LOCUS       NM_004933               2866 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cadherin 15 (CDH15), mRNA.
ACCESSION   NM_004933
VERSION     NM_004933.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2866)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2866)
  AUTHORS   Xiang,Q., Liu,Z., Lu,Y., Mao,J., Chen,S., Zhao,X., Zhou,S., Xie,Q.,
            Wang,Z., Mu,G., Jiang,J., Gong,Y. and Cui,Y.
  TITLE     A potential role for the CDH13/CDH15 gene in repeat
            revascularization after first percutaneous coronary intervention
  JOURNAL   Pharmacogenomics 21 (2), 91-99 (2020)
   PUBMED   31854260
  REMARK    GeneRIF: A potential role for the CDH13/CDH15 gene in repeat
            revascularization after first percutaneous coronary intervention.
REFERENCE   3  (bases 1 to 2866)
  AUTHORS   Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Association of genetic variants with hemorrhagic stroke in Japanese
            individuals
  JOURNAL   Int J Mol Med 25 (4), 649-656 (2010)
   PUBMED   20198315
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 2866)
  AUTHORS   Oguri,M., Kato,K., Yokoi,K., Yoshida,T., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Assessment of a polymorphism of SDK1 with hypertension in Japanese
            Individuals
  JOURNAL   Am J Hypertens 23 (1), 70-77 (2010)
   PUBMED   19851296
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 2866)
  AUTHORS   Bhalla,K., Luo,Y., Buchan,T., Beachem,M.A., Guzauskas,G.F.,
            Ladd,S., Bratcher,S.J., Schroer,R.J., Balsamo,J., DuPont,B.R.,
            Lilien,J. and Srivastava,A.K.
  TITLE     Alterations in CDH15 and KIRREL3 in patients with mild to severe
            intellectual disability
  JOURNAL   Am J Hum Genet 83 (6), 703-713 (2008)
   PUBMED   19012874
  REMARK    GeneRIF: Alterations in CDH15 in patients with mild to severe
            intellectual disability are reported.
REFERENCE   6  (bases 1 to 2866)
  AUTHORS   Shibata,T., Shimoyama,Y., Gotoh,M. and Hirohashi,S.
  TITLE     Identification of human cadherin-14, a novel neurally specific type
            II cadherin, by protein interaction cloning
  JOURNAL   J Biol Chem 272 (8), 5236-5240 (1997)
   PUBMED   9030594
REFERENCE   7  (bases 1 to 2866)
  AUTHORS   Hulsken,J., Birchmeier,W. and Behrens,J.
  TITLE     E-cadherin and APC compete for the interaction with beta-catenin
            and the cytoskeleton
  JOURNAL   J Cell Biol 127 (6 Pt 2), 2061-2069 (1994)
   PUBMED   7806582
REFERENCE   8  (bases 1 to 2866)
  AUTHORS   Bornemann,A. and Schmalbruch,H.
  TITLE     Immunocytochemistry of M-cadherin in mature and regenerating rat
            muscle
  JOURNAL   Anat Rec 239 (2), 119-125 (1994)
   PUBMED   8059975
REFERENCE   9  (bases 1 to 2866)
  AUTHORS   Kaupmann,K., Becker-Follmann,J., Scherer,G., Jockusch,H. and
            Starzinski-Powitz,A.
  TITLE     The gene for the cell adhesion molecule M-cadherin maps to mouse
            chromosome 8 and human chromosome 16q24.1-qter and is near the
            E-cadherin (uvomorulin) locus in both species
  JOURNAL   Genomics 14 (2), 488-490 (1992)
   PUBMED   1427864
REFERENCE   10 (bases 1 to 2866)
  AUTHORS   Donalies,M., Cramer,M., Ringwald,M. and Starzinski-Powitz,A.
  TITLE     Expression of M-cadherin, a member of the cadherin multigene
            family, correlates with differentiation of skeletal muscle cells
  JOURNAL   Proc Natl Acad Sci U S A 88 (18), 8024-8028 (1991)
   PUBMED   1840697
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009113.8, D83542.1 and
            AW452260.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_004933.2.
