LOCUS       NM_144985               3415 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens cadherin 24 (CDH24), transcript variant 2, mRNA.
ACCESSION   NM_144985
VERSION     NM_144985.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3415)
  AUTHORS   An,C.H., Je,E.M., Yoo,N.J. and Lee,S.H.
  TITLE     Frameshift mutations of cadherin genes DCHS2, CDH10 and CDH24 genes
            in gastric and colorectal cancers with high microsatellite
            instability
  JOURNAL   Pathol Oncol Res 21 (1), 181-185 (2015)
   PUBMED   24898286
  REMARK    GeneRIF: Unconventional CDH10, CDH24 and DCHS2 genes harbored
            frameshift mutations.
REFERENCE   2  (bases 1 to 3415)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   3  (bases 1 to 3415)
  AUTHORS   Katafiasz,B.J., Nieman,M.T., Wheelock,M.J. and Johnson,K.R.
  TITLE     Characterization of cadherin-24, a novel alternatively spliced type
            II cadherin
  JOURNAL   J Biol Chem 278 (30), 27513-27519 (2003)
   PUBMED   12734196
  REMARK    GeneRIF: cadherin-24 is a novel alternatively spliced type II
            cadherin
REFERENCE   4  (bases 1 to 3415)
  AUTHORS   Hulsken,J., Birchmeier,W. and Behrens,J.
  TITLE     E-cadherin and APC compete for the interaction with beta-catenin
            and the cytoskeleton
  JOURNAL   J Cell Biol 127 (6 Pt 2), 2061-2069 (1994)
   PUBMED   7806582
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC310509.1, AY260900.1, AY358199.1 and BC009332.2.
            
            On Aug 14, 2020 this sequence version replaced NM_144985.3.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.499615.1,
                                           SRR14038194.961567.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000487137.7/ ENSP00000434821.2
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               DC310509.1         19-167
            150-1756            AY260900.1         1-1607
            1757-3255           AY358199.1         1731-3229
            3256-3415           BC009332.2         1430-1589
FEATURES             Location/Qualifiers
     source          1..3415
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..3415
                     /gene="CDH24"
                     /gene_synonym="CDH11L"
                     /note="cadherin 24"
                     /db_xref="GeneID:64403"
                     /db_xref="HGNC:HGNC:14265"
                     /db_xref="MIM:618599"
     exon            1..118
                     /gene="CDH24"
                     /gene_synonym="CDH11L"
                     /inference="alignment:Splign:2.1.0"
     exon            119..443
                     /gene="CDH24"
                     /gene_synonym="CDH11L"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..2588
                     /gene="CDH24"
                     /gene_synonym="CDH11L"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cadherin 24, type 2"
                     /codon_start=1
                     /product="cadherin-24 isoform 2"
                     /protein_id="NP_659422.2"
                     /db_xref="CCDS:CCDS9586.1"
                     /db_xref="GeneID:64403"
                     /db_xref="HGNC:HGNC:14265"
                     /db_xref="MIM:618599"
                     /translation="MWGLVRLLLAWLGGWGCMGRLAAPARAWAGSREHPGPALLRTRR
                     SWVWNQFFVIEEYAGPEPVLIGKLHSDVDRGEGRTKYLLTGEGAGTVFVIDEATGNIH
                     VTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPIFPLGPYHATVP
                     EMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGLPFFSVDPQTGVVRTAIPNMDRE
                     TQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVVETAGPGT
                     LVGRLRAQDPDLGDNALMAYSILDGEGSEAFSISTDLQGRDGLLTVRKPLDFESQRSY
                     SFRVEATNTLIDPAYLRRGPFKDVASVRVAVQDAPEPPAFTQAAYHLTVPENKAPGTL
                     VGQISAADLDSPASPIRYSILPHSDPERCFSIQPEEGTIHTAAPLDREARAWHNLTVL
                     ATELDSSAQASRVQVAIQTLDENDNAPQLAEPYDTFVCDSAAPGQLIQVIRALDRDEV
                     GNSSHVSFQGPLGPDANFTVQDNRDGSASLLLPSRPAPPRHAPYLVPIELWDWGQPAL
                     SSTATVTVSVCRCQPDGSVASCWPEAHLSAAGLSTGALLAIITCVGALLALVVLFVAL
                     RRQKQEALMVLEEEDVRENIITYDDEGGGEEDTEAFDITALQNPDGAAPPAPGPPARR
                     DVLPRARVSRQPRPPGPADVAQLLALRLREADEDPGVPPYDSVQVYGYEGRGSSCGSL
                     SSLGSGSEAGGAPGPAEPLDDWGPLFRTLAELYGAKEPPAP"
     exon            444..738
                     /gene="CDH24"
                     /gene_synonym="CDH11L"
                     /inference="alignment:Splign:2.1.0"
     exon            739..858
                     /gene="CDH24"
                     /gene_synonym="CDH11L"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1026
                     /gene="CDH24"
                     /gene_synonym="CDH11L"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1214
                     /gene="CDH24"
                     /gene_synonym="CDH11L"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1468
                     /gene="CDH24"
                     /gene_synonym="CDH11L"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1605
                     /gene="CDH24"
                     /gene_synonym="CDH11L"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1727
                     /gene="CDH24"
                     /gene_synonym="CDH11L"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1839
                     /gene="CDH24"
                     /gene_synonym="CDH11L"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..2088
                     /gene="CDH24"
                     /gene_synonym="CDH11L"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..3107
                     /gene="CDH24"
                     /gene_synonym="CDH11L"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3415
                     /gene="CDH24"
                     /gene_synonym="CDH11L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3394..3399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH24"
                     /gene_synonym="CDH11L"
                     /note="hexamer: AACAAA"
     polyA_site      3415
                     /gene="CDH24"
                     /gene_synonym="CDH11L"
                     /note="major polyA site"
ORIGIN      
        1 agacctgcag cggagccgcg gcgcccgctc caatcggctc ggggctgtgc ccccgggacc
       61 cggcgacggg ggcgggcggg ggcgcttccc gccggcctgg gcccctcggc agtgccaggt
      121 gtggatccat ggggtagcct caacgcatct gcccctccac cccagccagc tcatgggcca
      181 cgtggcctgg cccagcctca gcacccaggg ccagtgaaca gagccctggc tggagtccaa
      241 acatgtgggg cctggtgagg ctcctgctgg cctggctggg tggctggggc tgcatggggc
      301 gtctggcagc cccagcccgg gcctgggcag ggtcccggga acacccaggg cctgctctgc
      361 tgcggactcg aaggagctgg gtctggaacc agttctttgt cattgaggaa tatgctggtc
      421 cagagcctgt tctcattggc aagctgcact cggatgttga ccggggagag ggccgcacca
      481 agtacctgtt gaccggggag ggggcaggca ccgtatttgt gattgatgag gccacaggca
      541 atattcatgt taccaagagc cttgaccggg aggaaaaggc gcaatatgtg ctactggccc
      601 aagccgtgga ccgagcctcc aaccggcccc tggagccccc atcagagttc atcatcaaag
