LOCUS       NM_001797               6722 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens cadherin 11 (CDH11), transcript variant 1, mRNA.
ACCESSION   NM_001797
VERSION     NM_001797.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6722)
  AUTHORS   Wang,S., Xu,L., Wang,D., Zhao,S., Li,K., Ma,F., Yao,Q., Zhang,Y.,
            Wu,Z., Shao,Y., Song,S. and Yan,W.
  TITLE     YTHDF1 promotes the osteolytic bone metastasis of breast cancer via
            inducing EZH2 and CDH11 translation
  JOURNAL   Cancer Lett 597, 217047 (2024)
   PUBMED   38871245
  REMARK    GeneRIF: YTHDF1 promotes the osteolytic bone metastasis of breast
            cancer via inducing EZH2 and CDH11 translation.
REFERENCE   2  (bases 1 to 6722)
  AUTHORS   Shirai,R., Biebighauser,T., Walker,D., Oviedo,J., Nelson-Taylor,S.,
            Bodlak,A., Porfilio,T., Oike,N., Goodspeed,A. and Hayashi,M.
  TITLE     Cadherin-11 contributes to the heterogenous and dynamic
            Wnt-Wnt-beta-catenin pathway activation in Ewing sarcoma
  JOURNAL   PLoS One 19 (6), e0305490 (2024)
   PUBMED   38875295
  REMARK    GeneRIF: Cadherin-11 contributes to the heterogenous and dynamic
            Wnt-Wnt-beta-catenin pathway activation in Ewing sarcoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6722)
  AUTHORS   Hou,M., Luo,F., Ding,Y., Bao,X., Chen,X., Liu,L. and Wu,M.
  TITLE     Let-7c-3p suppresses lens epithelial-mesenchymal transition by
            inhibiting cadherin-11 expression in fibrotic cataract
  JOURNAL   Mol Cell Biochem 479 (4), 743-759 (2024)
   PUBMED   37171723
  REMARK    GeneRIF: Let-7c-3p suppresses lens epithelial-mesenchymal
            transition by inhibiting cadherin-11 expression in fibrotic
            cataract.
REFERENCE   4  (bases 1 to 6722)
  AUTHORS   Liu,Y., Lei,P., Samuel,R.Z., Kashyap,A.M., Groth,T., Bshara,W.,
            Neelamegham,S. and Andreadis,S.T.
  TITLE     Cadherin-11 increases tumor cell proliferation and metastatic
            potential via Wnt pathway activation
  JOURNAL   Mol Oncol 17 (10), 2056-2073 (2023)
   PUBMED   37558205
  REMARK    GeneRIF: Cadherin-11 increases tumor cell proliferation and
            metastatic potential via Wnt pathway activation.
REFERENCE   5  (bases 1 to 6722)
  AUTHORS   Karagoz,Z., Passanha,F.R., Robeerst,L., van Griensven,M.,
            LaPointe,V.L.S. and Carlier,A.
  TITLE     Computational evidence for multi-layer crosstalk between the
            cadherin-11 and PDGFR pathways
  JOURNAL   Sci Rep 13 (1), 15804 (2023)
   PUBMED   37737289
  REMARK    GeneRIF: Computational evidence for multi-layer crosstalk between
            the cadherin-11 and PDGFR pathways.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6722)
  AUTHORS   Getsios,S., Chen,G.T., Stephenson,M.D., Leclerc,P., Blaschuk,O.W.
            and MacCalman,C.D.
  TITLE     Regulated expression of cadherin-6 and cadherin-11 in the glandular
            epithelial and stromal cells of the human endometrium
  JOURNAL   Dev Dyn 211 (3), 238-247 (1998)
   PUBMED   9520111
REFERENCE   7  (bases 1 to 6722)
  AUTHORS   Hulsken,J., Birchmeier,W. and Behrens,J.
  TITLE     E-cadherin and APC compete for the interaction with beta-catenin
            and the cytoskeleton
  JOURNAL   J Cell Biol 127 (6 Pt 2), 2061-2069 (1994)
   PUBMED   7806582
REFERENCE   8  (bases 1 to 6722)
  AUTHORS   Okazaki,M., Takeshita,S., Kawai,S., Kikuno,R., Tsujimura,A.,
            Kudo,A. and Amann,E.
