LOCUS       NM_017675               4173 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens cadherin related family member 2 (CDHR2), transcript
            variant 2, mRNA.
ACCESSION   NM_017675
VERSION     NM_017675.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4173)
  AUTHORS   Gray,M.E., Johnson,Z.R., Modak,D., Tamilselvan,E., Tyska,M.J. and
            Sotomayor,M.
  TITLE     Heterophilic and homophilic cadherin interactions in intestinal
            intermicrovillar links are species dependent
  JOURNAL   PLoS Biol 19 (12), e3001463 (2021)
   PUBMED   34871294
  REMARK    GeneRIF: Heterophilic and homophilic cadherin interactions in
            intestinal intermicrovillar links are species dependent.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4173)
  AUTHORS   Choi,M.S., Graves,M.J., Matoo,S., Storad,Z.A., El Sheikh
            Idris,R.A., Weck,M.L., Smith,Z.B., Tyska,M.J. and Crawley,S.W.
  TITLE     The small EF-hand protein CALML4 functions as a critical myosin
            light chain within the intermicrovillar adhesion complex
  JOURNAL   J Biol Chem 295 (28), 9281-9296 (2020)
   PUBMED   32209652
REFERENCE   3  (bases 1 to 4173)
  AUTHORS   Crawley,S.W., Shifrin,D.A. Jr., Grega-Larson,N.E., McConnell,R.E.,
            Benesh,A.E., Mao,S., Zheng,Y., Zheng,Q.Y., Nam,K.T., Millis,B.A.,
            Kachar,B. and Tyska,M.J.
  TITLE     Intestinal brush border assembly driven by protocadherin-based
            intermicrovillar adhesion
  JOURNAL   Cell 157 (2), 433-446 (2014)
   PUBMED   24725409
  REMARK    GeneRIF: Study found that brush border assembly is driven by the
            formation of Ca(2+)-dependent adhesion links between adjacent
            microvilli. Intermicrovillar links are composed of protocadherin-24
            and mucin-like protocadherin, which target to microvillar tips and
            interact to form a trans-heterophilic complex.
REFERENCE   4  (bases 1 to 4173)
  AUTHORS   Behrendt,M., Krahn,M.P., Al-Bayati,H., Amiri,M., Rizk,S. and
            Naim,H.Y.
  TITLE     Cadherin-related protein 24 induces morphological changes and
            partial cell polarization by facilitating direct cell-cell
            interactions
  JOURNAL   Biol Chem 393 (6), 495-503 (2012)
   PUBMED   22628312
  REMARK    GeneRIF: CDHR24 is directly involved in cell and tissue
            morphogenesis
REFERENCE   5  (bases 1 to 4173)
  AUTHORS   McConnell,R.E., Benesh,A.E., Mao,S., Tabb,D.L. and Tyska,M.J.
  TITLE     Proteomic analysis of the enterocyte brush border
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 300 (5), G914-G926 (2011)
   PUBMED   21330445
REFERENCE   6  (bases 1 to 4173)
  AUTHORS   Ose,R., Yanagawa,T., Ikeda,S., Ohara,O. and Koga,H.
  TITLE     PCDH24-induced contact inhibition involves downregulation of
            beta-catenin signaling
  JOURNAL   Mol Oncol 3 (1), 54-66 (2009)
   PUBMED   19383367
  REMARK    GeneRIF: suppression of beta-catenin signaling by PCDH24 leads to
            contact inhibition
REFERENCE   7  (bases 1 to 4173)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 4173)
  AUTHORS   Okazaki,N., Takahashi,N., Kojima,S., Masuho,Y. and Koga,H.
  TITLE     Protocadherin LKC, a new candidate for a tumor suppressor of colon
            and liver cancers, its association with contact inhibition of cell
            proliferation
  JOURNAL   Carcinogenesis 23 (7), 1139-1148 (2002)
   PUBMED   12117771
REFERENCE   9  (bases 1 to 4173)
  AUTHORS   Suzuki,S.T.
  TITLE     Recent progress in protocadherin research
  JOURNAL   Exp Cell Res 261 (1), 13-18 (2000)
   PUBMED   11082270
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091934.2.
            
            On May 5, 2021 this sequence version replaced NM_017675.5.
