LOCUS       NM_004361              12136 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens cadherin 7 (CDH7), transcript variant b, mRNA.
ACCESSION   NM_004361
VERSION     NM_004361.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12136)
  AUTHORS   Li,X., Wang,Q., He,K., Li,Z., Chen,J., Li,W., Wen,Z., Shen,J.,
            Qiang,Y., Ji,J., Feng,G., He,G., Lin,H., Wang,Y. and Shi,Y.
  TITLE     Common variants in the CDH7 gene are associated with major
            depressive disorder in the Han Chinese population
  JOURNAL   Behav Genet 44 (2), 97-101 (2014)
   PUBMED   24554215
  REMARK    GeneRIF: Our results support CDH7 to be a risk factor of major
            depressive disorder in the Han Chinese population
REFERENCE   2  (bases 1 to 12136)
  AUTHORS   Yu,B., Barbalic,M., Brautbar,A., Nambi,V., Hoogeveen,R.C., Tang,W.,
            Mosley,T.H., Rotter,J.I., deFilippi,C.R., O'Donnell,C.J.,
            Kathiresan,S., Rice,K., Heckbert,S.R., Ballantyne,C.M., Psaty,B.M.
            and Boerwinkle,E.
  CONSRTM   CARDIoGRAM Consortium
  TITLE     Association of genome-wide variation with highly sensitive cardiac
            troponin-T levels in European Americans and Blacks: a meta-analysis
            from atherosclerosis risk in communities and cardiovascular health
            studies
  JOURNAL   Circ Cardiovasc Genet 6 (1), 82-88 (2013)
   PUBMED   23247143
REFERENCE   3  (bases 1 to 12136)
  AUTHORS   Chung,S., Low,S.K., Zembutsu,H., Takahashi,A., Kubo,M., Sasa,M. and
            Nakamura,Y.
  TITLE     A genome-wide association study of chemotherapy-induced alopecia in
            breast cancer patients
  JOURNAL   Breast Cancer Res 15 (5), R81 (2013)
   PUBMED   24025145
REFERENCE   4  (bases 1 to 12136)
  AUTHORS   Redies,C., Hertel,N. and Hubner,C.A.
  TITLE     Cadherins and neuropsychiatric disorders
  JOURNAL   Brain Res 1470, 130-144 (2012)
   PUBMED   22765916
  REMARK    Review article
REFERENCE   5  (bases 1 to 12136)
  AUTHORS   Winklmeier,A., Contreras-Shannon,V., Arndt,S., Melle,C. and
            Bosserhoff,A.K.
  TITLE     Cadherin-7 interacts with melanoma inhibitory activity protein and
            negatively modulates melanoma cell migration
  JOURNAL   Cancer Sci 100 (2), 261-268 (2009)
   PUBMED   19200257
  REMARK    GeneRIF: Cadherin-7 interacts with melanoma inhibitory activity
            protein and negatively modulates melanoma cell migration.
REFERENCE   6  (bases 1 to 12136)
  AUTHORS   Kools,P., Van Imschoot,G. and van Roy,F.
  TITLE     Characterization of three novel human cadherin genes (CDH7, CDH19,
            and CDH20) clustered on chromosome 18q22-q23 and with high homology
            to chicken cadherin-7
  JOURNAL   Genomics 68 (3), 283-295 (2000)
   PUBMED   10995570
REFERENCE   7  (bases 1 to 12136)
  AUTHORS   Shimoyama,Y., Tsujimoto,G., Kitajima,M. and Natori,M.
  TITLE     Identification of three human type-II classic cadherins and
            frequent heterophilic interactions between different subclasses of
            type-II classic cadherins
  JOURNAL   Biochem J 349 (Pt 1), 159-167 (2000)
   PUBMED   10861224
REFERENCE   8  (bases 1 to 12136)
  AUTHORS   Kremmidiotis,G., Baker,E., Crawford,J., Eyre,H.J., Nahmias,J. and
            Callen,D.F.
