LOCUS       NM_001257               7876 bp    mRNA    linear   PRI 28-APR-2025
DEFINITION  Homo sapiens cadherin 13 (CDH13), transcript variant 1, mRNA.
ACCESSION   NM_001257
VERSION     NM_001257.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7876)
  AUTHORS   Andreeva,A.V., Han,J., Kutuzov,M.A., Profirovic,J., Tkachuk,V.A.
            and Voyno-Yasenetskaya,T.A.
  TITLE     T-cadherin modulates endothelial barrier function
  JOURNAL   J Cell Physiol 223 (1), 94-102 (2010)
   PUBMED   20039275
  REMARK    GeneRIF: Data implicate T-cadherin in regulation of endothelial
            barrier function, and suggest a complex signaling network that
            links T-cadherin and regulation of barrier function.
REFERENCE   2  (bases 1 to 7876)
  AUTHORS   Semina,E.V., Rubina,K.A., Rutkevich,P.N., Voyno-Yasenetskaya,T.A.,
            Parfyonova,Y.V. and Tkachuk,V.A.
  TITLE     T-cadherin activates Rac1 and Cdc42 and changes endothelial
            permeability
  JOURNAL   Biochemistry (Mosc) 74 (4), 362-370 (2009)
   PUBMED   19463088
  REMARK    GeneRIF: T-cadherin transcriptionally activated Rac1 and Cdc42.
REFERENCE   3  (bases 1 to 7876)
  AUTHORS   Takeuchi,T., Adachi,Y., Ohtsuki,Y. and Furihata,M.
  TITLE     Adiponectin receptors, with special focus on the role of the third
            receptor, T-cadherin, in vascular disease
  JOURNAL   Med Mol Morphol 40 (3), 115-120 (2007)
   PUBMED   17874043
  REMARK    Review article
REFERENCE   4  (bases 1 to 7876)
  AUTHORS   Philippova,M., Banfi,A., Ivanov,D., Gianni-Barrera,R.,
            Allenspach,R., Erne,P. and Resink,T.
  TITLE     Atypical GPI-anchored T-cadherin stimulates angiogenesis in vitro
            and in vivo
  JOURNAL   Arterioscler Thromb Vasc Biol 26 (10), 2222-2230 (2006)
   PUBMED   16873731
REFERENCE   5  (bases 1 to 7876)
  AUTHORS   Joshi,M.B., Philippova,M., Ivanov,D., Allenspach,R., Erne,P. and
            Resink,T.J.
  TITLE     T-cadherin protects endothelial cells from oxidative stress-induced
            apoptosis
  JOURNAL   FASEB J 19 (12), 1737-1739 (2005)
   PUBMED   16099944
  REMARK    GeneRIF: T-cad overexpression in vascular endothelial cells
            protects against stress-induced apoptosis through activation of the
            PI3K/Akt/mTOR survival signal pathway and concomitant suppression
            of the p38 MAPK proapoptotic pathway
REFERENCE   6  (bases 1 to 7876)
  AUTHORS   Hug,C., Wang,J., Ahmad,N.S., Bogan,J.S., Tsao,T.S. and Lodish,H.F.
  TITLE     T-cadherin is a receptor for hexameric and high-molecular-weight
            forms of Acrp30/adiponectin
  JOURNAL   Proc Natl Acad Sci U S A 101 (28), 10308-10313 (2004)
   PUBMED   15210937
REFERENCE   7  (bases 1 to 7876)
  AUTHORS   Ivanov,D., Philippova,M., Tkachuk,V., Erne,P. and Resink,T.
  TITLE     Cell adhesion molecule T-cadherin regulates vascular cell adhesion,
            phenotype and motility
  JOURNAL   Exp Cell Res 293 (2), 207-218 (2004)
   PUBMED   14729458
  REMARK    GeneRIF: Coating of culture plates with recombinant T-cad protein
            or with antibody against the first amino-terminal domain of T-cad
            (anti-EC1) significantly decreased adhesion and spreading of smooth
            muscle cells and HUVEC.
REFERENCE   8  (bases 1 to 7876)
  AUTHORS   Niermann,T., Kern,F., Erne,P. and Resink,T.