            
            Summary: This gene is a member of the protocadherin family, which
            represents a subset of the larger cadherin superfamily. The members
            of the protocadherin family encode non-classical cadherins that
            function as calcium-dependent cell-cell adhesion molecules. This
            protocadherin represents a new candidate for tumor suppression.
            Alternatively spliced transcript variants that encode the same
            protein have been identified. [provided by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB047004.1, SRR11853567.25084.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261944.10/ ENSP00000261944.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AC091934.2         113754-113826       c
            74-140              AC091934.2         97764-97830         c
            141-212             AC091934.2         97425-97496         c
            213-352             AC091934.2         94351-94490         c
            353-403             AC091934.2         94158-94208         c
            404-493             AC091934.2         91866-91955         c
            494-583             AC091934.2         88996-89085         c
            584-709             AC091934.2         87959-88084         c
            710-856             AC091934.2         87742-87888         c
            857-932             AC091934.2         87587-87662         c
            933-1048            AC091934.2         87329-87444         c
            1049-1282           AC091934.2         86983-87216         c
            1283-1438           AC091934.2         85614-85769         c
            1439-1600           AC091934.2         85370-85531         c
            1601-1662           AC091934.2         85073-85134         c
            1663-1906           AC091934.2         84560-84803         c
            1907-2146           AC091934.2         81586-81825         c
            2147-2216           AC091934.2         78909-78978         c
            2217-2822           AC091934.2         78153-78758         c
            2823-2894           AC091934.2         77143-77214         c
            2895-2944           AC091934.2         76326-76375         c
            2945-3096           AC091934.2         73986-74137         c
            3097-3205           AC091934.2         73730-73838         c
            3206-3294           AC091934.2         73552-73640         c
            3295-3363           AC091934.2         73022-73090         c
            3364-3441           AC091934.2         72838-72915         c
            3442-3502           AC091934.2         72683-72743         c
            3503-3627           AC091934.2         72481-72605         c
            3628-3741           AC091934.2         71845-71958         c
            3742-3822           AC091934.2         71684-71764         c
            3823-3880           AC091934.2         70388-70445         c
            3881-4173           AC091934.2         67344-67636         c
FEATURES             Location/Qualifiers
     source          1..4173
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.2"
     gene            1..4173
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /note="cadherin related family member 2"
                     /db_xref="GeneID:54825"
                     /db_xref="HGNC:HGNC:18231"
                     /db_xref="MIM:619713"
     exon            1..73
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            74..140
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..4021
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /note="protocadherin-24"
                     /codon_start=1
                     /product="cadherin-related family member 2 precursor"
                     /protein_id="NP_060145.3"
                     /db_xref="CCDS:CCDS34297.1"
                     /db_xref="GeneID:54825"
                     /db_xref="HGNC:HGNC:18231"
                     /db_xref="MIM:619713"
                     /translation="MAQLWLSCFLLPALVVSVAANVAPKFLANMTSVILPEDLPVGAQ
                     AFWLVAEDQDNDPLTYGMSGPNAYFFAVTPKTGEVKLASALDYETLYTFKVTISVSDP
                     YIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVV
                     YSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFT
                     IQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPV
                     IYSISYSTRPGWFDIGADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAK
                     VSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMV
                     VYDPDKGSNGTFLLSLGGPDAEAFSVSPERAVGSASVQVLVRVSALVDYERQTAMAVQ
                     VVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDP
                     DTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNL
                     SSSTTLQIHLLDINDNAPVVSGSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNL
                     LPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVT
                     ITVEDINDNLPIFNQSSYNFTVKEEDPGVLVGVVKAWDADQTEANNRISFSLSGSGAN
                     YFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNV
                     KDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGV
                     DVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSL
                     LITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVD
                     FISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLGP
                     FLEATTTLNLFTVDQSYRSRLQFSTPKEEVGANRQAINAALTQATRTTVYIVDIQDID
                     SAARARPHSYLDAYFVFPNGSALTLDELSVMIRNDQDSLTQLLQLGLVVLGSQESQES
                     DLSKQLISVIIGLGVALLLVLVIMTMAFVCVRKSYNRKLQAMKAAKEARKTAAGVMPS
                     APAIPGTNMYNTERANPMLNLPNKDLGLEYLSPSNDLDSVSVNSLDDNSVDVDKNSQE
                     IKEHRPPHTPPEPDPEPLSVVLLGRQAGASGQLEGPSYTNAGLDTTDL"
     exon            141..212
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            213..352
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            353..403
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            404..493
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            494..583
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            584..709
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            710..856
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            857..932
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1048
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1282
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1438
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1600
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1662
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1906
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2146
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2216
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2822
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..2894
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..2944
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            2945..3096
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3205
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..3294
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            3295..3363
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            3364..3441
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            3442..3502
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            3503..3627
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            3628..3741
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            3742..3822
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            3823..3880
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     exon            3881..4173
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4098..4103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /note="hexamer: AATATA"
     polyA_site      4118
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /note="major polyA site"
     polyA_site      4173
                     /gene="CDHR2"
                     /gene_synonym="PCDH24; PCLCK; PCLKC"
                     /note="major polyA site"
ORIGIN      
        1 gcagagggtg cccacctgtg tgccagcgcc tgtccggcgc ctgcctgccg cctccgtggc
       61 gaaggggaca caggtccctg cggatgtgat ggcccagcta tggctgtcct gcttcctcct
      121 tcctgccctc gtggtgtctg tggcagccaa cgtggccccg aagttcctag ccaacatgac
      181 gtcagtgatc ctgcctgagg acctgcctgt gggtgcccag gccttctggt tggtagcgga
      241 agaccaggac aatgaccctc tgacctatgg gatgagcggc cccaatgcct acttcttcgc
      301 tgtcactccg aaaactgggg aagtgaagct ggccagcgct ctggactacg agacactcta
      361 cacattcaaa gtcaccatct ccgtgagcga cccctacatc caggtgcaga gggagatgct
      421 ggtgattgtg gaagatagaa acgacaacgc acccgttttc cagaacaccg ctttctccac
      481 cagcatcaac gagaccctgc ccgtgggcag tgtggtgttc tccgtgctgg ccgtggataa
      541 agacatgggg tctgcaggca tggtcgtgta ctccatagag aaggtcatcc ctagcactgg