  TITLE     Localization of human cadherin genes to chromosome regions
            exhibiting cancer-related loss of heterozygosity
  JOURNAL   Genomics 49 (3), 467-471 (1998)
   PUBMED   9615235
REFERENCE   9  (bases 1 to 12136)
  AUTHORS   Auffray,C., Behar,G., Bois,F., Bouchier,C., Da Silva,C.,
            Devignes,M.D., Duprat,S., Houlgatte,R., Jumeau,M.N., Lamy,B. et al.
  TITLE     [IMAGE: molecular integration of the analysis of the human genome
            and its expression]
  JOURNAL   C R Acad Sci III 318 (2), 263-272 (1995)
   PUBMED   7757816
REFERENCE   10 (bases 1 to 12136)
  AUTHORS   Hulsken,J., Birchmeier,W. and Behrens,J.
  TITLE     E-cadherin and APC compete for the interaction with beta-catenin
            and the cytoskeleton
  JOURNAL   J Cell Biol 127 (6 Pt 2), 2061-2069 (1994)
   PUBMED   7806582
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090358.16 and AC023394.11.
            
            On Nov 22, 2018 this sequence version replaced NM_004361.4.
            
            Summary: This gene encodes a type II classical cadherin of the
            cadherin superfamily. Alternative splicing results in multiple
            transcript variants, at least one of which encodes a preproprotein
            that is proteolytically processed to generate the mature
            glycoprotein. This calcium dependent cell-cell adhesion molecule is
            comprised of five extracellular cadherin repeats, a transmembrane
            region and a highly conserved cytoplasmic tail. Type II (atypical)
            cadherins are defined based on their lack of a
            histidine-alanine-valine (HAV) cell adhesion recognition sequence
            specific to type I cadherins. Cadherins mediate cell-cell binding
            in a homophilic manner, contributing to the sorting of
            heterogeneous cell types. Mutations in this gene may be associated
            with bipolar disease in human patients. This gene is present in a
            gene cluster on chromosome 18. [provided by RefSeq, May 2016].
            
            Transcript Variant: This variant (b) represents the longest
            transcript and encodes the longer isoform (1).  Variants a, b and d
            encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.228257.1,
                                           SRR1803613.222601.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMN03267750
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397968.4/ ENSP00000381058.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AC090358.16        122103-122241
            140-545             AC090358.16        133738-134143
            546-840             AC023394.11        33023-33317
            841-960             AC023394.11        37804-37923
            961-1128            AC023394.11        45400-45567
            1129-1316           AC023394.11        47963-48150
            1317-1570           AC023394.11        67131-67384
            1571-1707           AC023394.11        81135-81271
            1708-1829           AC023394.11        82244-82365
            1830-1947           AC023394.11        83027-83144
            1948-2199           AC023394.11        85985-86236
            2200-12136          AC023394.11        103720-113656
FEATURES             Location/Qualifiers
     source          1..12136
