LOCUS       NM_001796               9316 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens cadherin 8 (CDH8), transcript variant 1, mRNA.
ACCESSION   NM_001796
VERSION     NM_001796.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9316)
  AUTHORS   Shen-Gunther,J., Wang,C.M., Poage,G.M., Lin,C.L., Perez,L.,
            Banks,N.A. and Huang,T.H.
  TITLE     Molecular Pap smear: HPV genotype and DNA methylation of ADCY8,
            CDH8, and ZNF582 as an integrated biomarker for high-grade cervical
            cytology
  JOURNAL   Clin Epigenetics 8 (1), 96 (2016)
   PUBMED   27651839
  REMARK    GeneRIF: Results show that promoter hypermethylation of ADCY8,
            CDH8, and ZNF582 are correlated with high-grade squamous
            intraepithelial lesion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9316)
  AUTHORS   El Shawa,H., Abbott,C.W. 3rd and Huffman,K.J.
  TITLE     Prenatal ethanol exposure disrupts intraneocortical circuitry,
            cortical gene expression, and behavior in a mouse model of FASD
  JOURNAL   J Neurosci 33 (48), 18893-18905 (2013)
   PUBMED   24285895
REFERENCE   3  (bases 1 to 9316)
  AUTHORS   Walker,S. and Scherer,S.W.
  TITLE     Identification of candidate intergenic risk loci in autism spectrum
            disorder
  JOURNAL   BMC Genomics 14, 499 (2013)
   PUBMED   23879678
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9316)
  AUTHORS   Cheng,Y., Quinn,J.F. and Weiss,L.A.
  TITLE     An eQTL mapping approach reveals that rare variants in the SEMA5A
            regulatory network impact autism risk
  JOURNAL   Hum Mol Genet 22 (14), 2960-2972 (2013)
   PUBMED   23575222
REFERENCE   5  (bases 1 to 9316)
  AUTHORS   Kalantari-Dehaghi,M., Anhalt,G.J., Camilleri,M.J.,
            Chernyavsky,A.I., Chun,S., Felgner,P.L., Jasinskas,A.,
            Leiferman,K.M., Liang,L., Marchenko,S., Nakajima-Sasaki,R.,
            Pittelkow,M.R., Zone,J.J. and Grando,S.A.
  TITLE     Pemphigus vulgaris autoantibody profiling by proteomic technique
  JOURNAL   PLoS One 8 (3), e57587 (2013)
   PUBMED   23505434
REFERENCE   6  (bases 1 to 9316)
  AUTHORS   Redies,C., Hertel,N. and Hubner,C.A.
  TITLE     Cadherins and neuropsychiatric disorders
  JOURNAL   Brain Res 1470, 130-144 (2012)
   PUBMED   22765916
  REMARK    Review article
REFERENCE   7  (bases 1 to 9316)
  AUTHORS   Kremmidiotis,G., Baker,E., Crawford,J., Eyre,H.J., Nahmias,J. and
            Callen,D.F.
  TITLE     Localization of human cadherin genes to chromosome regions
            exhibiting cancer-related loss of heterozygosity
  JOURNAL   Genomics 49 (3), 467-471 (1998)
   PUBMED   9615235
REFERENCE   8  (bases 1 to 9316)
  AUTHORS   Kido,M., Obata,S., Tanihara,H., Rochelle,J.M., Seldin,M.F.,
            Taketani,S. and Suzuki,S.T.
  TITLE     Molecular properties and chromosomal location of cadherin-8
  JOURNAL   Genomics 48 (2), 186-194 (1998)
   PUBMED   9521872
REFERENCE   9  (bases 1 to 9316)
  AUTHORS   Tanihara,H., Sano,K., Heimark,R.L., St John,T. and Suzuki,S.
  TITLE     Cloning of five human cadherins clarifies characteristic features
            of cadherin extracellular domain and provides further evidence for
            two structurally different types of cadherin
  JOURNAL   Cell Adhes Commun 2 (1), 15-26 (1994)
   PUBMED   7982033
REFERENCE   10 (bases 1 to 9316)
  AUTHORS   Suzuki,S., Sano,K. and Tanihara,H.
  TITLE     Diversity of the cadherin family: evidence for eight new cadherins
            in nervous tissue
  JOURNAL   Cell Regul 2 (4), 261-270 (1991)
   PUBMED   2059658
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK124734.1, BC113416.1,
            AC092125.2 and R49605.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001796.4.
