LOCUS       NM_177980               4602 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cadherin 26 (CDH26), transcript variant a, mRNA.
ACCESSION   NM_177980
VERSION     NM_177980.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4602)
  AUTHORS   Liu,T., Sun,Y., Guo,Z. and Bai,W.
  TITLE     Knockdown of Cadherin 26 Prevents the Inflammatory Responses of
            Allergic Rhinitis
  JOURNAL   Laryngoscope 133 (7), 1558-1567 (2023)
   PUBMED   36069256
  REMARK    GeneRIF: Knockdown of Cadherin 26 Prevents the Inflammatory
            Responses of Allergic Rhinitis.
REFERENCE   2  (bases 1 to 4602)
  AUTHORS   Wagner,R., Li,H., Ayoub,L., Kahnamoui,S., Patel,D., Stefanovici,C.,
            Lacher,M. and Keijzer,R.
  TITLE     Epithelial cell-adhesion protein cadherin 26 is dysregulated in
            congenital diaphragmatic hernia and congenital pulmonary airway
            malformation
  JOURNAL   Pediatr Surg Int 37 (1), 49-57 (2021)
   PUBMED   33161446
  REMARK    GeneRIF: Epithelial cell-adhesion protein cadherin 26 is
            dysregulated in congenital diaphragmatic hernia and congenital
            pulmonary airway malformation.
REFERENCE   3  (bases 1 to 4602)
  AUTHORS   Lachowicz-Scroggins,M.E., Gordon,E.D., Wesolowska-Andersen,A.,
            Jackson,N.D., MacLeod,H.J., Sharp,L.Z., Sun,M., Seibold,M.A. and
            Fahy,J.V.
  TITLE     Cadherin-26 (CDH26) regulates airway epithelial cell cytoskeletal
            structure and polarity
  JOURNAL   Cell Discov 4, 7 (2018)
   PUBMED   29449961
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4602)
  AUTHORS   Caldwell,J.M., Collins,M.H., Kemme,K.A., Sherrill,J.D., Wen,T.,
            Rochman,M., Stucke,E.M., Amin,L., Tai,H., Putnam,P.E.,
            Jimenez-Dalmaroni,M.J., Wormald,M.R., Porollo,A., Abonia,J.P. and
            Rothenberg,M.E.
  TITLE     Cadherin 26 is an alpha integrin-binding epithelial receptor
            regulated during allergic inflammation
  JOURNAL   Mucosal Immunol 10 (5), 1190-1201 (2017)
   PUBMED   28051089
  REMARK    GeneRIF: this study shows that cadherin 26 is an alpha
            integrin-binding epithelial receptor regulated during allergic
            inflammation
REFERENCE   5  (bases 1 to 4602)
  AUTHORS   Ferreira,M.A., Zhao,Z.Z., Thomsen,S.F., James,M., Evans,D.M.,
            Postmus,P.E., Kyvik,K.O., Backer,V., Boomsma,D.I., Martin,N.G.,
            Montgomery,G.W. and Duffy,D.L.
  TITLE     Association and interaction analyses of eight genes under asthma
            linkage peaks
  JOURNAL   Allergy 64 (11), 1623-1628 (2009)
   PUBMED   19824886
  REMARK    GeneRIF: Observational study of gene-disease association, gene-gene
            interaction, and gene-environment interaction. (HuGE Navigator)
REFERENCE   6  (bases 1 to 4602)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   7  (bases 1 to 4602)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB234033.1, AK055202.1,
            AL109928.33 and AK074477.1.
            
            On May 17, 2019 this sequence version replaced NM_177980.3.
            
            Summary: This gene encodes a member of the cadherin protein family.
            Cadherins are a family of calcium-dependent adhesion molecules that
            mediate cell-cell adhesion in all solid tissues and modulate a wide
            variety of processes, including cell polarization, migration and
            differentiation. Cadherin domains occur as repeats in the
            extracellular region and are thought to contribute to the sorting
            of heterogeneous cell types and the maintenance of orderly
            structures such as epithelium. This protein is expressed in
            gastrointestinal epithelial cells and may be upregulated during
            allergic inflammation. This protein interacts with alpha integrins
            and may also be involved in leukocyte migration and adhesion.
