LOCUS       NM_004934               4793 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens cadherin 18 (CDH18), transcript variant 1, mRNA.
ACCESSION   NM_004934
VERSION     NM_004934.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4793)
  AUTHORS   Banerjee,P., Sood,A., Midha,V., Narang,V., Grover,J. and
            Senapati,S.
  TITLE     A duodenal mucosa transcriptome study identified reduced expression
            of a novel gene CDH18 in celiac disease
  JOURNAL   Dig Liver Dis 56 (2), 258-264 (2024)
   PUBMED   37813809
  REMARK    GeneRIF: A duodenal mucosa transcriptome study identified reduced
            expression of a novel gene CDH18 in celiac disease.
REFERENCE   2  (bases 1 to 4793)
  AUTHORS   Zhao,B., Wu,J., Cha,X., Mao,G., Shi,H., Fei,S. and Miao,B.
  TITLE     Effect of COP1 in Promoting the Tumorigenesis of Gastric Cancer by
            Down-Regulation of CDH18 via PI3K/AKT Signal Pathway
  JOURNAL   Anal Cell Pathol (Amst) 2023, 5617875 (2023)
   PUBMED   37025097
  REMARK    GeneRIF: Effect of COP1 in Promoting the Tumorigenesis of Gastric
            Cancer by Down-Regulation of CDH18 via PI3K/AKT Signal Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4793)
  AUTHORS   Klein,M.E., Dickson,M.A., Antonescu,C., Qin,L.X., Dooley,S.J.,
            Barlas,A., Manova,K., Schwartz,G.K., Crago,A.M., Singer,S., Koff,A.
            and Tap,W.D.
  TITLE     PDLIM7 and CDH18 regulate the turnover of MDM2 during CDK4/6
            inhibitor therapy-induced senescence
  JOURNAL   Oncogene 37 (37), 5066-5078 (2018)
   PUBMED   29789718
  REMARK    GeneRIF: A role for PDLIM7 and CDH18, regulating MDM2 protein in
            CDK4/6 inhibitor-treated cells.
REFERENCE   4  (bases 1 to 4793)
  AUTHORS   Bai,Y.H., Zhan,Y.B., Yu,B., Wang,W.W., Wang,L., Zhou,J.Q.,
            Chen,R.K., Zhang,F.J., Zhao,X.W., Duan,W.C., Wang,Y.M., Liu,J.,
            Bao,J.J., Zhang,Z.Y. and Liu,X.Z.
  TITLE     A Novel Tumor-Suppressor, CDH18, Inhibits Glioma Cell Invasiveness
            Via UQCRC2 and Correlates with the Prognosis of Glioma Patients
  JOURNAL   Cell Physiol Biochem 48 (4), 1755-1770 (2018)
   PUBMED   30078018
  REMARK    GeneRIF: CDH18 overexpression significantly inhibited the invasion
            and migration ability but not proliferation ability in glioma cell
            lines.
REFERENCE   5  (bases 1 to 4793)
  AUTHORS   Liu,H., Irwanto,A., Fu,X., Yu,G., Yu,Y., Sun,Y., Wang,C., Wang,Z.,
            Okada,Y., Low,H., Li,Y., Liany,H., Chen,M., Bao,F., Li,J., You,J.,
            Zhang,Q., Liu,J., Chu,T., Andiappan,A.K., Wang,N., Niu,G., Liu,D.,
            Yu,X., Zhang,L., Tian,H., Zhou,G., Rotzschke,O., Chen,S., Zhang,X.,
            Liu,J. and Zhang,F.
  TITLE     Discovery of six new susceptibility loci and analysis of
            pleiotropic effects in leprosy
  JOURNAL   Nat Genet 47 (3), 267-271 (2015)
   PUBMED   25642632
REFERENCE   6  (bases 1 to 4793)
  AUTHORS   Shimoyama,Y., Tsujimoto,G., Kitajima,M. and Natori,M.
  TITLE     Identification of three human type-II classic cadherins and
            frequent heterophilic interactions between different subclasses of
            type-II classic cadherins
  JOURNAL   Biochem J 349 (Pt 1), 159-167 (2000)
   PUBMED   10861224
REFERENCE   7  (bases 1 to 4793)
  AUTHORS   Shimoyama,Y., Takeda,H., Yoshihara,S., Kitajima,M. and Hirohashi,S.
