LOCUS       NM_004063               3670 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens cadherin 17 (CDH17), transcript variant 1, mRNA.
ACCESSION   NM_004063
VERSION     NM_004063.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3670)
  AUTHORS   Jacobsen,F., Pushpadevan,R., Viehweger,F., Freytag,M.,
            Schlichter,R., Gorbokon,N., Buscheck,F., Luebke,A.M., Putri,D.,
            Kluth,M., Hube-Magg,C., Hinsch,A., Hoflmayer,D., Fraune,C.,
            Bernreuther,C., Lebok,P., Sauter,G., Minner,S., Steurer,S.,
            Simon,R., Burandt,E., Dum,D., Lutz,F., Marx,A.H., Krech,T. and
            Clauditz,T.S.
  TITLE     Cadherin-17 (CDH17) expression in human cancer: A tissue microarray
            study on 18,131 tumors
  JOURNAL   Pathol Res Pract 256, 155175 (2024)
   PUBMED   38452580
  REMARK    GeneRIF: Cadherin-17 (CDH17) expression in human cancer: A tissue
            microarray study on 18,131 tumors.
REFERENCE   2  (bases 1 to 3670)
  AUTHORS   Yui,A., Kuroda,D., Maruno,T., Nakakido,M., Nagatoishi,S.,
            Uchiyama,S. and Tsumoto,K.
  TITLE     Molecular mechanism underlying the increased risk of colorectal
            cancer metastasis caused by single nucleotide polymorphisms in
            LI-cadherin gene
  JOURNAL   Sci Rep 13 (1), 6493 (2023)
   PUBMED   37081068
  REMARK    GeneRIF: Molecular mechanism underlying the increased risk of
            colorectal cancer metastasis caused by single nucleotide
            polymorphisms in LI-cadherin gene.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3670)
  AUTHORS   Liu,X., Zeng,J., Zhang,X., Gu,J., Zhang,F., Han,Y., Zhang,P., Li,W.
            and Gu,R.
  TITLE     The Relationship between Cadherin Polymorphisms and the Risk of
            Delayed Encephalopathy after Acute Carbon Monoxide Poisoning in the
            Chinese Han Population
  JOURNAL   Behav Neurol 2022, 3155703 (2022)
   PUBMED   35140817
  REMARK    GeneRIF: The Relationship between Cadherin Polymorphisms and the
            Risk of Delayed Encephalopathy after Acute Carbon Monoxide
            Poisoning in the Chinese Han Population.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3670)
  AUTHORS   Yui,A., Caaveiro,J.M.M., Kuroda,D., Nakakido,M., Nagatoishi,S.,
            Goda,S., Maruno,T., Uchiyama,S. and Tsumoto,K.
  TITLE     Mechanism of dimerization and structural features of human
            LI-cadherin
  JOURNAL   J Biol Chem 297 (3), 101054 (2021)
   PUBMED   34364873
  REMARK    GeneRIF: Mechanism of dimerization and structural features of human
            LI-cadherin.
REFERENCE   5  (bases 1 to 3670)
  AUTHORS   Ma,H., Xiao,W., Wang,M. and Shi,X.
  TITLE     CDH17+/CDX2+ Can be Helpful in Providing Support for Small
            Intestinal Origin Versus Pancreatic or Biliary Origin
  JOURNAL   Appl Immunohistochem Mol Morphol 29 (7), 541-545 (2021)
   PUBMED   33958523
  REMARK    GeneRIF: CDH17+/CDX2+ Can be Helpful in Providing Support for Small
            Intestinal Origin Versus Pancreatic or Biliary Origin.
REFERENCE   6  (bases 1 to 3670)
  AUTHORS   Gessner,R. and Tauber,R.
  TITLE     Intestinal cell adhesion molecules. Liver-intestine cadherin
  JOURNAL   Ann N Y Acad Sci 915, 136-143 (2000)
   PUBMED   11193569
  REMARK    Review article
REFERENCE   7  (bases 1 to 3670)
  AUTHORS   Chalmers,I.J., Hofler,H. and Atkinson,M.J.
  TITLE     Mapping of a cadherin gene cluster to a region of chromosome 5
            subject to frequent allelic loss in carcinoma
  JOURNAL   Genomics 57 (1), 160-163 (1999)
   PUBMED   10191097
REFERENCE   8  (bases 1 to 3670)
  AUTHORS   Kremmidiotis,G., Baker,E., Crawford,J., Eyre,H.J., Nahmias,J. and
            Callen,D.F.
