LOCUS       NM_021153               6297 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens cadherin 19 (CDH19), transcript variant 1, mRNA.
ACCESSION   NM_021153 XM_005266688
VERSION     NM_021153.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6297)
  AUTHORS   Yu,J., Sun,X., Yu,Y. and Cui,X.
  TITLE     The cadherin protein CDH19 mediates cervical carcinoma progression
            by regulating AKT/NF-kappaB signaling
  JOURNAL   Acta Biochim Pol 70 (4), 955-961 (2023)
   PUBMED   38052007
  REMARK    GeneRIF: The cadherin protein CDH19 mediates cervical carcinoma
            progression by regulating AKT/NF-kappaB signaling.
REFERENCE   2  (bases 1 to 6297)
  AUTHORS   Sung,Y.J., de las Fuentes,L., Schwander,K.L., Simino,J. and
            Rao,D.C.
  TITLE     Gene-smoking interactions identify several novel blood pressure
            loci in the Framingham Heart Study
  JOURNAL   Am J Hypertens 28 (3), 343-354 (2015)
   PUBMED   25189868
REFERENCE   3  (bases 1 to 6297)
  AUTHORS   Zorniak,M., Clark,P.A. and Kuo,J.S.
  TITLE     Myelin-forming cell-specific cadherin-19 is a marker for minimally
            infiltrative glioblastoma stem-like cells
  JOURNAL   J Neurosurg 122 (1), 69-77 (2015)
   PUBMED   25361488
  REMARK    GeneRIF: Gene expression profiling of Glioblastoma stem-like cells
            has shown CDH19 to be an exciting new target for drug development
            and study of glioblastoma multiforme tumorigenesis
REFERENCE   4  (bases 1 to 6297)
  AUTHORS   Zayed,H., Chao,R., Moshrefi,A., Lopezjimenez,N., Delaney,A.,
            Chen,J., Shaw,G.M. and Slavotinek,A.M.
  TITLE     A maternally inherited chromosome 18q22.1 deletion in a male with
            late-presenting diaphragmatic hernia and microphthalmia-evaluation
            of DSEL as a candidate gene for the diaphragmatic defect
  JOURNAL   Am J Med Genet A 152A (4), 916-923 (2010)
   PUBMED   20358601
REFERENCE   5  (bases 1 to 6297)
  AUTHORS   Niu,J., Azfer,A., Zhelyabovska,O., Fatma,S. and Kolattukudy,P.E.
  TITLE     Monocyte chemotactic protein (MCP)-1 promotes angiogenesis via a
            novel transcription factor, MCP-1-induced protein (MCPIP)
  JOURNAL   J Biol Chem 283 (21), 14542-14551 (2008)
   PUBMED   18364357
REFERENCE   6  (bases 1 to 6297)
  AUTHORS   Tariq,M., Chishti,M.S., Ali,G. and Ahmad,W.
  TITLE     A novel locus for ectodermal dysplasia of hairs, nails and teeth
            type maps to chromosome 18q22.1-22.3
  JOURNAL   Ann Hum Genet 72 (Pt 1), 19-25 (2008)
   PUBMED   18184143
REFERENCE   7  (bases 1 to 6297)
  AUTHORS   Blons,H., Laccourreye,O., Houllier,A.M., Carnot,F., Brasnu,D.,
            Beaune,P., Zucman-Rossi,J. and Laurent-Puig,P.
  TITLE     Delineation and candidate gene mutation screening of the 18q22
            minimal region of deletion in head and neck squamous cell carcinoma
  JOURNAL   Oncogene 21 (32), 5016-5023 (2002)
   PUBMED   12118382
REFERENCE   8  (bases 1 to 6297)
  AUTHORS   Kools,P., Van Imschoot,G. and van Roy,F.
  TITLE     Characterization of three novel human cadherin genes (CDH7, CDH19,
            and CDH20) clustered on chromosome 18q22-q23 and with high homology
            to chicken cadherin-7
  JOURNAL   Genomics 68 (3), 283-295 (2000)
   PUBMED   10995570
REFERENCE   9  (bases 1 to 6297)
  AUTHORS   Kremmidiotis,G., Baker,E., Crawford,J., Eyre,H.J., Nahmias,J. and
            Callen,D.F.