            
            Summary: This gene encodes a type II classical cadherin from the
            cadherin superfamily, integral membrane proteins that mediate
            calcium-dependent cell-cell adhesion. Mature cadherin proteins are
            composed of a large N-terminal extracellular domain, a single
            membrane-spanning domain, and a small, highly conserved C-terminal
            cytoplasmic domain. The extracellular domain consists of 5
            subdomains, each containing a cadherin motif, and appears to
            determine the specificity of the protein's homophilic cell adhesion
            activity. Type II (atypical) cadherins are defined based on their
            lack of a HAV cell adhesion recognition sequence specific to type I
            cadherins. This particular cadherin is expressed in brain and is
            putatively involved in synaptic adhesion, axon outgrowth and
            guidance. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.239128.1,
                                           SRR1660805.223224.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000577390.6/ ENSP00000462701.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-463               AK124734.1         398-860
            464-2768            BC113416.1         1-2305
            2769-2769           AC092125.2         81610-81610
            2770-3230           BC113416.1         2307-2767
            3231-4339           AC092125.2         82072-83180
            4340-4555           R49605.1           11-226              c
            4556-9316           AC092125.2         83397-88157
FEATURES             Location/Qualifiers
     source          1..9316
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..9316
                     /gene="CDH8"
                     /gene_synonym="Nbla04261"
                     /note="cadherin 8"
                     /db_xref="GeneID:1006"
                     /db_xref="HGNC:HGNC:1767"
                     /db_xref="MIM:603008"
     exon            1..359
                     /gene="CDH8"
                     /gene_synonym="Nbla04261"
                     /inference="alignment:Splign:2.1.0"
     exon            360..810
                     /gene="CDH8"
                     /gene_synonym="Nbla04261"
                     /inference="alignment:Splign:2.1.0"
     CDS             559..2958
                     /gene="CDH8"
                     /gene_synonym="Nbla04261"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; cadherin 8, type 2"
                     /codon_start=1
                     /product="cadherin-8 isoform 1 preproprotein"
                     /protein_id="NP_001787.2"
                     /db_xref="CCDS:CCDS10802.1"
                     /db_xref="GeneID:1006"
                     /db_xref="HGNC:HGNC:1767"
                     /db_xref="MIM:603008"
                     /translation="MPERLAEMLLDLWTPLIILWITLPPCIYMAPMNQSQVLMSGSPL
                     ELNSLGEEQRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSG
                     DGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDI
                     NDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSI
                     EPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKF
                     AQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQD
                     GIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFS
                     SPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITL
                     ATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENG
                     KPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNR
                     QKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMGAL
                     IAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDI
                     ATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPNGVDVDEFINVRLHEADNDPTAPP
                     YDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELYSVGESDKE
                     T"
     exon            811..1105
                     /gene="CDH8"
                     /gene_synonym="Nbla04261"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1225
                     /gene="CDH8"
                     /gene_synonym="Nbla04261"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1393
                     /gene="CDH8"
                     /gene_synonym="Nbla04261"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1581
                     /gene="CDH8"
                     /gene_synonym="Nbla04261"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1835
                     /gene="CDH8"
                     /gene_synonym="Nbla04261"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1972
                     /gene="CDH8"
                     /gene_synonym="Nbla04261"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2094
                     /gene="CDH8"
                     /gene_synonym="Nbla04261"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2212
                     /gene="CDH8"
                     /gene_synonym="Nbla04261"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2464
                     /gene="CDH8"
                     /gene_synonym="Nbla04261"
                     /inference="alignment:Splign:2.1.0"
     exon            2465..9316
                     /gene="CDH8"
                     /gene_synonym="Nbla04261"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3801..3806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH8"
                     /gene_synonym="Nbla04261"
                     /note="hexamer: AATAAA"
     polyA_site      3823
                     /gene="CDH8"
                     /gene_synonym="Nbla04261"
     regulatory      4537..4542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH8"
                     /gene_synonym="Nbla04261"
                     /note="hexamer: AATATA"
     polyA_site      4554
                     /gene="CDH8"
                     /gene_synonym="Nbla04261"
                     /note="major polyA site"
     regulatory      9291..9296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH8"
                     /gene_synonym="Nbla04261"
                     /note="hexamer: AATAAA"
     polyA_site      9306
                     /gene="CDH8"
                     /gene_synonym="Nbla04261"
ORIGIN      
        1 acagttacat ttggcaggca ggcgggctcg cacgccggag cgctcagccc agaattagtg
       61 gatttatttg gaatctccct gcctcctcca agctccgccg ccgccgccgg cttgtgcata
      121 gacggtagcg tcaagacacc agctgcactt tgggttgcgg acacccagag cccagcgcgc
      181 ccgccctgcg tctccgcacc aagccctgta gctccgagag gcatgaacgg aatccggagg
      241 cgcctgccta gcgagcgagg accggtcggc gcttgccgcc ctcgggagct aaccccgagc
      301 acctccagcc atttgtgaac ctggaggctt gacattcgcc agcgcagggc cccacaagag
      361 aaatttcaat gaaaagaaaa gccaatggat tgtggtctta gaaaagctgc ttagatgatg
      421 tctgtttccc gtgctataga cacgtggcag agctgtaagt aaatgctcgg cactgcatga
      481 tgaattggat ggctgcagac cggagacaaa aaaaataatt gtctcatttt cgtggtgatt
      541 tgcttaactg gtgggaccat gccagaacgg ctagcggaaa tgctcttgga tctctggact
      601 ccattaataa tattatggat tactcttccc ccttgcattt acatggctcc gatgaatcag
      661 tctcaagttt taatgagtgg atcccctttg gaactaaaca gtctgggtga agaacagcga
