LOCUS       NM_021248               3897 bp    mRNA    linear   PRI 17-APR-2022
DEFINITION  Homo sapiens cadherin 22 (CDH22), mRNA.
ACCESSION   NM_021248
VERSION     NM_021248.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3897)
  AUTHORS   Kelly NJ, Varga JFA, Specker EJ, Romeo CM, Coomber BL and Uniacke
            J.
  TITLE     Hypoxia activates cadherin-22 synthesis via eIF4E2 to drive cancer
            cell migration, invasion and adhesion
  JOURNAL   Oncogene 37 (5), 651-662 (2018)
   PUBMED   28991229
  REMARK    GeneRIF: cadherin-22 is upregulated in hypoxia via
            mTORC1-independent translational control by the initiation factor
            eIF4E2 functioning as a hypoxia-specific cell-surface molecule
            involved in cancer cell migration, invasion and adhesion.
REFERENCE   2  (bases 1 to 3897)
  AUTHORS   Martin-Sanchez E, Mendaza S, Ulazia-Garmendia A,
            Monreal-Santesteban I, Cordoba A, Vicente-Garcia F, Blanco-Luquin
            I, De La Cruz S, Aramendia A and Guerrero-Setas D.
  TITLE     CDH22 hypermethylation is an independent prognostic biomarker in
            breast cancer
  JOURNAL   Clin Epigenetics 9, 7 (2017)
   PUBMED   28149335
  REMARK    GeneRIF: Results present evidence that CDH22 is hypermethylated and
            its expression is downregulated in breast cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3897)
  AUTHORS   Lauc G, Huffman JE, Pucic M, Zgaga L, Adamczyk B, Muzinic A,
            Novokmet M, Polasek O, Gornik O, Kristic J, Keser T, Vitart V,
            Scheijen B, Uh HW, Molokhia M, Patrick AL, McKeigue P, Kolcic I,
            Lukic IK, Swann O, van Leeuwen FN, Ruhaak LR, Houwing-Duistermaat
            JJ, Slagboom PE, Beekman M, de Craen AJ, Deelder AM, Zeng Q, Wang
            W, Hastie ND, Gyllensten U, Wilson JF, Wuhrer M, Wright AF, Rudd
            PM, Hayward C, Aulchenko Y, Campbell H and Rudan I.
  TITLE     Loci associated with N-glycosylation of human immunoglobulin G show
            pleiotropy with autoimmune diseases and haematological cancers
  JOURNAL   PLoS Genet. 9 (1), e1003225 (2013)
   PUBMED   23382691
REFERENCE   4  (bases 1 to 3897)
  AUTHORS   Lewis JP, Palmer ND, Ellington JB, Divers J, Ng MC, Lu L, Langefeld
            CD, Freedman BI and Bowden DW.
  TITLE     Analysis of candidate genes on chromosome 20q12-13.1 reveals
            evidence for BMI mediated association of PREX1 with type 2 diabetes
            in European Americans
  JOURNAL   Genomics 96 (4), 211-219 (2010)
   PUBMED   20650312
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   5  (bases 1 to 3897)
  AUTHORS   Liu Y, Zhou J, Chen J, Gao W, Le Y, Ding Y and Li J.
  TITLE     PRL-3 promotes epithelial mesenchymal transition by regulating
            cadherin directly
  JOURNAL   Cancer Biol. Ther. 8 (14), 1352-1359 (2009)
   PUBMED   19440036
  REMARK    GeneRIF: PRL-3 promoted downregulation of CDH22 expression.
REFERENCE   6  (bases 1 to 3897)
  AUTHORS   Zhou J, Li J, Chen J, Liu Y, Gao W and Ding Y.
  TITLE     Over-expression of CDH22 is associated with tumor progression in
            colorectal cancer
  JOURNAL   Tumour Biol. 30 (3), 130-140 (2009)
   PUBMED   19546606
  REMARK    GeneRIF: Our results reveal for the first time a new role of CDH22
            in progression of colorectal cancer.
REFERENCE   7  (bases 1 to 3897)
  AUTHORS   Bento JL, Palmer ND, Zhong M, Roh B, Lewis JP, Wing MR, Pandya H,
            Freedman BI, Langefeld CD, Rich SS, Bowden DW and Mychaleckyj JC.