  TITLE     The glycosyl phosphatidylinositol anchor of human T-cadherin binds
            lipoproteins
  JOURNAL   Biochem Biophys Res Commun 276 (3), 1240-1247 (2000)
   PUBMED   11027617
REFERENCE   9  (bases 1 to 7876)
  AUTHORS   Sato,M., Mori,Y., Sakurada,A., Fujimura,S. and Horii,A.
  TITLE     The H-cadherin (CDH13) gene is inactivated in human lung cancer
  JOURNAL   Hum Genet 103 (1), 96-101 (1998)
   PUBMED   9737784
  REMARK    Erratum:[Hum Genet 1998 Oct;103(4):532]
REFERENCE   10 (bases 1 to 7876)
  AUTHORS   Lee,S.W.
  TITLE     H-cadherin, a novel cadherin with growth inhibitory functions and
            diminished expression in human breast cancer
  JOURNAL   Nat Med 2 (7), 776-782 (1996)
   PUBMED   8673923
REFERENCE   11 (bases 1 to 7876)
  AUTHORS   Tanihara,H., Sano,K., Heimark,R.L., St John,T. and Suzuki,S.
  TITLE     Cloning of five human cadherins clarifies characteristic features
            of cadherin extracellular domain and provides further evidence for
            two structurally different types of cadherin
  JOURNAL   Cell Adhes Commun 2 (1), 15-26 (1994)
   PUBMED   7982033
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC376661.1, BC028624.2,
            BI756586.1, CN263227.1, CA445317.1, BG911233.1, BU627784.1,
            R41787.1 and AC009119.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001257.4.
            
            Summary: This gene encodes a member of the cadherin superfamily.
            The encoded protein is localized to the surface of the cell
            membrane and is anchored by a GPI moiety, rather than by a
            transmembrane domain. The protein lacks the cytoplasmic domain
            characteristic of other cadherins, and so is not thought to be a
            cell-cell adhesion glycoprotein. This protein acts as a negative
            regulator of axon growth during neural differentiation. It also
            protects vascular endothelial cells from apoptosis due to oxidative
            stress, and is associated with resistance to atherosclerosis. The
            gene is hypermethylated in many types of cancer. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.137525.1,
                                           SRR1803617.264891.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000567109.6/ ENSP00000479395.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DC376661.1         176-208
            34-713              BC028624.2         1-680
            714-724             BI756586.1         693-703
            725-981             BC028624.2         692-948
            982-1303            CN263227.1         181-502
            1304-1748           BC028624.2         1271-1715
            1749-2194           CA445317.1         139-584             c
            2195-2314           BG911233.1         258-377
            2315-3242           BC028624.2         2282-3209
            3243-3441           BU627784.1         406-604             c
            3442-3835           BC028624.2         3409-3802
            3836-3846           R41787.1           8-18                c
            3847-7876           AC009119.10        26110-30139
FEATURES             Location/Qualifiers
     source          1..7876
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.3"
     gene            1..7876
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
                     /note="cadherin 13"
                     /db_xref="GeneID:1012"