  TITLE     Localization of human cadherin genes to chromosome regions
            exhibiting cancer-related loss of heterozygosity
  JOURNAL   Genomics 49 (3), 467-471 (1998)
   PUBMED   9615235
REFERENCE   9  (bases 1 to 3670)
  AUTHORS   Dantzig,A.H., Hoskins,J.A., Tabas,L.B., Bright,S., Shepard,R.L.,
            Jenkins,I.L., Duckworth,D.C., Sportsman,J.R., Mackensen,D.,
            Rosteck,P.R. Jr. et al.
  TITLE     Association of intestinal peptide transport with a protein related
            to the cadherin superfamily
  JOURNAL   Science 264 (5157), 430-433 (1994)
   PUBMED   8153632
REFERENCE   10 (bases 1 to 3670)
  AUTHORS   Gilston,A.
  TITLE     Reducing the hazard of disconnected tubes
  JOURNAL   Anaesthesia 32 (9), 922 (1977)
   PUBMED   603017
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB009107.1, X83228.1, U07969.1,
            BF591263.1 and AP003351.2.
            
            On Nov 22, 2018 this sequence version replaced NM_004063.3.
            
            Summary: This gene is a member of the cadherin superfamily, genes
            encoding calcium-dependent, membrane-associated glycoproteins. The
            encoded protein is cadherin-like, consisting of an extracellular
            region, containing 7 cadherin domains, and a transmembrane region
            but lacking the conserved cytoplasmic domain. The protein is a
            component of the gastrointestinal tract and pancreatic ducts,
            acting as an intestinal proton-dependent peptide transporter in the
            first step in oral absorption of many medically important
            peptide-based drugs. The protein may also play a role in the
            morphological organization of liver and intestine. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jan 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X83228.1, U07969.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000027335.8/ ENSP00000027335.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DB009107.1         32-32
            2-1429              X83228.1           1-1428
            1430-2033           U07969.1           1424-2027
            2034-3655           X83228.1           2033-3654
            3656-3666           BF591263.1         6-16                c
            3667-3670           AP003351.2         157725-157728       c
FEATURES             Location/Qualifiers
     source          1..3670
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.1"
     gene            1..3670
                     /gene="CDH17"
                     /gene_synonym="CDH16; HPT-1; HPT1"
                     /note="cadherin 17"
                     /db_xref="GeneID:1015"
                     /db_xref="HGNC:HGNC:1756"
                     /db_xref="MIM:603017"
     exon            1..73
                     /gene="CDH17"
                     /gene_synonym="CDH16; HPT-1; HPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            74..144
                     /gene="CDH17"
                     /gene_synonym="CDH16; HPT-1; HPT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..2592
                     /gene="CDH17"
                     /gene_synonym="CDH16; HPT-1; HPT1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; human intestinal peptide-associated transporter
                     HPT-1; LI cadherin; liver-intestine cadherin; cadherin-16;
                     cadherin 17, LI cadherin (liver-intestine); human peptide
                     transporter 1; HPT-1 cadherin"
                     /codon_start=1
                     /product="cadherin-17 isoform 1 precursor"
                     /protein_id="NP_004054.3"
                     /db_xref="CCDS:CCDS6260.1"
                     /db_xref="GeneID:1015"
                     /db_xref="HGNC:HGNC:1756"
                     /db_xref="MIM:603017"
                     /translation="MILQAHLHSLCLLMLYLATGYGQEGKFSGPLKPMTFSIYEGQEP
                     SQIIFQFKANPPAVTFELTGETDNIFVIEREGLLYYNRALDRETRSTHNLQVAALDAN
                     GIIVEGPVPITIKVKDINDNRPTFLQSKYEGSVRQNSRPGKPFLYVNATDLDDPATPN
                     GQLYYQIVIQLPMINNVMYFQINNKTGAISLTREGSQELNPAKNPSYNLVISVKDMGG