  TITLE     Heterogeneity in gene loci associated with type 2 diabetes on human
            chromosome 20q13.1
  JOURNAL   Genomics 92 (4), 226-234 (2008)
   PUBMED   18602983
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3897)
  AUTHORS   Wu J, Jester WF Jr, Laslett AL, Meinhardt A and Orth JM.
  TITLE     Expression of a novel factor, short-type PB-cadherin, in Sertoli
            cells and spermatogenic stem cells of the neonatal rat testis
  JOURNAL   J. Endocrinol. 176 (3), 381-391 (2003)
   PUBMED   12630923
REFERENCE   9  (bases 1 to 3897)
  AUTHORS   Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M,
            Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow
            KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE,
            Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C,
            Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee
            CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A,
            Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA,
            Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths
            MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S,
            Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K,
            Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A,
            Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM,
            Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray
            AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver
            K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ,
            Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE,
            Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C,
            Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L,
            Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis
            JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA,
            Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S and
            Rogers J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   10 (bases 1 to 3897)
  AUTHORS   Sugimoto K, Honda S, Yamamoto T, Ueki T, Monden M, Kaji A,
            Matsumoto K and Nakamura T.
  TITLE     Molecular cloning and characterization of a newly identified member
            of the cadherin family, PB-cadherin
  JOURNAL   J. Biol. Chem. 271 (19), 11548-11556 (1996)
   PUBMED   8626716
  REMARK    GeneRIF: This paper deals primarily with the rat ortholog of the
            human CDH22 gene.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK289584.1, BC039056.1 and
            BQ102264.1.
            
            On May 17, 2019 this sequence version replaced NM_021248.2.
            
            Summary: This gene is a member of the cadherin superfamily. The
            gene product is composed of five cadherin repeat domains and a
            cytoplasmic tail similar to the highly conserved cytoplasmic region
            of classical cadherins. Expressed predominantly in the brain, this
            putative calcium-dependent cell adhesion protein may play an
            important role in morphogenesis and tissue formation in neural and
            non-neural cells during development and maintenance of the brain
            and neuroendocrine organs. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289584.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968832 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000537909.4/ ENSP00000437790.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2398              AK289584.1         1-2398
            2399-3477           BC039056.1         344-1422
            3478-3897           BQ102264.1         18-437              c
FEATURES             Location/Qualifiers
     source          1..3897
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..3897
                     /gene="CDH22"
                     /gene_synonym="C20orf25; dJ998H6.1"
                     /note="cadherin 22"
                     /db_xref="GeneID:64405"
                     /db_xref="HGNC:HGNC:13251"
                     /db_xref="MIM:609920"
     exon            1..244
                     /gene="CDH22"
                     /gene_synonym="C20orf25; dJ998H6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            245..898
                     /gene="CDH22"