                     /db_xref="HGNC:HGNC:1753"
                     /db_xref="MIM:601364"
     exon            1..169
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2266
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
                     /EC_number="3.6.1.3"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; T-cadherin; heart cadherin; cadherin 13,
                     H-cadherin (heart)"
                     /codon_start=1
                     /product="cadherin-13 isoform 1 preproprotein"
                     /protein_id="NP_001248.1"
                     /db_xref="CCDS:CCDS58486.1"
                     /db_xref="GeneID:1012"
                     /db_xref="HGNC:HGNC:1753"
                     /db_xref="MIM:601364"
                     /translation="MQPRTPLVLCVLLSQVLLLTSAEDLDCTPGFQQKVFHINQPAEF
                     IEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVGKTLFVHARTPH
                     AEDMAELVIVGGKDIQGSLQDIFKFARTSPVPRQKRSIVVSPILIPENQRQPFPRDVG
                     KVVDSDRPERSKFRLTGKGVDQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETT
                     DVNGKTLEGPVPLEVIVIDQNDNRPIFREGPYIGHVMEGSPTGTTVMRMTAFDADDPA
                     TDNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVTVVSPALLDRETLENPKYELIIEAQ
                     DMAGLDVGLTGTATATIMIDDKNDHSPKFTKKEFQATVEEGAVGVIVNLTVEDKDDPT
                     TGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKPLDYEISAFHTLLIKVENEDPL
                     VPDVSYGPSSTATVHITVLDVNEGPVFYPDPMMVTRQEDLSVGSVLLTVNATDPDSLQ
                     HQTIRYSVYKDPAGWLNINPINGTVDTTAVLDRESPFVDNSVYTALFLAIDSGNPPAT
                     GTGTLLITLEDVNDNAPFIYPTVAEVCDDAKNLSVVILGASDKDLHPNTDPFKFEIHK
                     QAVPDKVWKISKINNTHALVSLLQNLNKANYNLPIMVTDSGKPPMTNITDLRVQVCSC
                     RNSKVDCNAAGALRFSLPSVLLLSLFSLACL"
     exon            170..281
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
                     /inference="alignment:Splign:2.1.0"
     exon            282..490
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
                     /inference="alignment:Splign:2.1.0"
     exon            491..607
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
                     /inference="alignment:Splign:2.1.0"
     exon            608..760
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
                     /inference="alignment:Splign:2.1.0"
     exon            761..905
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1084
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1225
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1408
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1662
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1805
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..2039
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2258
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..7876
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3808..3813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
                     /note="hexamer: AATAAA"
     polyA_site      3832
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
                     /note="major polyA site"
     regulatory      4931..4936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
                     /note="hexamer: ATTAAA"
     polyA_site      4962
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
     regulatory      5161..5166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