  TITLE     Biochemical characterization and functional analysis of two type II
            classic cadherins, cadherin-6 and -14, and comparison with
            E-cadherin
  JOURNAL   J Biol Chem 274 (17), 11987-11994 (1999)
   PUBMED   10207020
REFERENCE   8  (bases 1 to 4793)
  AUTHORS   Chalmers,I.J., Hofler,H. and Atkinson,M.J.
  TITLE     Mapping of a cadherin gene cluster to a region of chromosome 5
            subject to frequent allelic loss in carcinoma
  JOURNAL   Genomics 57 (1), 160-163 (1999)
   PUBMED   10191097
REFERENCE   9  (bases 1 to 4793)
  AUTHORS   Shibata,T., Shimoyama,Y., Gotoh,M. and Hirohashi,S.
  TITLE     Identification of human cadherin-14, a novel neurally specific type
            II cadherin, by protein interaction cloning
  JOURNAL   J Biol Chem 272 (8), 5236-5240 (1997)
   PUBMED   9030594
REFERENCE   10 (bases 1 to 4793)
  AUTHORS   Hulsken,J., Birchmeier,W. and Behrens,J.
  TITLE     E-cadherin and APC compete for the interaction with beta-catenin
            and the cytoskeleton
  JOURNAL   J Cell Biol 127 (6 Pt 2), 2061-2069 (1994)
   PUBMED   7806582
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA368944.1, BC031051.1,
            AC118463.2, U59325.1, AC025173.5, DA132038.1 and CR747663.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004934.4.
            
            Summary: This gene encodes a type II classical cadherin from the
            cadherin superfamily of integral membrane proteins that mediate
            calcium-dependent cell-cell adhesion. Mature cadherin proteins are
            composed of a large N-terminal extracellular domain, a single
            membrane-spanning domain, and a small, highly conserved C-terminal
            cytoplasmic domain. Type II (atypical) cadherins are defined based
            on their lack of a HAV cell adhesion recognition sequence specific
            to type I cadherins. This particular cadherin is expressed
            specifically in the central nervous system and is putatively
            involved in synaptic adhesion, axon outgrowth and guidance.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, May
            2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1, 3, 5, 6, and 7 encode the same protein (isoform
            1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.251642.1,
                                           SRR1660805.77831.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968832,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382275.6/ ENSP00000371710.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-432               DA368944.1         132-563
            433-1098            BC031051.1         433-1098
            1099-1099           AC118463.2         68680-68680
            1100-3057           U59325.1           923-2880
            3058-3291           AC025173.5         46334-46567         c
            3292-3731           DA132038.1         103-542
            3732-4365           AC025173.5         45260-45893         c
            4366-4793           CR747663.1         28-455              c
FEATURES             Location/Qualifiers
     source          1..4793
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p14.3"
     gene            1..4793
                     /gene="CDH18"
                     /gene_synonym="CDH14; CDH14L; CDH24"
                     /note="cadherin 18"
                     /db_xref="GeneID:1016"
                     /db_xref="HGNC:HGNC:1757"
                     /db_xref="MIM:603019"
     exon            1..115