                     QSENSFSDTTSVDIIVTENIWKAPKPVEMVENSTDPHPIKITQVRWNDPGAQYSLVDK
                     EKLPRFPFSIDQEGDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDIN
                     DNPPTCPSPVTVFEVQENERLGNSIGTLTAHDRDEENTANSFLNYRIVEQTPKLPMDG
                     LFLIQTYAGMLQLAKQSLKKQDTPQYNLTIEVSDKDFKTLCFVQINVIDINDQIPIFE
                     KSDYGNLTLAEDTNIGSTILTIQATDADEPFTGSSKILYHIIKGDSEGRLGVDTDPHT
                     NTGYVIIKKPLDFETAAVSNIVFKAENPEPLVFGVKYNASSFAKFTLIVTDVNEAPQF
                     SQHVFQAKVSEDVAIGTKVGNVTAKDPEGLDISYSLRGDTRGWLKIDHVTGEIFSVAP
                     LDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPPRLAKDYTGLFFCHPLSA
                     PGSLIFEATDDDQHLFRGPHFTFSLGSGSLQNDWEVSKINGTHARLSTRHTEFEEREY
                     VVLIRINDGGRPPLEGIVSLPVTFCSCVEGSCFRPAGHQTGIPTVGMAVGILLTTLLV
                     IGIILAVVFIRIKKDKGKDNVESAQASEVKPLRS"
     exon            145..243
                     /gene="CDH17"
                     /gene_synonym="CDH16; HPT-1; HPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            244..378
                     /gene="CDH17"
                     /gene_synonym="CDH16; HPT-1; HPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            379..517
                     /gene="CDH17"
                     /gene_synonym="CDH16; HPT-1; HPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..676
                     /gene="CDH17"
                     /gene_synonym="CDH16; HPT-1; HPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            677..876
                     /gene="CDH17"
                     /gene_synonym="CDH16; HPT-1; HPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1008
                     /gene="CDH17"
                     /gene_synonym="CDH16; HPT-1; HPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1159
                     /gene="CDH17"
                     /gene_synonym="CDH16; HPT-1; HPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1375
                     /gene="CDH17"
                     /gene_synonym="CDH16; HPT-1; HPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1452
                     /gene="CDH17"
                     /gene_synonym="CDH16; HPT-1; HPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1644
                     /gene="CDH17"
                     /gene_synonym="CDH16; HPT-1; HPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1889
                     /gene="CDH17"
                     /gene_synonym="CDH16; HPT-1; HPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2020
                     /gene="CDH17"
                     /gene_synonym="CDH16; HPT-1; HPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2260
                     /gene="CDH17"
                     /gene_synonym="CDH16; HPT-1; HPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2377
                     /gene="CDH17"
                     /gene_synonym="CDH16; HPT-1; HPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2491
                     /gene="CDH17"
                     /gene_synonym="CDH16; HPT-1; HPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..3670
                     /gene="CDH17"
                     /gene_synonym="CDH16; HPT-1; HPT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3636..3641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH17"
                     /gene_synonym="CDH16; HPT-1; HPT1"
                     /note="hexamer: AATAAA"
     polyA_site      3670
                     /gene="CDH17"
                     /gene_synonym="CDH16; HPT-1; HPT1"
                     /note="major polyA site"
ORIGIN      
        1 agtcgtagca agagtctcga ccactgaatg gaagaaaagg acttttaacc accattttgt
       61 gacttacaga aaggaatttg aataaagaaa actatgatac ttcaggccca tcttcactcc
      121 ctgtgtcttc ttatgcttta tttggcaact ggatatggcc aagaggggaa gtttagtgga
      181 cccctgaaac ccatgacatt ttctatttat gaaggccaag aaccgagtca aattatattc
      241 cagtttaagg ccaatcctcc tgctgtgact tttgaactaa ctggggagac agacaacata
      301 tttgtgatag aacgggaggg acttctgtat tacaacagag ccttggacag ggaaacaaga
      361 tctactcaca atctccaggt tgcagccctg gacgctaatg gaattatagt ggagggtcca