      721 attttgaacc gctccaaaag aggctgggtt tggaatcaaa tgtttgtcct ggaagagttt
      781 tctggacctg aaccgattct tgttggccgg ctacacacag acctggatcc tgggagcaaa
      841 aaaatcaagt atatcctatc aggtgatgga gctgggacca tatttcaaat aaatgatgta
      901 actggagata tccatgctat aaaaagactt gaccgggagg aaaaggctga gtatacccta
      961 acagctcaag cagtggactg ggagacaagc aaacctctgg agcctccttc tgaatttatt
     1021 attaaagttc aagacatcaa tgacaatgca ccagagtttc ttaatggacc ctatcatgct
     1081 actgtgccag aaatgtccat tttgggtaca tctgtcacta acgtcactgc gaccgacgct
     1141 gatgacccag tttatggaaa cagtgcaaag ttggtttata gtatattgga agggcagcct
     1201 tatttttcca ttgagcctga aacagctatt ataaaaactg cccttcccaa catggacaga
     1261 gaagccaagg aggagtacct ggttgttatc caagccaaag atatgggtgg acactctggt
     1321 ggcctgtctg ggaccacgac acttacagtg actcttactg atgttaatga caatcctcca
     1381 aaatttgcac agagcctgta tcacttctca gtaccggaag atgtggttct tggcactgca
     1441 ataggaaggg tgaaggccaa tgatcaggat attggtgaaa atgcacagtc atcatatgat
     1501 atcatcgatg gagatggaac agcacttttt gaaatcactt ctgatgccca ggcccaggat
     1561 ggcattataa ggctaagaaa acctctggac tttgagacca aaaaatccta tacgctaaag
     1621 gtagaggcag ccaatgtcca tattgaccca cgcttcagtg gcagggggcc ctttaaagac
     1681 acggcgacag tcaaaatcgt ggttgaagat gctgatgagc ctccggtctt ctcttcaccg
     1741 acttacctac ttgaagttca tgaaaatgct gctctaaact ccgtgattgg gcaagtgact
     1801 gctcgtgacc ctgatatcac ttccagtcct ataaggtttt ccatcgaccg gcacactgac
     1861 ctggagaggc agttcaacat taatgcagac gatgggaaga taacgctggc aacaccactt
     1921 gacagagaat taagtgtatg gcacaacata acaatcattg ctactgaaat taggaaccac
     1981 agtcagatat cacgagtacc tgttgctatt aaagtgctgg atgtcaatga caacgcccct
     2041 gaattcgcat ccgaatatga ggcattttta tgtgaaaatg gaaaacccgg ccaagtcatt
     2101 caaactgtta gcgccatgga caaagatgat cccaaaaacg gacattattt cttatacagt
     2161 ctccttccag aaatggtcaa caatccgaat ttcaccatca agaaaaatga agataattcc
     2221 ctcagtattt tggcaaagca taatggattc aaccgccaga agcaagaagt ctatctttta
     2281 ccaatcataa tcagtgatag tggaaatcct ccactgagca gcactagcac cttgacaatc
     2341 agggtctgtg gctgcagcaa tgacggtgtc gtccagtctt gcaatgtcga agcttatgtc
     2401 cttccaattg gactcagtat gggcgcctta attgccatat tagcatgcat cattttgctg
     2461 ttagtcatcg tggtgctgtt tgtaactcta cggcggcata aaaatgaacc attaattatc
     2521 aaagatgatg aagacgttcg agaaaacatc attcgctacg atgatgaagg aggaggggag
     2581 gaggacacag aggcttttga cattgcaact ttacaaaatc cagatggaat taatggattt
     2641 ttaccccgta aggatattaa accagatttg cagtttatgc caaggcaagg gcttgctcca
     2701 gttccaaatg gtgttgatgt cgatgaattt ataaatgtaa ggctgcatga ggcagataat
     2761 gatcccacgg ccccgccata tgactccatt cagatatatg gctatgaagg ccgagggtca
     2821 gtggctggct ccctcagctc cttggagtcc accacatcag actcagacca gaattttgac
     2881 tacctcagtg actggggtcc ccgctttaag agactgggcg aactctactc tgttggtgaa
     2941 agtgacaaag aaacttgaca gtggattata aataaatcac tggaactgag cattctgtaa
     3001 tattctaggg tcactcccct tagatacaac caatgtggct atttgtttta gaggcaagtt
     3061 tagcaccagt catctataaa ctcaaccaca ttttaatgtt gaaccaaaaa aagataataa
     3121 aataaaaaag tatatgttag gaggttataa atcttgtgga gtgtgaatta agtatgtgga
     3181 gtgtctagaa gtccttggat atttgatatt tacctgacca ccacagacaa agattgggat
     3241 cctggctaat ccttagataa atggtttaaa tagaggaaaa aatcataatt aaaaggtgct
     3301 ttcttagaaa aaaaaatacg gacctgcaag gaatctgctg ctgatatgtg tcttctgcaa
     3361 ggatttttat gaatgcaaat ggttttttcc ccttcaccaa taaggatccc gccacaaatg
     3421 ataaagcaat acttggtctg ctgtacatta taactttttg gagttttgag aggcctccta
     3481 gattatacag tacggtgacc acacattgta cataattgtt ggccccactc actagagact
     3541 gaatagcatc tttaaatatt gtgtcgagcc ttaaaatatt cacatgttcg taatccattc