                     /gene="CDH18"
                     /gene_synonym="CDH14; CDH14L; CDH24"
                     /inference="alignment:Splign:2.1.0"
     exon            116..234
                     /gene="CDH18"
                     /gene_synonym="CDH14; CDH14L; CDH24"
                     /inference="alignment:Splign:2.1.0"
     exon            235..718
                     /gene="CDH18"
                     /gene_synonym="CDH14; CDH14L; CDH24"
                     /inference="alignment:Splign:2.1.0"
     CDS             491..2863
                     /gene="CDH18"
                     /gene_synonym="CDH14; CDH14L; CDH24"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; cadherin-like 24; cadherin-14; ey-cadherin;
                     cadherin 18, type 2"
                     /codon_start=1
                     /product="cadherin-18 isoform 1 preproprotein"
                     /protein_id="NP_004925.1"
                     /db_xref="CCDS:CCDS3889.1"
                     /db_xref="GeneID:1016"
                     /db_xref="HGNC:HGNC:1757"
                     /db_xref="MIM:603019"
                     /translation="MKITSTSCICPVLVCLCFVQRCYGTAHHSSIKVMRNQTKHIEGE
                     TEVHHRPKRGWVWNQFFVLEEHMGPDPQYVGKLHSNSDKGDGSVKYILTGEGAGTIFI
                     IDDTTGDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFT
                     DGPYIVTVPEMSDMGTSVLQVTATDADDPTYGNSARVVYSILQGQPYFSVDPKTGVIR
                     TALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLY
                     VPESAQVGSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDKETREGILSLKKP
                     LNYEKKKSYTLNIEGANTHLDFRFSHLGPFKDATMLKIIVGDVDEPPLFSMPSYLMEV
                     YENAKIGTVVGTVLAQDPDSTNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREE
                     TPWYNITVTASEIDNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHT
                     ISATDKDDFANGPRFNFFLDERLPVNPNFTLKDNEDNTASILTRRRRFSRTVQDVYYL
                     PIMISDGGIPSLSSSSTLTIRVCACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVL
                     ILLAIVVLFITLRRSKKEPLIISEEDVRENVVTYDDEGGGEEDTEAFDITALRNPSAA
                     EELKYRRDIRPEVKLTPRHQTSSTLESIDVQEFIKQRLAEADLDPSVPPYDSLQTYAY
                     EGQRSEAGSISSLDSATTQSDQDYHYLGDWGPEFKKLAELYGEIESERTT"
     exon            719..1013
                     /gene="CDH18"
                     /gene_synonym="CDH14; CDH14L; CDH24"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1133
                     /gene="CDH18"
                     /gene_synonym="CDH14; CDH14L; CDH24"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1301
                     /gene="CDH18"
                     /gene_synonym="CDH14; CDH14L; CDH24"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1489
                     /gene="CDH18"
                     /gene_synonym="CDH14; CDH14L; CDH24"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1743
                     /gene="CDH18"
                     /gene_synonym="CDH14; CDH14L; CDH24"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1880
                     /gene="CDH18"
                     /gene_synonym="CDH14; CDH14L; CDH24"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2002
                     /gene="CDH18"
                     /gene_synonym="CDH14; CDH14L; CDH24"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2120
                     /gene="CDH18"
                     /gene_synonym="CDH14; CDH14L; CDH24"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2372
                     /gene="CDH18"
