attgcccatt taaggcattg
     4681 caaatctgtg gggcccggag tcaaatgctt tccttggaag ctctcagctt caatgcaagt
     4741 aaaatgaggt tctgagaagg ctgaaggggg acttaataac tgcttataag cccattaaga
     4801 atgattaaaa gggccgggtg aggtggctca tgcctgtaat cccagcactc tgggaggctg
     4861 aggcaggtgg atcacctgag gtcaggagtt tgagaccagc ctggccaaca tggtgaaacc
     4921 ctgtctctac taaaaaatag aaaaattagc tggacgtgtt agcaggcacc tgtaatccca
     4981 gctactcagg aggctgaggc aagagaatcg cttgaaccca ggaggcagaa gttgcagtgg
     5041 gctgagattg cgccactgca ctccagcctg ggtgacaagg gcaaaactct gtgtcaagaa
     5101 aaaaaaaaaa aaaagaataa ttaaaaggag agagtggtga gcagctggtc tttcttctcc
     5161 agtgatgaca gggcaagagg gaattgtgct taatggccag agaagagatt taagtcaggc
     5221 accaagaggg acttcctgaa gcctggggcc tctctgaaga gctcagtgtc ttctctggtg
     5281 ataggcagga agagctgagt gtcttcctag tcgcaaggca agcctcgaga aactcaagaa
     5341 ataggggcaa gagtgcgcca ggaggagaga acacctgctg ccccgtttct tttgtatatc
     5401 cggctatttg gttcggggaa atccagaagt caaagtgtca ccggtggagg gtcttgactg
     5461 caagttgtcc aagttcttgg agttttgaac aaagaatgga acaaaatgcc cagcaaagca
     5521 gagaaagaat gaggcaacga aagaatgaaa gcagggattt attgaaaacc aaagtacact
     5581 ccacagtgtg ggaacgggcc tgagcaagtg actcaagggc ccagatacag tcttctcagt
     5641 ccaaataccc cttggaggtt tccccttggc cacttcatgc tcacctcatg gaaatgaagt
     5701 agtggaccac aattggtctg attggttgca ggaagcaacc aatcagagac tgaagtggag
     5761 ttacaaaggt cacgctcctg tgcaaacatc tgattggttg caaaaagcaa ccaatcagag
     5821 gctaaggtga agttacaacg ttgcaacgaa gactcggctg gcaatcagtc tgattggtta
     5881 cagacagcca atttcccagc gttgaccagg ttttgggggg aacaaaatta tctgaataaa
     5941 atgaagacag caaccgtcgt ggatttggtg aaagttttct cccatctccc tctcaaggcc
     6001 ttaaacaggt atgagttgat tatagccaat gtttactttt ctcattctga ttcattataa
     6061 aactggggta aatacgttca ggaattagac cacgtaacaa ttataattgt cgaagacttt
     6121 gaaactgcat agtagattgt gacattggag ctttttgttg tgctcattag aaagcagggt
     6181 ctgaaactca gcctgtgtag caagcacggg tggctcacaa gcagaactgg gaaatgacac
     6241 ttctgctccc cagagccccc tttcacatct ggggttctca ttgtttgcct ttttacttaa
     6301 tgtattttgt aatggctgtg aaaattaagc tacaaaatga gtgaacattg aagacaatga
     6361 ttgctattga aacttaggat ttctcatttc aaacttagcg tgtgtttatc cttcgtattc
     6421 attcaataaa tatctgtgga gcaactac
//
