LOCUS       NM_001792               4016 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cadherin 2 (CDH2), transcript variant 1, mRNA.
ACCESSION   NM_001792
VERSION     NM_001792.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4016)
  AUTHORS   Kim,D., Olson,J.M. and Cooper,J.A.
  TITLE     N-cadherin dynamically regulates pediatric glioma cell migration in
            complex environments
  JOURNAL   J Cell Biol 223 (6) (2024)
   PUBMED   38477830
  REMARK    GeneRIF: N-cadherin dynamically regulates pediatric glioma cell
            migration in complex environments.
REFERENCE   2  (bases 1 to 4016)
  AUTHORS   Wang,L., Tsakiroglou,P., Gonzales,R., Cho,S., Li,A., Dos
            Remedios,C., Wright,N. and Kontrogianni-Konstantopoulos,A.
  TITLE     Essential role of obscurin kinase-1 in cardiomyocyte coupling via
            N-cadherin phosphorylation
  JOURNAL   JCI Insight 9 (3), e162178 (2024)
   PUBMED   38127465
  REMARK    GeneRIF: Essential role of obscurin kinase-1 in cardiomyocyte
            coupling via N-cadherin phosphorylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4016)
  AUTHORS   Wu,S., Liu,M., Zhang,M., Ye,X., Gu,H., Jiang,C., Zhu,H., Ye,X.,
            Li,Q., Huang,X. and Cao,M.
  TITLE     The gene expression of CALD1, CDH2, and POSTN in fibroblast are
            related to idiopathic pulmonary fibrosis
  JOURNAL   Front Immunol 15, 1275064 (2024)
   PUBMED   38370408
  REMARK    GeneRIF: The gene expression of CALD1, CDH2, and POSTN in
            fibroblast are related to idiopathic pulmonary fibrosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4016)
  AUTHORS   Zou,L., Wang,Y., Hu,Y., Liu,L., Luo,L., Chen,Z., Zhuo,Y., Li,P. and
            Zhou,Q.
  TITLE     N-cadherin Alleviates Apoptosis and Senescence of Nucleus Pulposus
            Cells via Suppressing ROS-dependent ERS in the Hyper-osmolarity
            Microenvironment
  JOURNAL   Int J Med Sci 21 (2), 341-356 (2024)
   PUBMED   38169592
  REMARK    GeneRIF: N-cadherin Alleviates Apoptosis and Senescence of Nucleus
            Pulposus Cells via Suppressing ROS-dependent ERS in the
            Hyper-osmolarity Microenvironment.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4016)
  AUTHORS   Alimperti,S. and Andreadis,S.T.
  TITLE     CDH2 and CDH11 act as regulators of stem cell fate decisions
  JOURNAL   Stem Cell Res 14 (3), 270-282 (2015)
   PUBMED   25771201
  REMARK    GeneRIF: Existing knowledge regarding the role of CDH2 and CDH11
            during development and differentiation in vivo and in vitro is
            reviewed. [review]
            Review article
REFERENCE   6  (bases 1 to 4016)
  AUTHORS   Sacco,P.A., McGranahan,T.M., Wheelock,M.J. and Johnson,K.R.
  TITLE     Identification of plakoglobin domains required for association with
            N-cadherin and alpha-catenin
  JOURNAL   J Biol Chem 270 (34), 20201-20206 (1995)
   PUBMED   7650039
REFERENCE   7  (bases 1 to 4016)
  AUTHORS   Knudsen,K.A. and Wheelock,M.J.
  TITLE     Plakoglobin, or an 83-kD homologue distinct from beta-catenin,
            interacts with E-cadherin and N-cadherin
  JOURNAL   J Cell Biol 118 (3), 671-679 (1992)
   PUBMED   1639850
REFERENCE   8  (bases 1 to 4016)
  AUTHORS   Salomon,D., Ayalon,O., Patel-King,R., Hynes,R.O. and Geiger,B.
  TITLE     Extrajunctional distribution of N-cadherin in cultured human
            endothelial cells
  JOURNAL   J Cell Sci 102 (Pt 1), 7-17 (1992)
   PUBMED   1500442
REFERENCE   9  (bases 1 to 4016)
  AUTHORS   Reid,R.A. and Hemperly,J.J.
  TITLE     Human N-cadherin: nucleotide and deduced amino acid sequence
  JOURNAL   Nucleic Acids Res 18 (19), 5896 (1990)
   PUBMED   2216790
REFERENCE   10 (bases 1 to 4016)
  AUTHORS   Walsh,F.S., Barton,C.H., Putt,W., Moore,S.E., Kelsell,D., Spurr,N.
            and Goodfellow,P.N.