     3601 cagggtgggg cttgccaatt cagtggtggg aggagagaaa tcccattcaa acatgcttgt
     3661 tttctagaag caggattcct cgttccctcc tcttcatctt cttccacaag gacacaaaga
     3721 taaactgtat cacacagtgg actacataag agacagatgg ttttattgct agcgcgtgaa
     3781 tttatttgtt taatcctcga aataaatatt ttattgatgt ccattaatgc ttttatttat
     3841 taaggtcggt aatctataga ttaaggggat atatgggaaa aaactaaatt atatccatta
     3901 ataatccttt agattgtttt atataaatat atatacaatg aatgtttaat acatgtacat
     3961 tttgatgaga tgagtatggc aggcaatatt atcgaaagga gagctaatag tctctttaga
     4021 gtagaaagtg ttattgtaac tggagatggc aggaacagca tcttcccaga caaacttttg
     4081 gactgttttc tattttgttc ataatcctag tatttggtgt ttttactaca agcacaaaca
     4141 tcctaaagta tattgattcc tgtgaatatt taaactctag acttttagat acctacatca
     4201 tgccctgccc aataaacatg cttcaattta cccccacagt tttagagcag gaactgattt
     4261 gtacataatt tcactgttta cgtttttagc actcctatcc ctgatcttca tggtgatgca
     4321 cagaatgtct tagactccaa aaaggaacag cactagaaga tgtgagcata tttaatttgt
     4381 aatgcaaacc tgccatttag gagtagaaaa tgtatgataa aactcaagta ttacatgcag
     4441 atcattttaa ttttctactt tgctttaatg caatattgtt tattcactcc atgtattgta
     4501 ttcagagaaa ctcctgtatt gtttcctact ttgtgaaata tatttttata aatacctttg
     4561 ttgtcattaa tttttttttc aatcagtgga agatctatta acagaatcat caactcaaac
     4621 taaaattcta gaatactcaa ccaaatcatc ccaagggtca cttttgtttg taagactctt
     4681 tattatagag aaacagagaa gagaaatggc ttgccagtga tcacacagca agataccagc
     4741 agggacataa gaggaacatg gaacacctaa aggctagtcc agctgtgtca tttgggtcct
     4801 tctggaagca gacgcattgg gcagggaaaa ccttcagaca agtttgcaga cctaaaactt
     4861 gtaacaatag agggattggg agcaggattt ggcaagagag tcttagactg cagtgcggac
     4921 ctggcaaaat ctctgccagt ctgacagggg gttctagagt gaaaacacat ccattaaagc
     4981 agtcaggctg tggtcctctg tcatctcagt cattggtgcg gggctgctaa gaagagaacg
     5041 gtttttgact caaaagctga acgcaccaac ttctagaggc caccttcact gtgacagaaa
     5101 ctgcatgttt aaatactata ctaacaattt ataactatcc ggtggcttaa tcaacttttt
     5161 attgagtttc tgttgctgag aataagtcat cttttatgcg tattattacg gctagtgaac
     5221 actttttctt gaggtcaaag ggatggtcca acatgacttt aaaatatact aggacttggc
     5281 acagtgtcta aaacaagtgc ttggtgaatg taaattatta gtagtagttg cagtaataac
     5341 caatagtaat attccaacta tcttacacct tccaaaccaa ggagagatta ttatgtttta
     5401 tgtatctctt gaacaccaga ctcatttcta gtgtactttg aagtgcccaa agattataga
     5461 cacacaaata tgtctaacag aataattaca gtatttttta aggagtataa aatctgtatc
     5521 ctcaaatatt ggtaatcaac aggataatct tcgtacagtg gtttctgtga gcaggagata
     5581 atgtctgctc tactagttgc ccaaatatcg cctaagtatt ctctttgcct aggaacacag
     5641 aatgaaagct tgcatctctt gctgactttc tttgccacca cagtgtcagc attttgtgtt
     5701 taaaagccta tttcaggtct tgtaacatag aataaagtga ctaatacctt gatcctaata
     5761 agattgacct atacttttag agtgtcatga attaaactaa aaatctcagg aactatctct
     5821 ctctttctct ctttctctct ctctctctct ctctctctca cacacacaca cacacacaca
     5881 cacacacaca cacaacaaac aaataaaaaa cacacatttt gacttgaagt tttactttag
     5941 caatagactt gccaggactt tcccaaccaa aagatatcaa taaggttcct aacattttct
     6001 aagatttaag tatcccatgc tcaatttgtt aaataacaca ttttaaaaac tttattgaaa
     6061 tgactatatt tttaaagcta tgtgcattgt tgtctgtttc atcaacattg acatagcaga
     6121 aacaagagta ctctctgcta aatagagaag aatgattaag ttggagccaa gtgagacaaa
     6181 gttatctccc tctgcctacc tcacaattca aggttcccac ctagggaact gatgcatccc
     6241 tgggtgattg gacacaacat gggatcaatt cagcctctac tctgcctatg atttgatcaa
     6301 atcatattag caaagtgtct cttaaacatc catatatgaa tattaaagag tattaagggg
     6361 ggcatttctt aacaatattt ttatgagtat agttataagt ttctaaacat ttataatacg
     6421 atgactaaaa tatgctattt ttaaattcaa gtgttaacct tgccacacag aattatgact
