LOCUS       NM_001795               4057 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens cadherin 5 (CDH5), mRNA.
ACCESSION   NM_001795
VERSION     NM_001795.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4057)
  AUTHORS   Serafin,D.S., Harris,N.R., Balint,L., Douglas,E.S. and Caron,K.M.
  TITLE     Proximity interactome of lymphatic VE-cadherin reveals mechanisms
            of junctional remodeling and reelin secretion
  JOURNAL   Nat Commun 15 (1), 7734 (2024)
   PUBMED   39232006
  REMARK    GeneRIF: Proximity interactome of lymphatic VE-cadherin reveals
            mechanisms of junctional remodeling and reelin secretion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4057)
  AUTHORS   Zhou,L., Yang,Y., Ye,Y., Qiao,Q., Mi,Y., Liu,H., Zheng,Y., Wang,Y.,
            Liu,M. and Zhou,Y.
  TITLE     Notch1 signaling pathway promotes growth and metastasis of gastric
            cancer via modulating CDH5
  JOURNAL   Aging (Albany NY) 16 (16), 11893-11903 (2024)
   PUBMED   39172098
  REMARK    GeneRIF: Notch1 signaling pathway promotes growth and metastasis of
            gastric cancer via modulating CDH5.
REFERENCE   3  (bases 1 to 4057)
  AUTHORS   Olson,S.A., Osborn,B.K., Cotton,M.E., Krocker,J.D., Koami,H.,
            White,N. and Cardenas,J.C.
  TITLE     Fibrinogen Fragment X Mediates Endothelial Barrier Disruption via
            Suppression of VE-Cadherin
  JOURNAL   J Surg Res 293, 639-646 (2024)
   PUBMED   37837820
  REMARK    GeneRIF: Fibrinogen Fragment X Mediates Endothelial Barrier
            Disruption via Suppression of VE-Cadherin.
REFERENCE   4  (bases 1 to 4057)
  AUTHORS   Tang,J., Kang,Y., Zhou,Y., Shang,N., Li,X., Wang,H., Lan,J.,
            Wang,S., Wu,L. and Peng,Y.
  TITLE     TIMP2 ameliorates blood-brain barrier disruption in traumatic brain
            injury by inhibiting Src-dependent VE-cadherin internalization
  JOURNAL   J Clin Invest 134 (3), e164199 (2023)
   PUBMED   38015626
  REMARK    GeneRIF: TIMP2 ameliorates blood-brain barrier disruption in
            traumatic brain injury by inhibiting Src-dependent VE-cadherin
            internalization.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4057)
  AUTHORS   Zhang,Y., Zhang,Y., Hutterer,E., Hultin,S., Bergman,O.,
            Kolbeinsdottir,S., Jin,H., Forteza,M.J., Ketelhuth,D.F.J., Roy,J.,
            Hedin,U., Enge,M., Matic,L., Eriksson,P. and Holmgren,L.
  TITLE     The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic
            inflammation and the formation of abdominal aortic aneurysms
  JOURNAL   Nat Cardiovasc Res 2 (7), 629-644 (2023)
   PUBMED   39195920
  REMARK    GeneRIF: The VE-cadherin/AmotL2 mechanosensory pathway suppresses
            aortic inflammation and the formation of abdominal aortic
            aneurysms.
REFERENCE   6  (bases 1 to 4057)
  AUTHORS   Giannotta,M., Trani,M. and Dejana,E.
  TITLE     VE-cadherin and endothelial adherens junctions: active guardians of
            vascular integrity
  JOURNAL   Dev Cell 26 (5), 441-454 (2013)
   PUBMED   24044891
  REMARK    Review article
REFERENCE   7  (bases 1 to 4057)
  AUTHORS   Breviario,F., Caveda,L., Corada,M., Martin-Padura,I., Navarro,P.,
            Golay,J., Introna,M., Gulino,D., Lampugnani,M.G. and Dejana,E.
  TITLE     Functional properties of human vascular endothelial cadherin
            (7B4/cadherin-5), an endothelium-specific cadherin
  JOURNAL   Arterioscler Thromb Vasc Biol 15 (8), 1229-1239 (1995)
   PUBMED   7627717
REFERENCE   8  (bases 1 to 4057)
  AUTHORS   Hulsken,J., Birchmeier,W. and Behrens,J.