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q22.1"
     gene            1..12136
                     /gene="CDH7"
                     /gene_synonym="CDH7L1"
                     /note="cadherin 7"
                     /db_xref="GeneID:1005"
                     /db_xref="HGNC:HGNC:1766"
                     /db_xref="MIM:605806"
     exon            1..139
                     /gene="CDH7"
                     /gene_synonym="CDH7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            140..545
                     /gene="CDH7"
                     /gene_synonym="CDH7L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             336..2693
                     /gene="CDH7"
                     /gene_synonym="CDH7L1"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant b; cadherin 7, type 2"
                     /codon_start=1
                     /product="cadherin-7 isoform 1 preproprotein"
                     /protein_id="NP_004352.2"
                     /db_xref="CCDS:CCDS11993.1"
                     /db_xref="GeneID:1005"
                     /db_xref="HGNC:HGNC:1766"
                     /db_xref="MIM:605806"
                     /translation="MKLGKVEFCHFLQLIALFLCFSGMSQAELSRSRSKPYFQSGRSR
                     TKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTG
                     DIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTA
                     GVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNM
                     DREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLP
                     VASVVARIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAK
                     TSYTLRIEAANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQV
                     GNIIGTVAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNI
                     TVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDK
                     DEPSNGHQFYFSLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVD
                     SGSPSLSSTNTLTIRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLI
                     LLIVTMRRRKKEPLIFDEERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVIRDTKT
                     RRDVTPEIQFLSRPAFKSIPDNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGS
                     VAESLSSLDSISSNSDQNYDYLSDWGPRFKRLADMYGTGQESLYS"
     exon            546..840
                     /gene="CDH7"
                     /gene_synonym="CDH7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            841..960
                     /gene="CDH7"
                     /gene_synonym="CDH7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1128
                     /gene="CDH7"
                     /gene_synonym="CDH7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1316
                     /gene="CDH7"
                     /gene_synonym="CDH7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1570
                     /gene="CDH7"
                     /gene_synonym="CDH7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1707
                     /gene="CDH7"
                     /gene_synonym="CDH7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1829
                     /gene="CDH7"
                     /gene_synonym="CDH7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1947
                     /gene="CDH7"
                     /gene_synonym="CDH7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2199
