LOCUS       NM_004932               8540 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens cadherin 6 (CDH6), transcript variant 1, mRNA.
ACCESSION   NM_004932
VERSION     NM_004932.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8540)
  AUTHORS   Park,A., Kim,S.E., Yu,J., Son,D., Kim,K.S., Koh,E. and Park,K.S.
  TITLE     Cadherin-6 is a novel mediator for the migration of mesenchymal
            stem cells to glioblastoma cells in response to stromal
            cell-derived factor-1
  JOURNAL   FEBS Open Bio 14 (7), 1192-1204 (2024)
   PUBMED   38719785
  REMARK    GeneRIF: Cadherin-6 is a novel mediator for the migration of
            mesenchymal stem cells to glioblastoma cells in response to stromal
            cell-derived factor-1.
REFERENCE   2  (bases 1 to 8540)
  AUTHORS   Liu,G.Y., Wang,H., Ran,R., Wang,Y.C. and Li,Y.
  TITLE     The GLI2/CDH6 axis enhances migration, invasion and mitochondrial
            fission of stomach adenocarcinoma cells
  JOURNAL   Biochem Biophys Res Commun 676, 182-189 (2023)
   PUBMED   37523816
  REMARK    GeneRIF: The GLI2/CDH6 axis enhances migration, invasion and
            mitochondrial fission of stomach adenocarcinoma cells.
REFERENCE   3  (bases 1 to 8540)
  AUTHORS   Zhou,W., Santos,L. and Dimitriadis,E.
  TITLE     Characterization of the role for cadherin 6 in the regulation of
            human endometrial receptivity
  JOURNAL   Reprod Biol Endocrinol 18 (1), 66 (2020)
   PUBMED   32600462
  REMARK    GeneRIF: Characterization of the role for cadherin 6 in the
            regulation of human endometrial receptivity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8540)
  AUTHORS   Ahmad,S., Milan,M.D.C., Hansson,O., Demirkan,A., Agustin,R.,
            Saez,M.E., Giagtzoglou,N., Cabrera-Socorro,A., Bakker,M.H.M.,
            Ramirez,A., Hankemeier,T., Stomrud,E., Mattsson-Carlgren,N.,
            Scheltens,P., van der Flier,W.M., Ikram,M.A., Malarstig,A.,
            Teunissen,C.E., Amin,N. and van Duijn,C.M.
  TITLE     CDH6 and HAGH protein levels in plasma associate with Alzheimer's
            disease in APOE epsilon4 carriers
  JOURNAL   Sci Rep 10 (1), 8233 (2020)
   PUBMED   32427856
  REMARK    GeneRIF: CDH6 and HAGH protein levels in plasma associate with
            Alzheimer's disease in APOE epsilon4 carriers.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8540)
  AUTHORS   Shimoyama,Y., Takeda,H., Yoshihara,S., Kitajima,M. and Hirohashi,S.
  TITLE     Biochemical characterization and functional analysis of two type II
            classic cadherins, cadherin-6 and -14, and comparison with
            E-cadherin
  JOURNAL   J Biol Chem 274 (17), 11987-11994 (1999)
   PUBMED   10207020
REFERENCE   6  (bases 1 to 8540)
  AUTHORS   Chalmers,I.J., Hofler,H. and Atkinson,M.J.
  TITLE     Mapping of a cadherin gene cluster to a region of chromosome 5
            subject to frequent allelic loss in carcinoma
  JOURNAL   Genomics 57 (1), 160-163 (1999)
   PUBMED   10191097
REFERENCE   7  (bases 1 to 8540)
  AUTHORS   MacCalman,C.D., Getsios,S. and Chen,G.T.
  TITLE     Type 2 cadherins in the human endometrium and placenta: their
            putative roles in human implantation and placentation
  JOURNAL   Am J Reprod Immunol 39 (2), 96-107 (1998)
   PUBMED   9506208
  REMARK    Review article
REFERENCE   8  (bases 1 to 8540)
  AUTHORS   Paul,R., Ewing,C.M., Robinson,J.C., Marshall,F.F., Johnson,K.R.,
            Wheelock,M.J. and Isaacs,W.B.