  TITLE     E-cadherin and APC compete for the interaction with beta-catenin
            and the cytoskeleton
  JOURNAL   J Cell Biol 127 (6 Pt 2), 2061-2069 (1994)
   PUBMED   7806582
REFERENCE   9  (bases 1 to 4057)
  AUTHORS   Lampugnani,M.G., Resnati,M., Raiteri,M., Pigott,R., Pisacane,A.,
            Houen,G., Ruco,L.P. and Dejana,E.
  TITLE     A novel endothelial-specific membrane protein is a marker of
            cell-cell contacts
  JOURNAL   J Cell Biol 118 (6), 1511-1522 (1992)
   PUBMED   1522121
REFERENCE   10 (bases 1 to 4057)
  AUTHORS   Suzuki,S., Sano,K. and Tanihara,H.
  TITLE     Diversity of the cadherin family: evidence for eight new cadherins
            in nervous tissue
  JOURNAL   Cell Regul 2 (4), 261-270 (1991)
   PUBMED   2059658
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X59796.1, AB209908.1,
            BQ716387.1 and X79981.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001795.4.
            
            Summary: This gene encodes a classical cadherin of the cadherin
            superfamily. The encoded preproprotein is proteolytically processed
            to generate the mature glycoprotein. This calcium-dependent
            cell-cell adhesion molecule is comprised of five extracellular
            cadherin repeats, a transmembrane region and a highly conserved
            cytoplasmic tail. Functioning as a classical cadherin by imparting
            to cells the ability to adhere in a homophilic manner, this protein
            plays a role in endothelial adherens junction assembly and
            maintenance. This gene is located in a gene cluster in a region on
            the long arm of chromosome 16 that is involved in loss of
            heterozygosity events in breast and prostate cancer. [provided by
            RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.55864.1,
                                           SRR1803611.47904.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341529.8/ ENSP00000344115.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1094              X59796.1           5-1098
            1095-3295           AB209908.1         1079-3279
            3296-3904           BQ716387.1         80-688
            3905-4057           X79981.1           3840-3992
FEATURES             Location/Qualifiers
     source          1..4057
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..4057
                     /gene="CDH5"
                     /gene_synonym="7B4; CD144"
                     /note="cadherin 5"
                     /db_xref="GeneID:1003"
                     /db_xref="HGNC:HGNC:1764"
                     /db_xref="MIM:601120"
     exon            1..68
                     /gene="CDH5"
                     /gene_synonym="7B4; CD144"
                     /inference="alignment:Splign:2.1.0"
     exon            69..297
                     /gene="CDH5"
                     /gene_synonym="7B4; CD144"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..2442
                     /gene="CDH5"
                     /gene_synonym="7B4; CD144"
                     /note="cadherin 5, type 2, VE-cadherin (vascular
                     epithelium); endothelial-specific cadherin; 7B4 antigen;
                     cd144 antigen; vascular endothelial cadherin; cadherin 5,
                     type 2 (vascular endothelium)"
                     /codon_start=1
                     /product="cadherin-5 preproprotein"
                     /protein_id="NP_001786.2"
                     /db_xref="CCDS:CCDS10804.1"
                     /db_xref="GeneID:1003"
                     /db_xref="HGNC:HGNC:1764"
                     /db_xref="MIM:601120"
                     /translation="MQRLMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRR
                     QKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNAKYLLKGEYVGKVFRVDAETGDV
                     FAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASV
                     PESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDNSGRIITITKSLDRE
                     KQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTS
                     VGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYS
                     FIVEATDPTIDLRYMSPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQKKPLIGT
                     VLAMDPDAARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKEL
                     DSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDIT
                     PRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRT
                     GTSTLTVAVCKCNEQGEFTFCEDMAAQVGVSIQAVVAILLCILTITVITLLIFLRRRL
                     RKQARAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRRGGAKPPRPALDARP
                     SLYAQVQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIA
                     ESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYGSDPREELLY"
     exon            298..586
                     /gene="CDH5"
                     /gene_synonym="7B4; CD144"
                     /inference="alignment:Splign:2.1.0"
     exon            587..703
                     /gene="CDH5"
                     /gene_synonym="7B4; CD144"
                     /inference="alignment:Splign:2.1.0"
     exon            704..868
                     /gene="CDH5"
                     /gene_synonym="7B4; CD144"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1056
                     /gene="CDH5"
                     /gene_synonym="7B4; CD144"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1304
                     /gene="CDH5"
                     /gene_synonym="7B4; CD144"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1447
                     /gene="CDH5"
                     /gene_synonym="7B4; CD144"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1572
                     /gene="CDH5"
                     /gene_synonym="7B4; CD144"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1678
                     /gene="CDH5"
                     /gene_synonym="7B4; CD144"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1924
                     /gene="CDH5"
                     /gene_synonym="7B4; CD144"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..4057
                     /gene="CDH5"
                     /gene_synonym="7B4; CD144"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4030..4035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH5"
                     /gene_synonym="7B4; CD144"
                     /note="hexamer: AATAAA"
     regulatory      4034..4039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH5"
                     /gene_synonym="7B4; CD144"
                     /note="hexamer: AAGAAA"
     polyA_site      4054
                     /gene="CDH5"
                     /gene_synonym="7B4; CD144"
     polyA_site      4057
                     /gene="CDH5"
                     /gene_synonym="7B4; CD144"
                     /note="major polyA site"
ORIGIN      
        1 actcacgctc agccctggac ggacaggcag tccaacggaa cagaaacatc cctcagccca
       61 caggcacgat ctgttcctcc tgggaagatg cagaggctca tgatgctcct cgccacatcg
      121 ggcgcctgcc tgggcctgct ggcagtggca gcagtggcag cagcaggtgc taaccctgcc
      181 caacgggaca cccacagcct gctgcccacc caccggcgcc aaaagagaga ttggatttgg
      241 aaccagatgc acattgatga agagaaaaac acctcacttc cccatcatgt aggcaagatc
      301 aagtcaagcg tgagtcgcaa gaatgccaag tacctgctca aaggagaata tgtgggcaag
      361 gtcttccggg tcgatgcaga gacaggagac gtgttcgcca ttgagaggct ggaccgggag
      421 aatatctcag agtaccacct cactgctgtc attgtggaca aggacactgg cgaaaacctg
      481 gagactcctt ccagcttcac catcaaagtt catgacgtga acgacaactg gcctgtgttc
      541 acgcatcggt tgttcaatgc gtccgtgcct gagtcgtcgg ctgtggggac ctcagtcatc
      601 tctgtgacag cagtggatgc agacgacccc actgtgggag accacgcctc tgtcatgtac
      661 caaatcctga aggggaaaga gtattttgcc atcgataatt ctggacgtat tatcacaata
      721 acgaaaagct tggaccgaga gaagcaggcc aggtatgaga tcgtggtgga agcgcgagat
      781 gcccagggcc tccgggggga ctcgggcacg gccaccgtgc tggtcactct gcaagacatc