                     /note="hexamer: AATAAA"
     polyA_site      5186
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
     regulatory      7852..7857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
                     /note="hexamer: AATAAA"
     polyA_site      7876
                     /gene="CDH13"
                     /gene_synonym="CDHH; P105"
ORIGIN      
        1 atttgggaag ttggctggct ggcgaggcag agcctctcct caaagcctgg ctcccacgga
       61 aaatatgctc agtgcagccg cgtgcatgaa tgaaaacgcc gccgggcgct tctagtcgga
      121 caaaatgcag ccgagaactc cgctcgttct gtgcgttctc ctgtcccagg tgctgctgct
      181 aacatctgca gaagatttgg actgcactcc tggatttcag cagaaagtgt tccatatcaa
      241 tcagccagct gaattcattg aggaccagtc aattctaaac ttgaccttca gtgactgtaa
      301 gggaaacgac aagctacgct atgaggtctc gagcccatac ttcaaggtga acagcgatgg
      361 cggcttagtt gctctgagaa acataactgc agtgggcaaa actctgttcg tccatgcacg
      421 gaccccccat gcggaagata tggcagaact cgtgattgtc ggggggaaag acatccaggg
      481 ctccttgcag gatatattta aatttgcaag aacttctcct gtcccaagac aaaagaggtc
      541 cattgtggta tctcccattt taattccaga gaatcagaga cagcctttcc caagagatgt
      601 tggcaaggta gtcgatagtg acaggccaga aaggtccaag ttccggctca ctggaaaggg
      661 agtggatcaa gagcctaaag gaattttcag aatcaatgag aacacaggga gcgtctccgt
      721 gacacggacc ttggacagag aagtaatcgc tgtttatcaa ctatttgtgg agaccactga
      781 tgtcaatggc aaaactctcg aggggccggt gcctctggaa gtcattgtga ttgatcagaa
      841 tgacaaccga ccgatctttc gggaaggccc ctacatcggc cacgtcatgg aagggtcacc
      901 cacaggcacc acagtgatgc ggatgacagc ctttgatgca gatgacccag ccaccgataa
      961 tgccctcctg cggtataata tccgtcagca gacgcctgac aagccatctc ccaacatgtt
     1021 ctacatcgat cctgagaaag gagacattgt cactgttgtg tcacctgcgc tgctggaccg
     1081 agagactctg gaaaatccca agtatgaact gatcatcgag gctcaagata tggctggact
     1141 ggatgttgga ttaacaggca cggccacagc cacgatcatg atcgatgaca aaaatgatca
     1201 ctcaccaaaa ttcaccaaga aagagtttca agccacagtc gaggaaggag ctgtgggagt
     1261 tattgtcaat ttgacagttg aagataagga tgaccccacc acaggtgcat ggagggctgc
     1321 ctacaccatc atcaacggaa accccgggca gagctttgaa atccacacca accctcaaac
     1381 caacgaaggg atgctttctg ttgtcaaacc attggactat gaaatttctg ccttccacac
     1441 cctgctgatc aaagtggaaa atgaagaccc actcgtaccc gacgtctcct acggccccag
     1501 ctccacagcc accgtccaca tcactgtcct ggatgtcaac gagggcccag tcttctaccc
     1561 agaccccatg atggtgacca ggcaggagga cctctctgtg ggcagcgtgc tgctgacagt
     1621 gaatgccacg gaccccgact ccctgcagca tcaaaccatc aggtattctg tttacaagga
     1681 cccagcaggt tggctgaata ttaaccccat caatgggact gttgacacca cagctgtgct
     1741 ggaccgtgag tccccatttg tcgacaacag cgtgtacact gctctcttcc tggcaattga
     1801 cagtggcaac cctcccgcta cgggcactgg gactttgctg ataaccctgg aggacgtgaa
     1861 tgacaatgcc ccgttcattt accccacagt agctgaagtc tgtgatgatg ccaaaaacct
     1921 cagtgtagtc attttgggag catcagataa ggatcttcac ccgaatacag atcctttcaa
     1981 atttgaaatc cacaaacaag ctgttcctga taaagtctgg aagatctcca agatcaacaa
     2041 tacacacgcc ctggtaagcc ttcttcaaaa tctgaacaaa gcaaactaca acctgcccat
     2101 catggtgaca gattcaggga aaccacccat gacgaatatc acagatctca gggtacaagt
     2161 gtgctcctgc aggaattcca aagtggactg caacgcggca ggggccctgc gcttcagcct
     2221 gccctcagtc ctgctcctca gcctcttcag cttagcttgt ctgtgagaac tcctgacgtc
     2281 tgaagcttga ctcccaagtt tccatagcaa caggaaaaaa aaaaatctat ccaaatctga
     2341 agattgcggt ttacagctat cgaacttcac aactaggcct caattgttcc ggttttttat
