LOCUS       NP_001784                829 aa            linear   PRI 28-APR-2025
DEFINITION  cadherin-3 isoform 1 preproprotein [Homo sapiens].
ACCESSION   NP_001784
VERSION     NP_001784.2
DBSOURCE    REFSEQ: accession NM_001793.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 829)
  AUTHORS   Faraj Tabrizi,P., Peters,I., Schimansky,I., Dubrowinskaja,N.,
            Reese,C., Tezval,H., Kuczyk,M.A. and Serth,J.
  TITLE     Alteration of Cadherin 3 Expression and DNA Methylation in
            Association with Aggressive Renal Cell Carcinoma
  JOURNAL   Int J Mol Sci 24 (22), 16476 (2023)
   PUBMED   38003666
  REMARK    GeneRIF: Alteration of Cadherin 3 Expression and DNA Methylation in
            Association with Aggressive Renal Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 829)
  AUTHORS   Wu,T., Xiao,Z., Li,Y., Jiao,Z., Liang,X., Zhang,Y., Liu,H. and
            Yang,A.
  TITLE     CDH3 is associated with poor prognosis by promoting the malignancy
            and chemoresistance in oral squamous cell carcinoma
  JOURNAL   Asian J Surg 45 (12), 2651-2658 (2022)
   PUBMED   35305877
  REMARK    GeneRIF: CDH3 is associated with poor prognosis by promoting the
            malignancy and chemoresistance in oral squamous cell carcinoma.
REFERENCE   3  (residues 1 to 829)
  AUTHORS   Ren,Y., Liu,J., Yao,D., Hua,H., Guo,X., Dai,H., Dang,N., Huang,Y.
            and Yu,D.
  TITLE     Novel compound heterozygous cadherin 3 mutations in hypotrichosis
            and juvenile macular dystrophy
  JOURNAL   Chin Med J (Engl) 135 (12), 1503-1505 (2022)
   PUBMED   35853629
  REMARK    GeneRIF: Novel compound heterozygous cadherin 3 mutations in
            hypotrichosis and juvenile macular dystrophy.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 829)
  AUTHORS   Naydenov,N.G., Lechuga,S., Zalavadia,A., Mukherjee,P.K.,
            Gordon,I.O., Skvasik,D., Vidovic,P., Huang,E., Rieder,F. and
            Ivanov,A.I.
  TITLE     P-Cadherin Regulates Intestinal Epithelial Cell Migration and
            Mucosal Repair, but Is Dispensable for Colitis Associated Colon
            Cancer
  JOURNAL   Cells 11 (9), 1467 (2022)
   PUBMED   35563773
  REMARK    GeneRIF: P-Cadherin Regulates Intestinal Epithelial Cell Migration
            and Mucosal Repair, but Is Dispensable for Colitis Associated Colon
            Cancer.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 829)
  AUTHORS   Paredes,J., Figueiredo,J., Albergaria,A., Oliveira,P., Carvalho,J.,
            Ribeiro,A.S., Caldeira,J., Costa,A.M., Simoes-Correia,J.,
            Oliveira,M.J., Pinheiro,H., Pinho,S.S., Mateus,R., Reis,C.A.,
            Leite,M., Fernandes,M.S., Schmitt,F., Carneiro,F., Figueiredo,C.,
            Oliveira,C. and Seruca,R.
  TITLE     Epithelial E- and P-cadherins: role and clinical significance in
            cancer
  JOURNAL   Biochim Biophys Acta 1826 (2), 297-311 (2012)
   PUBMED   22613680
  REMARK    Review article
REFERENCE   6  (residues 1 to 829)
  AUTHORS   Palacios,J., Benito,N., Pizarro,A., Suarez,A., Espada,J., Cano,A.
            and Gamallo,C.
  TITLE     Anomalous expression of P-cadherin in breast carcinoma. Correlation
            with E-cadherin expression and pathological features
  JOURNAL   Am J Pathol 146 (3), 605-612 (1995)
   PUBMED   7534041
REFERENCE   7  (residues 1 to 829)
  AUTHORS   Kaupmann,K., Becker-Follmann,J., Scherer,G., Jockusch,H. and
            Starzinski-Powitz,A.
  TITLE     The gene for the cell adhesion molecule M-cadherin maps to mouse
            chromosome 8 and human chromosome 16q24.1-qter and is near the
            E-cadherin (uvomorulin) locus in both species
  JOURNAL   Genomics 14 (2), 488-490 (1992)
   PUBMED   1427864
REFERENCE   8  (residues 1 to 829)
  AUTHORS   Herrenknecht,K., Ozawa,M., Eckerskorn,C., Lottspeich,F., Lenter,M.
            and Kemler,R.
  TITLE     The uvomorulin-anchorage protein alpha catenin is a vinculin
            homologue
  JOURNAL   Proc Natl Acad Sci U S A 88 (20), 9156-9160 (1991)
   PUBMED   1924379
REFERENCE   9  (residues 1 to 829)
  AUTHORS   Shimoyama,Y., Yoshida,T., Terada,M., Shimosato,Y., Abe,O. and
            Hirohashi,S.
