LOCUS       NM_001793               4452 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens cadherin 3 (CDH3), transcript variant 1, mRNA.
ACCESSION   NM_001793
VERSION     NM_001793.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4452)
  AUTHORS   Faraj Tabrizi,P., Peters,I., Schimansky,I., Dubrowinskaja,N.,
            Reese,C., Tezval,H., Kuczyk,M.A. and Serth,J.
  TITLE     Alteration of Cadherin 3 Expression and DNA Methylation in
            Association with Aggressive Renal Cell Carcinoma
  JOURNAL   Int J Mol Sci 24 (22), 16476 (2023)
   PUBMED   38003666
  REMARK    GeneRIF: Alteration of Cadherin 3 Expression and DNA Methylation in
            Association with Aggressive Renal Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4452)
  AUTHORS   Wu,T., Xiao,Z., Li,Y., Jiao,Z., Liang,X., Zhang,Y., Liu,H. and
            Yang,A.
  TITLE     CDH3 is associated with poor prognosis by promoting the malignancy
            and chemoresistance in oral squamous cell carcinoma
  JOURNAL   Asian J Surg 45 (12), 2651-2658 (2022)
   PUBMED   35305877
  REMARK    GeneRIF: CDH3 is associated with poor prognosis by promoting the
            malignancy and chemoresistance in oral squamous cell carcinoma.
REFERENCE   3  (bases 1 to 4452)
  AUTHORS   Ren,Y., Liu,J., Yao,D., Hua,H., Guo,X., Dai,H., Dang,N., Huang,Y.
            and Yu,D.
  TITLE     Novel compound heterozygous cadherin 3 mutations in hypotrichosis
            and juvenile macular dystrophy
  JOURNAL   Chin Med J (Engl) 135 (12), 1503-1505 (2022)
   PUBMED   35853629
  REMARK    GeneRIF: Novel compound heterozygous cadherin 3 mutations in
            hypotrichosis and juvenile macular dystrophy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4452)
  AUTHORS   Naydenov,N.G., Lechuga,S., Zalavadia,A., Mukherjee,P.K.,
            Gordon,I.O., Skvasik,D., Vidovic,P., Huang,E., Rieder,F. and
            Ivanov,A.I.
  TITLE     P-Cadherin Regulates Intestinal Epithelial Cell Migration and
            Mucosal Repair, but Is Dispensable for Colitis Associated Colon
            Cancer
  JOURNAL   Cells 11 (9), 1467 (2022)
   PUBMED   35563773
  REMARK    GeneRIF: P-Cadherin Regulates Intestinal Epithelial Cell Migration
            and Mucosal Repair, but Is Dispensable for Colitis Associated Colon
            Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4452)
  AUTHORS   Paredes,J., Figueiredo,J., Albergaria,A., Oliveira,P., Carvalho,J.,
            Ribeiro,A.S., Caldeira,J., Costa,A.M., Simoes-Correia,J.,
            Oliveira,M.J., Pinheiro,H., Pinho,S.S., Mateus,R., Reis,C.A.,
            Leite,M., Fernandes,M.S., Schmitt,F., Carneiro,F., Figueiredo,C.,
            Oliveira,C. and Seruca,R.
  TITLE     Epithelial E- and P-cadherins: role and clinical significance in
            cancer
  JOURNAL   Biochim Biophys Acta 1826 (2), 297-311 (2012)
   PUBMED   22613680
  REMARK    Review article
REFERENCE   6  (bases 1 to 4452)
  AUTHORS   Palacios,J., Benito,N., Pizarro,A., Suarez,A., Espada,J., Cano,A.
            and Gamallo,C.
  TITLE     Anomalous expression of P-cadherin in breast carcinoma. Correlation
            with E-cadherin expression and pathological features
  JOURNAL   Am J Pathol 146 (3), 605-612 (1995)
   PUBMED   7534041
REFERENCE   7  (bases 1 to 4452)
  AUTHORS   Kaupmann,K., Becker-Follmann,J., Scherer,G., Jockusch,H. and
            Starzinski-Powitz,A.
  TITLE     The gene for the cell adhesion molecule M-cadherin maps to mouse
            chromosome 8 and human chromosome 16q24.1-qter and is near the
            E-cadherin (uvomorulin) locus in both species
  JOURNAL   Genomics 14 (2), 488-490 (1992)
   PUBMED   1427864
REFERENCE   8  (bases 1 to 4452)
  AUTHORS   Herrenknecht,K., Ozawa,M., Eckerskorn,C., Lottspeich,F., Lenter,M.
            and Kemler,R.