  TITLE     Localization of human cadherin genes to chromosome regions
            exhibiting cancer-related loss of heterozygosity
  JOURNAL   Genomics 49 (3), 467-471 (1998)
   PUBMED   9615235
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK315257.1, AJ007607.1,
            AC091643.6 and AC090393.9.
            
            On May 17, 2019 this sequence version replaced NM_021153.3.
            
            Summary: This gene is one of three related type II cadherin genes
            situated in a cluster on chromosome 18. The encoded protein is a
            calcium dependent cell-cell adhesion glycoprotein containing five
            extracellular cadherin repeats. Loss of cadherins may be associated
            with cancer formation. Alternative splicing results in multiple
            transcript variants for this gene. [provided by RefSeq, Aug 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.41232.1,
                                           SRR1660805.116685.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262150.7/ ENSP00000262150.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AK315257.1         51-161
            112-195             AJ007607.1         1-84
            196-197             AC091643.6         110804-110805
            198-1943            AJ007607.1         87-1832
            1944-1944           AC090393.9         14148-14148
            1945-3067           AJ007607.1         1834-2956
            3068-6297           AC090393.9         18964-22193
FEATURES             Location/Qualifiers
     source          1..6297
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q22.1"
     gene            1..6297
                     /gene="CDH19"
                     /gene_synonym="CDH7; CDH7L2"
                     /note="cadherin 19"
                     /db_xref="GeneID:28513"
                     /db_xref="HGNC:HGNC:1758"
                     /db_xref="MIM:603016"
     exon            1..137
                     /gene="CDH19"
                     /gene_synonym="CDH7; CDH7L2"
                     /inference="alignment:Splign:2.1.0"
     exon            138..444
                     /gene="CDH19"
                     /gene_synonym="CDH7; CDH7L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..2568
                     /gene="CDH19"
                     /gene_synonym="CDH7; CDH7L2"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; cadherin 19, type 2"
                     /codon_start=1
                     /product="cadherin-19 isoform 1 preproprotein"
                     /protein_id="NP_066976.1"
                     /db_xref="CCDS:CCDS11994.1"
                     /db_xref="GeneID:28513"
                     /db_xref="HGNC:HGNC:1758"
                     /db_xref="MIM:603016"
                     /translation="MNCYLLLRFMLGIPLLWPCLGATENSQTKKVKQPVRSHLRVKRG
                     WVWNQFFVPEEMNTTSHHIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAI
                     QKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEM
                     SPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRISSKMDRELQD
                     EYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIG
                     TIMAYDNDIGENAEMDYSIEEDDSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRA
                     KVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVV
                     SATDPDNRKSPIRYSITRSKVFNINDNGTITTSNSLDREISAWYNLSITATEKYNIEQ
                     ISSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFN
                     LSVEDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTL
                     TIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLTLGLKQRRKQ
                     ILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTRKTTSAEIRSLY
                     RQSLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAV
                     SDQDESYDYLNELGPRFKRLACMFGSAVQSNN"
     exon            445..739
                     /gene="CDH19"
                     /gene_synonym="CDH7; CDH7L2"
                     /inference="alignment:Splign:2.1.0"
     exon            740..859
                     /gene="CDH19"
                     /gene_synonym="CDH7; CDH7L2"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1024
                     /gene="CDH19"
                     /gene_synonym="CDH7; CDH7L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1209
                     /gene="CDH19"
                     /gene_synonym="CDH7; CDH7L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1463
                     /gene="CDH19"
                     /gene_synonym="CDH7; CDH7L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1585
                     /gene="CDH19"
                     /gene_synonym="CDH7; CDH7L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1707
                     /gene="CDH19"
                     /gene_synonym="CDH7; CDH7L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1825
                     /gene="CDH19"
                     /gene_synonym="CDH7; CDH7L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..2077
                     /gene="CDH19"
                     /gene_synonym="CDH7; CDH7L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..6297
                     /gene="CDH19"
                     /gene_synonym="CDH7; CDH7L2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3210..3215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH19"
                     /gene_synonym="CDH7; CDH7L2"
                     /note="hexamer: AATAAA"
     polyA_site      3230
                     /gene="CDH19"
                     /gene_synonym="CDH7; CDH7L2"
                     /note="major polyA site"
     regulatory      5699..5704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH19"
                     /gene_synonym="CDH7; CDH7L2"
                     /note="hexamer: AATAAA"
     polyA_site      5728
                     /gene="CDH19"
                     /gene_synonym="CDH7; CDH7L2"
     regulatory      6169..6174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH19"
                     /gene_synonym="CDH7; CDH7L2"
                     /note="hexamer: AATAAA"
     polyA_site      6193
                     /gene="CDH19"
                     /gene_synonym="CDH7; CDH7L2"
                     /note="major polyA site"
ORIGIN      
        1 gcaatggggc acatcgagag tttgctgaga agactgtgaa gcaaaaagaa gaaagttttt
       61 cctactcttc cttatgtgtc caacacgaag tttgctgttc agttttcaca gaacttctag
      121 aagttgaagt tacaaaggta tatagaaggt acacagaatc agaaaagatt ataaaagaaa
      181 gcaagatttt tgttagtgac gtcctgtttc ctctgaagag taatagttgg aatcaaaaga
      241 gtcaacgcaa tgaactgtta tttactgctg cgttttatgt tgggaattcc tctcctatgg
      301 ccttgtcttg gagcaacaga aaactctcaa acaaagaaag tcaagcagcc agtgcgatct
      361 catttgagag tgaagcgtgg ctgggtgtgg aaccaatttt ttgtaccaga ggaaatgaat
      421 acgactagtc atcacatcgg ccagctaaga tctgatttag acaatggaaa caattctttc
      481 cagtacaagc ttttgggagc tggagctgga agtactttta tcattgatga aagaacaggt
      541 gacatatatg ccatacagaa gcttgataga gaggagcgat ccctctacat cttaagagcc
      601 caggtaatag acatcgctac tggaagggct gtggaacctg agtctgagtt tgtcatcaaa
