LOCUS       NM_033100               6877 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens cadherin related family member 1 (CDHR1), transcript
            variant 1, mRNA.
ACCESSION   NM_033100
VERSION     NM_033100.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6877)
  AUTHORS   Malechka,V.V., Cukras,C.A., Chew,E.Y., Sergeev,Y.V., Blain,D.,
            Jeffrey,B.G., Ullah,E., Hufnagel,R.B., Brooks,B.P., Huryn,L.A. and
            Zein,W.M.
  TITLE     Clinical Phenotypes of CDHR1-Associated Retinal Dystrophies
  JOURNAL   Genes (Basel) 13 (5), 925 (2022)
   PUBMED   35627310
  REMARK    GeneRIF: Clinical Phenotypes of CDHR1-Associated Retinal
            Dystrophies.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6877)
  AUTHORS   Mermeklieva,E., Kamenarova,K., Mihova,K., Shakola,F. and Kaneva,R.
  TITLE     A rare case of RGR/CDHR1 haplotype identified in Bulgarian patient
            with cone-rod dystrophy
  JOURNAL   Ophthalmic Genet 42 (6), 747-752 (2021)
   PUBMED   34229535
  REMARK    GeneRIF: A rare case of RGR/CDHR1 haplotype identified in Bulgarian
            patient with cone-rod dystrophy.
REFERENCE   3  (bases 1 to 6877)
  AUTHORS   Yusuf,I.H., McClements,M.E., MacLaren,R.E. and Charbel Issa,P.
  TITLE     Deep phenotyping of the Cdhr1-/- mouse validates its use in
            pre-clinical studies for human CDHR1-associated retinal
            degeneration
  JOURNAL   Exp Eye Res 208, 108603 (2021)
   PUBMED   33964272
  REMARK    GeneRIF: Deep phenotyping of the Cdhr1(-/-) mouse validates its use
            in pre-clinical studies for human CDHR1-associated retinal
            degeneration.
REFERENCE   4  (bases 1 to 6877)
  AUTHORS   Ba-Abbad,R., Robson,A.G., Mahroo,O.A., Wright,G., Schiff,E.,
            Duignan,E.S., Michaelides,M., Arno,G. and Webster,A.R.
  TITLE     A clinical study of patients with novel CDHR1 genotypes associated
            with late-onset macular dystrophy
  JOURNAL   Eye (Lond) 35 (5), 1482-1489 (2021)
   PUBMED   32681094
  REMARK    GeneRIF: A clinical study of patients with novel CDHR1 genotypes
            associated with late-onset macular dystrophy.
REFERENCE   5  (bases 1 to 6877)
  AUTHORS   Gan,L., Yang,C., Shu,Y., Liu,F., Sun,R., Deng,B., Xu,J., Huang,G.,
            Qu,C., Gong,B. and Li,J.
  TITLE     Identification of a novel homozygous nonsense mutation in the CDHR1
            gene in a Chinese family with autosomal recessive retinitis
            pigmentosa
  JOURNAL   Clin Chim Acta 507, 17-22 (2020)
   PUBMED   32277948
  REMARK    GeneRIF: Identification of a novel homozygous nonsense mutation in
            the CDHR1 gene in a Chinese family with autosomal recessive
            retinitis pigmentosa.
REFERENCE   6  (bases 1 to 6877)
  AUTHORS   Ostergaard,E., Batbayli,M., Duno,M., Vilhelmsen,K. and Rosenberg,T.
  TITLE     Mutations in PCDH21 cause autosomal recessive cone-rod dystrophy
  JOURNAL   J Med Genet 47 (10), 665-669 (2010)
   PUBMED   20805371
  REMARK    GeneRIF: To our knowledge, this is the first report of mutations in
            PCDH21 as a cause of human disease, autosomal recessive cone-rod
            dystrophy.
REFERENCE   7  (bases 1 to 6877)
  AUTHORS   Elledge,H.M., Kazmierczak,P., Clark,P., Joseph,J.S., Kolatkar,A.,
            Kuhn,P. and Muller,U.