  TITLE     Cadherin-6, a cell adhesion molecule specifically expressed in the
            proximal renal tubule and renal cell carcinoma
  JOURNAL   Cancer Res 57 (13), 2741-2748 (1997)
   PUBMED   9205085
REFERENCE   9  (bases 1 to 8540)
  AUTHORS   Shimoyama,Y., Gotoh,M., Terasaki,T., Kitajima,M. and Hirohashi,S.
  TITLE     Isolation and sequence analysis of human cadherin-6 complementary
            DNA for the full coding sequence and its expression in human
            carcinoma cells
  JOURNAL   Cancer Res 55 (10), 2206-2211 (1995)
   PUBMED   7743525
REFERENCE   10 (bases 1 to 8540)
  AUTHORS   Suzuki,S., Sano,K. and Tanihara,H.
  TITLE     Diversity of the cadherin family: evidence for eight new cadherins
            in nervous tissue
  JOURNAL   Cell Regul 2 (4), 261-270 (1991)
   PUBMED   2059658
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC353791.1, D31784.1 and
            AC091898.2.
            
            On Nov 23, 2018 this sequence version replaced NM_004932.3.
            
            Summary: This gene encodes a member of the cadherin superfamily.
            Cadherins are membrane glycoproteins that mediate homophilic
            cell-cell adhesion and play critical roles in cell differentiation
            and morphogenesis. The encoded protein is a type II cadherin and
            may play a role in kidney development as well as endometrium and
            placenta formation. Decreased expression of this gene may be
            associated with tumor growth and metastasis. [provided by RefSeq,
            May 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.149418.1,
                                           SRR1660809.232331.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265071.3/ ENSP00000265071.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               DC353791.1         32-240
            210-4524            D31784.1           1-4315
            4525-8540           AC091898.2         31311-35326         c
FEATURES             Location/Qualifiers
     source          1..8540
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.3"
     gene            1..8540
                     /gene="CDH6"
                     /gene_synonym="CAD6; KCAD"
                     /note="cadherin 6"
                     /db_xref="GeneID:1004"
                     /db_xref="HGNC:HGNC:1765"
                     /db_xref="MIM:603007"
     exon            1..201
                     /gene="CDH6"
                     /gene_synonym="CAD6; KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            202..557
                     /gene="CDH6"
                     /gene_synonym="CAD6; KCAD"
                     /inference="alignment:Splign:2.1.0"
     CDS             330..2702
                     /gene="CDH6"
                     /gene_synonym="CAD6; KCAD"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; cadherin 6, type 2, K-cadherin (fetal kidney)"
                     /codon_start=1
                     /product="cadherin-6 isoform 1 preproprotein"
                     /protein_id="NP_004923.1"
                     /db_xref="CCDS:CCDS3894.1"
                     /db_xref="GeneID:1004"
                     /db_xref="HGNC:HGNC:1765"
                     /db_xref="MIM:603007"
                     /translation="MRTYRYFLLLFWVGQPYPTLSTPLSKRTSGFPAKKRALELSGNS
                     KNELNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFI
                     INENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFT
                     KEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIK
                     TALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFK
                     TPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKL
                     LDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQI
                     REDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRET
                     LLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQT
                     LHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLL
                     PVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIV
                     ILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEA
                     IEDNKLRRDIVPEALFLPRRTPTARDNTDVRDFINQRLKENDTDPTAPPYDSLATYAY
                     EGTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADMYGGVDSDKDS"
     exon            558..852
                     /gene="CDH6"
                     /gene_synonym="CAD6; KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            853..972
                     /gene="CDH6"
                     /gene_synonym="CAD6; KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1140
                     /gene="CDH6"
                     /gene_synonym="CAD6; KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1328
                     /gene="CDH6"
                     /gene_synonym="CAD6; KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1582
                     /gene="CDH6"
                     /gene_synonym="CAD6; KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1719
                     /gene="CDH6"
                     /gene_synonym="CAD6; KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1841
                     /gene="CDH6"
                     /gene_synonym="CAD6; KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1959
                     /gene="CDH6"
                     /gene_synonym="CAD6; KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2211
                     /gene="CDH6"
                     /gene_synonym="CAD6; KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..8540
                     /gene="CDH6"
                     /gene_synonym="CAD6; KCAD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3310..3315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH6"
                     /gene_synonym="CAD6; KCAD"
                     /note="hexamer: ATTAAA"
     polyA_site      3334
                     /gene="CDH6"
                     /gene_synonym="CAD6; KCAD"
                     /note="major polyA site"
     regulatory      3953..3958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH6"
                     /gene_synonym="CAD6; KCAD"
                     /note="hexamer: ATTAAA"
     polyA_site      3981
                     /gene="CDH6"
                     /gene_synonym="CAD6; KCAD"
                     /note="major polyA site"
     regulatory      8520..8525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH6"
                     /gene_synonym="CAD6; KCAD"
                     /note="hexamer: AATAAA"
     polyA_site      8540
                     /gene="CDH6"
                     /gene_synonym="CAD6; KCAD"
                     /note="major polyA site"
ORIGIN      
        1 cccacttcat tcacttgcaa atcagtgtgt gcccacaaga gccagctctc ccgagcccgt
       61 aaccttcgca tcccaagagc tgcagtttca gccgcgacag caagaacggc agagccggcg
      121 accgcggcgg cggcggcggc ggaggcagga gcagcctggg cgggtcgcag ggtctccgcg