      421 gtccctatca ccataaaagt gaaggacatc aacgacaatc gacccacgtt tctccagtca
      481 aagtacgaag gctcagtaag gcagaactct cgcccaggaa agcccttctt gtatgtcaat
      541 gccacagacc tggatgatcc ggccactccc aatggccagc tttattacca gattgtcatc
      601 cagcttccca tgatcaacaa tgtcatgtac tttcagatca acaacaaaac gggagccatc
      661 tctcttaccc gagagggatc tcaggaattg aatcctgcta agaatccttc ctataatctg
      721 gtgatctcag tgaaggacat gggaggccag agtgagaatt ccttcagtga taccacatct
      781 gtggatatca tagtgacaga gaatatttgg aaagcaccaa aacctgtgga gatggtggaa
      841 aactcaactg atcctcaccc catcaaaatc actcaggtgc ggtggaatga tcccggtgca
      901 caatattcct tagttgacaa agagaagctg ccaagattcc cattttcaat tgaccaggaa
      961 ggagatattt acgtgactca gcccttggac cgagaagaaa aggatgcata tgttttttat
     1021 gcagttgcaa aggatgagta cggaaaacca ctttcatatc cgctggaaat tcatgtaaaa
     1081 gttaaagata ttaatgataa tccacctaca tgtccgtcac cagtaaccgt atttgaggtc
     1141 caggagaatg aacgactggg taacagtatc gggaccctta ctgcacatga cagggatgaa
     1201 gaaaatactg ccaacagttt tctaaactac aggattgtgg agcaaactcc caaacttccc
     1261 atggatggac tcttcctaat ccaaacctat gctggaatgt tacagttagc taaacagtcc
     1321 ttgaagaagc aagatactcc tcagtacaac ttaacgatag aggtgtctga caaagatttc
     1381 aagacccttt gttttgtgca aatcaacgtt attgatatca atgatcagat ccccatcttt
     1441 gaaaaatcag attatggaaa cctgactctt gctgaagaca caaacattgg gtccaccatc
     1501 ttaaccatcc aggccactga tgctgatgag ccatttactg ggagttctaa aattctgtat
     1561 catatcataa agggagacag tgagggacgc ctgggggttg acacagatcc ccataccaac
     1621 accggatatg tcataattaa aaagcctctt gattttgaaa cagcagctgt ttccaacatt
     1681 gtgttcaaag cagaaaatcc tgagcctcta gtgtttggtg tgaagtacaa tgcaagttct
     1741 tttgccaagt tcacgcttat tgtgacagat gtgaatgaag cacctcaatt ttcccaacac
     1801 gtattccaag cgaaagtcag tgaggatgta gctataggca ctaaagtggg caatgtgact
     1861 gccaaggatc cagaaggtct ggacataagc tattcactga ggggagacac aagaggttgg
     1921 cttaaaattg accacgtgac tggtgagatc tttagtgtgg ctccattgga cagagaagcc
     1981 ggaagtccat atcgggtaca agtggtggcc acagaagtag gggggtcttc cttgagctct
     2041 gtgtcagagt tccacctgat ccttatggat gtgaatgaca accctcccag gctagccaag
     2101 gactacacgg gcttgttctt ctgccatccc ctcagtgcac ctggaagtct cattttcgag
     2161 gctactgatg atgatcagca cttatttcgg ggtccccatt ttacattttc cctcggcagt
     2221 ggaagcttac aaaacgactg ggaagtttcc aaaatcaatg gtactcatgc ccgactgtct
     2281 accaggcaca cagagtttga ggagagggag tatgtcgtct tgatccgcat caatgatggg
     2341 ggtcggccac ccttggaagg cattgtttct ttaccagtta cattctgcag ttgtgtggaa
     2401 ggaagttgtt tccggccagc aggtcaccag actgggatac ccactgtggg catggcagtt
     2461 ggtatactgc tgaccaccct tctggtgatt ggtataattt tagcagttgt gtttatccgc
     2521 ataaagaagg ataaaggcaa agataatgtt gaaagtgctc aagcatctga agtcaaacct
     2581 ctgagaagct gaatttgaaa aggaatgttt gaatttatat agcaagtgct atttcagcaa
     2641 caaccatctc atcctattac ttttcatcta acgtgcatta taatttttta aacagatatt
     2701 ccctcttgtc ctttaatatt tgctaaatat ttcttttttg aggtggagtc ttgctctgtc
     2761 gcccaggctg gagtacagtg gtgtgatccc agctcactgc aacctccgcc tcctgggttc
     2821 acatgattct cctgcctcag cttcctaagt agctgggttt acaggcaccc accaccatgc
     2881 ccagctaatt tttgtatttt taatagagac ggggtttcgc catttggcca ggctggtctt
     2941 gaactcctga cgtcaagtga tctgcctgcc ttggtctccc aatacaggca tgaaccactg
     3001 cacccaccta cttagatatt tcatgtgcta tagacattag agagattttt catttttcca
     3061 tgacattttt cctctctgca aatggcttag ctacttgtgt ttttcccttt tggggcaaga
     3121 cagactcatt aaatattctg tacatttttt ctttatcaag gagatatatc agtgttgtct
     3181 catagaactg cctggattcc atttatgttt tttctgattc catcctgtgt ccccttcatc
     3241 cttgactcct ttggtatttc actgaatttc aaacatttgt cagagaagaa aaacgtgagg
     3301 actcaggaaa aataaataaa taaaagaaca gccttttccc ttagtattaa cagaaatgtt
     3361 tctgtgtcat taaccatctt taatcaatgt gacatgttgc tctttggctg aaattcttca
     3421 acttggaaat gacacagacc cacagaaggt gttcaaacac aacctactct gcaaaccttg
     3481 gtaaaggaac cagtcagctg gccagatttc ctcactacct gccatgcata catgctgcgc
     3541 atgttttctt cattcgtatg ttagtaaagt tttggttatt atatatttaa catgtggaag
     3601 aaaacaagac atgaaaagag tggtgacaaa tcaagaataa acactggttg tagtcagttt
     3661 tgtttgttga
//