  TITLE     Structure of the N terminus of cadherin 23 reveals a new adhesion
            mechanism for a subset of cadherin superfamily members
  JOURNAL   Proc Natl Acad Sci U S A 107 (23), 10708-10712 (2010)
   PUBMED   20498078
REFERENCE   8  (bases 1 to 6877)
  AUTHORS   Henderson,R.H., Li,Z., Abd El Aziz,M.M., Mackay,D.S.,
            Eljinini,M.A., Zeidan,M., Moore,A.T., Bhattacharya,S.S. and
            Webster,A.R.
  TITLE     Biallelic mutation of protocadherin-21 (PCDH21) causes retinal
            degeneration in humans
  JOURNAL   Mol Vis 16, 46-52 (2010)
   PUBMED   20087419
  REMARK    GeneRIF: Biallelic mutations in the photoreceptor-specific gene
            PCDH21 cause recessive retinal degeneration in humans.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 6877)
  AUTHORS   Bolz,H., Ebermann,I. and Gal,A.
  TITLE     Protocadherin-21 (PCDH21), a candidate gene for human retinal
            dystrophies
  JOURNAL   Mol Vis 11, 929-933 (2005)
   PUBMED   16288196
  REMARK    GeneRIF: PCDH21 mutations are not a major cause of the retinal
            diseases investigated herein, and the corresponding human phenotype
            remains to be determined.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 6877)
  AUTHORS   Nakajima,D., Nakayama,M., Kikuno,R., Hirosawa,M., Nagase,T. and
            Ohara,O.
  TITLE     Identification of three novel non-classical cadherin genes through
            comprehensive analysis of large cDNAs
  JOURNAL   Brain Res Mol Brain Res 94 (1-2), 85-95 (2001)
   PUBMED   11597768
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022389.9, AB593154.1,
            AB593155.1, BM674749.1 and AA576346.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_033100.3.
            
            Summary: This gene belongs to the cadherin superfamily of
            calcium-dependent cell adhesion molecules. The encoded protein is a
            photoreceptor-specific cadherin that plays a role in outer segment
            disc morphogenesis. Mutations in this gene are associated with
            inherited retinal dystrophies. Alternatively spliced transcript
            variants encoding different isoforms have been identified.
            [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB593155.1, AB053448.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000623527.4/ ENSP00000485478.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                AC022389.9         52951-53048
            99-2807             AB593154.1         1-2709
            2808-5546           AB593155.1         2696-5434
            5547-6202           AC022389.9         75778-76433
            6203-6874           BM674749.1         15-686              c
            6875-6877           AA576346.1         10-12               c
FEATURES             Location/Qualifiers
     source          1..6877
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.1"
     gene            1..6877
                     /gene="CDHR1"
                     /gene_synonym="CORD15; PCDH21; PRCAD; RP65"
                     /note="cadherin related family member 1"
                     /db_xref="GeneID:92211"
                     /db_xref="HGNC:HGNC:14550"
                     /db_xref="MIM:609502"
     exon            1..279
                     /gene="CDHR1"
                     /gene_synonym="CORD15; PCDH21; PRCAD; RP65"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..2804
                     /gene="CDHR1"