      181 ggcgcaggaa ggcgagcaga gatatcctct gagagccaag caaagaacat taaggaagga
      241 aggaggaatg aggctggata cggtgcagtg aaaaaggcac ttccaagagt ggggcactca
      301 ctacgcacag actcgacggt gccatcagca tgagaactta ccgctacttc ttgctgctct
      361 tttgggtggg ccagccctac ccaactctct caactccact atcaaagagg actagtggtt
      421 tcccagcaaa gaaaagggcc ctggagctct ctggaaacag caaaaatgag ctgaaccgtt
      481 caaaaaggag ctggatgtgg aatcagttct ttctcctgga ggaatacaca ggatccgatt
      541 atcagtatgt gggcaagtta cattcagacc aggatagagg agatggatca cttaaatata
      601 tcctttcagg agatggagca ggagatctct tcattattaa tgaaaacaca ggcgacatac
      661 aggccaccaa gaggctggac agggaagaaa aacccgttta catccttcga gctcaagcta
      721 taaacagaag gacagggaga cccgtggagc ccgagtctga attcatcatc aagatccatg
      781 acatcaatga caatgaacca atattcacca aggaggttta cacagccact gtccctgaaa
      841 tgtctgatgt cggtacattt gttgtccaag tcactgcgac ggatgcagat gatccaacat
      901 atgggaacag tgctaaagtt gtctacagta ttctacaggg acagccctat ttttcagttg
      961 aatcagaaac aggtattatc aagacagctt tgctcaacat ggatcgagaa aacagggagc
     1021 agtaccaagt ggtgattcaa gccaaggata tgggcggcca gatgggagga ttatctggga
     1081 ccaccaccgt gaacatcaca ctgactgatg tcaacgacaa ccctccccga ttcccccaga
     1141 gtacatacca gtttaaaact cctgaatctt ctccaccggg gacaccaatt ggcagaatca
     1201 aagccagcga cgctgatgtg ggagaaaatg ctgaaattga gtacagcatc acagacggtg
     1261 aggggctgga tatgtttgat gtcatcaccg accaggaaac ccaggaaggg attataactg
     1321 tcaaaaagct cttggacttt gaaaagaaga aagtgtatac ccttaaagtg gaagcctcca
     1381 atccttatgt tgagccacga tttctctact tggggccttt caaagattca gccacggtta
     1441 gaattgtggt ggaggatgta gatgagccac ctgtcttcag caaactggcc tacatcttac
     1501 aaataagaga agatgctcag ataaacacca caataggctc cgtcacagcc caagatccag
     1561 atgctgccag gaatcctgtc aagtactctg tagatcgaca cacagatatg gacagaatat
     1621 tcaacattga ttctggaaat ggttcgattt ttacatcgaa acttcttgac cgagaaacac
     1681 tgctatggca caacattaca gtgatagcaa cagagatcaa taatccaaag caaagtagtc
     1741 gagtacctct atatattaaa gttctagatg tcaatgacaa cgccccagaa tttgctgagt
     1801 tctatgaaac ttttgtctgt gaaaaagcaa aggcagatca gttgattcag accctgcatg
     1861 ctgttgacaa ggatgaccct tatagtggac accaattttc gttttccttg gcccctgaag
     1921 cagccagtgg ctcaaacttt accattcaag acaacaaaga caacacggcg ggaatcttaa
     1981 ctcggaaaaa tggctataat agacacgaga tgagcaccta tctcttgcct gtggtcattt
     2041 cagacaacga ctacccagtt caaagcagca ctgggacagt gactgtccgg gtctgtgcat
     2101 gtgaccacca cgggaacatg caatcctgcc atgcggaggc gctcatccac cccacgggac
     2161 tgagcacggg ggctctggtt gccatccttc tgtgcatcgt gatcctacta gtgacagtgg
     2221 tgctgtttgc agctctgagg cggcagcgaa aaaaagagcc tttgatcatt tccaaagagg
     2281 acatcagaga taacattgtc agttacaacg acgaaggtgg tggagaggag gacacccagg
     2341 cttttgatat cggcaccctg aggaatcctg aagccataga ggacaacaaa ttacgaaggg
     2401 acattgtgcc cgaagccctt ttcctacccc gacggactcc aacagctcgc gacaacaccg
     2461 atgtcagaga tttcattaac caaaggttaa aggaaaatga cacggacccc actgccccgc
     2521 catacgactc cttggccact tacgcctatg aaggcactgg ctccgtggcg gattccctga
     2581 gctcgctgga gtcagtgacc acggatgcag atcaagacta tgattacctt agtgactggg
     2641 gacctcgatt caaaaagctt gcagatatgt atggaggagt ggacagtgac aaagactcct
     2701 aatctgttgc ctttttcatt ttccaatacg acactgaaat atgtgaagtg gctatttctt
     2761 tatatttatc cactactccg tgaaggcttc tctgttctac ccgttccaaa agccaatggc
     2821 tgcagtccgt gtggatccaa tgttagagac ttttttctag tacactttta tgagcttcca
     2881 aggggcaaat ttttattttt tagtgcatcc agttaaccaa gtcagcccaa caggcaggtg
     2941 ccggagggga ggacagggaa cagtatttcc acttgttctc agggcagcgt gcccgcttcc