      661 tgcaagacat caacgacaat ccacccattt ttccccttgg gccctaccat gccaccgtgc
      721 ccgagatgtc caatgtcggg acatcagtga tccaggtgac tgctcacgat gctgatgacc
      781 ccagctatgg gaacagtgcc aagctggtgt acactgttct ggatggactg cctttcttct
      841 ctgtggaccc ccagactgga gtggtgcgta cagccatccc caacatggac cgggagacac
      901 aggaggagtt cttggtggtg atccaggcca aggacatggg cggccacatg ggggggctgt
      961 caggcagcac tacggtgact gtcacgctca gcgatgtcaa cgacaacccc cccaagttcc
     1021 cacagagcct ataccagttc tccgtggtgg agacagctgg acctggcaca ctggtgggcc
     1081 ggctccgggc ccaggaccca gacctggggg acaacgccct gatggcatac agcatcctgg
     1141 atggggaggg gtctgaggcc ttcagcatca gcacagactt gcagggtcga gacgggctcc
     1201 tcactgtccg caagccccta gactttgaga gccagcgctc ctactccttc cgtgtcgagg
     1261 ccaccaacac gctcattgac ccagcctatc tgcggcgagg gcccttcaag gatgtggcct
     1321 ctgtgcgtgt ggcagtgcaa gatgccccag agccacctgc cttcacccag gctgcctacc
     1381 acctgacagt gcctgagaac aaggccccgg ggaccctggt aggccagatc tccgcggctg
     1441 acctggactc ccctgccagc ccaatcagat actccatcct cccccactca gatccggagc
     1501 gttgcttctc tatccagccc gaggaaggca ccatccatac agcagcaccc ctggatcgcg
     1561 aggctcgcgc ctggcacaac ctcactgtgc tggctacaga gctcgacagt tctgcacagg
     1621 cctcgcgcgt gcaagtggcc atccagaccc tggatgagaa tgacaatgct ccccagctgg
     1681 ctgagcccta cgatactttt gtgtgtgact ctgcagctcc tggccagctg attcaggtca
     1741 tccgggccct ggacagagat gaagttggca acagtagcca tgtctccttt caaggtcctc
     1801 tgggccctga tgccaacttt actgtccagg acaaccgaga tggctccgcc agcctgctgc
     1861 tgccctcccg ccctgctcca ccccgccatg ccccctactt ggttcccata gaactgtggg
     1921 actgggggca gccggcgctg agcagcactg ccacagtgac tgttagtgtg tgccgctgcc
     1981 agcctgacgg ctctgtggca tcctgctggc ctgaggctca cctctcagct gctgggctca
     2041 gcaccggcgc cctgcttgcc atcatcacct gtgtgggtgc cctgcttgcc ctggtggtgc
     2101 tcttcgtggc cctgcggcgg cagaagcaag aagcactgat ggtactggag gaggaggacg
     2161 tccgagagaa catcatcacc tacgacgacg agggcggcgg cgaggaggac accgaggcct
     2221 tcgacatcac ggccttgcag aacccggacg gggcggcccc cccggcgccc ggccctcccg
     2281 cgcgccgaga cgtgttgccc cgggcccggg tgtcgcgcca gcccagaccc cccggccccg
     2341 ccgacgtggc gcagctcctg gcgctgcggc tccgcgaggc ggacgaggac cccggcgtac
     2401 ccccgtacga ctcggtgcag gtgtacggct acgagggccg cggctcctct tgcggctccc
     2461 tcagctccct gggctccggc agcgaagccg gcggcgcccc cggccccgcg gagccgctgg
     2521 acgactgggg tccgctcttc cgcaccctgg ccgagctgta tggggccaag gagcccccgg
     2581 ccccctgagc gcccgggctg gcccggccca ccgcgggggg ggggcagcgg gcacaggccc
     2641 tctgagtgag ccccacgggg tccaggcggg cggcagcagc ccaggggccc caggcctcct
     2701 ccctgtcctt gtgtccctcc ttgcttcccc ggggcaccct cgctctcacc tccctcctcc
     2761 tgagtcggtg tgtgtgtctc tctccaggaa tctttgtctc tatctgtgac acgctcctct
     2821 gtccgggcct gggtttcctg ccctggccct ggccctgcga tctctcactg tgattcctct
     2881 ccttcctccg tggcgttttg tctctgcagt tctgaagctc acacatagtc tccctgcgtc
     2941 ttccttgccc atacacatgc tctgtgtctg tctcctgccc acatctccct tccttctctc
     3001 tgggtccctg tgactggctt tttgtttttt tctgttgtcc atcccaaaat caagagaaac
     3061 ttccagccac tgctgcccac cctcctgcag gggatgttgt gccccagacc tgcctgcatg
     3121 gttccatcca ttactcatgg cctcagcctc atcctggctc cactggcctc cagctgagag
     3181 agggaaccag cctgcctccc agggcaagag ctccagcctc ccgtgtggcc gcctccctgg
     3241 agctctgccc agctgtcagc ttcccctggg catcccagcc ctgggcattg tcttgtgtgc
     3301 ttcctgaggg agtagggaaa ggaaaggggg aggcggctgg ggaaggggaa agagggagga
     3361 aggggagggg cctccatctc taatttcata ataaacaaac actttatttt gtaaa
//