                     /gene_synonym="CORD15; PCDH21; PRCAD; RP65"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; photoreceptor cadherin; protocadherin-21;
                     MT-protocadherin"
                     /codon_start=1
                     /product="cadherin-related family member 1 isoform 1
                     precursor"
                     /protein_id="NP_149091.1"
                     /db_xref="CCDS:CCDS7372.1"
                     /db_xref="GeneID:92211"
                     /db_xref="HGNC:HGNC:14550"
                     /db_xref="MIM:609502"
                     /translation="MRRCRWAALALGLLRLCLAQANFAPHFFDNGVGSTNGNMALFSL
                     PEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDRERED
                     EIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAV
                     DRDTGSGGSVTYFLQNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGR
                     LHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRG
                     KPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQ
                     ATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGLKITVNDSDQGAN
                     AKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPE
                     KFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVK
                     YSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDMEGKYSVAEVFITL
                     LDVNDHPPQFGKSVQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDINS
                     HTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITDAETL
                     SRSPMAAFLIQTKDNPMKAVGVLAGTMATVVAITVLISTATFWRNKKSNKVLPMRRVL
                     RKRPSPAPRTIRIEWLKSKSTKAATKFMLKEKPPNENCNNNSPESSLLPRAPALPPPP
                     SVAPSTGAAQWTVPTVSGSLTPQPTQPPPKPKTMGSPVQSTLISELKQKFEKKSVHNK
                     AYF"
     exon            280..375
                     /gene="CDHR1"
                     /gene_synonym="CORD15; PCDH21; PRCAD; RP65"
                     /inference="alignment:Splign:2.1.0"
     exon            376..521
                     /gene="CDHR1"
                     /gene_synonym="CORD15; PCDH21; PRCAD; RP65"
                     /inference="alignment:Splign:2.1.0"
     exon            522..572
                     /gene="CDHR1"
                     /gene_synonym="CORD15; PCDH21; PRCAD; RP65"
                     /inference="alignment:Splign:2.1.0"
     exon            573..662
                     /gene="CDHR1"
                     /gene_synonym="CORD15; PCDH21; PRCAD; RP65"
                     /inference="alignment:Splign:2.1.0"
     exon            663..749
                     /gene="CDHR1"
                     /gene_synonym="CORD15; PCDH21; PRCAD; RP65"
                     /inference="alignment:Splign:2.1.0"
     exon            750..863
                     /gene="CDHR1"
                     /gene_synonym="CORD15; PCDH21; PRCAD; RP65"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1007
                     /gene="CDHR1"
                     /gene_synonym="CORD15; PCDH21; PRCAD; RP65"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1086
                     /gene="CDHR1"
                     /gene_synonym="CORD15; PCDH21; PRCAD; RP65"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1187
                     /gene="CDHR1"
                     /gene_synonym="CORD15; PCDH21; PRCAD; RP65"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1391
                     /gene="CDHR1"