                     /gene_synonym="CDH14; CDH14L; CDH24"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..4793
                     /gene="CDH18"
                     /gene_synonym="CDH14; CDH14L; CDH24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3109..3114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH18"
                     /gene_synonym="CDH14; CDH14L; CDH24"
                     /note="hexamer: AATAAA"
     polyA_site      3138
                     /gene="CDH18"
                     /gene_synonym="CDH14; CDH14L; CDH24"
                     /note="major polyA site"
     polyA_site      3156
                     /gene="CDH18"
                     /gene_synonym="CDH14; CDH14L; CDH24"
                     /note="major polyA site"
     regulatory      4764..4769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH18"
                     /gene_synonym="CDH14; CDH14L; CDH24"
                     /note="hexamer: AATAAA"
     polyA_site      4793
                     /gene="CDH18"
                     /gene_synonym="CDH14; CDH14L; CDH24"
ORIGIN      
        1 gagtctgggc tttccgagga cggcgagcag ctgtgcccag agctctggga aagtcccctc
       61 tctttgcttc ttataaatta agttcctttc caccagttag ggcaagtccg ccaagataga
      121 ctgaagagga gcaagaacag aaacagggag ccagttacag atctatccca agaattctgg
      181 ggagagatga tggtgtctgc agcagagtga cagcagtgga gattgagaga aaaggttgaa
      241 aatggttgct tgtgttcaac tactgtgaag agttggaatc agacaactac ggctttgatt
      301 ttccaagtgg ttcagaatgt aaatatgatc tgacctttcc ctgatggaca gttaaatcat
      361 ggacacgcta aacaatttac tttggactgt ccttcctaaa gatgctctgg cttctctctt
      421 gaatgctcac taagctttcg tagctgacaa ggaaaggaag gaaaactgtg aactggaaag
      481 ttatcttaca atgaaaatta ctagcacatc ttgcatctgt ccagtcctag tgtgtctctg
      541 ttttgtgcag aggtgttatg gaactgctca ccacagctcc atcaaggtga tgagaaacca
      601 aaccaaacac attgaaggtg aaaccgaagt ccatcatcgt cccaaaaggg gatgggtatg
      661 gaatcagttc tttgttttag aagaacatat gggaccagat cctcagtatg ttggaaagct
      721 gcactccaat tctgacaaag gtgatggatc tgtcaagtac atccttactg gagagggtgc
      781 tgggactata tttatcattg acgataccac gggtgatatc cactcaacaa aaagcctaga
      841 cagagagcag aagacccact atgtgcttca tgctcaagct attgatagac gtacaaacaa
      901 acctcttgag cctgaatccg agttcatcat caaagtgcaa gacatcaatg acaacgctcc
      961 aaaattcaca gatggaccat acattgttac tgtgcctgaa atgtcagata tgggtacctc
     1021 tgttctacag gtgacagcta ctgatgcaga tgaccctacc tatggaaaca gcgctcgggt
     1081 ggtttacagc attctccaag gacaacccta cttctccgtc gaccctaaaa caggagttat
     1141 tagaacggcc ttacataaca tggacagaga agccagagaa cattactccg tagtcattca
     1201 agccaaagac atggctgggc aagttggagg gctttcagga tctacaacag tcaacatcac
     1261 cttaaccgat gtcaatgaca acccaccacg ctttcctcaa aaacactatc agctatatgt
     1321 tcctgagtca gctcaagttg gttcagctgt tgggaaaatc aaggcaaatg atgctgacac
     1381 tggctcaaat gctgacatga cctactccat cataaatggt gatggcatgg gaatattctc
     1441 aatctccact gacaaagaga ccagagaagg aatcctttct ttaaagaagc cactgaacta
     1501 tgagaaaaag aagtcatata ccctcaacat agaaggagca aatacacatc ttgattttcg
     1561 cttttctcac ttgggtcctt ttaaagatgc tactatgctg aagatcattg ttggggatgt
     1621 agatgaacca ccactatttt ccatgccttc ctacctcatg gaagtctacg aaaatgccaa
     1681 gattgggacc gtcgttggta cagttttggc acaagatcct gacagtacta acagcttagt
     1741 aagatacttc atcaactaca atgttgaaga cgacagattt ttcaacattg atgccaatac
     1801 tgggaccatt aggactacaa aggttctcga cagagaagaa actccatggt acaacatcac
     1861 agtcactgct tcagaaattg ataatcctga tttgctgagc catgtcacag tgggtattag
     1921 agttctggat gtcaatgaca atccacccga acttgccagg gaatatgata ttattgtatg
