LOCUS       NM_004061               4258 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens cadherin 12 (CDH12), transcript variant 1, mRNA.
ACCESSION   NM_004061
VERSION     NM_004061.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4258)
  AUTHORS   Golawski,K., Soczewica,R., Kacperczyk-Bartnik,J., Manka,G.,
            Kiecka,M., Lipa,M., Warzecha,D., Spaczynski,R., Piekarski,P.,
            Banaszewska,B., Jakimiuk,A., Issat,T., Rokita,W., Mlodawski,J.,
            Szubert,M., Sieroszewski,P., Raba,G., Szczupak,K., Kluz,T.,
            Kluza,M., Wielgos,M., Koc-Zorawska,E., Zorawski,M. and Laudanski,P.
  TITLE     The Role of Cadherin 12 (CDH12) in the Peritoneal Fluid among
            Patients with Endometriosis and Endometriosis-Related Infertility
  JOURNAL   Int J Environ Res Public Health 19 (18), 11586 (2022)
   PUBMED   36141853
  REMARK    GeneRIF: The Role of Cadherin 12 (CDH12) in the Peritoneal Fluid
            among Patients with Endometriosis and Endometriosis-Related
            Infertility.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4258)
  AUTHORS   Gouin,K.H. 3rd, Ing,N., Plummer,J.T., Rosser,C.J., Ben Cheikh,B.,
            Oh,C., Chen,S.S., Chan,K.S., Furuya,H., Tourtellotte,W.G.,
            Knott,S.R.V. and Theodorescu,D.
  TITLE     An N-Cadherin 2 expressing epithelial cell subpopulation predicts
            response to surgery, chemotherapy and immunotherapy in bladder
            cancer
  JOURNAL   Nat Commun 12 (1), 4906 (2021)
   PUBMED   34385456
  REMARK    GeneRIF: An N-Cadherin 2 expressing epithelial cell subpopulation
            predicts response to surgery, chemotherapy and immunotherapy in
            bladder cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4258)
  AUTHORS   Charfeddine,C., Dallali,H., Abdessalem,G., Ghedira,K., Hamdi,Y.,
            Elouej,S., Landoulsi,Z., Delague,V., Lagarde,A., Levy,N.,
            El-Amraoui,A., Boubaker,M.S., Abdelhak,S. and Mokni,M.
  TITLE     Identification of a CDH12 potential candidate genetic variant for
            an autosomal dominant form of transgrediens and progrediens
            palmoplantar keratoderma in a Tunisian family
  JOURNAL   J Hum Genet 65 (4), 397-410 (2020)
   PUBMED   31911611
  REMARK    GeneRIF: Identification of a CDH12 potential candidate genetic
            variant for an autosomal dominant form of transgrediens and
            progrediens palmoplantar keratoderma in a Tunisian family.
REFERENCE   4  (bases 1 to 4258)
  AUTHORS   Ma,J., Zhao,J., Lu,J., Wang,P., Feng,H., Zong,Y., Ou,B., Zheng,M.
            and Lu,A.
  TITLE     Cadherin-12 enhances proliferation in colorectal cancer cells and
            increases progression by promoting EMT
  JOURNAL   Tumour Biol 37 (7), 9077-9088 (2016)
   PUBMED   26762412
  REMARK    GeneRIF: CDH12 may influence CRC cell progression.
REFERENCE   5  (bases 1 to 4258)
  AUTHORS   Zhao,J., Li,P., Feng,H., Wang,P., Zong,Y., Ma,J., Zhang,Z.,
            Chen,X., Zheng,M., Zhu,Z. and Lu,A.
  TITLE     Cadherin-12 contributes to tumorigenicity in colorectal cancer by
            promoting migration, invasion, adhersion and angiogenesis
  JOURNAL   J Transl Med 11, 288 (2013)
   PUBMED   24237488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4258)
  AUTHORS   Selig,S., Bruno,S., Scharf,J.M., Wang,C.H., Vitale,E., Gilliam,T.C.
            and Kunkel,L.M.
  TITLE     Expressed cadherin pseudogenes are localized to the critical region
            of the spinal muscular atrophy gene
  JOURNAL   Proc Natl Acad Sci U S A 92 (9), 3702-3706 (1995)
   PUBMED   7731968
REFERENCE   7  (bases 1 to 4258)
  AUTHORS   Hulsken,J., Birchmeier,W. and Behrens,J.
  TITLE     E-cadherin and APC compete for the interaction with beta-catenin
            and the cytoskeleton
  JOURNAL   J Cell Biol 127 (6 Pt 2), 2061-2069 (1994)
   PUBMED   7806582
REFERENCE   8  (bases 1 to 4258)
  AUTHORS   Gyapay,G., Morissette,J., Vignal,A., Dib,C., Fizames,C.,
            Millasseau,P., Marc,S., Bernardi,G., Lathrop,M. and Weissenbach,J.