                     /gene_synonym="C20orf25; dJ998H6.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             644..3130
                     /gene="CDH22"
                     /gene_synonym="C20orf25; dJ998H6.1"
                     /note="cadherin-like 22; ortholog of rat PB-cadherin;
                     cadherin 22, type 2; pituitary and brain cadherin"
                     /codon_start=1
                     /product="cadherin-22 precursor"
                     /protein_id="NP_067071.1"
                     /db_xref="CCDS:CCDS13395.1"
                     /db_xref="GeneID:64405"
                     /db_xref="HGNC:HGNC:13251"
                     /db_xref="MIM:609920"
                     /translation="MRPRPEGRGLRAGVALSPALLLLLLLPPPPTLLGRLWAAGTPSP
                     SAPGARQDGALGAGRVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGAIKYTIS
                     GEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQD
                     INDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFT
                     VDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPR
                     FPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKDESSSGGDVFKVTTDSD
                     TQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPP
                     EFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRESDLDQIFDIDADTGA
                     IVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVC
                     EDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDNTAAVHTQHVG
                     FNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCNTTAFVMAASLSP
                     GALIALLVCVLILVVLVLLILTLRRHHKSHLSSDEDEDMRDNVIKYNDEGGGEQDTEA
                     YDMSALRSLYDFGELKGGDGGGSAGGGAGGGSGGGAGSPPQAHLPSERHSLPQGPPSP
                     EPDFSVFRDFISRKVALADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGSSGSEQD
                     FAYLSSWGPRFRPLAALYAGHRGDDEAQAS"
     exon            899..1193
                     /gene="CDH22"
                     /gene_synonym="C20orf25; dJ998H6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1313
                     /gene="CDH22"
                     /gene_synonym="C20orf25; dJ998H6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1481
                     /gene="CDH22"
                     /gene_synonym="C20orf25; dJ998H6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1675
                     /gene="CDH22"
                     /gene_synonym="C20orf25; dJ998H6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1929
                     /gene="CDH22"
                     /gene_synonym="C20orf25; dJ998H6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2066
                     /gene="CDH22"
                     /gene_synonym="C20orf25; dJ998H6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2188
                     /gene="CDH22"
                     /gene_synonym="C20orf25; dJ998H6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2306
                     /gene="CDH22"
                     /gene_synonym="C20orf25; dJ998H6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2558
                     /gene="CDH22"
                     /gene_synonym="C20orf25; dJ998H6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..3897
                     /gene="CDH22"
                     /gene_synonym="C20orf25; dJ998H6.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3874..3879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH22"
                     /gene_synonym="C20orf25; dJ998H6.1"
                     /note="hexamer: AATAAA"
     polyA_site      3897
                     /gene="CDH22"
                     /gene_synonym="C20orf25; dJ998H6.1"
                     /note="major polyA site"
ORIGIN      
        1 agacacgcac actccctcgc tcccgctcgc tcgctcactc cctcgctctc tcgctctctc
       61 gctctctcgc tcacacacac gcgcgcacac gccgccgcgg ctccccctct cgctcccgct
      121 ctccctccgg ctcctgcggg cggccgcggg gctccggact cgcccgctgc ccgcgccggg
      181 gctcccgccc cacgcagcgt cccgaggcgg caggactagg gggagccccg ggccgctccc
      241 cgaggctcct gatggaaagg gaaggcccct agtcctggca ggatctgccg gccccaaccc
      301 gcatcctttc tgcgcaggaa ccatggcgct tccccgactc tggagctgtc caggtgctgc
      361 ctggtgatcc gcacgcgacg cggcgacggg ggcgcgggcg ggcaccccgg gggctgtcca
      421 tgccccggat gcggccgcgc cccctccccc tccagccggg tacccccgcg gctgggcggc