      601 ggacagcgag catctcttcc ggatcctggc caatggctcc atagtcctca atggcagcct
      661 cagctacaac aacaagagcg ctttctacca gctggagctg aaggcctgtg acttgggcgg
      721 catgtaccac aacaccttca ccatccagtg ctccctgcct gtcttcctgt ccatctccgt
      781 ggtggaccag cctgaccttg acccccagtt tgtcagggag ttttactcgg cctctgtggc
      841 tgaggatgca gccaagggaa cctcggtgct gacggtggag gctgtggatg gcgacaaagg
      901 catcaatgac cctgtgatct acagcatctc ctactccacg cggcccggct ggtttgacat
      961 cggggcagat ggggtgatca gggtcaacgg ctccctggac cgtgagcagc tgctggaggc
     1021 ggatgaggag gtgcagctgc aggtcacggc caccgagaca cacctcaaca tctacgggca
     1081 ggaggccaag gtgagcatct gggtgacagt gagagtgatg gacgtcaatg accacaaacc
     1141 tgagttttac aactgcagcc tcccagcctg caccttcacc cccgaagagg cccaagtgaa
     1201 cttcactggc tacgtggacg agcatgcctc cccccgcatc cccatcgatg acctcaccat
     1261 ggtggtctac gacccggaca agggcagcaa tggcaccttc ctgttgtcgc tggggggccc
     1321 cgatgcagaa gccttcagcg tctccccgga gcgggcagtg ggctcagcct ccgttcaggt
     1381 gctggtgaga gtatccgcgc tggtggacta cgagaggcag acggcgatgg cggtgcaggt
     1441 tgtggccaca gactccgtca gccagaactt ctccgtcgcc atggtgacca tccaccttag
     1501 agacattaat gaccacaggc ccacgtttcc ccagagcttg tacgtcctca cggtgccaga
     1561 gcacagcgcc accggctctg tggtcaccga cagcatccac gccacggacc cagacacggg
     1621 cgcgtggggc caaattacct acagcctgct cccaggaaat ggggcagacc tcttccaagt
     1681 ggatcccgtc tcagggacgg tgacggtgag gaacggtgag ctgctggacc gggagagcca
     1741 ggccgtgtac tacctgacgc tgcaggccac agacggcggg aacctgtcct cctccaccac
     1801 actgcagatc cacctgctgg acatcaacga caatgcaccc gtggttagcg gctcctacaa
     1861 catcttcgtc caggaggagg agggcaatgt ctccgtgacc atccaggccc acgacaatga
     1921 tgagccgggc accaacaaca gccgtctgct cttcaacctg ctgcctggcc cctacagcca
     1981 caacttctcc ttggaccctg acacagggct cctcagaaac ctggggcccc tggacagaga
     2041 ggccatcgac cccgccctgg agggccgcat tgtgctgaca gtgcttgtgt ctgactgcgg
     2101 cgagcctgtc ctcggcacca aagtcaatgt caccatcact gtggaggaca tcaatgataa
     2161 cctgcccatc ttcaatcagt ccagctacaa ctttacggtg aaggaggagg atccaggagt
     2221 gctagtgggc gtggtgaagg cctgggacgc ggaccagacg gaagccaaca accgcatcag
     2281 cttcagcctg tcggggagtg gtgccaacta cttcatgatc cgaggcttgg tgctgggggc
     2341 tgggtgggct gagggctacc tccggctgcc cccggacgtg agcctggatt acgagacaca
     2401 gcccgtcttc aacttgacag tgagtgctga gaacccagac ccccaggggg gtgagaccat
     2461 agtagacgtc tgcgtgaatg tgaaagacgt gaacgacaat ccccccaccc tggatgtagc
     2521 ctcactccgg ggcatccgtg tggctgagaa tggctcacag cacggccagg tggctgtggt
     2581 ggttgcctcg gatgtggaca ccagtgccca gctggagata cagcttgtga acattctctg
     2641 caccaaggcc ggggtcgatg tgggcagcct atgctggggc tggttctcag tggcggccaa
     2701 cggctctgtg tacatcaacc agagcaaagc catcgactac gaggcctgtg acctggtcac
     2761 gctggttgtg cgggcctgtg acctagccac ggaccccggc ttccaggcct acagcaacaa
     2821 tggaagcctc ctcattacca ttgaggacgt gaatgacaat gcaccctatt ttctgcctga
     2881 gaataagact tttgtgatca tccctgaact cgtgctgccc aaccgggagg tggcttctgt
     2941 ccgggccaga gacgatgatt cagggaacaa tggcgtcatc ctgttctcca tcctccgagt
     3001 agacttcatc tctaaggacg gggccaccat ccctttccag ggtgtcttct cgatcttcac
     3061 ctcctccgag gccgacgtgt tcgctgggag cattcagccg gtgaccagcc tcgactccac
     3121 tctccaaggc acctaccaag tgacagtcca ggccagggac agaccttcct tgggtccttt
     3181 cctggaagcc accaccaccc tgaatctctt caccgtggac cagagttacc gctcgcggct
     3241 gcagttctcc acaccgaagg aggaggtggg cgccaacaga caggcgatta atgcggctct
     3301 tacccaggca accaggacta cagtatacat tgtggacatt caggacatag attctgcagc
     3361 tcgggcccga cctcactcct acctcgatgc ctactttgtc ttccccaatg ggtcagccct
     3421 gacccttgat gagctgagtg tgatgatccg gaatgatcag gactcgctga cgcagctgct
     3481 gcagctgggg ctggtggtgc tgggctccca ggagagccag gagtcagacc tgtcgaaaca
     3541 gctcatcagt gtcatcatag gattgggagt ggctttgctg ctggtccttg tgatcatgac
     3601 catggccttc gtgtgtgtgc ggaagagcta caaccggaag cttcaagcta tgaaggctgc
     3661 caaggaggcc aggaagacag cagcaggggt gatgccctca gcccctgcca tcccagggac
     3721 taacatgtac aacactgagc gagccaaccc catgctgaac ctccccaaca aagacctggg
     3781 cttggagtac ctctctccct ccaatgacct ggactctgtc agcgtcaact ccctggacga
     3841 caactctgtg gatgtggaca agaacagtca ggaaatcaag gagcacaggc caccacacac
     3901 accaccagag ccagatccag agcccctgag cgtggtcctg ttaggacggc aggcaggcgc
     3961 aagtggacag ctggaggggc catcctacac caacgctggc ctggacacca cggacctgtg
     4021 acaggggccc ccactcttct ggaccccttg aagaggccct accacaccct aactgcacct
     4081 gtctccctgg agatgaaaat atatgacgct gccctgcctc ctgcttttgg ccaatcacgg
     4141 cagacagggg ttggggaaat attttattac caa
//