     6481 tctagggtgt aaactttaaa gtgaaactgt tttgaaaaaa atctgcagtt aagtgtatgt
     6541 gtatatatag aagaaaagga aacttagatt tactggtatc accagtgaag caagaatgct
     6601 tagaaagata caaatgtgtc tttgggagag tctgcttaat cagatgctta aagtaagaca
     6661 agtctctgca tgagacttag aaatctccta ggagcagctg gattccacac tgagactcaa
     6721 cagagttctg ggctatgctg tattttggaa aaggaaaagc gggtgctgag agctaagtag
     6781 ccaattactc tttatagcca cataaggact gaaggcaagt aggcccttcc aacaagttgt
     6841 attatgcgat cactggcttt gcagggaatc tcacgaatgt ataaccttct gattgccttt
     6901 ttgattgaaa gttccatctg agatcagggc agtgtaacca gtaataagat ttcaaaaaaa
     6961 tcccatcact ggcactgtcg gaaaggctga gcatgactga aatcctatca ttgtcagtca
     7021 aaaagataag gtaacagcgg gcatcactat aaaagctcta taaatgcaca acttaaacat
     7081 gaatatcaac attaaaaaga atatatatat ccttatacat atatttataa atatattcat
     7141 atatataaat atgcacatat atacacaatt cagttactgg ggataattta tagttttaat
     7201 ttttcatctc ataatctcac gcactgccaa caaattgaaa ttgtggctct ctgttttcat
     7261 gaatctaacc ttgaatttga aagaagttga attgagggta aagggtttta aaagcagctt
     7321 tttatttgtg aacagaataa tggctcataa tacctgggat tagaattaaa tatgtcacgt
     7381 tgtgaggctg tacttagact ttttaaatgt cattgtattt ttttgtggac aaaataattg
     7441 tagaatatac tttgcaggaa atacttttct atattttttc aatttcaata ctgttttatt
     7501 tgctataaaa agtgtctttg cactgttact cagccaaaca gtgttgaatg tattatttgc
     7561 ccttgtaatt attgcttctt atgataattg tagaagagca tgtctttatg atctatcatt
     7621 taaaaataca tttattgtca ttgtagtttt agtcaacaca aatttatgga ttacatggta
     7681 tactgttgct attgaagata ttctagtcct agtattttga gcacagacct agcgttatgg
     7741 aggacataaa atttaaaaat ttcctgactt gatggactat ctgaggaaaa agaattttgt
     7801 ctgtcacatt tattgagtat ctatcagtac agaaattaag ctacatggtt gatacagaaa
     7861 gattaaatac agtagcattc tcaaacttat tttctttatt tataaaatgt acctaatcaa
     7921 tctcataaga actaattgtt gaattttttt tttatctatg gataaatact atttgagtct
     7981 gggtttaagt ttggttgatc tgacactaaa tccccttaac tttcaactaa acagttatct
     8041 ctgtaattat gagacttttg atgataagaa atagaaacta agttatatat agtgctatgg
     8101 aagtactgag gaggaagtaa gggaccccat atgggaagac tcaagaagac gtcacggtga
     8161 aattttccaa aaagatggga actcaagaat gggtgcaaca gaaatcacag cttttccaaa
     8221 tactaaaagg gaaaattata aaaagcacca atggcacact tttggacatt cagaaagatc
     8281 cagaaattag gtgcttatag gaaactctag gtttgccaaa ttgtagtgtt ttatggatag
     8341 gaaaaatgaa gttcagaaac gttataagga attttcaggg ttaaattaca catcaaatat
     8401 gtgagagaaa cagaaattac atgctggtat ttggggtcat ctcctgagtt gtaatgttgt
     8461 aagtgttttt gtatgtattc tcctccttcc tttatgtgtg gaagtttcat ctaggtctca
     8521 aggttagtag gcatttgctg gtgaaaatag tgcctttggg tactatttcc ccaacttgag
     8581 ttacctgcca ccatctaatt cacatcttga atgcaagtat tatttcttgc aagtatccct
     8641 actaatagat aatagatatt tctattatta tccacagatt acagaagagg gttgctagga
     8701 ggaatatcac aagatgctgt ctgaagagaa agactgtgga aaaccatggc ttcaatgaac
     8761 tcagaggtca ggaccagaaa aggaaatgag aggtcaccaa agccaaatgt taatttcttg
     8821 ggatttcttc tgtacatgca aagaacttca ggccatccta tgattcctca aaaataagag
     8881 gaaaatttta acaattatgc tctaagatgg accatgacaa tttaggagtc attgggatca
     8941 ccccccaaag ccaaatgtta atttcttggg atttcttctg tacatgcaaa gaacttcagg
     9001 ccatcctatg atccctcaca aataagagga agattttaac aattatgctc taagatggaa
     9061 catgacaatt taggagtcac tgggatcacc ccccccacct ttccaacgtt actctgcttt
     9121 aactacaaat atgtcgaatg gttttctaat ttttctttaa cttaacctct aaagttcgag
     9181 agctgtcatc tttgtcaagt ctgattgttg agtatgtgaa tggatgtttt tggctcaatg
     9241 ttagagccaa aatttataaa taataattat ttatacataa tgatattgca aataaacttt
     9301 aagaaagagc tttaaa
//