            [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (a) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK055202.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144335 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000348616.9/ ENSP00000339390.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DB234033.1         28-31
            5-2810              AK055202.1         1-2806
            2811-4097           AL109928.33        30738-32024         c
            4098-4602           AK074477.1         1991-2495
FEATURES             Location/Qualifiers
     source          1..4602
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..4602
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /note="cadherin 26"
                     /db_xref="GeneID:60437"
                     /db_xref="HGNC:HGNC:15902"
                     /db_xref="MIM:617685"
     exon            1..373
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..2803
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /note="isoform a precursor is encoded by transcript
                     variant a; cadherin-like protein VR20; cadherin-like 26;
                     cadherin-like protein 26"
                     /codon_start=1
                     /product="cadherin-like protein 26 isoform a precursor"
                     /protein_id="NP_817089.1"
                     /db_xref="CCDS:CCDS13485.1"
                     /db_xref="GeneID:60437"
                     /db_xref="HGNC:HGNC:15902"
                     /db_xref="MIM:617685"
                     /translation="MAMRSGRHPSLLLLLVLLLWLLQVSIIDSVQQETDDLTKQTKEK
                     IYQPLRRSKRRWVITTLELEEEDPGPFPKLIGELFNNMSYNMSLMYLISGPGVDEYPE
                     IGLFSLEDHENGRIYVHRPVDREMTPSFTVYFDVVERSTGKIVDTSLIFNIRISDVND
                     HAPQFPEKEFNITVQENQSAGQPIFQMLAVDLDEENTPNSQVLYFLISQTPLLKESGF
                     RVDRLSGEIRLSGCLDYETAPQFTLLIRARDCGEPSLSSTTTVHVDVQEGNNHRPAFT
                     QENYKVQIPEGRASQGVLRLLVQDRDSPFTSAWRAKFNILHGNEEGHFDISTDPETNE
                     GILNVIKPLDYETRPAQSLIIVVENEERLVFCERGKLQPPRKAAASATVSVQVTDAND
                     PPAFHPQSFIVNKEEGARPGTLLGTFNAMDPDSQIRYELVHDPANWVSVDKNSGVVIT
                     VEPIDRESPHVNNSFYVIIIHAVDDGFPPQTATGTLMLFLSDINDNVPTLRPRSRYME
                     VCESAVHEPLHIEAEDPDLEPFSDPFTFELDNTWGNAEDTWKLGRNWGQSVELLTLRS
                     LPRGNYLVPLFIGDKQGLSQKQTVHVRICPCASGLTCVELADAEVGLHVGALFPVCAA
                     FVALAVALLFLLRCYFVLEPKRHGCSVSNDEGHQTLVMYNAESKGTSAQTWSDVEGQR
                     PALLICTAAAGPTQGVKDLEEVPPSAASQSAQARCALGSWGYGKPFEPRSVKNIHSTP
                     AYPDATMHRQLLAPVEGRMAETLNQKLHVANVLEDDPGYLPHVYSEEGECGGAPSLSS
                     LASLEQELQPDLLDSLGSKATPFEEIYSESGVPS"
     exon            374..430
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /inference="alignment:Splign:2.1.0"
     exon            431..535
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /inference="alignment:Splign:2.1.0"
     exon            536..697
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /inference="alignment:Splign:2.1.0"
     exon            698..845
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1012
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1141
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1327
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1587
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1730
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1970
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2192
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2323