  TITLE     The 1993-94 Genethon human genetic linkage map
  JOURNAL   Nat Genet 7 (2 Spec No), 246-339 (1994)
   PUBMED   7545953
REFERENCE   9  (bases 1 to 4258)
  AUTHORS   Weissenbach,J., Gyapay,G., Dib,C., Vignal,A., Morissette,J.,
            Millasseau,P., Vaysseix,G. and Lathrop,M.
  TITLE     A second-generation linkage map of the human genome
  JOURNAL   Nature 359 (6398), 794-801 (1992)
   PUBMED   1436057
REFERENCE   10 (bases 1 to 4258)
  AUTHORS   Suzuki,S., Sano,K. and Tanihara,H.
  TITLE     Diversity of the cadherin family: evidence for eight new cadherins
            in nervous tissue
  JOURNAL   Cell Regul 2 (4), 261-270 (1991)
   PUBMED   2059658
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC109455.2, AC026716.5,
            AC093263.3, AC138854.2, AC139497.3, AC138940.3, AC140171.3 and
            AC140132.3.
            
            On May 17, 2019 this sequence version replaced NM_004061.4.
            
            Summary: This gene encodes a type II classical cadherin of the
            cadherin superfamily. Alternative splicing of this gene results in
            multiple transcript variants. At least one of these variants
            encodes a preproprotein that is proteolytically processed to
            generate the mature cadherin protein. These integral membrane
            proteins mediate calcium-dependent cell-cell adhesion and are
            composed of a large N-terminal extracellular domain, a single
            membrane-spanning domain, and a small, highly conserved C-terminal
            cytoplasmic domain. Type II (atypical) cadherins are defined based
            on their lack of a histidine-alanine-valine (HAV) cell adhesion
            recognition sequence specific to type I cadherins. This particular
            cadherin appears to be expressed specifically in the brain and its
            temporal pattern of expression would be consistent with a role
            during a critical period of neuronal development, perhaps
            specifically during synaptogenesis. [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Variants 1, 2, and
            4-8 all encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.175164.1,
                                           SRR1803615.183309.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968832 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382254.6/ ENSP00000371689.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-287               AC109455.2         79949-80235
            288-382             AC026716.5         13527-13621         c
            383-477             AC093263.3         17108-17202
            478-623             AC138854.2         120091-120236
            624-1040            AC139497.3         113641-114057       c
            1041-1335           AC138940.3         10660-10954
            1336-1455           AC140171.3         16377-16496
            1456-1623           AC140171.3         28839-29006
            1624-1811           AC140171.3         54035-54222
            1812-2065           AC140171.3         68747-69000
            2066-2202           AC140171.3         87673-87809
            2203-2324           AC140132.3         179051-179172       c
            2325-2442           AC140132.3         174631-174748       c
            2443-2694           AC140132.3         169664-169915       c
            2695-4258           AC140132.3         164746-166309       c
FEATURES             Location/Qualifiers
     source          1..4258
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p14.3"
     gene            1..4258
                     /gene="CDH12"
                     /gene_synonym="CDHB"
                     /note="cadherin 12"
                     /db_xref="GeneID:1010"
                     /db_xref="HGNC:HGNC:1751"
                     /db_xref="MIM:600562"
     exon            1..287
                     /gene="CDH12"
                     /gene_synonym="CDHB"
                     /inference="alignment:Splign:2.1.0"
     exon            288..382
                     /gene="CDH12"
                     /gene_synonym="CDHB"
                     /inference="alignment:Splign:2.1.0"
     exon            383..477
                     /gene="CDH12"
                     /gene_synonym="CDHB"
                     /inference="alignment:Splign:2.1.0"
     exon            478..623
                     /gene="CDH12"
                     /gene_synonym="CDHB"
                     /inference="alignment:Splign:2.1.0"