      661 gtttcggata tcaatgacaa tgaaccaaaa ttcctagatg aaccttatga ggccattgta
      721 ccagagatgt ctccagaagg aacattagtt atccaggtga cagcaagtga tgctgacgat
      781 ccctcaagtg gtaataatgc tcgtctcctc tacagcttac ttcaaggcca gccatatttt
      841 tctgttgaac caacaacagg agtcataaga atatcttcta aaatggatag agaactgcaa
      901 gatgagtatt gggtaatcat tcaagccaag gacatgattg gtcagccagg agcgttgtct
      961 ggaacaacaa gtgtattaat taaactttca gatgttaatg acaataagcc tatatttaaa
     1021 gaaagtttat accgcttgac tgtctctgaa tctgcaccca ctgggacttc tataggaaca
     1081 atcatggcat atgataatga cataggagag aatgcagaaa tggattacag cattgaagag
     1141 gatgattcgc aaacatttga cattattact aatcatgaaa ctcaagaagg aatagttata
     1201 ttaaaaaaga aagtggattt tgagcaccag aaccactacg gtattagagc aaaagttaaa
     1261 aaccatcatg ttcctgagca gctcatgaag taccacactg aggcttccac cactttcatt
     1321 aagatccagg tggaagatgt tgatgagcct cctcttttcc tccttccata ttatgtattt
     1381 gaagtttttg aagaaacccc acagggatca tttgtaggcg tggtgtctgc cacagaccca
     1441 gacaatagga aatctcctat caggtattct attactagga gcaaagtgtt caatatcaat
     1501 gataatggta caatcactac aagtaactca ctggatcgtg aaatcagtgc ttggtacaac
     1561 ctaagtatta cagccacaga aaaatacaat atagaacaga tctcttcgat cccactgtat
     1621 gtgcaagttc ttaacatcaa tgatcatgct cctgagttct ctcaatacta tgagacttat
     1681 gtttgtgaaa atgcaggctc tggtcaggta attcagacta tcagtgcagt ggatagagat
     1741 gaatccatag aagagcacca tttttacttt aatctatctg tagaagacac taacaattca
     1801 agttttacaa tcatagataa tcaagataac acagctgtca ttttgactaa tagaactggt
     1861 tttaaccttc aagaagaacc tgtcttctac atctccatct taattgccga caatggaatc
     1921 ccgtcactta caagtacaaa cacccttacc atccatgtct gtgactgtgg tgacagtggg
     1981 agcacacaga cctgccagta ccaggagctt gtgctttcca tgggattcaa gacagaagtc
     2041 atcattgcta ttctcatttg cattatgatc atatttgggt ttattttttt gactttgggt
     2101 ttaaaacaac ggagaaaaca gattctattt cctgagaaaa gtgaagattt cagagagaat
     2161 atattccaat atgatgatga agggggtgga gaagaagata cagaggcctt tgatatagca
     2221 gagctgagga gtagtaccat aatgcgggaa cgcaagactc ggaaaaccac aagcgctgag
     2281 atcaggagcc tatacaggca gtctttgcaa gttggccccg acagtgccat attcaggaaa
     2341 ttcattctgg aaaagctcga agaagctaat actgatccgt gtgcccctcc ttttgattcc
     2401 ctccagacct acgcttttga gggaacaggg tcattagctg gatccctgag ctccttagaa
     2461 tcagcagtct ctgatcagga tgaaagctat gattacctta atgagttggg acctcgcttt
     2521 aaaagattag catgcatgtt tggttctgca gtgcagtcaa ataattaggg ctttttacca
     2581 tcaaaatttt taaaagtgct aatgtgtatt cgaacccaat ggtagtctta aagagttttg
     2641 tgccctggct ctatggcggg gaaagcccta gtctatggag ttttctgatt tccctggagt
     2701 aaatactcca tggttatttt aagctaccta catgctgtca ttgaacagag atgtggggag
     2761 aaatgtaaac aatcagctca caggcatcaa tacaaccaga tttgaagtaa aataatttag
     2821 gaagatatta aaagtagatg agaggacaca agatgtagtc gatccttatg cgattatatc
     2881 attatttact taggaaagag taaaaatacc aaacgagaaa atttaaagga gcaaaaattt
     2941 gcaagtcaaa tagaaatgta caaatcgaga taacatttac atttctatca tattgacatg
     3001 aaaattgaaa atgtatagtc agagaaattt tcatgaatta ttccatgaag tattgtttcc
     3061 tttatttaaa aaaaaaaaaa aaaaaaaaga atgctaggta atcttcgtag aaaactagaa
     3121 agtatgataa acaacagttg gaggaatcca tggaaaatag acgagaaaat gtaaataagg
     3181 ctttctgggg atcacagaac ttttgtatga ataaaagcct tataaaacca gctctggcat
     3241 atgactaaaa tattcctcta ctatttttca atgtcatcta atgcaaacgc tcaacctttt
     3301 taaatggtta atgtgagaaa ggcactgaat taagatatct tagtgttatt ttatttactc
     3361 aattttcatc tttcacactg taagaataaa atgtttttgt ggttaagttc ctgatactat
     3421 atagagataa actttaaaac tttaacacct aggataatgt gggtgattac ataaatgttt