                     /gene="CDH7"
                     /gene_synonym="CDH7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..12136
                     /gene="CDH7"
                     /gene_synonym="CDH7L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4414..4419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH7"
                     /gene_synonym="CDH7L1"
                     /note="hexamer: AATAAA"
     polyA_site      4435
                     /gene="CDH7"
                     /gene_synonym="CDH7L1"
                     /note="major polyA site"
     regulatory      6917..6922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH7"
                     /gene_synonym="CDH7L1"
                     /note="hexamer: AATAAA"
     polyA_site      6936
                     /gene="CDH7"
                     /gene_synonym="CDH7L1"
     regulatory      7937..7942
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH7"
                     /gene_synonym="CDH7L1"
                     /note="hexamer: ATTAAA"
     polyA_site      7958
                     /gene="CDH7"
                     /gene_synonym="CDH7L1"
     regulatory      12117..12122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH7"
                     /gene_synonym="CDH7L1"
                     /note="hexamer: ATTAAA"
     polyA_site      12136
                     /gene="CDH7"
                     /gene_synonym="CDH7L1"
                     /note="major polyA site"
ORIGIN      
        1 agtctgcccc gcgcgcggag ctgcgcgcac tgggtcccca agagcccgcg ggcgtccggc
       61 agccgagcgc acgttctttc ggatgcacac gcccgggtcc ctggcgtctg acgccgtggg
      121 gagggcagcg aggccccagg tacttactac accattcttt ggcgaaggct attcagcagt
      181 ggtgacctct tccaatccaa cactctacag attattatct ctggactccc agctgacacc
      241 ctgccggagg caagagctac taagccaact ggaactgtgc cttttctctt gtcaaggttt
      301 ttttcttaca caggaaaaag aaagaaaaaa aaaagatgaa gttgggcaaa gtggagttct
      361 gccattttct gcagctaata gctcttttcc tgtgtttttc tgggatgagt caagcagaac
      421 tctcaaggtc cagatcaaag ccctatttcc aatcagggag gtcccggacc aagcgcagct
      481 gggtgtggaa tcagttcttt gtgctggagg aatacatggg ttcagacccc ctctatgtag
      541 gaaagcttca ctctgatgtt gataaaggag atggttccat caaatacatc ttgtcaggcg
      601 aaggggcaag ttccattttc attattgatg agaacactgg ggatattcat gccaccaaga
      661 gactggatcg tgaggagcag gcctactaca cgctccgagc tcaagcgctg gataggctca
      721 ccaacaaacc cgtggagccc gagtcggagt ttgtcatcaa aattcaggat atcaacgaca
      781 atgaacccaa atttttggat ggcccataca cggcaggagt tcccgaaatg tctcccgtgg
      841 ggacctcagt ggtacaagtg acagcgacgg atgctgatga tcctacatat ggcaacagtg
      901 ccagagtggt ctacagtatt ctgcaaggac agccgtactt ctcagtggag ccaaagacag
      961 gagtcatcaa gactgccctt ccaaacatgg atagagaggc taaagaccag tatttgcttg
     1021 tcattcaggc aaaggatatg gttggtcaaa atggaggact gtcaggaact acatcagtca
     1081 ctgtgaccct aactgatgtc aacgataatc cacctcgctt tcctcgaagg tcttatcaat
     1141 ataacgtccc agagtcatta cctgtagcct cagttgtggc cagaattaaa gctgctgatg
     1201 cagatattgg agctaatgct gaaatggagt acaagattgt ggatggtgat ggtttgggca
     1261 tttttaagat ttctgttgac aaagaaaccc aggaaggaat cattactata cagaaggagc
     1321 tggattttga agccaaaaca agttacacgc tacggataga agctgcaaat aaagatgccg
     1381 accctcgctt tctgagcttg ggtccgttca gtgacacgac aactgtgaag ataattgtgg