     2401 tttctttaca atttcactta gtctgtactt catcattttg acagcatctt cctccctcct
     2461 ttaattaatg gaatcttctg aattttccct gaatgtttaa agatcatgac atatgacttg
     2521 atcttctggg agcaggaaca atgactactt tttctggtgt gttaacatgt cgctagccag
     2581 tgctccaggc acccagcttt gtctgtgggt tagtattggt gtatgtatga gtatctgtat
     2641 gtatatatac acggtattta tagagagaga ctatcctgga gaagcctcgt tttgatgcca
     2701 ttcttccttg caaggttaag caaggtgggt ggaaactaag acacctgaac cctccagggc
     2761 ctcccgcatc aaggtcagca tgaggacaga ccacagagct gtcacttttg ctccgaagct
     2821 acttctccac tgtcccgttc agtctgaatg ctgccacaac cagccaggca ggtccacaga
     2881 gagggagagc agagaaagaa gtcctttctc tttattgagt tcgaggacta caaccaattt
     2941 acactgccat ctgatgccgt gatcctgagc caaggaggtg aggagcagag caggcaattt
     3001 caccaccaaa tgccaagaaa agggctgaca ttttctttca tgggcaccaa cctgcatttg
     3061 tatgtgtccc gaatccacag tcgtactgat tctaatgggg acacagatca tggtagagaa
     3121 tctctccctc ctcagtaaat gtacaactgc acctgtcatc atggaggtca tacatgcata
     3181 caaagaggtg tacaggtacc atcttgtata cacatatata cccacatgta cagacataca
     3241 tttatgcaca ttcacgctgt ttgtttcata tatacaggca taaaatagag taaatacagg
     3301 tagttttaaa agtacccttt tgtgtgaatt gactaccgtt gtttgcaaac ccgaaaataa
     3361 aagacgttca ttatgtatga aaagtaactg atttgtattc tgtgagcatg taaaagcgga
     3421 aagttagtgc ttgttctaag attaccttct tgttgataaa ccataaatga atcatcaaag
     3481 ctcacaccaa atttttctat caaataaaac tagtgacagc ttgtggcttt ttattagagc
     3541 tcgccacgaa ctagggtaag gtgagtgtct tagcatattt taatgcagtt gcttactaaa
     3601 ggttttaacc gcacatgcac acacacacgc tttcttatgc aatctatgtt tgcacttgtg
     3661 ctttcagtta gccttctgta ggaagtagaa gtcatatgtt gtctttgttg tagtgaaatt
     3721 atacagatag agttccatat attgtatttg tttcaatggt aaatcctttt ggaacatata
     3781 gaatgcagag attttttttt ccattaaaat aaatgggtat tggtggttaa aactgctgga
     3841 cagtaactgt tctctgattt ctatcttgtg tccaatgtca ctgatgttgg gtcttgtctt
     3901 agtgcaagtt cacatttttg acagaccatt tggggtccgt cgtacatctc tggttggtga
     3961 gtgagtctat gaagacagaa gtaccagttc tcagcatggg ccatggactc atcttgtcca
     4021 cctcatgata tgatctgagg gtgtcataat cagctataaa ggtaattgca tactcaaaga
     4081 tgagacggac cattctcagt tgatgaccac attaagcata gtcatggcca tctgtcaaca
     4141 gtcccaagac ctggggattt ttctctggaa caaatcctgt tgctggatca ggagatgcca
     4201 caccttgaac ttgatagggt cattctccac gagcacatgc ccccgactca gggacagggg
     4261 aatctaagcc tgtgcattca cactccacaa gatttcctct actggcttta cagggcactg
     4321 tcacgcgtct cccgggcgca ccttgctccc ctcttcctgc aaggcagggg gagaacgttc
     4381 atccttgaac aaacaaagag catcctcagc cagtcaggcg gctggtagcc ggacacatat
     4441 gctaactggc aatcaggaag tcaccctcca atgtaaactt cagccacatg cagggagaaa
     4501 cacagcagct gagtggccat tcactcaagg aaacaaatac agcatgactc cttttctctc
     4561 aagctggtag gctctcctgc actttgtgaa ccgaaccaga agattaactt cgctgaaaat
     4621 tcagaaaaat aggagtaaag tgcacacttc attaataaat agaatatgcc tcaactttcc
     4681 cttatttaaa catattctct gtccccacag ttctaatcag gacagagata cttctgtcat
     4741 gttgttcctc ctaatagttt ccagaaaaaa aggaaaataa accaattctt ataggccaaa
     4801 gtggtagcat ttcctgaatc ataagatgtt ttgttcattt gctggaatat attacattgt
     4861 ttactgaaaa ccatagtaga atcaaaatgt tatttcatta ttacctatgc attttatctg
     4921 agtccaactt attaaaaaac gaagtcaagt aaggaccaga aattgctttt cccaattact
     4981 gagcacaggt ctgagggttt tatttccact gagcaaatag tcacaccttc acttcttttt
     5041 attaatactc aaccaactta gttgattaaa aatcacattt tctccctcat tttacatacg
     5101 ataaattaat tattttggat aatttgtttt aataagaata tgcacacatt ttctaatttc