  TITLE     N-cadherin gene maps to human chromosome 18 and is not linked to
            the E-cadherin gene
  JOURNAL   J Neurochem 55 (3), 805-812 (1990)
   PUBMED   2384753
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006249.1, AC015933.9 and
            AC110015.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001792.4.
            
            Summary: This gene encodes a classical cadherin and member of the
            cadherin superfamily. Alternative splicing results in multiple
            transcript variants, at least one of which encodes a preproprotein
            is proteolytically processed to generate a calcium-dependent cell
            adhesion molecule and glycoprotein. This protein plays a role in
            the establishment of left-right asymmetry, development of the
            nervous system and the formation of cartilage and bone. [provided
            by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036470.1, S42303.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269141.8/ ENSP00000269141.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               AC006249.1         154023-154190
            169-280             AC006249.1         183369-183480
            281-507             AC015933.9         125784-126010       c
            508-654             AC015933.9         123947-124093       c
            655-810             AC015933.9         121818-121973       c
            811-955             AC015933.9         117950-118094       c
            956-1128            AC015933.9         115098-115270       c
            1129-1266           AC110015.5         165134-165271       c
            1267-1452           AC110015.5         164289-164474       c
            1453-1706           AC110015.5         161731-161984       c
            1707-1849           AC110015.5         160158-160300       c
            1850-2083           AC110015.5         157162-157395       c
            2084-2317           AC110015.5         156634-156867       c
            2318-2457           AC110015.5         154578-154717       c
            2458-2622           AC110015.5         134991-135155       c
            2623-4016           AC110015.5         122600-123993       c
FEATURES             Location/Qualifiers
     source          1..4016
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..4016
                     /gene="CDH2"
                     /gene_synonym="ACOGS; ADHD8; ARVD14; CD325; CDHN; CDw325;
                     NCAD"
                     /note="cadherin 2"
                     /db_xref="GeneID:1000"
                     /db_xref="HGNC:HGNC:1759"
                     /db_xref="MIM:114020"
     exon            1..168
                     /gene="CDH2"
                     /gene_synonym="ACOGS; ADHD8; ARVD14; CD325; CDHN; CDw325;
                     NCAD"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..2829
                     /gene="CDH2"
                     /gene_synonym="ACOGS; ADHD8; ARVD14; CD325; CDHN; CDw325;
                     NCAD"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; neural cadherin; calcium-dependent adhesion
                     protein, neuronal; N-cadherin 1; cadherin 2, type 1,
                     N-cadherin (neuronal)"
                     /codon_start=1
                     /product="cadherin-2 isoform 1 preproprotein"
                     /protein_id="NP_001783.2"
                     /db_xref="CCDS:CCDS11891.1"
                     /db_xref="GeneID:1000"
                     /db_xref="HGNC:HGNC:1759"
                     /db_xref="MIM:114020"
                     /translation="MCRIAGALRTLLPLLAALLQASVEASGEIALCKTGFPEDVYSAV
                     LSKDVHEGQPLLNVKFSNCNGKRKVQYESSEPADFKVDEDGMVYAVRSFPLSSEHAKF
                     LIYAQDKETQEKWQVAVKLSLKPTLTEESVKESAEVEEIVFPRQFSKHSGHLQRQKRD
                     WVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQ
                     LSVTKPLDREQIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGTV
                     PEGSKPGTYVMTVTAIDADDPNALNGMLRYRIVSQAPSTPSPNMFTINNETGDIITVA
                     AGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVP
                     ENRVDIIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFAIQTDPNSNDGLVTVVKPI
                     DFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEE
                     GLHAGTMLTTFTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNV
                     KNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPDPNSINIT
                     ALDYDIDPNAGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLKIKFLEAGIYEVPIII
                     TDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVL
                     MFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEP
                     DAIKPVGIRRMDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLL
                     VFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYGGGDD"
     exon            169..280
                     /gene="CDH2"
                     /gene_synonym="ACOGS; ADHD8; ARVD14; CD325; CDHN; CDw325;
                     NCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            281..507
                     /gene="CDH2"
                     /gene_synonym="ACOGS; ADHD8; ARVD14; CD325; CDHN; CDw325;
                     NCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            508..654
                     /gene="CDH2"
                     /gene_synonym="ACOGS; ADHD8; ARVD14; CD325; CDHN; CDw325;
                     NCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            655..810
                     /gene="CDH2"
                     /gene_synonym="ACOGS; ADHD8; ARVD14; CD325; CDHN; CDw325;
                     NCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            811..955
                     /gene="CDH2"
                     /gene_synonym="ACOGS; ADHD8; ARVD14; CD325; CDHN; CDw325;
                     NCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1128
                     /gene="CDH2"
                     /gene_synonym="ACOGS; ADHD8; ARVD14; CD325; CDHN; CDw325;
                     NCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1266
                     /gene="CDH2"
                     /gene_synonym="ACOGS; ADHD8; ARVD14; CD325; CDHN; CDw325;
                     NCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1452
                     /gene="CDH2"
                     /gene_synonym="ACOGS; ADHD8; ARVD14; CD325; CDHN; CDw325;
                     NCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1706
                     /gene="CDH2"
                     /gene_synonym="ACOGS; ADHD8; ARVD14; CD325; CDHN; CDw325;
                     NCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1849
                     /gene="CDH2"
                     /gene_synonym="ACOGS; ADHD8; ARVD14; CD325; CDHN; CDw325;
                     NCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2083
                     /gene="CDH2"
                     /gene_synonym="ACOGS; ADHD8; ARVD14; CD325; CDHN; CDw325;
                     NCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2317
                     /gene="CDH2"
                     /gene_synonym="ACOGS; ADHD8; ARVD14; CD325; CDHN; CDw325;
                     NCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2457
                     /gene="CDH2"
                     /gene_synonym="ACOGS; ADHD8; ARVD14; CD325; CDHN; CDw325;
                     NCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2622
                     /gene="CDH2"
                     /gene_synonym="ACOGS; ADHD8; ARVD14; CD325; CDHN; CDw325;
                     NCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..4016
                     /gene="CDH2"
                     /gene_synonym="ACOGS; ADHD8; ARVD14; CD325; CDHN; CDw325;
                     NCAD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3992..3997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH2"
                     /gene_synonym="ACOGS; ADHD8; ARVD14; CD325; CDHN; CDw325;
                     NCAD"
                     /note="hexamer: AATAAA"
     polyA_site      4016
                     /gene="CDH2"
                     /gene_synonym="ACOGS; ADHD8; ARVD14; CD325; CDHN; CDw325;
                     NCAD"
                     /note="major polyA site"
ORIGIN      
        1 gccgtttctc cgcgccgctg ttggtgctgc cgctgcctcc tcctcctccg ccgccgccgc
       61 cgccgccgcc gcctcctccg gctcttcgct cggcccctct ccgcctccat gtgccggata
      121 gcgggagcgc tgcggaccct gctgccgctg ctggcggccc tgcttcaggc gtctgtagag
      181 gcttctggtg aaatcgcatt atgcaagact ggatttcctg aagatgttta cagtgcagtc
      241 ttatcgaagg atgtgcatga aggacagcct cttctcaatg tgaagtttag caactgcaat
      301 ggaaaaagaa aagtacaata tgagagcagt gagcctgcag attttaaggt ggatgaagat
      361 ggcatggtgt atgccgtgag aagctttcca ctctcttctg agcatgccaa gttcctgata
      421 tatgcccaag acaaagagac ccaggaaaag tggcaagtgg cagtaaaatt gagcctgaag