            
            Summary: This gene is a member of the cadherin superfamily of
            genes, encoding calcium-dependent intercellular adhesion
            glycoproteins. Cadherins consist of an extracellular domain
            containing 5 cadherin domains, a transmembrane region, and a
            conserved cytoplasmic domain. Transcripts from this particular
            cadherin are expressed in myoblasts and upregulated in
            myotubule-forming cells. The protein is thought to be essential for
            the control of morphogenetic processes, specifically myogenesis,
            and may provide a trigger for terminal muscle cell differentiation.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D83542.1, BC008951.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155751, SAMEA2162946
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000289746.3/ ENSP00000289746.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC009113.8         94684-94690         c
            8-2840              D83542.1           1-2833
            2841-2866           AW452260.1         17-42               c
FEATURES             Location/Qualifiers
     source          1..2866
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.3"
     gene            1..2866
                     /gene="CDH15"
                     /gene_synonym="CDH14; CDH3; CDHM; MCAD; MRD3"
                     /note="cadherin 15"
                     /db_xref="GeneID:1013"
                     /db_xref="HGNC:HGNC:1754"
                     /db_xref="MIM:114019"
     exon            1..126
                     /gene="CDH15"
                     /gene_synonym="CDH14; CDH3; CDHM; MCAD; MRD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..2529
                     /gene="CDH15"
                     /gene_synonym="CDH14; CDH3; CDHM; MCAD; MRD3"
                     /note="muscle-cadherin; cadherin-14; cadherin-3; cadherin
                     15, type 1, M-cadherin (myotubule)"
                     /codon_start=1
                     /product="cadherin-15 preproprotein"
                     /protein_id="NP_004924.1"
                     /db_xref="CCDS:CCDS10976.1"
                     /db_xref="GeneID:1013"
                     /db_xref="HGNC:HGNC:1754"
                     /db_xref="MIM:114019"
                     /translation="MDAAFLLVLGLLAQSLCLSLGVPGWRRPTTLYPWRRAPALSRVR
                     RAWVIPPISVSENHKRLPYPLVQIKSDKQQLGSVIYSIQGPGVDEEPRGVFSIDKFTG
                     KVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAFTGR
                     VLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPELFSIDELTGEIRTVQVGL
                     DREVVAVYNLTLQVADMSGDGLTATASAIITLDDINDNAPEFTRDEFFMEAIEAVSGV
                     DVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCE
                     HYELKVSVQNEAPLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGT
                     LVATFSARDPDTEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYR
                     AIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLLLGATDE
                     DLPPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQVPEGLHRLSLLLRDSGQ
                     PPQQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALVIVLASALLLLVLVLLV
                     ALRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPL
                     GPPPLRRDAPQGRLHPQPPRVLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYE
                     GDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYGHPCGLEYGARWDHQARE
                     GLSPGALLPRHRGRTA"
     exon            127..285
                     /gene="CDH15"
                     /gene_synonym="CDH14; CDH3; CDHM; MCAD; MRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            286..441
                     /gene="CDH15"
                     /gene_synonym="CDH14; CDH3; CDHM; MCAD; MRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            442..586
                     /gene="CDH15"
                     /gene_synonym="CDH14; CDH3; CDHM; MCAD; MRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            587..747
                     /gene="CDH15"
                     /gene_synonym="CDH14; CDH3; CDHM; MCAD; MRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            748..876
                     /gene="CDH15"
                     /gene_synonym="CDH14; CDH3; CDHM; MCAD; MRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1062
                     /gene="CDH15"
                     /gene_synonym="CDH14; CDH3; CDHM; MCAD; MRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1316
                     /gene="CDH15"
                     /gene_synonym="CDH14; CDH3; CDHM; MCAD; MRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1459