                     /gene_synonym="CORD15; PCDH21; PRCAD; RP65"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1544
                     /gene="CDHR1"
                     /gene_synonym="CORD15; PCDH21; PRCAD; RP65"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1709
                     /gene="CDHR1"
                     /gene_synonym="CORD15; PCDH21; PRCAD; RP65"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1777
                     /gene="CDHR1"
                     /gene_synonym="CORD15; PCDH21; PRCAD; RP65"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..2006
                     /gene="CDHR1"
                     /gene_synonym="CORD15; PCDH21; PRCAD; RP65"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2264
                     /gene="CDHR1"
                     /gene_synonym="CORD15; PCDH21; PRCAD; RP65"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..6877
                     /gene="CDHR1"
                     /gene_synonym="CORD15; PCDH21; PRCAD; RP65"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5528..5533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDHR1"
                     /gene_synonym="CORD15; PCDH21; PRCAD; RP65"
                     /note="hexamer: AATAAA"
     polyA_site      5549
                     /gene="CDHR1"
                     /gene_synonym="CORD15; PCDH21; PRCAD; RP65"
                     /note="major polyA site"
     regulatory      6850..6855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDHR1"
                     /gene_synonym="CORD15; PCDH21; PRCAD; RP65"
                     /note="hexamer: AATAAG"
     polyA_site      6877
                     /gene="CDHR1"
                     /gene_synonym="CORD15; PCDH21; PRCAD; RP65"
ORIGIN      
        1 gctaattggt ctcgtcaggc ggccggcagg agcagatccg agccgtgtca tcctcttagc
       61 gccctcacgc cacccgccgc tcccgccccg tgccccctcc cgccgcggct gcagtcgccg
      121 ctacccccat tgtggtctct gccctccccg cgggcccagg gcatgctccg tgcccctgcg
      181 cccggtctcg gcggcggcag gcgacactcc gcgccggcgg agacatgagg cgctgccggt
      241 gggccgccct ggccctgggg ctgctgcgcc tctgcttggc tcaggccaac ttcgccccgc
      301 acttcttcga caacggggtc ggcagcacca acggaaacat ggctctgttc agcctcccag
      361 aggacacccc tgtaggctct cacgtataca ccctgaatgg gacagaccct gagggagacc
      421 ccatctccta ccacatcagc tttgacccca gcactagaag cgtcttttct gttgacccca
      481 cttttggaaa catcaccctg gttgaagagc tggacagaga gagggaagat gagattgaag
      541 ccatcatcag catttctgat ggcctgaatc tggtggccga aaaagtcgtg atcctggtga
      601 ccgatgccaa tgatgaggcg cccaggttca tccaggagcc ttatgttgcc ctggttcccg
      661 aggacatacc tgctgggagc atcatcttta aggtccatgc agtggacagg gacacaggct
      721 ctggagggag tgtcacctac ttcctgcaga acctgcactc cccatttgcc gtggaccgcc
      781 acagcggtgt gctgcgcctc caggctgggg ccactctgga ctacgagagg tcccggaccc
      841 actacatcac cgtggtcgcc aaggatggcg gtgggaggct tcatggggct gatgtggtgt
      901 tctcagccac caccacggtc acggtcaatg tggaggatgt tcaggacatg gcccctgtct
      961 tcgtgggcac accctactat ggctatgtgt acgaggacac ccttccgggc tcggaggtac
     1021 tgaaggtggt cgccatggat ggagaccggg gcaaacccaa tcgaattctc tacagccttg
     1081 taaatgggaa cgatggagcc tttgaaatta atgagacatc tggagccatc tccatcactc
     1141 agagcccggc ccagctccag agagaggtgt atgagctgca tgtacaggtg actgaaatga
     1201 gccctgcggg gagcccagct gcccaggcca ccgtcccagt caccatcagg attgtggacc
     1261 tcaacaacca cccgccaaca ttctatggag agagcggacc ccaaaacagg tttgagctgt
     1321 ccatgaatga gcacccaccc cagggagaga tcctgcgggg cctcaagatc accgtcaatg