     1441 aagatgtaga tgagccccct gtgttctctt cacccttgta ccctatggag gtgtcggaag
     1501 ctacccaggt tgggaatatc attggcactg tagcagctca tgacccagat tcttccaata
     1561 gccctgtgag gtactcaatt gacagaaaca cagacttgga gagatacttc aatattgatg
     1621 ccaacagtgg ggtcatcaca actgccaagt ctttggatcg agagacaaat gctattcaca
     1681 atatcacagt ccttgcaatg gagagccaga atccatctca agtaggaaga ggctatgtgg
     1741 ccatcactat acttgacatc aatgataacg cccctgaatt tgccatggac tatgagacca
     1801 ccgtctgtga aaatgcccag ccggggcagg ttatccagaa aatcagtgct gtggataaag
     1861 atgagccatc caatggacac cagttttact tcagcttaac aacggatgca acaaataacc
     1921 acaacttttc attgaaagat aacaaagaca acacagcctc aatactgacc aggagaaacg
     1981 gcttccggag acaggaacaa tcagtttact atctgccaat tttcattgtg gacagtggat
     2041 ctccctcact tagcagcacc aacaccctca ccatccgcgt gtgtgactgt gatgctgacg
     2101 gcgtagccca gacctgcaat gcagaggcct atgtcctacc tgctggcctc agtacaggag
     2161 ccctgatagc catactcgcc tgtgtcttga cattattggt gttgatcctc cttatcgtca
     2221 ctatgagaag acggaaaaaa gagcccctta tttttgacga agaaagagac atcagagaaa
     2281 atattgtgag atacgatgac gagggcgggg gagaggagga cacggaagcg tttgacatgg
     2341 ctgcactgag aaacctcaac gtcatccgag acaccaagac ccggagggat gtgactccag
     2401 aaattcaatt cctgagtcga ccagctttta aaagcatccc agataatgtc atctttaggg
     2461 aatttatttg ggaaagatta aaagaagccg atgttgatcc tggtgctcct ccttatgact
     2521 ccctgcagac atatgctttt gaaggaaatg gctcagttgc tgaatcactc agctctttag
     2581 attccatcag ctcaaactct gatcagaact atgactacct aagtgactgg ggacctcgct
     2641 ttaaacgact cgcggacatg tatgggactg gccaagagag tttgtactca tagccttgga
     2701 accttaattc gaaatgtact gaagaaaaag taacagcaaa aaataaaata aaatgaaata
     2761 aaataataaa ccactacata cagaaaacaa gaactcccct tgctggagac agatggttgt
     2821 aaatatttct ccatttttaa ttgtttagat ttctgccttg gtgaggcata tcttcattag
     2881 acttatctaa aggactgcac tgaccacaga ctctgagcat ttgaaggttt tttgataaaa
     2941 ataaatgctc agtggtttgt gaatagatag caactctcat atacctgcaa aggcaccaaa
     3001 cctctatgag aaagtagtgc cctgtgttgt cagtgagtca aagatgccct gtacatacct
     3061 tcatggtact gtcattgaga ggaatagaac atgatgagct attgaaaaac cctggaactt
     3121 gttgcatatc aaaacttggg acaaatttaa tttacagaga tgcttatagc ttactatatt
     3181 atagaatcca acagaattat gttgctcttg attaacagaa atattttatt taggaatata
     3241 taaattccca gaaattcctt cctaactgaa aaccctacca caaaagccag taaaatttag
     3301 tttaaggcaa tataaaccat tgtttatcca ataaattatg aagtgttcca aataagaaaa
     3361 aggtaaataa tttgatagtt ttgagatgct tgtgtaggta tgataaaaaa aaaagttgct
     3421 gtctgttcat tgatttttat tatctcttct gatttgtaca ggagaatatc ttttcttttt
     3481 tatttgacac atggtgttgt atttattttg gagctccaat ctccactaaa ttcaggtcca
     3541 tcatactgcc tcatagtatt aaactcatca gaacatgctg atttttctcc agcccgagct
     3601 acatgaagga aatgaagcat ggaaatggag aactaatagt aaagcaattg agccctgttg
     3661 caggtcacat ctcaaagagg agcacagcta caaggacata taaattgttc ttctgagcca
     3721 ttagaatgtc aaaacattgg aataaaatat ttgtatttta gaaagacttc agagagaatt
     3781 gagattttct ttgatgcaag aattattttt caagatcatg agttctacat gctccaaaga
     3841 cgatttcaag aacacaacct ttcttgctgc aaacctattg agtaaaatat tgagttttta
     3901 aaagtcttaa tataatgtta taaaaattaa aatccatctt taaattctga tgcaaatatg
     3961 tccctcaaga attaaccaag caatgtatga tttctgtgtg gtttagatgt gccaaaggaa
     4021 ggaaggcaat tgcaagtcat catgtgttta agtttgagtt gagcttgtta gagtatgact
     4081 ttcatgacca aaatgatgtt tctacctatt atttttccta gattaatact agtttaatgt