  TITLE     Molecular cloning of a human Ca2+-dependent cell-cell adhesion
            molecule homologous to mouse placental cadherin: its low expression
            in human placental tissues
  JOURNAL   J Cell Biol 109 (4 Pt 1), 1787-1794 (1989)
   PUBMED   2793940
REFERENCE   10 (residues 1 to 829)
  AUTHORS   Shimoyama,Y., Hirohashi,S., Hirano,S., Noguchi,M., Shimosato,Y.,
            Takeichi,M. and Abe,O.
  TITLE     Cadherin cell-adhesion molecules in human epithelial tissues and
            carcinomas
  JOURNAL   Cancer Res 49 (8), 2128-2133 (1989)
   PUBMED   2702654
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC041846.1, BU543746.1,
            BC014462.1, CN365479.1, CA489015.1, BQ945506.1, AW339148.1 and
            AC099314.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 3, 2001 this sequence version replaced NP_001784.1.
            
            Summary: This gene encodes a classical cadherin of the cadherin
            superfamily. Alternative splicing results in multiple transcript
            variants, at least one of which encodes a preproprotein that is
            proteolytically processed to generate the mature glycoprotein. This
            calcium-dependent cell-cell adhesion protein is comprised of five
            extracellular cadherin repeats, a transmembrane region and a highly
            conserved cytoplasmic tail. This gene is located in a gene cluster
            in a region on the long arm of chromosome 16 that is involved in
            loss of heterozygosity events in breast and prostate cancer. In
            addition, aberrant expression of this protein is observed in
            cervical adenocarcinomas. Mutations in this gene are associated
            with hypotrichosis with juvenile macular dystrophy and ectodermal
            dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS).
            [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041846.1, X63629.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264012.9/ ENSP00000264012.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..829
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     Protein         1..829
                     /product="cadherin-3 isoform 1 preproprotein"
                     /note="calcium-dependent adhesion protein, placental;
                     cadherin 3, type 1, P-cadherin (placental)"
                     /calculated_mol_wt=88896
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2541
     Region          26..>96
                     /region_name="Cadherin_pro"
                     /note="Cadherin prodomain like; cl07391"
                     /db_xref="CDD:471661"
     mat_peptide     108..829
                     /product="Cadherin-3. /id=PRO_0000003746"
                     /note="propagated from UniProtKB/Swiss-Prot (P22223.2)"
                     /calculated_mol_wt=79516
     Region          113..211
                     /region_name="CA_like"
                     /note="Cadherin repeat-like domain; cl46864"
                     /db_xref="CDD:481204"
     Site            order(118..119,174,176,207,209..210)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206635"
     Site            200
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P22223.2)"
     Region          219..324
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(226..227,287,289,320,322..323)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          333..436
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(339..340,397,399,433,435..436)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          446..544
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(451..452,502,504,540,542..543)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          551..638
                     /region_name="CA_like"
                     /note="Cadherin repeat-like domain; cl46864"
                     /db_xref="CDD:481204"
     Site            566
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P22223.2)"
     Site            655..677
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P22223.2)"
     Region          765..824
                     /region_name="CADH_Y-type_LIR"
                     /note="Cadherin, Y-type LIR-motif; pfam01049"
                     /db_xref="CDD:460041"
     CDS             1..829
                     /gene="CDH3"
                     /gene_synonym="CDHP; HJMD; PCAD"
                     /coded_by="NM_001793.6:71..2560"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS10868.1"
                     /db_xref="GeneID:1001"
                     /db_xref="HGNC:HGNC:1762"
                     /db_xref="MIM:114021"
ORIGIN      
        1 mglprgplas llllqvcwlq caasepcrav freaevtlea ggaeqepgqa lgkvfmgcpg
       61 qepalfstdn ddftvrnget vqerrslker nplkifpskr ilrrhkrdwv vapisvpeng
      121 kgpfpqrlnq lksnkdrdtk ifysitgpga dsppegvfav eketgwllln kpldreeiak
      181 yelfghavse ngasvedpmn isiivtdqnd hkpkftqdtf rgsvlegvlp gtsvmqvtat
      241 deddaiytyn gvvaysihsq epkdphdlmf tihrstgtis vissgldrek vpeytltiqa
      301 tdmdgdgstt tavavveild andnapmfdp qkyeahvpen avghevqrlt vtdldapnsp
      361 awratylimg gddgdhftit thpesnqgil ttrkgldfea knqhtlyvev tneapfvlkl
      421 ptstativvh vedvneapvf vppskvvevq egiptgepvc vytaedpdke nqkisyrilr
      481 dpagwlamdp dsgqvtavgt ldredeqfvr nniyevmvla mdngsppttg tgtllltlid
      541 vndhgpvpep rqiticnqsp vrqvlnitdk dlsphtspfq aqltddsdiy wtaevneegd
      601 tvvlslkkfl kqdtydvhls lsdhgnkeql tviratvcdc hghvetcpgp wkggfilpvl
      661 gavlallfll lvllllvrkk rkikeplllp eddtrdnvfy ygeegggeed qdyditqlhr
      721 glearpevvl rndvaptiip tpmyrprpan pdeignfiie nlkaantdpt appydtllvf
      781 dyegsgsdaa slssltssas dqdqdydyln ewgsrfkkla dmygggedd
//