     exon            624..1040
                     /gene="CDH12"
                     /gene_synonym="CDHB"
                     /inference="alignment:Splign:2.1.0"
     CDS             810..3194
                     /gene="CDH12"
                     /gene_synonym="CDHB"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; brain-cadherin; neuronal cadherin 2; cadherin,
                     neural type, 2; N-cadherin 2; Br-cadherin; neural type
                     cadherin 2"
                     /codon_start=1
                     /product="cadherin-12 isoform 1 preproprotein"
                     /protein_id="NP_004052.2"
                     /db_xref="CCDS:CCDS3890.1"
                     /db_xref="GeneID:1010"
                     /db_xref="HGNC:HGNC:1751"
                     /db_xref="MIM:600562"
                     /translation="MLTRNCLSLLLWVLFDGGLLTPLQPQPQQTLATEPRENVIHLPG
                     QRSHFQRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVF
                     TIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKF
                     LDGPYVATVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVI
                     RTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHL
                     KVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKK
                     PLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTME
                     VYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRE
                     STAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQ
                     IVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYF
                     LPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCI
                     VILLAIVVLYVALRRQKKKDTLMTSKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPK
                     VIEENKIRRDIKPDSLCLPRQRPPMEDNTDIRDFIHQRLQENDVDPTAPPYDSLATYA
                     YEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLADMFGEEESYNPDKVT"
     exon            1041..1335
                     /gene="CDH12"
                     /gene_synonym="CDHB"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1455
                     /gene="CDH12"
                     /gene_synonym="CDHB"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1623
                     /gene="CDH12"
                     /gene_synonym="CDHB"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1811
                     /gene="CDH12"
                     /gene_synonym="CDHB"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..2065
                     /gene="CDH12"
                     /gene_synonym="CDHB"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2202
                     /gene="CDH12"
                     /gene_synonym="CDHB"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2324
                     /gene="CDH12"
                     /gene_synonym="CDHB"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2442
                     /gene="CDH12"
                     /gene_synonym="CDHB"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2694
                     /gene="CDH12"
                     /gene_synonym="CDHB"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..4258
                     /gene="CDH12"
                     /gene_synonym="CDHB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4039..4044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH12"
                     /gene_synonym="CDHB"
                     /note="hexamer: AATAAA"
     polyA_site      4067
                     /gene="CDH12"
                     /gene_synonym="CDHB"
                     /note="major polyA site"
ORIGIN      
        1 attattgatc tgaagggtaa atgtggaggg agccacagag aggggtccag gcttttctga
       61 gaagagaggc agcctcttcc aggaagaaag tggtgtctac tggctgcccg gcctggagaa
      121 ccttctttga atgaaaacgg acaaaatgca aagcagtgtg ttggcacagt gatttggaaa
      181 ggggaaacag aagagaaggg tctcaccttc cgcgcaaggc tgagctgttg gcaccctgct
      241 gcggccgtcg gtgctgctgc tcctgcagct gccttttctg ccatcagctt tgttacctaa
      301 cagcttggct cttttgggaa atatagacaa gctggaaccc aggagcagtt gggagtttta
      361 aagaatgcca gcctttttaa agctttgatg tccagtgcta tagaatcaag ttactgtgga
      421 ggtcaaaaca atttgagata cataagctgg ccttagaaaa taaattgcct ctaacttaca
      481 gtgaggagct caacataaca gggaaaagga gcacaggatg cagctacttg gagggtgttg
      541 attgaaaact tcgatctccc caccccattc acggttgatt tgacggattt ctcacctcgt
      601 tcacagagaa aatttcaatt aaggcccctt tagatggaat ataatacagc agaagccttt