     4141 gcatatacat tcaagtaaga atggatttat tttttccttc ctttctcctt ttaaaaataa
     4201 ttcattgttg ggttcctaat acatttacag atagtaaaca ctgtgtagag aatcatgttc
     4261 taaaagtgct ttttgaaagg tagacagtgg aattagaata ttaatatgtt gattacacaa
     4321 agaagaacta tgtaggattc tgtaaacttg cagcccaact ttagaaatga agtatgtaaa
     4381 agtggccttc aacttcataa gtataaataa tccaataaat ttcattacct gcaaacagtt
     4441 ctttaatttg aatagagttt tgtagacatt gttttatgac tatatagata tgcttcttgc
     4501 tgtattaata tgcatatata ttttaaaaaa ttataacagt gaaagatact gttcataact
     4561 tttaatcaca catgcaagtt tttcaaacta aaaaataaca aacaaacaaa aaaacacgcg
     4621 tatttaccca gttcaataaa atcagagtgt ggtgcaggaa ttacagagtt gttaagtcag
     4681 caaggtgctg agaaaacagt ttgtaataat ccccttgttg tctgcaagaa gatgaaatag
     4741 tttagtacat ttggatgatg tcaaaactgc tgattgttgc acataccact aaacggaggt
     4801 gtggatgtat tttagaaaag gaacacacat cattcaccct gctttttctg cttttaaaat
     4861 gtgtgttttt tctcattaat tttttcaaat ggttaccaat gatagattgg aaaaagaaag
     4921 gttcatgttt aaataataat ttaaaattat tgcatatacc caattgctat ttatgtgtgg
     4981 atgattatat gaatacagta ttacatttca ttcagtggta ttttttaatt aaaaaaatta
     5041 atttaaaaaa ttaatttttg agatggctgg aagaatgttc ctaatatagg tagtatttat
     5101 atgaagtatt ctaagcttaa ttgtaatagt agtaaatttt ttgccgttgc ttattttagt
     5161 tttctttttt cttctgaaat ctaatgctat atatgatgac tgtcaatact tgagatatag
     5221 gctttgtttt aaaaacagtg attgaagagc tgattgataa aattaatatt aagtctagtt
     5281 ggaaaattct ccaaatatga tttaaataaa tatatattat caagttgctt aaattcagta
     5341 ttatactgaa accaactaga atgagctcac aggaactaat tcttcatatc tcttcccaac
     5401 tccaggtaca gtgatatcat tttggtaggt tgatgtcagc cttggtggga ttatttagac
     5461 cacaacagta atcagcaaac actacccttt tctctggaga acaagttgtt aaacatttac
     5521 cagcactcta ctgcttaaat tattttataa aatgaaatgt cataattgta aatatagtat
     5581 gaatttatat gatttaaaat aatgacatga aaggaattta tgctatattt tactactaaa
     5641 taacaatgta tgtggtagtg atttcctgaa gtgaaatcct tggagctact tgtagacagg
     5701 gagaggagtc acttctttat ggaaaacaat ggctaaattt caagtagaga taatagttca
     5761 ggaagtcaat atatttaatt attttccact tgtccataca ggagcatcaa tagaaactca
     5821 gggtttgcca aattatgccc attttgaaca gtttaattta ttgaaaaatc agatgcattt
     5881 tacttcttac tgtctatgtc aaggaaatac acccaagccc ttaatctgaa ttgtcaccat
     5941 tgcattatta aaaatcaaca taaaaatata aaaatcaaat cttaaggaaa tggatttctg
     6001 gagatcaagc ctaaattatc aatctcaatt cacaaattag tctctgaaag aaatattcca
     6061 agatcagcca gctaaggaac aaaatcagga aagagacatc aataaaaaat taggtagtaa
     6121 tttgcaggca ataagtagat ttttgatttt tctacaagca atcaccagat ctgggatctg
     6181 gtaaatgtct ttatttgcca ggaagctctg ctgatgacta caattgaggt tagttgtcta
     6241 caagatacat gcaggaggta gtagtggtta agtaatggta gctgcctttt cactctgccc
     6301 tctgaggaag ttttaaatta ttttatcttc atgcacaatt acatttacta cattggatgg
     6361 tagacatagg caattatttt catgtcaacg gcatagttac acaatgtagg aatgatattt
     6421 gtgaagtgat ccacatgccc aagaaatgca aatgcaaata gtgttgttag catttatatt
     6481 gaaatataaa atctaaagca gcttaaaata agctaagcta aacaaactgc aagaagctaa
     6541 atgatttaaa catgttaaag ttttaaagca ctagctgtaa atattaatct tcagattttc
     6601 aatttaacat gtattcactt acaaactgtt ctaataataa cactaattat tttccaagtc
     6661 accatttaaa gttttattta cagttgacct aatccaattg aagttgatga aagcttcaac
     6721 ttatttttta actctttctg gtccacgatg cctggaggca agtgaaatat atatgacaaa