                     /gene="CDH15"
                     /gene_synonym="CDH14; CDH3; CDHM; MCAD; MRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1699
                     /gene="CDH15"
                     /gene_synonym="CDH14; CDH3; CDHM; MCAD; MRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1939
                     /gene="CDH15"
                     /gene_synonym="CDH14; CDH3; CDHM; MCAD; MRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2076
                     /gene="CDH15"
                     /gene_synonym="CDH14; CDH3; CDHM; MCAD; MRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2235
                     /gene="CDH15"
                     /gene_synonym="CDH14; CDH3; CDHM; MCAD; MRD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2866
                     /gene="CDH15"
                     /gene_synonym="CDH14; CDH3; CDHM; MCAD; MRD3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2845
                     /gene="CDH15"
                     /gene_synonym="CDH14; CDH3; CDHM; MCAD; MRD3"
                     /note="major polyA site"
ORIGIN      
        1 cccgcgcact tgcgctgtca ctcagcctgg acgcgcttct tcgggtcgcg ggtgcactcc
       61 ggcccggctc ccgcctcggc cccgatggac gccgcgttcc tcctcgtcct cgggctgttg
      121 gcccagagcc tctgcctgtc tttgggggtt cctggatgga ggaggcccac caccctgtac
      181 ccctggcgcc gggcgcctgc cctgagccgc gtgcggaggg cctgggtcat ccccccgatc
      241 agcgtatccg agaaccacaa gcgtctcccc taccccctgg ttcagatcaa gtcggacaag
      301 cagcagctgg gcagcgtcat ctacagcatc cagggacccg gcgtggatga ggagccccgg
      361 ggcgtcttct ctatcgacaa gttcacaggg aaggtcttcc tcaatgccat gctggaccgc
      421 gagaagactg atcgcttcag gctaagagcg tttgccctgg acctgggagg atccaccctg
      481 gaggacccca cggacctgga gattgtagtt gtggatcaga atgacaaccg gccagccttc
      541 ctgcaggagg cgttcactgg ccgcgtgctg gagggtgcag tcccaggcac ctatgtgacc
      601 agggcagagg ccacagatgc cgacgacccc gagacggaca acgcagcgct gcggttctcc
      661 atcctgcagc agggcagccc cgagctcttc agcatcgacg agctcacagg agagatccgc
      721 acagtgcaag tggggctgga ccgcgaggtg gtcgcggtgt acaatctgac cctgcaggtg
      781 gcggacatgt ctggagacgg cctcacagcc actgcctcag ccatcatcac ccttgatgac
      841 atcaatgaca atgcccccga gttcaccagg gatgagttct tcatggaggc catagaggcc
      901 gtcagcggag tggatgtggg acgcctggaa gtggaggaca gggacctgcc aggctcccca
      961 aactgggtgg ccaggttcac catcctggaa ggcgaccccg atgggcagtt caccatccgc
     1021 acggacccca agaccaacga gggtgttctg tccattgtga aggccctgga ctatgagagc
     1081 tgtgaacact acgaactcaa agtgtcggtg cagaatgagg ccccgctgca ggcggctgcc
     1141 cttagggctg agcggggcca ggccaaggtc cgcgtgcatg tgcaggacac caacgagccc
     1201 cccgtgttcc aggagaaccc acttcggacc agcctagcag agggggcacc cccaggcact
     1261 ctggtggcca ccttctctgc ccgggaccct gacacagagc agctgcagag gctcagctac
     1321 tccaaggact acgacccgga agactggctg caagtggacg cagccactgg ccggatccag
     1381 acccagcacg tgctcagccc ggcgtccccc ttcctcaagg gcggctggta cagagccatc
     1441 gtcctggccc aggatgacgc ctcccagccc cgcaccgcca ccggcaccct gtccatcgag
     1501 atcctggagg tgaacgacca tgcacctgtg ctggccccgc cgccgccggg cagcctgtgc
     1561 agcgagccac accaaggccc aggcctcctc ctgggcgcca cggatgagga cctgcccccc
     1621 cacggggccc ccttccactt ccagctgagc cccaggctcc cagagctcgg ccggaactgg
     1681 agcctcagcc aggtcaacgt gagccacgcg cgcctgcggc cgcgacacca ggtccccgaa
     1741 ggcctgcacc gcctcagcct gctgctccgg gactcggggc agccgcccca gcagcgcgag
     1801 cagcctctga acgtgaccgt gtgccgctgc ggcaaggacg gcgtctgcct gccgggggcc
     1861 gcagcgctgc tggcgggggg cacaggcctc agcctgggcg cactggtcat cgtgctggcc
     1921 agcgccctcc tgctgctggt gctggtcctg ctcgtggcac tccgggcgcg gttctggaag
     1981 cagtctcggg gcaaggggct gctgcacggc ccccaggacg accttcgaga caatgtcctc
     2041 aactacgatg agcaaggagg cggggaggag gaccaggacg cctacgacat cagccagctg
     2101 cgtcacccga cagcgctgag cctgcctctg ggaccgccgc cacttcgcag agatgccccg
     2161 cagggccgcc tgcaccccca gccaccccga gtgctgccca ccagccccct ggacatcgcc
     2221 gacttcatca atgatggctt ggaggctgca gatagtgacc ccagtgtgcc gccttacgac
     2281 acagccctca tctatgacta cgagggtgac ggctcggtgg cggggacgct gagctccatc
     2341 ctgtccagcc agggcgatga ggaccaggac tacgactacc tcagagactg ggggccccgc
     2401 ttcgcccggc tggcagacat gtatgggcac ccgtgcgggt tggagtacgg ggccagatgg
     2461 gaccaccagg ccagggaggg tctttctcct ggggcactgc tacccagaca cagaggccgg
     2521 acagcctgac cctggggcgc aactggacat gccactcccc ggcctcgtgg cagtgatggc
     2581 ccctgcagag gcagcctgag gtcaccgggc ccgacccccc tgggcctggg gcagcctcct
     2641 tcctgtaggc gagggcccaa gtctgggggc agaacctgag tgtggatggg gcggccagga
     2701 agaggcccct tcctgccggg gtgggaagag tttctctcca tcggccccat gcgggtcacc
     2761 tccctagtcc cacctttgcc tcctaccagt gaacctcatc tttgtatgaa agacagcaac
     2821 ctcctgggta aatctgaatg aaaaacgtgc tagtctcttt catgca
//