      661 tcatcaaaag gattaatgcc tgcatcatca tttctgcaat aaaacaagaa gctaagtggt
      721 ggaggccaca gacacctcaa acctggattc cacaattcta cgttaagtgt tggagttttt
      781 attactctgc tgtaggaaag cctttgccaa tgcttacaag gaactgttta tccctgcttc
      841 tctgggttct gtttgatgga ggtctcctaa caccactaca accacagcca cagcagactt
      901 tagccacaga gccaagagaa aatgttatcc atctgccagg acaacggtca catttccaac
      961 gtgttaaacg tggctgggta tggaatcaat tttttgtgct ggaagaatac gtgggctccg
     1021 agcctcagta tgtgggaaag ctccattccg acttagacaa gggagagggc actgtgaaat
     1081 acaccctctc aggagatggc gctggcaccg tttttaccat tgatgaaacc acaggggaca
     1141 ttcatgcaat aaggagccta gatagagaag agaaaccttt ctacactctt cgtgctcagg
     1201 ctgtggacat agaaaccaga aagcccctgg agcctgaatc agaattcatc atcaaagtgc
     1261 aggatattaa tgataatgag ccaaagtttt tggatggacc ttatgttgct actgttccag
     1321 aaatgtctcc tgtgggtgca tatgtactcc aggtcaaggc cacagatgca gatgacccga
     1381 cctatggaaa cagtgccaga gtcgtttaca gcattcttca gggacaacct tatttctcta
     1441 ttgatcccaa gacaggtgtt attagaacag ctttgccaaa catggacaga gaagtcaaag
     1501 aacaatatca agtactcatc caagccaagg atatgggagg acagcttgga ggattagccg
     1561 gaacaacaat agtcaacatc actctcaccg atgtcaatga caatccacct cgattcccca
     1621 aaagcatctt ccacttgaaa gttcctgagt cttcccctat tggttcagct attggaagaa
     1681 taagagctgt ggatcctgat tttggacaaa atgcagaaat tgaatacaat attgttccag
     1741 gagatggggg aaatttgttt gacatcgtca cagatgagga tacacaagag ggagtcatca
     1801 aattgaaaaa gcctttagat tttgaaacaa agaaggcata cactttcaaa gttgaggctt
     1861 ccaaccttca ccttgaccac cggtttcact cggcgggccc tttcaaagac acagctacgg
     1921 tgaagatcag cgtgctggac gtagatgagc caccggtttt cagcaagccg ctctacacca
     1981 tggaggttta tgaagacact ccggtaggga ccatcattgg cgctgtcact gctcaagacc
     2041 tggatgtagg cagcagtgct gttaggtact tcatagattg gaagagtgat ggggacagct
     2101 actttacaat agatggaaat gaaggaacca tcgccactaa tgaattacta gacagagaaa
     2161 gcactgcgca gtataatttc tccataattg cgagtaaagt tagtaaccct ttattgacca
     2221 gcaaagtcaa tatactgatt aatgtcttag atgtaaatga atttcctcca gaaatatctg
     2281 tgccatatga gacagccgtg tgtgaaaatg ccaagccagg acagataatt cagatagtca
     2341 gtgctgcaga ccgagatctt tcacctgctg ggcaacaatt ctcctttaga ttatcacctg
     2401 aggctgctat caaaccaaat tttacagttc gtgacttcag aaacaacaca gcggggattg
     2461 aaacccgaag aaatggatac agccgcaggc agcaagagtt gtatttcctc cctgttgtaa
     2521 tagaagacag cagctaccct gtccagagca gcacaaacac aatgactatt cgagtctgta
     2581 gatgtgactc tgatggcacc atcctgtctt gtaatgtgga agcaattttt ctacctgtag
     2641 gacttagcac tggggcgttg attgcaattc tactatgcat tgttatactc ttagccatag
     2701 ttgtactgta tgtagcactg cgaaggcaga agaaaaaaga caccctgatg acctctaaag
     2761 aagacatcag agacaacgtc atccattacg atgatgaagg aggtggggag gaagataccc
     2821 aggctttcga catcggggct ctgagaaacc caaaagtgat tgaggagaac aaaattcgca
     2881 gggatataaa accagactct ctctgtttac ctcgtcagag accacccatg gaagataaca
     2941 cagacataag ggatttcatt catcaaaggc tacaggaaaa tgatgtggat ccaactgccc
     3001 caccatacga ttcactggcc acatatgcct acgaagggag tgggtccgtg gcagagtccc
     3061 tcagctctat agactctctc accacagaag ccgaccagga ctatgactat ctgacagact
     3121 ggggaccccg ctttaaagtc ttggcagaca tgtttggcga agaagagagt tataaccctg
     3181 ataaagtcac ttaagggagt cgtggaggct aaaatacaac cgagagggga gatttttaaa
     3241 aaagaaaaag aaacacaaat attaatagaa atctctctca cacacacaca cacacacaaa
     3301 cacacacaca cacacacaca ctctgggaca agattccttt gattacctgg tttctagtaa
     3361 gttactaaat taatcatatt gtcagttttg gtttattctg ccaacaagag atacatccta
     3421 taatgtgtac ttgctttgtt ttgttgtttt gttttttcac aatcacactg agacaagctc
     3481 aggcctattc aatacaattt actgacatga caacctagaa cgaagatagc tatgtggcat
     3541 cacggtggaa gagtgttaga tttttcttaa ttccactaaa gtgcctattg aaactcttat
     3601 catttaaagt ggtgtacagt acactctgct gtgatggtat tgcgggattc agagataaag
     3661 acataaaaca aagacaccgt ctttatgtca agaagcaata gcgacactct gactctcctc
     3721 attccttttg agaacaaaag aagaacactt tctgatctcc accttcttct aattcaaaag
     3781 gttttctttt tcttttttaa actgtatgct aaaacgtatt tgtttatcct atcctttcag
     3841 aaaattgaaa taaatatgaa aatatcaagt tcaatatgta agtcccaaat tctagaaaca
     3901 atgtttgatc ttaacattag ttcacattaa agctgttcat taaaatgtta ctttcttttc
     3961 caaaaaaaaa agaaagaaaa aaaagaaaaa atattcctct ttataaagag aggcctcagg
     4021 gctcaaatta cacattaaaa taaatattgg ttttgcttaa tattgtactg gtgtgtggaa
     4081 aattggtttt aacagtcacc agattcagct tttagtcata gatgtaattt caagttgtgt
     4141 ttctatgaaa attcttagaa gaaaaaagtg ccattcattt aagcatggaa agagaaattc
     4201 attatacagt ttctcagagt ttcttacaat ctagtgattc tttgatgagc agcaaaaa
//