     3001 gctgtcctgg tgttttacta cactccatgt caggtcagcc aactgcccta actgtacatt
     3061 tcacaggcta atgggataaa ggactgtgct ttaaagataa aaatatcatc atagtaaaag
     3121 aaatgagggc atatcggctc acaaagagat aaactacata ggggtgttta tttgtgtcac
     3181 aaagaattta aaataacact tgcccatgct atttgttctt caagaacttt ctctgccatc
     3241 aactactatt caaaacctca aatccaccca tatgttaaaa ttctcattac tcttaaggaa
     3301 tagaagcaaa ttaaacggta acatccaaaa gcaaccacaa acctagtacg acttcattcc
     3361 ttccactaac tcatagtttg ttatatccta gactagacat gcgaaagttt gcctttgtac
     3421 catataaagg gggagggaaa tagctaataa tgttaaccaa ggaaatatat tttaccatac
     3481 atttaaagtt ttggccacca catgtatcac gggtcacttg aaattctttc agctatcagt
     3541 aggctaatgt caaaattgtt taaaaattct tgaaagaatt ttcctgagac aaattttaac
     3601 ttcttgtcta tagttgtcag tattattcta ctatactgta catgaaagta gcagtgtgaa
     3661 gtacaataat tcatattctt catatccttc ttacacgact aagttgaatt agtaaagtta
     3721 gattaaataa aacttaaatc tcactctagg agttcagtgg agaggttaga gccagccaca
     3781 cttgaaccta ataccctgcc cttgacatct ggaaacctct acatatttat ataacgtgat
     3841 acatttggat aaacaacatt gagattatga tgaaaaccta catattccat gtttggaaga
     3901 cccttggaag aggaaaattg gattccctta aacaaaagtg tttaagattg taattaaaat
     3961 gatagttgat tttcaaaagc attaattttt tttcattgtt tttaactttg ctttcatgac
     4021 catcctgcca tccttgactt tgaactaatg ataaagtaat gatctcaaac tatgacagaa
     4081 aagtaatgta aaatccatcc aatctattat ttctctaatt atgcaattag cctcatagtt
     4141 attatccaga ggacccaact gaactgaact aatccttctg gcagattcaa atcgtttatt
     4201 tcacacgctg ttctaatggc acttatcatt agaatcttac cttgtgcagt catcagaaat
     4261 tccagcgtac tataatgaaa acatccttgt tttgaaaacc taaaagacag gctctgtata
     4321 tatatatact taagaatatg ctgacttcac ttattagtct tagggattta ttttcaatta
     4381 atattaattt tctacaaata attttagtgt catttccatt tggggatatt gtcatatcag
     4441 cacatatttt ctgtttggaa acacactgtt gtttagttaa gttttaaata ggtgtattac
     4501 ccaagaagta aagatggaaa cgttaaaaga agagaaatgt agtattttgg gttacctgat
     4561 tagagtgaaa attttttaca atcatattat tccttgtgtc ttctgaatgg tttccgattt
     4621 tataatggac tgccctatat agtaacaagt atttcatgct tgagctattt cctgctttca
     4681 gggtttcttt tttctagttc ttcatacaca cacatacaca cacacacaca cacacacaca
     4741 cacacacacg aatgcaaaca aaaggctata tgaggtcttc actctaatga attgatatgt
     4801 atcatagtca caggtaagtg ttgaaaaaag cttagtaaag ttagaagcta cttactcata
     4861 gcaatagaac agcaccttaa tcacacgatt tactgtaaaa ttaaagaggt ctctatctgt
     4921 atgtttcatg tcacgtaaca aattgaatca aggaagatag tcctgtaaaa agaaaggtat
     4981 catctgaagt tgaggattga cactagcagt ttccaatgtt taaaggtaag atctgagttc
     5041 tcctaataag taaaagtaag tagttctata gcagaatatc tgagatgtaa ttggcaaggt
     5101 attttatccc tccctgcaga tgacacagca taccaagaac aggttaatat gattacttat
     5161 ggaaataact ttaatctctt atcataaaag ctgatgatga agtaaattta taggaaattg
     5221 gataatttga gactggggct aaatatttag taccagggta ctgtaagtat caagttggag
     5281 tgacgttttc ctataattca gactctttga catcgtggaa ccaataagag tcatagttcc
     5341 atcattctcc agcttcgtct cacttccttc ccaccccacc tgagtatcag gtcaaacatc
     5401 attgcatgcg caggtttttt ttttaattgc taggtcccag gcaacatgaa agattattgg
     5461 agaaaaaaat aattttcagc ccagtttttt cattgtctgt ttcctaattt tagatgttgg
     5521 tgatgggaaa gatggaagga gagtgggaag aagtaaaatt ttaatatttg tttcaatcac
     5581 tttgaaacta aaattcatta agcataacca gattgctttt gtgggttgtt tcaaggacat
     5641 tgagagcttt ctgatgatat gtttttgccc tctattcaaa agcaagagtt cctttaaact
     5701 actaagatat tccctagaat aagctgaatt taaaaaaaca ttaagccatt gtttaaagcc