     5161 aataaaagtc accttcaata ccgccagttc tctccaaatg agcatcattc caggcagata
     5221 tacctgctgt gcctcttggc cgacaccagc aaatctaagc attataacga aataaatcca
     5281 gccagatttc atggtaggta tcaaataaga ctttggctct taaagaacat cgttagaaat
     5341 tttgatagct cattccagag tttcagaatg tcatttaaaa cagtctgata aatggaacaa
     5401 ccatctacca tcacactcat agagtagctc aaattgcatt ttacccaaat aaatacactg
     5461 ggtcttaatc ttaagatgtg acaactaaaa aatttttaac aagtctgtgt ttgatcctgg
     5521 atttagtgca gttgcaccca ggcacgagct ctccagatga ttctgaggaa aggagtctac
     5581 aattttccta gggggtgtat gaacatggta ccaaaaaggt gattaataat tataataatg
     5641 gtttatattt atcaactgct tattatgtgc ccacactgta caaaatcctt acagatagta
     5701 actcattaat ccctccagta acatatgaga caagcactac tatcttctcc aactcacaga
     5761 taaagaaggc tgaggctcag aaaaattgaa tggcttgccc aaggtaagtg gcctccagaa
     5821 ccaaacctca ggctatctgg ctccagggtt catgttcttc cgacaacatc acaatgccac
     5881 tctcaaccca ggagcaaaac cagacaaagt gcctactgca gaccggaaga ccctcgtttg
     5941 aagcctccat tagcgtgact atgcagctag accaacttac tgttaagcaa cagtaccttt
     6001 tactatgagg taccctttac tattaagtac cttttactaa cagtatcttc tgttacctat
     6061 tattaagttc atgctatact tcttcaatct gaaagctttc tgttaaaaaa aaaaatgtta
     6121 acatcgttct aaattaatat tgagacctta gaaatttttc ctgtgcaaga taacgtaatt
     6181 atttgcccct tcccttccat ggcttgttag caggtagatg aggggcttct cctagattaa
     6241 tttaacatct cagttaatca aaagtagccg ggcatggtga ctcatgcctg taatcccagc
     6301 cctttgggag gcagaggcgg gtggatcact taaggtcagg agttcaagac cagcctggcc
     6361 agcatggtga aaccctatct ctactaaaaa atacaaaaat tagctgggtg tggtggtgca
     6421 cacctgaaac cccagctact caggaggctg aggcaggaga atcgcttgaa cccaggaggc
     6481 agagtttgca gtgagccatt gcactccagc ctgggcaaca gagcaagact ccgtcaaaaa
     6541 aaaaaaaaaa aaaaaagaaa gaaaaggaaa tttatgaact ccagagtacc cattcactac
     6601 caaaccaact gaggggagag aaaactgagg gagaaagtgg ggtggggtct caaagggttt
     6661 gcactgtgct ttgctataaa tcattcaaag gggcaaattc taaaggatct ctaagtagtt
     6721 gctgattttg taaaggtagc ccataaatct gtttacgtgt agctgcctta aacatgagtc
     6781 aacagggtaa gtcacaccaa caggaaaccc aagcactaaa aaagccacct accttttctg
     6841 tttaccaaat actaagaata ataatctaat aatctggcta catctttcat aaagacctcc
     6901 atcttctctc cttaactgac tgttgagatt tgataatttt cacagtctaa tgataaaatg
     6961 ctttcaaaat ggttcatcta acacaattaa caattctttt actatatgca atgtgttacc
     7021 cttactatat ttcctattgc taatagatta gcccactatt gaaaaaattc tgcagttgtg
     7081 accgtgttca catgaaagca tatacaagac atggagagac agcaaaaaat ggtgggaatg
     7141 ggtgtgtgta tgagggtttc agataagaac ttcaattata taatttaaga agagtcagtc
     7201 tataatttaa gcagaaataa ttgagatact catcaaatta agtaagcgga aaaatttcct
     7261 ctctctcata ctatgttgct atcatcacat ctatcgttgg agggttgctg agcttgatac
     7321 gcctttgaac cattttattt gactttccac gtgccgtctc attggtaggg agatggtgaa
     7381 aagcgttggg tggtgtagga cgagggaggt tttcactctg aagctatgaa gatttggaga
     7441 aaggggctta tagaagcact atgaaaataa actggagact atttttttgc tactttttaa
     7501 aaagcttttt ctttagagag tactaaagcc attctatatc tgtcgtacac atgaattcag
     7561 actattatta gagagttata tctgtgttgt catgcacatg tcaacactgt cctgatgaca
     7621 aaattttatg tatcccccca gataaaaatt ttaagaaatt ttaaatgctt tttattcaca
     7681 cacacttttc aaaagggata aaagttaatc atgttaaaat attcagtcta tggcagatgt
     7741 cgctcctttg ggccctcact gctgaattgc ttacagtttc tgagctgtaa actaacattt
     7801 gctttactat gtagttacag agaaatgtgc aacttgtttg tgaaacattc aaataaagct
     7861 tatctgggat ttttaa
//