     1381 actccgacca gggagccaat gccaaattca acttgcagct ggtgggaccc aggggcatct
     1441 tccgagtggt tccacagaca gtcctgaatg aagcccaagt cacaatcatt gtggagaact
     1501 cagctgccat tgactttgaa aagtccaaag tattaacctt caagctcctg gctgttgaag
     1561 tgaacacccc agagaagttc agttccacag cggatgttgt gatccagctc ctggacacca
     1621 atgacaatgt ccccaagttc gactccctct actacgttgc caggattcct gagaacgccc
     1681 cagggggctc cagcgtggtg gctgtcacag ctgtggatcc agatacagga ccctggggcg
     1741 aagtgaaata ttccacctat gggactgggg cagacctctt cctgatccac ccatccactg
     1801 ggcttatcta cacccagccc tgggctagcc tggacgctga ggccactgcc aggtacaact
     1861 tctatgtgaa ggcagaggac atggaaggca agtacagcgt agctgaggtg tttatcacac
     1921 tgctggatgt caatgaccac ccccctcagt ttggaaagag cgttcagaag aagacgatgg
     1981 tgctagggac cccagtgaaa attgaggcca tagacgagga tgcagaggaa cccaacaacc
     2041 tggtggacta ttccatcacc catgcagagc ccgccaacgt gttcgacatc aattcccaca
     2101 cgggggagat ctggctcaag aattccatcc gctccctgga tgccctgcac aacatcacac
     2161 ctggaaggga ctgcctatgg tccctagagg tgcaggccaa ggaccggggc tccccatcct
     2221 tcagcaccac agccttactc aagattgaca tcacagatgc tgagaccctc tcccggagcc
     2281 ccatggctgc cttcctgata cagaccaagg acaaccccat gaaggccgtg ggtgtgctgg
     2341 ccggcaccat ggccaccgtc gtggccatca ctgtcctcat ctccaccgcc accttctggc
     2401 gcaacaagaa gtctaacaag gtcctgccaa tgcggcgggt gctccgcaag cggcccagcc
     2461 ctgcgccccg caccatccgc attgagtggc tcaagtccaa gagcaccaaa gccgctacca
     2521 agttcatgct caaagagaaa cctcccaatg agaactgtaa caacaacagc ccagaaagct
     2581 ctctgctccc gagagctccg gctctccctc caccacccag cgtggcgccc agcactggcg
     2641 cagcccagtg gaccgtgcct actgtctctg gctctctcac tccgcagccg acccaacccc
     2701 cgccaaaacc caaaactatg ggaagccccg tccagtcaac tctgatctct gagctcaagc
     2761 aaaagtttga gaagaagagt gtgcacaaca aggcttactt ctagtgtatg ccctatgacc
     2821 ccccatcttt cctccgcccc tgacccccac caccctgctg ctcggactat gctccccttc
     2881 ctctgctcct taaggtcact gacccctgtt ttgcacaatg gtataatccc cactgtcctc
     2941 atctctaccg ccaccttctg gcgcaacaag aagttgcgct ctgacagggc tctagtcagg
     3001 gccttgggca agacattggg ctctaggatg caattggcaa atacgtcccc gttactcaaa
     3061 tccttggcac tactacaatg ccctccattc ttcagggctg agaattgacg agaagccagc
     3121 tcacccatcc cagacctcac agtccctcag gttctactgg gatctcatca tcatccttag
     3181 tcaagcagca gggccctggc cacgtggagc aacactgact agaatctgga tcctgacgcc
     3241 tgcagctgag agcaggagca ggaaaaggag gctcagcact gtctcaggct ggaggtcagc
     3301 gaacctcgtg ggctgtagga aagcaaatgt aggtaagggg agagcaagga tgcacagaaa
     3361 acacactgac tgtgggactg tgccaggatg catttggaaa gatagagcat tctgtctggg
     3421 cagagactgt ggaccctggt atgcccacgt gggacagagg acacagaggt ggaagattga
     3481 tcttgccaag agtgagggca gatgtctcca gccaggactg ccctgagccg caaaatgtca
     3541 aagctggagc tatagaggta gccctaaagg caactagaag agcatcaggg ctgctctctg
     3601 aggagctgcc ccaccagcca tccttgaaga gacaattcag ggcagttgat gaatatcagg
     3661 gctgagatgt ggtgagactt ccgtttttat ccagctcttt tgctcacatc gcgtaacctt
     3721 gggaaagctg tttaaagtcg ctgatcatcc tcttcctcat ctgtaaatga agaaagtagg
     3781 ccctgtctac ctcacatgca ggtctagggt gaggattgaa gaaaatagtg gtgatgaggg
     3841 ctttaaccaa gtgcaaagcg gcatgaatgc aaagtatttt tctgcagccc agttctgtgg
     3901 gtgcagctct tccagaaagt attaggagcc tcacatctac tctgccaagc gccccagcag
     3961 gcactgtgct gggcttaggg gctaccactg gatgatggca ttgccgtgac tcacacacct
     4021 ctacttctgt tcttccctca ctccatcccc gctaccgtcc tggccagcta ccgtcagaga
     4081 gaaccagagc tccaagtctt taatttgcca agatgaagaa aatgagttct caaggaggga