      481 ccaaccttaa ctgaggagtc agtgaaggag tcagcagaag ttgaagaaat agtgttccca
      541 agacaattca gtaagcacag tggccaccta caaaggcaga agagagactg ggtcatccct
      601 ccaatcaact tgccagaaaa ctccagggga ccttttcctc aagagcttgt caggatcagg
      661 tctgatagag ataaaaacct ttcactgcgg tacagtgtaa ctgggccagg agctgaccag
      721 cctccaactg gtatcttcat tatcaacccc atctcgggtc agctgtcggt gacaaagccc
      781 ctggatcgcg agcagatagc ccggtttcat ttgagggcac atgcagtaga tattaatgga
      841 aatcaagtgg agaaccccat tgacattgtc atcaatgtta ttgacatgaa tgacaacaga
      901 cctgagttct tacaccaggt ttggaatggg acagttcctg agggatcaaa gcctggaaca
      961 tatgtgatga ccgtaacagc aattgatgct gacgatccca atgccctcaa tgggatgttg
     1021 aggtacagaa tcgtgtctca ggctccaagc accccttcac ccaacatgtt tacaatcaac
     1081 aatgagactg gtgacatcat cacagtggca gctggacttg atcgagaaaa agtgcaacag
     1141 tatacgttaa taattcaagc tacagacatg gaaggcaatc ccacatatgg cctttcaaac
     1201 acagccacgg ccgtcatcac agtgacagat gtcaatgaca atcctccaga gtttactgcc
     1261 atgacgtttt atggtgaagt tcctgagaac agggtagaca tcatagtagc taatctaact
     1321 gtgaccgata aggatcaacc ccatacacca gcctggaacg cagtgtacag aatcagtggc
     1381 ggagatccta ctggacggtt cgccatccag accgacccaa acagcaacga cgggttagtc
     1441 accgtggtca aaccaatcga ctttgaaaca aataggatgt ttgtccttac tgttgctgca
     1501 gaaaatcaag tgccattagc caagggaatt cagcaccccc ctcagtcaac tgcaaccgtg
     1561 tctgttacag ttattgacgt aaatgaaaac ccttattttg cccccaatcc taagatcatt
     1621 cgccaagaag aagggcttca tgccggtacc atgttgacaa cattcactgc tcaggaccca
     1681 gatcgatata tgcagcaaaa tattagatac actaaattat ctgatcctgc caattggcta
     1741 aaaatagatc ctgtgaatgg acaaataact acaattgctg ttttggaccg agaatcacca
     1801 aatgtgaaaa acaatatata taatgctact ttccttgctt ctgacaatgg aattcctcct
     1861 atgagtggaa caggaacgct gcagatctat ttacttgata ttaatgacaa tgcccctcaa
     1921 gtgttacctc aagaggcaga gacttgcgaa actccagacc ccaattcaat taatattaca
     1981 gcacttgatt atgacattga tccaaatgct ggaccatttg cttttgatct tcctttatct
     2041 ccagtgacta ttaagagaaa ttggaccatc actcggctta atggtgattt tgctcagctt
     2101 aatttaaaga taaaatttct tgaagctggt atctatgaag ttcccatcat aatcacagat
     2161 tcgggtaatc ctcccaaatc aaatatttcc atcctgcgtg tgaaggtttg ccagtgtgac
     2221 tccaacgggg actgcacaga tgtggacagg attgtgggtg cggggcttgg caccggtgcc
     2281 atcattgcca tcctgctctg catcatcatc ctgcttatcc ttgtgctgat gtttgtggta
     2341 tggatgaaac gccgggataa agaacgccag gccaaacaac ttttaattga tccagaagat
     2401 gatgtaagag ataatatttt aaaatatgat gaagaaggtg gaggagaaga agaccaggac
     2461 tatgacttga gccagctgca gcagcctgac actgtggagc ctgatgccat caagcctgtg
     2521 ggaatccgac gaatggatga aagacccatc cacgccgagc cccagtatcc ggtccgatct
     2581 gcagccccac accctggaga cattggggac ttcattaatg agggccttaa agcggctgac
     2641 aatgacccca cagctccacc atatgactcc ctgttagtgt ttgactatga aggcagtggc
     2701 tccactgctg ggtccttgag ctcccttaat tcctcaagta gtggtggtga gcaggactat
     2761 gattacctga acgactgggg gccacggttc aagaaacttg ctgacatgta tggtggaggt
     2821 gatgactgaa cttcagggtg aacttggttt ttggacaagt acaaacaatt tcaactgata
     2881 ttcccaaaaa gcattcagaa gctaggcttt aactttgtag tctactagca cagtgcttgc
     2941 tggaggcttt ggcataggct gcaaaccaat ttgggctcag agggaatatc agtgatccat
     3001 actgtttgga aaaacactga gctcagttac acttgaattt tacagtacag aagcactggg
     3061 attttatgtg cctttttgta cctttttcag attggaatta gttttctgtt taaggcttta
     3121 atggtactga tttctgaaac gataagtaaa agacaaaata ttttgtggtg ggagcagtaa
     3181 gttaaaccat gatatgcttc aacacgcttt tgttacattg catttgcttt tattaaaata
     3241 caaaattaaa caaacaaaaa aactcatgga gcgattttat tatcttgggg gatgagacca
     3301 tgagattgga aaatgtacat tacttctagt tttagacttt agtttgtttt tttttttttc
     3361 actaaaatct taaaacttac tcagctggtt gcaaataaag ggagttttca tatcaccaat
     3421 ttgtagcaaa attgaatttt ttcataaact agaatgttag acacattttg gtcttaatcc
     3481 atgtacactt ttttatttct gtatttttcc acttcactgt aaaaatagta tgtgtacata
     3541 atgttttatt ggcatagtct atggagaagt gcagaaactt cagaacatgt gtatgtatta
     3601 tttggactat ggattcaggt tttttgcatg tttatatctt tcgttatgga taaagtattt
     3661 acaaaacagt gacatttgat tcaattgttg agctgtagtt agaatactca atttttaatt
     3721 tttttaattt ttttattttt tattttcttt ttggtttggg gagggagaaa agttcttagc
     3781 acaaatgttt tacataattt gtaccaaaaa aaaaaaaaaa ggaaaggaaa gaaaggggtg
     3841 gcctgacact ggtggcacta ctaagtgtgt gtttttttaa aaaaaaaatg gaaaaaaaaa
     3901 agcttttaaa ctggagagac ttctgacaac agctttgcct ctgtattgtg taccagaata
     3961 taaatgatac acctctgacc ccagcgttct gaataaaatg ctaattttgg atctgg
//