     3481 aaaaacattt accttatatg gaaagcagat ttctgactaa gatgccatga ttcattctag
     3541 tttgatattt taaaactttg ccaagagcac tctttaaaac tgatttcaaa tttgaacaga
     3601 tacttggtgt atacaaatta atcagagtta tatagtataa atttgtatta tttttgatat
     3661 tacaactttg tattaaaaag gaaaatatat ttaggtgttt gtcatagatt ttttttcata
     3721 tgcaactcaa aacacattct tatgtcaaaa tacaatagca aaatacaagt caatatttac
     3781 tcataattaa atgcaaactt tatgaaactg gtggaaagtg tggaaaaatt taagtaaatt
     3841 tttacctcta ctaaaaatta tttagacaac ttaaaggaat actggattca aacttcagtt
     3901 actattcact gtaaatatta tgatcaactg aactgactta ccattcatgg gataaaacat
     3961 gatacaattc tcagtatttg cttttctgtt aagagcttgg aatatgactg atgcttcagt
     4021 gtcatttttt tattattgaa tataaaatta ggtgcaatag atacatttat tgtagcctta
     4081 agaaggaaat caatgctaag ctgttgggca taaaacttta cagtaacatt agataacaag
     4141 ataataaaac actttaattt taatcgacct tttaagaatg atctttatta ttctatccaa
     4201 atcaaggtag acttcaaaat ttatggtttg aacaggaaga aagtagtgaa tacaaaattc
     4261 ttaaaattgg ttcatatgat cattttttta ttaatagcat gtgagactaa gctgaaccaa
     4321 actggccata tatgttaaat caaataattt gagtaatttt gaaatattga tgaagtagtt
     4381 aaatggttat aatatatttt attggtactt tgaaatttaa acatctatat cacataataa
     4441 agaaagtttt tcatcaatct gaaacaggca ccattaaatt ggtgacacaa atattatcat
     4501 ttcacaaaag cttgagaaaa ccagatttga agtgaaataa tttaggaaga tattaaaagt
     4561 ggatgagagg acataagatg tagtcaatcc ttaacgcaat gataccatta ttaggaaaga
     4621 ggaaaaatac caaacaagag aaaatttaaa ggagcaaaaa tttgcaagtc aaatagaaat
     4681 gcacaaatcg agagaacatt tacatttcta tcacattgac atgaaaattg aaaatgtata
     4741 gtcagagaaa ttttcatgaa ttattccatg aagtgttgtt tcctttattt aaaaagaatg
     4801 ctaggtaatc ttagtagaaa actaaaaagt atgataaaca acagatggaa gaattcatgg
     4861 aaaatagacg agaaaaagta aataaggctt tctggagatg acggaaattt tgtatgaata
     4921 aaagccttat aaacaatgaa tacatttgga taaacaactc attaaaatgc acattaatgg
     4981 aatacctgta caaatagttt taatacttgt gtccagtggc actaaagaga tatattaaaa
     5041 tagattctgg ttgagttgat tataagattg tcaatcatag gatacacagg gaaagcacag
     5101 acacgattgc tcatctcttt ggtagtctaa aatatgttcc ttttaaccac atcaaaagat
     5161 actatctgat tctaatacag aaggtgcaac ttcctaggaa ttatactttg tattatattc
     5221 aataattatt ttatgttttg catcacatgg gtgttgcaag aacacagctc ttaaactaaa
     5281 aaggcattac attaagaatt tatttttgta aattttaata aactctaaat taatgcaaaa
     5341 tatttatgaa aatagcacag cttcacatta atacccacag tacttaaata tctcccttag
     5401 ttgactcaca gctttgtatg taagcttcaa atttttaatg gtaaaaataa gaaaattagg
     5461 actagcgaac tgctagttgt tccctcagtg catgtgcttg agcctaacag atctttgttt
     5521 gaattagtta ctttcaatta agcgaacata taatatttgt taaactgctt aatctttcca
     5581 gatctcactt tgtaaaatga cgtccaatca acctatttca catggttgtt atgaagaatt
     5641 aataataaga tatgtaaaac cagcagcacc aatagtgcct gacaaaatat aactgctcaa
     5701 taaataacag tgaattatta taacaacagc taatggtatt ctattggaac acatggtctg
     5761 tttcttttcc aattctgagt gatctcaaca gcctcacggc acattgaaaa taaaagtcaa
     5821 cttcctcacc ttccccatag gccatggact ttcccatctc tacccacttg tgcagtttct
     5881 cctctttcct ctctcctcct cagttactaa agcaatcttc cttcaaacac ttctattttc
     5941 cattacatca cttcattcag gttggtgatc agctgcaact tcctcagaaa gaccactgct
     6001 gcttccagtg accctggctt tgtcttgctt tgtattagat tactcagctc cctggtatta
     6061 ttgttgtctt tatcgcttat tagaatgtaa cccttaatgg gcaagaaatt gtcagtcttg
     6121 ttcatttatc atcgtataaa aaatgtttct agcacacaga aagtgaccaa taaatatttc
     6181 tggaattaat gtagtaatga atccaatcta ttttacttag tgacttgtag aaattctttt
     6241 ggtttccatt gactattttt atagaatatt aatatggaat taaagtattt ttcaaaa
//