  TITLE     The uvomorulin-anchorage protein alpha catenin is a vinculin
            homologue
  JOURNAL   Proc Natl Acad Sci U S A 88 (20), 9156-9160 (1991)
   PUBMED   1924379
REFERENCE   9  (bases 1 to 4452)
  AUTHORS   Shimoyama,Y., Yoshida,T., Terada,M., Shimosato,Y., Abe,O. and
            Hirohashi,S.
  TITLE     Molecular cloning of a human Ca2+-dependent cell-cell adhesion
            molecule homologous to mouse placental cadherin: its low expression
            in human placental tissues
  JOURNAL   J Cell Biol 109 (4 Pt 1), 1787-1794 (1989)
   PUBMED   2793940
REFERENCE   10 (bases 1 to 4452)
  AUTHORS   Shimoyama,Y., Hirohashi,S., Hirano,S., Noguchi,M., Shimosato,Y.,
            Takeichi,M. and Abe,O.
  TITLE     Cadherin cell-adhesion molecules in human epithelial tissues and
            carcinomas
  JOURNAL   Cancer Res 49 (8), 2128-2133 (1989)
   PUBMED   2702654
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC041846.1, BU543746.1,
            BC014462.1, CN365479.1, CA489015.1, BQ945506.1, AW339148.1 and
            AC099314.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_001793.5.
            
            Summary: This gene encodes a classical cadherin of the cadherin
            superfamily. Alternative splicing results in multiple transcript
            variants, at least one of which encodes a preproprotein that is
            proteolytically processed to generate the mature glycoprotein. This
            calcium-dependent cell-cell adhesion protein is comprised of five
            extracellular cadherin repeats, a transmembrane region and a highly
            conserved cytoplasmic tail. This gene is located in a gene cluster
            in a region on the long arm of chromosome 16 that is involved in
            loss of heterozygosity events in breast and prostate cancer. In
            addition, aberrant expression of this protein is observed in
            cervical adenocarcinomas. Mutations in this gene are associated
            with hypotrichosis with juvenile macular dystrophy and ectodermal
            dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS).
            [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041846.1, X63629.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264012.9/ ENSP00000264012.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-681               BC041846.1         475-1155
            682-1266            BU543746.1         83-667
            1267-1695           BC014462.1         1584-2012
            1696-2249           CN365479.1         107-660
            2250-2480           CA489015.1         489-719
            2481-2713           BC014462.1         2896-3128
            2714-3197           BQ945506.1         32-515              c
            3198-3228           AW339148.1         5-35                c
            3229-4452           AC099314.3         42593-43816
FEATURES             Location/Qualifiers
     source          1..4452
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..4452
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
                     /note="cadherin 3"
                     /db_xref="GeneID:1001"
                     /db_xref="HGNC:HGNC:1762"
                     /db_xref="MIM:114021"
     exon            1..115
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..2560
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; calcium-dependent adhesion protein, placental;
                     cadherin 3, type 1, P-cadherin (placental)"
                     /codon_start=1
                     /product="cadherin-3 isoform 1 preproprotein"
                     /protein_id="NP_001784.2"
                     /db_xref="CCDS:CCDS10868.1"
                     /db_xref="GeneID:1001"
                     /db_xref="HGNC:HGNC:1762"
                     /db_xref="MIM:114021"
                     /translation="MGLPRGPLASLLLLQVCWLQCAASEPCRAVFREAEVTLEAGGAE
                     QEPGQALGKVFMGCPGQEPALFSTDNDDFTVRNGETVQERRSLKERNPLKIFPSKRIL
                     RRHKRDWVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAV
                     EKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQD
                     TFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRST
                     GTISVISSGLDREKVPEYTLTIQATDMDGDGSTTTAVAVVEILDANDNAPMFDPQKYE
                     AHVPENAVGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGILTT
                     RKGLDFEAKNQHTLYVEVTNEAPFVLKLPTSTATIVVHVEDVNEAPVFVPPSKVVEVQ
                     EGIPTGEPVCVYTAEDPDKENQKISYRILRDPAGWLAMDPDSGQVTAVGTLDREDEQF
                     VRNNIYEVMVLAMDNGSPPTTGTGTLLLTLIDVNDHGPVPEPRQITICNQSPVRQVLN
                     ITDKDLSPHTSPFQAQLTDDSDIYWTAEVNEEGDTVVLSLKKFLKQDTYDVHLSLSDH
                     GNKEQLTVIRATVCDCHGHVETCPGPWKGGFILPVLGAVLALLFLLLVLLLLVRKKRK
                     IKEPLLLPEDDTRDNVFYYGEEGGGEEDQDYDITQLHRGLEARPEVVLRNDVAPTIIP
                     TPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDTLLVFDYEGSGSDAASLSSLTSS
                     ASDQDQDYDYLNEWGSRFKKLADMYGGGEDD"
     exon            116..230
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            231..316
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            317..460
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            461..616
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            617..761
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            762..937
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1066
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1252
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1494
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1640
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1865
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2072
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2203
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2350
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..4452
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3179..3184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
                     /note="hexamer: ATTAAA"
     regulatory      3183..3188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
                     /note="hexamer: AAGAAA"
     polyA_site      3199
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
                     /note="major polyA site"
     polyA_site      3228
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
     regulatory      4432..4437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
                     /note="hexamer: AATAAA"
     polyA_site      4452
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
ORIGIN      
        1 aaaggggcaa gagctgagcg gaacaccggc ccgccgtcgc ggcagctgct tcacccctct
       61 ctctgcagcc atggggctcc ctcgtggacc tctcgcgtct ctcctccttc tccaggtttg
      121 ctggctgcag tgcgcggcct ccgagccgtg ccgggcggtc ttcagggagg ctgaagtgac
      181 cttggaggcg ggaggcgcgg agcaggagcc cggccaggcg ctggggaaag tattcatggg
      241 ctgccctggg caagagccag ctctgtttag cactgataat gatgacttca ctgtgcggaa
      301 tggcgagaca gtccaggaaa gaaggtcact gaaggaaagg aatccattga agatcttccc
      361 atccaaacgt atcttacgaa gacacaagag agattgggtg gttgctccaa tatctgtccc
      421 tgaaaatggc aagggtccct tcccccagag actgaatcag ctcaagtcta ataaagatag
      481 agacaccaag attttctaca gcatcacggg gccgggggca gacagccccc ctgagggtgt
      541 cttcgctgta gagaaggaga caggctggtt gttgttgaat aagccactgg accgggagga
      601 gattgccaag tatgagctct ttggccacgc tgtgtcagag aatggtgcct cagtggagga
      661 ccccatgaac atctccatca tcgtgaccga ccagaatgac cacaagccca agtttaccca
      721 ggacaccttc cgagggagtg tcttagaggg agtcctacca ggtacttctg tgatgcaggt
      781 gacagccacg gatgaggatg atgccatcta cacctacaat ggggtggttg cttactccat
      841 ccatagccaa gaaccaaagg acccacacga cctcatgttc accattcacc ggagcacagg
      901 caccatcagc gtcatctcca gtggcctgga ccgggaaaaa gtccctgagt acacactgac
      961 catccaggcc acagacatgg atggggacgg ctccaccacc acggcagtgg cagtagtgga
     1021 gatccttgat gccaatgaca atgctcccat gtttgacccc cagaagtacg aggcccatgt
     1081 gcctgagaat gcagtgggcc atgaggtgca gaggctgacg gtcactgatc tggacgcccc
     1141 caactcacca gcgtggcgtg ccacctacct tatcatgggc ggtgacgacg gggaccattt