     4141 atgctttgct tgaggccaca cagcaggttg gtagcaaaga tcttgtctag ccagggcagc
     4201 ccttatcagc ttgtgacaac cttccccagg acagaagtca tacaaggcct ctggggttaa
     4261 tacaaatagg ttgtgccctg ctttaaggaa cctgctatca ggaaatctac atgtgtgcac
     4321 agagagagaa aagtagaaca gttctttgca tttggctcta cttactaaca acccctctag
     4381 aatacattgg tgatttcatt taaagagatt gtatgcattt gtggctttcc tgatttctga
     4441 gtctgtgttt ggaggtgtta ctgagatgtg ccagtgtgca gaatccttgc tggggtttct
     4501 acagtcccca acgtgaacag tattaagcaa gaggtggact cgagcaatcc aggagcccag
     4561 actgagcaaa taagtacttt ccagcctgtg tttcaggaga ggactgtgct ggatcatgct
     4621 tgccctccac agggaataca gcatccttac agcttgcatg caatcaacct cttttgtaaa
     4681 tggaaaataa agtctgttac ccaaaggcca tgctgatccc ctgctccctg ctttcattta
     4741 tgtttgctga cctgtggaga ccagtctttc tgacacacag tgaagctcaa cttgcctcct
     4801 ggctgcttca gcaggtggat ccattcttcg acccccagat gtgactctaa agaaggctga
     4861 aaatttttgt ccaaattgcc atgcagatat cttgaacagc aggacatttg caggccttgt
     4921 ctactggact tttctcccaa acaggacaag cccaggcagg gctgcatgga gaggaatgga
     4981 acctggagct agaattaatt gcccactctc ccaccctacc agtgcagccc ggcaagggca
     5041 ggaattggga ggcctagggt gggcatgaaa gcttgggaag cactgtcgtc tctcagacag
     5101 gcgtcctaaa gacctctagg ctggaagctt gggcttgcaa gtggatccgg gaccgagggt
     5161 ggtctcttgg acaaccccag gaacttggac caaggcagag ccaatcttgc aaactggcca
     5221 tggatgggga agtgcccggt agccagcatg agccacacta ggaaagagga ggagggtgca
     5281 gccaaactta aggcaccggc aagtgttgtc agcactggag gagaccccgc cagtggggtg
     5341 aggccagcca agtccctgtg ttacgaatgg tgggccaagg ggctgtctgc taggtcccag
     5401 taggacaggc agagctccag gctggcacca tggtaggcct ccagggaaag agctgggagg
     5461 caggaatggc acactgggca ggcttgccca ttcctggccc tgagaatgga gctgtagcct
     5521 catggacaat aaatggatgt gacaccaaat actctgcaga gtcattttcc tcctgcggct
     5581 gagctcagat cttccaatca cgtgaaataa caaagtcctt tacagtttga cagccctagg
     5641 tctgaattct ggttctgcca ttaattgtga ctttgggcaa gaggtcaagt ctctctgggc
     5701 ctcactttcc tcattaacac agggtgcaaa gtatggttgc agagaggatg aaaagatcta
     5761 atatatgtaa agtgcctagc accggctttg tatctactta cacaagctca gtagacactt
     5821 gccgtgactg tggcccacat actagaacac catgtcctga aagagaggac cccctccatg
     5881 catcctcacc ccccaggatg tttccaccca cctgtaggtc cagaagcttt tacttcatgc
     5941 tagaaaaaga gaagagagtg gatccagagg ggagtggagg acagggcaga tgccacagca
     6001 tctgtggcct gtgtagccgg cagcctgcat ttgggcgttg acattccagg ggagttagga
     6061 acaatgagag gtctctaaga acttgtggca ctctgtcctc aagcagctgt ccctcagaat
     6121 cctgctagaa aagtgtgatc agagctggga aggagccacc atgctctgct tctctaagga
     6181 tttcggtgat tctattttta gggactgaag gcgttgaggg aatccaaggc cagtccacct
     6241 gccaggggtg ttggcatctg ttgacaggca gtggcacatc ctgacagtct tcaaggcctt
     6301 ggccaccaag ggatggagag ggagaatgga gaagatgcca catgaggaat gaggcaggag
     6361 actggcatgt gccacatgga ggacccctta ggaaactcac aaacaaccta gggaggggtt
     6421 ctctgaaggg cctagtttcc agaatgaggc ggtcatggct taagcgacca tcatttgatc
     6481 aataaagcag agtagcaaca ggctgatgtt ggggacatcg gtttgatgtt ataaaatcgt
     6541 gcacatgtac cccttttgag gcctgaatga ggttcggtta tttattcatt tctcaataat
     6601 ttactcagcc attcctaggg tgacaagttt ggagtatatc ttctgtgcca ggctctcttc
     6661 taggtgttag gtgtatgtct ctaacaagat agaaggaaag aagaaaagaa aaagaacaac
     6721 attcctctct ttaattgcta atcgcctggg cctagggagt cttcatttta aaagcaagta
     6781 gccctgctta caaatgtctc ctcaatcaaa ggcatttgcc ttaaacttgt atggtctaaa
     6841 ctctaaataa ataagcttct caagggcatg acaacta
//