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2401
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2470
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2524
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2599
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..4602
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3167..3172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /note="hexamer: AATAGA"
     polyA_site      3186
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /note="major polyA site"
     regulatory      3771..3776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /note="hexamer: AATAAA"
     polyA_site      3790
                     /gene="CDH26"
                     /gene_synonym="VR20"
     regulatory      4504..4509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /note="hexamer: AATAAA"
     polyA_site      4535
                     /gene="CDH26"
                     /gene_synonym="VR20"
     regulatory      4580..4585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH26"
                     /gene_synonym="VR20"
                     /note="hexamer: GATAAA"
     polyA_site      4602
                     /gene="CDH26"
                     /gene_synonym="VR20"
ORIGIN      
        1 agccagtctt ttgtgtacgt gcaggaccat ggtggcttta gtttctaccc cacccttcct
       61 aggaactcta cttgtggcaa acgtatgttc aagcttacaa gtcagcccac cccactctga
      121 taaatgcaag aaaagctgaa aagggaggag caagatggga tgaaagcatc tgggccaaag
      181 tgacctgaaa acctttagag aagaagctgc tggctgagaa ggaggtgtgt ggctccggtg
      241 agaccaccag cttggaggac tggtcatcag ctgcacgttc tgggtctgtc ttgggtattc
      301 ccatatggcc atgagatccg ggaggcaccc ctcgctgctg ctgcttctag tgctgctgct
      361 gtggctgctg caggtcagta tcattgacag tgttcaacag gaaacagatg atcttactaa
      421 gcaaacaaag gaaaagatct accagcctct acggcgatcc aagagaagat gggttatcac
      481 caccttggag ctggaggagg aagacccggg accctttccc aaactcattg gtgagctgtt
      541 caataatatg tcttataaca tgtcactaat gtatctaatc agtggacctg gtgtggatga
      601 atatccagag attggtttgt tttctctaga agatcatgag aacggaagga tatatgttca
      661 ccgccctgtc gatcgagaaa tgacaccatc tttcacggtt tattttgatg ttgtggagcg
      721 ctcaacagga aaaattgtgg atacatcctt gattttcaac attaggatca gtgatgtgaa
      781 tgatcatgca ccccagtttc cagagaagga atttaacatc actgtgcaag aaaaccaatc
      841 tgcagggcaa cctatttttc agatgttagc agtcgatttg gatgaagaaa acactccaaa
      901 ttctcaagtc ctttacttcc tcatttctca aacaccatta ctgaaagaaa gtggtttccg
      961 ggttgatcgc cttagtggag aaatacgact ctctggctgc ttagattatg agaccgctcc
     1021 tcagtttaca ctgctaatca gagccaggga ctgtggagaa ccgtcactgt catccacgac
     1081 caccgttcac gtggatgtgc aagaaggcaa caaccacagg cctgcattta cccaggagaa
     1141 ctataaggtt cagattcctg aaggccgagc cagccagggc gtgttgcgtc tcctggttca
     1201 agatcgagat tctccattta catcagcttg gagagcaaaa ttcaacatat tgcatggcaa
     1261 tgaagagggg cattttgaca tttcgactga ccctgagacc aacgaaggga tattaaatgt
     1321 tatcaagcct ttggattatg agactcgccc agcgcaaagc ctcatcattg tcgtggagaa
     1381 tgaggagagg ctcgtcttct gtgagagagg aaagcttcag ccgccaagga aggcagcagc
     1441 cagcgccact gtgagtgtgc aggtgacaga cgccaacgac ccaccagcct ttcaccccca
     1501 gagcttcatt gtcaataaag aggagggcgc caggcctggg accctgttgg gaacttttaa
     1561 tgccatggat ccagacagcc agataagata tgaactggtt catgacccag caaattgggt
     1621 cagcgtcgac aaaaactccg gagtggtcat caccgtggag ccaattgacc gagaatcccc
     1681 tcatgtaaat aacagttttt atgtaatcat cattcacgct gttgatgatg gcttcccacc
     1741 gcagactgct acagggaccc taatgctctt cctgtctgac atcaatgaca acgtcccgac