     5761 ccttcacttc ctggccactt acttctgaaa ggcctaaaaa acatttgtgc ccaaataagt
     5821 aaataaacca aatgggaaag aagcaaagat tattccatag aaccacaaga gagggaatgt
     5881 gggcacagta aatagatgtt tctttcagaa ctttcctgcc tttacagttt gtgtccataa
     5941 agggatgttc agcaatgaaa ttactccctt ttcagatgga acaaaacctg cccatttaat
     6001 tttaacgcag tataaaaaac gtgtggttta gtttttattt tcagctccca aagagttgtg
     6061 cagaaaatct taaaattttt tttttttttt tttttttttt tttgagacag aatctcgctc
     6121 tgtcgcccag gctggaatgc agtggcgcga tctctgctca ctacaagctc cgcctcccgg
     6181 gttcacgcca ttctcctgcc tcagcgcccc cagtagctgg gactacaggc acacaccacc
     6241 acgcccggct aatttttgtt gtatttttta gtggagacag ggtttcacca tgttagccag
     6301 gatgatctcc atctcctgac ctcgtggtcc gcccgcctcg gcctcccaaa gtgctgggat
     6361 tacaggcgtg agccaccgcg cccggcctta aaaattgaat ctgtagctta ggccatccaa
     6421 attttataaa tccaaattaa ctttagaatg tttctattac tttcactttt acatatataa
     6481 attttaagtg tcctgattgg ctgaacaata tctcacatca aatgctttgc ctggaaatag
     6541 atatcccact ggggatagtg gtgtgtaaac tatgacttgg acaattctat atactcaagc
     6601 accataaaaa gtatgcagtt gaaaagaaaa tcaaagttga ttcctgggtg ccaactaaat
     6661 attcaaatca ggtactcatc cttatcagct aaattcattt tcaccaggaa cagaccacca
     6721 aataaattat tttatcctaa taactagttt tgaagcagtg taattactct ggaagaaggc
     6781 tctaaaaagt catgattccc ccactatttt gaaatgtatc ctctaacaag gatcattata
     6841 gtgtaatctt aatttttatg ttttatcaag atgaaatctt gtttgaattg tgatattata
     6901 aaaggggact caaaaatcca agcagtctac tgtgtttaaa ttaacaccac aaccttcctt
     6961 atcagattat aagagtagaa aaattaacac ttggtgtgtg aatcttcagg aaaatgagct
     7021 atttcataag ctcaaacaag cagcttcctt ttccagagaa tatagaatta tattatggtc
     7081 tccttaaatg tttagtagct cttatggtca cagcattttt aatctcccta tggcatcttt
     7141 atggaataat tttctaaagg gtaattctct actaaaaata tcagaccccg accatattta
     7201 atgtggagag caataccctc ttagaaagaa aatacattga ctcatacact tgttaaaagt
     7261 taataaagaa atagctcatt tttaaagccg gaagtttatg gtctctgcat cgtcaattta
     7321 atttaagcat tgctgagaca atctttaatc tactcccctt tttgtaatac cttatttatg
     7381 gtgcattttc atttttattt gggggaaacg ttagcccaac agagccggca gatgaaagtg
     7441 ttgaaaagag gtcaaatgga aacaaaggct cttacccgct gtatttcaga caggactgag
     7501 gcacttagcc gaggagccac tgggttatta gattaatttc aaaagagctt ttacaagttg
     7561 cttaattcct tttttttttt tttttttttt caaaaaccca tgaaccacaa actcaaattt
     7621 ctcctcaaat ggggttaatc tgacaaacga ggcatggacc cagccttgtg gaaaaagcat
     7681 tccacgctaa tgagatcttg gtctttcttg tgaggctacg ttatttatgt aaatatgtct
     7741 ggaggcacct tctctaagct tttagttttc tatgatctat tagtttagtg tttattaaag
     7801 aatcaaatgt atagaattac caggcattcg tggggaatgc tgtgtagcaa atgtaaaact
     7861 gacctgctcg gaagaaacgt aggaacgctt caaacccact gtaatgtttg gtttgagatt
     7921 attttcattg ctttgagagt gaactgccta agagtaggcc ttataataaa tgctatgtgc
     7981 gtcttcagta gttccaagct aaagcaattt ggcattctcc cactgtgatt tgtgactttt
     8041 aaacccacaa aataaaagct ttttggtatt gattgttttt aattaaaaat acttccaagt
     8101 ataaattgaa acggatgcca cccttgaaga tttactggcg ggaatgctca ctcttgtcgt
     8161 tttcctcagt atcgttcatg tctttggcaa caagaacacc tgatgaaagc aagcaatgct
     8221 cagttcccat caacatttct agttaggggg attctcataa ccccacagtt tacctgagaa
     8281 agttttctgt gttagaagaa tggggtcgag agtattacct tttagctcag tgtggccggg
     8341 ccttttgttg cagtcaaatg gcaaatacgc actccttgaa atggcttctt ttatttggtt
     8401 ttgttttctt agacttataa atttgaaaag aatgcaattt aaaaagtgat ttctcacaaa
     8461 gagtaaatat gccttttgca aatcaatttt tgtaacaagt tatttatatg atattactta
     8521 ataaactggt ttttttctaa
//