     1981 tgaaaattct aagcctggcc aggttattca taccatcagt gccactgata aagatgattt
     2041 tgccaatgga ccaaggttta acttctttct tgatgaacgc ctgcctgtaa atccaaactt
     2101 cactctgaag gacaatgaag ataacacagc cagcattctg acaaggcgga ggagatttag
     2161 tcgaactgtt caggatgtgt attatctgcc cattatgatc tctgatggtg gaatcccctc
     2221 tctcagcagc agcagcaccc tcaccatcag ggtttgtgca tgcgagagag atgggcgtgt
     2281 gcggacctgc catgcagaag ccttcctgtc ctcggctggt ttgagtacag gagccttaat
     2341 cgctattctt ctctgtgttc tcattctcct ggcaattgtg gtacttttta tcaccctgag
     2401 gcgcagcaaa aaagagccct tgatcatttc agaagaggat gtacgggaga acgtggtcac
     2461 ctatgatgat gaaggaggcg gagaggaaga cacagaggcc tttgacatca cagccttgag
     2521 gaatccttct gctgctgagg agctcaagta ccggagggat atcagacctg aagtgaagct
     2581 cactcccaga caccagacat catccaccct ggaaagcata gatgttcagg aatttattaa
     2641 gcaaagactg gcagaagcag acctagaccc tagcgttccc ccttatgact ctcttcagac
     2701 ttatgcctat gagggtcaga gatcagaagc tgggtctatc agctcgctgg attcagcaac
     2761 gacacaatca gaccaggatt atcactacct tggagactgg ggacccgagt ttaaaaagtt
     2821 agctgaactc tatggagaaa tagaatctga aagaacaact tagggggtca gttcttgcaa
     2881 ccttgtggaa tttgcttcct gagtaagtgg atatacaacc tcagcaatga caaggaagaa
     2941 gtgtggaaac agtacttgga actgaggaag ctggacacag ctcctgtaga aacaagtgcc
     3001 cttttcatga tcgaaactgg gttatttaat tggaagaaag taaaaaaaaa aaaaaaaaga
     3061 caatacaaag aaaaagttat tgttccttgt gtatattttc aattgctcaa taaagtctgt
     3121 ggtactgttt attaagaata cctgaattaa gccaaacaat gatatttgtt tcaatatatt
     3181 gtgatttatt tttttcaaaa gcaaaactaa acagaaaggc tcaagatcac tggtggttat
     3241 gacttatagg ggtggtaaca ctaatacagg aaacttgtga aggtaatcac aacctctttt
     3301 atcacttttc tgggtgaaac cttgagaacc acactctgtt attataacag atctcattag
     3361 ccttgtcttg tgtttatatt acatgaggta tttccactct atcatggact tgtatgtacc
     3421 atttcccttt gccctcccca gttcttttct ccatacaaaa ctgatggagc atggggattt
     3481 gctgcctgca ctataatgta tgcaacttca gtgcaccagt tgtgtgctgt actgagcacg
     3541 agactattgt ctctatcccg tacaccccct tttattttaa tgggatactc ctatttttaa
     3601 atggacagaa agaatagttt aaggtatgtt atgaaaatct gatatgtcag ggaataattt
     3661 aattttaaaa atagccacac accttatctt ctaccaaatg ttggggaact ttttttttcc
     3721 ttttttccac ttgttttatt atatttaaat cagcaatttt ggtcatttct ctatttaaaa
     3781 ttaattgtca aatattttgc tggctggttt gtacttcagt ctaattcact tattttcaac
     3841 acgagcagta attaaaaata agtacctcac acaataacaa tgtagtctga aagactatcc
     3901 tccaatgaac gtaaatgtca tagaatcata gttgacttac atttattcct tacacagttt
     3961 cagatttttt ccatctcact gataattagt ttggtatcaa caggaaaatg tgtaggacta
     4021 ggagcaaaaa aggagattca cagttattat cctcagatat gtttccgaaa gtctctgtgt
     4081 tcagggtcca aaccacaaag tagagatggc aatgacttcc ctgcccacct cacagggttg
     4141 ttgtgaggat taaatgagca tctgtaaaat gctttgccaa ctgcaaagta ttcaattgca
     4201 taaaagcttg cagacgctta tctaattttc tagtttcatt agcttataaa tatatattta
     4261 catgcatctg gcataaaata ttatcacagg agaatttcat gaaatcttca acagtgaagc
     4321 tactgtttaa atatatgtac acaattccaa ttattttaat attttcataa gctaatttct
     4381 gagaatttgg gtggggcttt ttttttcaaa ttgttttaga taatgttttg ttgttgttgc
     4441 tattggcctt gaagtaagaa ttcataccat aatggtccta ttttctaaaa ctggccacat
     4501 ctatatattt cagaaatatt gaaattctta aatacatgaa ataggaatta gttgacaccg
     4561 gagtttttcc tttgctcttt aaatttatca ttatcagtgt ccccaaaagt tatatgacat
     4621 tttctgtctg tttctaccca tgtgcaaaat tttggatttt acctctgttt gcaattgccc
     4681 tgtgctatca tattataatt tgaggtatgg gaagtaagta agcttaattt gaataattct
     4741 caatttgtgt tttaagcctg aggaataaaa tgtaatttaa gctttttacg aca
//