     1801 tctccggcca cgttcccgct acatggaggt ctgtgagtct gctgtgcatg agcccctcca
     1861 catcgaggca gaggatccgg acctggagcc gttctctgac ccatttacat ttgaattgga
     1921 caatacctgg ggaaatgcgg aggacacatg gaagttgggg agaaattggg gtcaatcagt
     1981 tgaactttta accttgagaa gcctgccacg tggtaattac ttggtgccac tcttcattgg
     2041 agacaaacag ggactttccc agaagcaaac tgtccatgta aggatctgcc cctgtgccag
     2101 tgggctcaca tgtgtggagc ttgcagatgc agaagtgggg cttcatgtgg gggccctgtt
     2161 ccctgtctgt gcagcatttg tggctctggc agtggctctg ctttttctgt tgcgatgcta
     2221 ttttgtgctt gaacctaaga ggcatggatg ctctgtatcc aatgatgaag gccaccaaac
     2281 actggtcatg tataatgcgg agagcaaagg cacttcagcc cagacatggt cagatgttga
     2341 aggccagagg ccggctctgc tcatctgcac agctgcagca ggacccacgc agggagttaa
     2401 ggatctcgag gaagtgcctc catctgcagc gagtcagtca gcccaagcac gctgtgctct
     2461 ggggagctgg ggttatggca agccctttga gccaagaagt gtgaaaaaca tacactctac
     2521 tcctgcttac ccagatgcca caatgcacag acaactcctg gctccggtgg aaggaaggat
     2581 ggcagagaca ttgaatcaga aactccatgt tgccaatgtg ctggaagatg accccggcta
     2641 cctacctcac gtctacagcg aggaagggga gtgtggaggg gccccatccc tcagctctct
     2701 ggccagcttg gaacaggagt tgcaacctga tttgctggac tctttgggtt caaaagcgac
     2761 tccgtttgag gaaatatatt cagagtcagg tgttccttcc taaaaaaaaa agtctatttt
     2821 ggagaattga aataattcat ggaagggaat cactattcag ggatttttcc cctttgctct
     2881 tcttttccct ccttaaaaga aaaattacct tctagtccta ggatgaggac acactattag
     2941 tttgaattaa atgctttgat attctcagat cagccatctt gaaccaaagc aaaaccacaa
     3001 gttacacttt cttaaaattt gatttgtcat attttctaga gaaacttgaa tttaattgtg
     3061 ttattcttag cttccactgg cagcctagct ttgagggtaa atgaaaatat aacccataga
     3121 ttacccagcc acttgggaac agcaggtaat actgaagaaa aataaaaata gattttgaaa
     3181 acgttactta catttctatg attatgattc tgcttccatt taagggaaaa cttaggtaaa
     3241 tagagaaatt ttttctataa catttgtagt cagtatttga agtgattttt taaaaaataa
     3301 gtattggtcc ctgttcactt tttgattaga taaatagata aaatatgtta tcttgagaaa
     3361 aatgattatg ctgaaagctt tataaacagt atactcttta aaaaatgaag agctgacata
     3421 atttaacttg tatgtattat gtaagtaaaa gagttaggag cctttgaatg agtaagttct
     3481 gattagattt tatctttaaa caaaaccaca aaatttaatt ggtttttact tgtccactta
     3541 ctgctagtgt cagtttcagg ggaagaaatg gtttctttta aaaatcttaa taggggacat
     3601 atgccctaaa aatagtcagt tttctagtct gagtaataga taagagactg actaagcaaa
     3661 gtttaaaatg ctatttggac actttaatgc acatattgga tatctaaaag tctacagcca
     3721 tataaaaatt ttatataatt aatgagcaaa tgccgtctct catgccctaa aataaatcag
     3781 tagaaacatg tttgctggtg aatcagtgaa gcattatgtt aaacagtgag ttacagctca
     3841 gagttaaaac tttctccttc tttttgaaga agctgtgcaa atacttcttt ttaaggagat
     3901 ctggcctttt cctacctggt tacctcagtc ttcctctgct ttgggaagct gaaaaagaag
     3961 aaaaatcaca tttaaagcac tggaatgtct gaatgggacg cttgaatgtg tagaacagct
     4021 gtactgatcc tagcatgact cagaggacag tctagggcat tttctgggta attcaggata
     4081 aaagtatttt tttttttaag aaaaatacat gtttttggac aacaaaacaa agtaaacatt
     4141 agtttattcg attgcctcct tatacttgcc tctttcattc tgtcccctgt agatttttaa
     4201 aaaattatct cattttaaaa ctttattatt tcattttaaa taattgacat ataataattg
     4261 tacatattta gggggtacat agtcatgttt caatacattt acagtgatca gatcagggtg
     4321 gttaacgtaa tcattggctc aaacattttt catttctttg tattggtacg gagcattcaa
     4381 tatccatccc ccttctagct atctaaaact atgtattatt gttaactata ggcaacatat
     4441 aatggtatag agtgctagaa cgtattcctc ctaggaataa tttgctgtaa ttttgtatcc
     4501 tttaataaat ctctccctat ccctctttcc ccccaccctt cccagctgct gtgtcctctg
     4561 ttctaccttc tacttccgag ataaacttgg ttttagcttc ca
//