      481 gttcagggcc gcgggcccgt ccgggtgccc cgtcgggggc gacatcccgg cggccgcgct
      541 gaggccacca tgtgacacgg cgccgcatcg ttgtgcgacc aagcagcggc gccctggtgc
      601 ctctcgtcca tgctcctggg ccccagcccc gcgcaggcca aggatgaggc cgaggcccga
      661 aggtaggggg ctccgggcgg gagtcgcgct gtcccccgcg ctactgctgc tgctgctgct
      721 gccgccgccg ccgacgctgc tggggcgcct gtgggcagcg ggcacaccct cgccgtcggc
      781 gcccggagct cggcaggacg gcgcgctggg agccggccgc gtcaaacgcg gctgggtgtg
      841 gaaccagttc ttcgtggtag aggagtacac gggcacggag cccctgtatg tgggcaagat
      901 ccactccgac tcagacgagg gtgacggggc catcaagtac accatctcag gcgagggtgc
      961 tgggaccatc ttcctgatcg acgagctgac aggcgacatt catgccatgg agcgcctgga
     1021 ccgcgagcag aaaaccttct acacgctgcg ggcccaggct cgggatcgcg ccaccaaccg
     1081 cctactggag cccgagtcgg agttcatcat caaggtgcag gacatcaatg acagtgagcc
     1141 ccgcttcctg cacggcccct atattggcag cgtggccgag ctctcaccta caggcacgtc
     1201 ggtgatgcag gtgatggcct cggatgcgga tgaccccacg tacggcagca gcgctcggct
     1261 ggtgtacagc gtgctggacg gcgagcacca cttcaccgtg gaccccaaga ccggcgtaat
     1321 ccggacggct gtgcctgacc ttgaccgcga gagccaggag cgctacgagg tggtgatcca
     1381 ggccacagac atggcgggtc agctgggtgg cctctcgggc tccactaccg tcaccatcgt
     1441 agtcaccgac gtcaatgaca acccgccccg tttcccgcag aagatgtacc agttcagcat
     1501 ccaggagtca gcccccattg gaacggctgt gggacgtgtg aaggctgagg actcagacgt
     1561 gggagagaac acagacatga cttaccacct taaggacgag agcagcagcg gcggcgatgt
     1621 gttcaaggtc accacagaca gcgacactca ggaggccatc atcgtagtgc agaagcgcct
     1681 ggacttcgaa tcccagcccg tgcacaccgt gatcctggag gccctcaaca agttcgtgga
     1741 cccccgcttc gccgacctgg gcacgttccg cgaccaggcg atcgtgcgcg tggccgtgac
     1801 cgacgtggac gagccccccg agttccggcc gccctccggc ctcctggagg tgcaggagga
     1861 cgcgcaggtg ggctccctgg tcggcgtggt gacggcgcgg gaccccgacg ccgccaaccg
     1921 gcccgtccgg tacgccattg accgcgaatc agatttggac cagatcttcg atatcgatgc
     1981 ggacacaggc gccatcgtga ctggcaaggg gctggaccgc gagacggccg gctggcacaa
     2041 catcacagtg ctggccatgg aggcggacaa tcatgcacag ctatcccggg catccctaag
     2101 gatccgaatc ctggatgtga acgacaatcc cccagaactg gccacaccct acgaggcagc
     2161 tgtatgcgag gatgccaagc caggccagct catccagacc atcagcgtgg tggacagaga
     2221 cgagccccaa ggcgggcacc gcttctattt ccgcctggtg cctgaagctc ccagcaaccc
     2281 tcatttctct ctgcttgaca tccaagacaa caccgctgca gtgcacacgc agcacgtggg
     2341 cttcaaccgg caggagcagg acgtgttctt cctgcccatc ctggtggtag acagtgggcc
     2401 gcccacactg agcagcacag gcacgctcac catccgcatc tgtggctgcg acagctccgg
     2461 caccatccag tcctgcaaca ccacggcctt tgtcatggcc gcctccctca gccccggcgc
     2521 cctcatcgcc ctcttggtct gcgttctcat cctggttgtg ctggtgctgc tgatcctcac
     2581 cctcaggcgc caccacaaga gccacctgag ctcggacgag gatgaagaca tgcgggacaa
     2641 cgtcatcaaa tacaacgacg aaggcggcgg cgagcaggac accgaagcct acgacatgtc
     2701 ggcgctgcgg agcctctacg acttcggcga gctcaagggc ggcgacgggg gcggcagcgc
     2761 gggcggggga gcgggcgggg gctcgggcgg gggcgcgggc agccccccgc aggcccacct
     2821 gccctccgag cgccactcgc tgccgcaggg gccgccgagc cccgagccag acttctcagt
     2881 gttcagggac ttcatcagcc gcaaggtggc actggcggac ggggacctgt cggtgccgcc
     2941 ctacgacgcc ttccagacct acgccttcga gggcgcggac tcgccggccg cctcgctcag
     3001 ctccctgcac agcggctcgt cgggctccga gcaggacttc gcctatctca gcagctgggg
     3061 tccgcgcttc cggcccctgg ccgcgctcta cgccggccac cgcggggacg acgaggccca
     3121 ggcctcctag cccctcgccc tgccgtcggg gcgcggctgc tcacccgccc agcacacgcc
     3181 ggggccccag gacaacgcgt ttcccccgcg gacccccttt cctgccctcc cccaaccctc
     3241 ccttggcggc tggacggagg ggggacttgc taggagcgga ctcttccatt cctcctcctc
     3301 taggggtgca gctttggagc ccagaggtgc gggattctga ccaacggcat taaaactgag
     3361 gcgagaccgg gcacggtgtg gctctggggt tagaatggga gatgggggtg gcgttgcaga
     3421 gtcgggaagg ggcgggtcac tcaatcctgg cctgggggag aatgctggag ggagcacgcc
     3481 gctgagatgc ccccacccca ggtttccccc atcagagtta agaggaaaga aggctgttca
     3541 cttactaagc acctactgtg tgctgggacg ctgtacagag accagctcag tcgtcagaga
     3601 aaccatgagg tggtgtcctg cacggaatag aaggggaaag gaccccagag aagtggctgt
     3661 gacccgtcca agggcacctg gccagtgaat ggcagagcct ctggcactga ccagctgcct
     3721 ggcctcgggc aagtcacttc acttctctgg tcctcagttt cctcatctgt caaatggggt
     3781 taataacaga acctacctcg aagagttgtg aggctaaaaa gggttcatat gtgtcaagtg
     3841 gttaggacag tgcctggcac atagtaggtg ttcaataaat gctagccttt gttacta
//