      841 aatgacaact tccccttctt cacccagacc aagtacacat ttgtcgtgcc tgaagacacc
      901 cgtgtgggca cctctgtggg ctctctgttt gttgaggacc cagatgagcc ccagaaccgg
      961 atgaccaagt acagcatctt gcggggcgac taccaggacg ctttcaccat tgagacaaac
     1021 cccgcccaca acgagggcat catcaagccc atgaagcctc tggattatga atacatccag
     1081 caatacagct tcatcgtcga ggccacagac cccaccatcg acctccgata catgagccct
     1141 cccgcgggaa acagagccca ggtcattatc aacatcacag atgtggacga gccccccatt
     1201 ttccagcagc ctttctacca cttccagctg aaggaaaacc agaagaagcc tctgattggc
     1261 acagtgctgg ccatggaccc tgatgcggct aggcatagca ttggatactc catccgcagg
     1321 accagtgaca agggccagtt cttccgagtc acaaaaaagg gggacattta caatgagaaa
     1381 gaactggaca gagaagtcta cccctggtat aacctgactg tggaggccaa agaactggat
     1441 tccactggaa cccccacagg aaaagaatcc attgtgcaag tccacattga agttttggat
     1501 gagaatgaca atgccccgga gtttgccaag ccctaccagc ccaaagtgtg tgagaacgct
     1561 gtccatggcc agctggtcct gcagatctcc gcaatagaca aggacataac accacgaaac
     1621 gtgaagttca aattcatctt gaatactgag aacaacttta ccctcacgga taatcacgat
     1681 aacacggcca acatcacagt caagtatggg cagtttgacc gggagcatac caaggtccac
     1741 ttcctacccg tggtcatctc agacaatggg atgccaagtc gcacgggcac cagcacgctg
     1801 accgtggccg tgtgcaagtg caacgagcag ggcgagttca ccttctgcga ggatatggcc
     1861 gcccaggtgg gcgtgagcat ccaggcagtg gtagccatct tactctgcat cctcaccatc
     1921 acagtgatca ccctgctcat cttcctgcgg cggcggctcc ggaagcaggc ccgcgcgcac
     1981 ggcaagagcg tgccggagat ccacgagcag ctggtcacct acgacgagga gggcggcggc
     2041 gagatggaca ccaccagcta cgatgtgtcg gtgctcaact cggtgcgccg cggcggggcc
     2101 aagcccccgc ggcccgcgct ggacgcccgg ccttccctct atgcgcaggt gcagaagcca
     2161 ccgaggcacg cgcctggggc acacggaggg cccggggaga tggcagccat gatcgaggtg
     2221 aagaaggacg aggcggacca cgacggcgac ggccccccct acgacacgct gcacatctac
     2281 ggctacgagg gctccgagtc catagccgag tccctcagct ccctgggcac cgactcatcc
     2341 gactctgacg tggattacga cttccttaac gactggggac ccaggtttaa gatgctggct
     2401 gagctgtacg gctcggaccc ccgggaggag ctgctgtatt aggcggccga ggtcactctg
     2461 ggcctgggga cccaaacccc ctgcagccca ggccagtcag acgccaggca ccacagcctc
     2521 caaaaatggc agtgactccc cagcccagca ccccttcctc gtgggtccca gagacctcat
     2581 cagccttggg atagcaaact ccaggttcct gaaatatcca ggaatatatg tcagtgatga
     2641 ctattctcaa atgctggcaa atccaggctg gtgttctgtc tgggctcaga catccacata
     2701 accctgtcac ccacagaccg ccgtctaact caaagacttc ctctggctcc ccaaggctgc
     2761 aaagcaaaac agactgtgtt taactgctgc agggtctttt tctagggtcc ctgaacgccc
     2821 tggtaaggct ggtgaggtcc tggtgcctat ctgcctggag gcaaaggcct ggacagcttg
     2881 acttgtgggg caggattctc tgcagcccat tcccaaggga gactgaccat catgccctct
     2941 ctcgggagcc ctagccctgc tccaactcca tactccactc caagtgcccc accactcccc
     3001 aacccctctc caggcctgtc aagagggagg aaggggcccc atggcagctc ctgaccttgg
     3061 gtcctgaagt gacctcactg gcctgccatg ccagtaactg tgctgtactg agcactgaac
     3121 cacattcagg gaaatggctt attaaacttt gaagcaactg tgaattcatt ctggaggggc
     3181 agtggagatc aggagtgaca gatcacaggg tgagggccac ctccacaccc accccctctg
     3241 gagaaggcct ggaagagctg agaccttgct ttgagactcc tcagcacccc tccagttttg
     3301 cctgagaagg ggcagatgtt cccggagcag aagacgtctc cccttctctg cctcacctgg
     3361 tcgccaatcc atgctctctt tcttttctct gtctactcct tatcccttgg tttagaggaa
     3421 cccaagatgt ggcctttagc aaaactggac aatgtccaaa cccactcatg actgcatgac
     3481 ggagccgagc catgtgtctt tacacctcgc tgttgtcaca tctcagggaa ctgaccctca
     3541 ggcacacctt gcagaaggca aggccctgcc ctgcccaacc tctgtggtca cccatgcatc
     3601 ttccactgga acgtttcact gcaaacacac cttggagaag tggcatcagt caacagagag
     3661 gggcagggaa ggagacacca agctcaccct tcgtcatgga ccgaggttcc cactctgggc
     3721 aaagcccctc acactgcaag ggattgtaga taacactgac ttgtttgttt taaccaataa
     3781 ctagcttctt ataatgattt ttttactaat gatacttaca agtttctagc tctcacagac
     3841 atatagaata agggtttttg cataataagc aggttgttat ttaggttaac aatattaatt
     3901 caggtttttt agttggaaaa acaattcctg taaccttcta ttttctataa ttgtagtaat
     3961 tgctctacag ataatgtcta tatattggcc aaactggtgc atgacaagta ctgtattttt
     4021 ttatacctaa ataaagaaaa atctttagcc tgggcaa
//