     6781 taatagataa accaatttat tttctgttag tgtatgttta ttttttaatt attaataatg
     6841 tatattgtgt gtatatatga cggtgtatga aagttggcaa tgaaagctaa tacaatcatg
     6901 ttagtcggct ggatataata aagaacaaga aaggaataat agcatttgca ttttaaatgt
     6961 aattgaaact atttcagaag agtgggataa gcccttaaga aaaatgggag atgtttaagg
     7021 ctgtgatttg gccgacattg taacgtataa ttctgtggga aatttttcaa gcaaatcaag
     7081 acaggcagtg tgcgttgcat tctgacactt tttcattgtt atgctaactt ctactggctt
     7141 agaatgtaac tgaaaaggat gtgtgcctgt gttttttttt tttttttttt ttttgacgtg
     7201 gagtctcgct ctgtcgccca ggctggagtg cagtggtgcg atctcggctc actgcaagct
     7261 ccgcctccag ggttcacacc gttctcctgc ctcaacctcc ggagtagctg ggactacagg
     7321 cgcccgccac cgcgccccgc taattttttt gtatttttag tacagacggg gtttcaccgt
     7381 ggtctcgatc tcctgacctc gtgattcgcc cgcctcggcc tcccaaagtg ctgggattac
     7441 aggcgtgagc caccgcgccc ggccctgtgt gtgcgttttc atgtgtgtga ttgggaacct
     7501 tgagagatgt atctgaagta atgtaaaaat aagagtctca taattcctgg ttaatgctgg
     7561 cgtattgttg tcacctgcca agtgactgtt aggcaataag actagaaaat atggtaccga
     7621 atgaaaggag aaatatctta tttgctgtaa caatctaatt tatattaagg taaggatttt
     7681 ggtggctaag gaaagaacat ttagctgtta tttgtgtaat tgtcacatat tattgtgcag
     7741 atttaatctc attgttaaca gaatatagag tgtgaattat ttgttattaa atgttactgg
     7801 gctttggtgt cagtgtggta taccagaaat tacctctggt ctgtggttat aaaatctagg
     7861 tcagaagctc agtttcgcca catttttgct gtgccctaga tgccattttc attctctgaa
     7921 cttttatagc ttcatgatta aaattgagtt aattactatt gtgtttcaga ggcttgtgaa
     7981 tgattaagtg aaagactgtg taaacagtaa aacactataa aaagataaag ctttattatg
     8041 ggaaataatg ggaattatat aaaaaggttg ataattgtta tatggtaaac agagaatttc
     8101 tgtttggaga tacatacatt aaggaaaaat atatgcaact tggtatccta aattggaaaa
     8161 taatattcaa atagataatt gtcataatta attgaagcca ctcaaataca gttatttata
     8221 agatctcaga agattgcagt ttaactcaac ataattcaac cattcatatg aattaatgat
     8281 atccatatgt gaatgggatt ataaataaag aacaaatctt tcttacttat aatgataact
     8341 gagtggaaga taaaggactg cctttagatg atcccagcct cattgatgaa cacaaaacac
     8401 cagaatagag aaaaagacaa taatgagtat aagttaagtg gtcttccagg catccagagt
     8461 agataaagaa aatgaagttc tagagaatac aatacttttt aaagtcacag tgacatatgt
     8521 gtaattaata atttatacac ttgaaaaaat tagatgcaat gatattgact taacatgaaa
     8581 accatcctga atgcaatgca ctcttgatga ctcaaactca cttatatctt acaacagctc
     8641 atcttaatct cttacgaatg aagaaactct aggaaactaa aaaataatat ataatggata
     8701 ttactttttg tcagtgatgc caagatgaat gttaataagc tctcttctca actttagctc
     8761 ttagttatct ggttatttta tgctcatgtg aacagacact agaaacaaat atattaataa
     8821 ctatgtaact aatgagaatg ttgaaagtac agcatacttt cattcaaaaa caaacttgca
     8881 ttttcatttt attaatgaat ataatgatgt taatggttta tataagcagg aaaaacttat
     8941 atgattcact accctacagc ttcatgttct aattttgtga gtataaaccc tatgtttttg
     9001 tatatcaaga tctggaatat gttgtatact gtatatgacc aatactttaa gaacaatcaa
     9061 gtttttttat tattattatt atactttaag ttttagggta catgtgcaca atgtgcaggt
     9121 tagttacata tgtatacatg tgccatgctg gtgtgcggca cccattaact cgtcatttag
     9181 cattaggtat atctcctaat tctatccctc ccccctcccc ctaccccaca acagtcccta
     9241 gagtgtggtg ttccccttcc tgtgtaacta tatagcaatt tcattttaca tgcagtaatt
     9301 ttaaatgccc aaaaataaaa ggaaaaggaa aaataagtca ctacacaact tatatatatt
     9361 atgtatttgt ctttgaattt tgtgtgcgta tgtgtgtgtg tatatataga cagcatgcgc
     9421 acacatacat acacgtgtgc aggaacacac acaatttgag gcgaaatgtt gaagtaaagt