     1201 taccatcacc acccaccctg agagcaacca gggcatcctg acaaccagga agggtttgga
     1261 ttttgaggcc aaaaaccagc acaccctgta cgttgaagtg accaacgagg ccccttttgt
     1321 gctgaagctc ccaacctcca cagccaccat agtggtccac gtggaggatg tgaatgaggc
     1381 acctgtgttt gtcccaccct ccaaagtcgt tgaggtccag gagggcatcc ccactgggga
     1441 gcctgtgtgt gtctacactg cagaagaccc tgacaaggag aatcaaaaga tcagctaccg
     1501 catcctgaga gacccagcag ggtggctagc catggaccca gacagtgggc aggtcacagc
     1561 tgtgggcacc ctcgaccgtg aggatgagca gtttgtgagg aacaacatct atgaagtcat
     1621 ggtcttggcc atggacaatg gaagccctcc caccactggc acgggaaccc ttctgctaac
     1681 actgattgat gtcaatgacc atggcccagt ccctgagccc cgtcagatca ccatctgcaa
     1741 ccaaagccct gtgcgccagg tgctgaacat cacggacaag gacctgtctc cccacacctc
     1801 ccctttccag gcccagctca cagatgactc agacatctac tggacggcag aggtcaacga
     1861 ggaaggtgac acagtggtct tgtccctgaa gaagttcctg aagcaggata catatgacgt
     1921 gcacctttct ctgtctgacc atggcaacaa agagcagctg acggtgatca gggccactgt
     1981 gtgcgactgc catggccatg tcgaaacctg ccctggaccc tggaagggag gtttcatcct
     2041 ccctgtgctg ggggctgtcc tggctctgct gttcctcctg ctggtgctgc ttttgttggt
     2101 gagaaagaag cggaagatca aggagcccct cctactccca gaagatgaca cccgtgacaa
     2161 cgtcttctac tatggcgaag aggggggtgg cgaagaggac caggactatg acatcaccca
     2221 gctccaccga ggtctggagg ccaggccgga ggtggttctc cgcaatgacg tggcaccaac
     2281 catcatcccg acacccatgt accgtcctcg gccagccaac ccagatgaaa tcggcaactt
     2341 tataattgag aacctgaagg cggctaacac agaccccaca gccccgccct acgacaccct
     2401 cttggtgttc gactatgagg gcagcggctc cgacgccgcg tccctgagct ccctcacctc
     2461 ctccgcctcc gaccaagacc aagattacga ttatctgaac gagtggggca gccgcttcaa
     2521 gaagctggca gacatgtacg gtggcgggga ggacgactag gcggcctgcc tgcagggctg
     2581 gggaccaaac gtcaggccac agagcatctc caaggggtct cagttccccc ttcagctgag
     2641 gacttcggag cttgtcagga agtggccgta gcaacttggc ggagacaggc tatgagtctg
     2701 acgttagagt ggtggcttcc ttagcctttc aggatggagg aatgtgggca gtttgacttc
     2761 agcactgaaa acctctccac ctgggccagg gttgcctcag aggccaagtt tccagaagcc
     2821 tcttacctgc cgtaaaatgc tcaaccctgt gtcctgggcc tgggcctgct gtgactgacc
     2881 tacagtggac tttctctctg gaatggaacc ttcttaggcc tcctggtgca acttaatttt
     2941 tttttttaat gctatcttca aaacgttaga gaaagttctt caaaagtgca gcccagagct
     3001 gctgggccca ctggccgtcc tgcatttctg gtttccagac cccaatgcct cccattcgga
     3061 tggatctctg cgtttttata ctgagtgtgc ctaggttgcc ccttattttt tattttccct
     3121 gttgcgttgc tatagatgaa gggtgaggac aatcgtgtat atgtactaga acttttttat
     3181 taaagaaact tttcccagag gtgcctgggg agtgaactgt tttctaaata gaaggtttat
     3241 tggcatctaa ctcacatacc ataccattca cttgtttaac gtttacaatt caatggtttt
     3301 tagaattttc agagttctgc aaaaagagtg ggctctgttt accctgctgg cttcacccaa
     3361 gcttcctctc aatggcaggg gatactcagg gtcagcttcc atgcctaagt gggctcaggg
     3421 aggggagact tgccctcctt tgcaaagtca gttgctccat gagagagaac cattaacctc
     3481 ttaccccaag gctgagcccc tccacagccc cagcaaggtc tcttctggaa cagcggctgc
     3541 cctccctgca ggacagtgtg tgacgacttc ctcttctatg ctggaggggt ccctgttgaa
     3601 aggcaggggt tggggaacag ccagctctgc tacttgctag cacatttttt tttttttttt
     3661 tgagacggag tctcgttctg tcgcccaggc tggagtgcag tggtgtgatc ttggctcact
     3721 gcaagctctg cctcctgggt tcacgccatt ctcctgcctc agcctcccga gtagctggga
     3781 ctacaggtgc ctgccactat gcccagctaa ttttttttga gtgtgtgtgt ttttttagta
     3841 gagacggggt ttcactgtgt tagccaggat gtctcgatct cctgacctcg tgatccgccc
     3901 acgtcggcct cccaaagtgc taggattaca ggcttgagcc accgcgccca gcgctggcac
     3961 atcatttaac ctccagttgc ctcagatttt acatttacaa aatggggagt ttttgtggag
     4021 attaagtgaa ttaatatctg gcacatggtc catgcaatct gttagttggt aacagctacc
     4081 atttattcag tacttttaaa ggccagacag gacttcgatt atttcctcta aatcctcaca
     4141 atcaccctct gaggggactt tctcctttaa agaatggcca cattgtattt gtttttttaa
     4201 atgacatctg gtcatcatcg aaatcaagca aaacaaaatt aagagaacct acccaagatg
     4261 tcagtgaaat tggaacattc ctgacaatac cagggcataa atgcaggaat caggaatagg
     4321 cagcagtgat agaacaattc tgtttgtgcc cttgttaacg tgaagttcaa agtcatcttt
     4381 gcaattagcc aaaagaatct gaagtgaagc tgaggaaatt gctgatgttg aaataaacat
     4441 ttccttccat ga
//