     9481 aaatgacttt taaatatttt ctttttagct tttaagatgt ctattagatc caacctctac
     9541 aattaaatta tatgagcata ctgagggaga attgcacatt tgtaaagttt ctctttagta
     9601 gagatttcag aatttttttt ctcaaattta gaggaacgaa caattcacat tagtaaaaca
     9661 cacagcatta ctttcaatga aactataatt tttatgttta tgagattcca ttataattac
     9721 attaaaaaga aaaccacttt tataatattt ttgcttatgt aagagtcact tctatagtaa
     9781 aagagcctta aaaatgttaa ttcaattgac tgcagaattg atcctgaaaa tccagttcat
     9841 ttaaccttgg aaatgagaca tgaagcataa aacctggggt caggatgtat gtccaaactg
     9901 aatagattat tttcgttcag ctcaagtgct atctttcagg caaatagact cctacaatat
     9961 tcagtattgg agatgtttaa aacaaatata agaaagagta ctgtttcaga actaaccagc
    10021 gaagagatgt atacaaagtg tactctgaat tggaataagt gtaggaagac aagccgtgag
    10081 aatgtgagac ctcagtatat tgctgtgttt tattgtgtgt tttgctgtat ttttaaaaaa
    10141 taagaaaaaa ttatcacaga gtaagataca tagaagaaaa taatttccgc aattcttggt
    10201 acctcaaaag acctgacaca ctacaatgaa gacttctgtt gtcatcattc tcagctgtga
    10261 tggtggcgcc atcctggttt ccagcttata cctcctgaca actcggtaca gaaaatgagt
    10321 atcattgtaa ttaaagtttg atattttctt ctaagtgact gatttttaat ataaaagtat
    10381 cacaataaag tttttccaca gatatgtaat tttaagttag ataacattct aacatataca
    10441 tggtttcaat tttcttataa gtctgtgaat cactcaagtt aggcattgtt aggtttttta
    10501 aggaaaaact ttgatgccca gaataactgt aacttatgca aacacacaca cacacacaca
    10561 cactcacaca cacacgaagt aaatggtaga aatgaaagaa gaagaagaag aaaaaaacat
    10621 tgggacattt tgccctttat ctttttatta agactgtcaa taaatgatgg tttggtttaa
    10681 gaggataaga agatagctga aactctaata attggacttt ccaatcttaa ttatgcttta
    10741 gttcccttac caggattagg aaacttcttt gtgattcttt tttaaaaata atttaatcag
    10801 gaagtgacat taaattctgt ttcaatgtaa tgagaaaata gaaatattta tattgtcatt
    10861 acgatggcac ttcaccagta tgtcctaatc tattctctat tacgtctctg aggtgggaca
    10921 ttgttgtgag aatggacgag agcacaaaaa cacggcagac cagattttct gagggttacc
    10981 cgctatgcag attcataaac ttgttattga atagttggca cacaagggta ggagaaaaat
    11041 cccaacaacc cttccacctt ttccaaaaag aaaaaaaaga aagaaaaagc taaatcttat
    11101 gaagctaaac tgtcaacaaa cagttccact gaagttgcca tagggacagc tccaacccag
    11161 tgctgggctc gtggaaggca gcaaggtacc tgcatcaagc caagatccat gaaagtgcta
    11221 atgtcatttg aggccagttt cacccctacc tcccataaat cattttaaac caaatatgaa
    11281 ttagtagtca aaaatgacca aacacagacg ataacccacc atgaaggaga tggttcatag
    11341 aaatctccaa gaacttcaga taattcaggt aattatcaga aacatgacaa gaaaaagctt
    11401 tgtgtaaaat acagaataca acacaaggaa taatgaaaag atgatctatg atggtgtata
    11461 cttgcaaaat aactaaagag tgtatttaag atttaaatat atctttgaag ctagaagtac
    11521 tatggagatt gtatatacta tattagacac tgtgcaagaa ggaacttgtg aagctaaaaa
    11581 atagaatgca ataaattagc tagtctgcca catagagaaa aaaagataat ctgcaagaac
    11641 ataagggaca aggataaaat acggagttta acgtgcttat aaccagtgtg atccttgtta
    11701 atcagaattc tagaatgttc cattgcctta tgtgacacct ccactgcccc cactttttct
    11761 ttttttttga caaggtctca ttatgtttcc caggctggct tttaactcct ggcctcaagt
    11821 tatcctcctg cctctgcctc cttaaatact ggaattacag gtgtgagtca ccatgccagg
    11881 tgtctcccat tttttaatgg tagcttaact tcacctgaag cctcctatgc cactatcttt
    11941 ataggaagct ttaccgactt tgtacgactt ggtttaattt attcagctta atggtccatt
    12001 taaccaatat tgttataaat ttatgaagct tcaattctag caaaaataaa ctatgtgcac
    12061 tcatcaaaat gtgtggcaca cctatgaaaa gtgatcagga tgcccaagca attttaatta
    12121 aaatcagata attaaa
//