  TITLE     Molecular cloning and characterization of OB-cadherin, a new member
            of cadherin family expressed in osteoblasts
  JOURNAL   J Biol Chem 269 (16), 12092-12098 (1994)
   PUBMED   8163513
REFERENCE   9  (bases 1 to 6722)
  AUTHORS   Tanihara,H., Sano,K., Heimark,R.L., St John,T. and Suzuki,S.
  TITLE     Cloning of five human cadherins clarifies characteristic features
            of cadherin extracellular domain and provides further evidence for
            two structurally different types of cadherin
  JOURNAL   Cell Adhes Commun 2 (1), 15-26 (1994)
   PUBMED   7982033
REFERENCE   10 (bases 1 to 6722)
  AUTHORS   Suzuki,S., Sano,K. and Tanihara,H.
  TITLE     Diversity of the cadherin family: evidence for eight new cadherins
            in nervous tissue
  JOURNAL   Cell Regul 2 (4), 261-270 (1991)
   PUBMED   2059658
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK291251.1, AC137643.3,
            AC010533.6 and BQ007417.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001797.3.
            
            Summary: This gene encodes a type II classical cadherin from the
            cadherin superfamily, integral membrane proteins that mediate
            calcium-dependent cell-cell adhesion. Mature cadherin proteins are
            composed of a large N-terminal extracellular domain, a single
            membrane-spanning domain, and a small, highly conserved C-terminal
            cytoplasmic domain. Type II (atypical) cadherins are defined based
            on their lack of a HAV cell adhesion recognition sequence specific
            to type I cadherins. Expression of this particular cadherin in
            osteoblastic cell lines, and its upregulation during
            differentiation, suggests a specific function in bone development
            and maintenance. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.166003.1,
                                           SRR1660805.23910.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268603.9/ ENSP00000268603.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AK291251.1         1-211
            212-212             AC137643.3         122539-122539
            213-1597            AK291251.1         213-1597
            1598-1598           AC010533.6         110722-110722       c
            1599-3020           AK291251.1         1599-3020
            3021-6259           AC010533.6         72754-75992         c
            6260-6722           BQ007417.1         15-477              c
FEATURES             Location/Qualifiers
     source          1..6722
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..6722
                     /gene="CDH11"
                     /gene_synonym="CAD11; CDHOB; ESWS; OB; OSF-4; TBHS2"
                     /note="cadherin 11"
                     /db_xref="GeneID:1009"
                     /db_xref="HGNC:HGNC:1750"
                     /db_xref="MIM:600023"
     exon            1..184
                     /gene="CDH11"
                     /gene_synonym="CAD11; CDHOB; ESWS; OB; OSF-4; TBHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            185..309
                     /gene="CDH11"
                     /gene_synonym="CAD11; CDHOB; ESWS; OB; OSF-4; TBHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            310..709
                     /gene="CDH11"
                     /gene_synonym="CAD11; CDHOB; ESWS; OB; OSF-4; TBHS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             482..2872
                     /gene="CDH11"
                     /gene_synonym="CAD11; CDHOB; ESWS; OB; OSF-4; TBHS2"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; cadherin 11, type 2, OB-cadherin (osteoblast)"
                     /codon_start=1
                     /product="cadherin-11 isoform 1 preproprotein"
                     /protein_id="NP_001788.2"
                     /db_xref="CCDS:CCDS10803.1"
                     /db_xref="GeneID:1009"
                     /db_xref="HGNC:HGNC:1750"
                     /db_xref="MIM:600023"
                     /translation="MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKE
                     GQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGTIFV
                     IDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFL
                     HETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIR
                     TALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMS
                     VSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKP
                     VDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEV
                     QENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
                     TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQ
                     PIVTISADDKDDTANGPRFIFSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQD
                     LYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAIL
                     ACIVILLVIVVLFVTLRRQKKEPLIVFEEEDVRENIITYDDEGGGEEDTEAFDIATLQ
                     NPDGINGFIPRKDIKPEYQYMPRPGLRPAPNSVDVDDFINTRIQEADNDPTAPPYDSI
                     QIYGYEGRGSVAGSLSSLESATTDSDLDYDYLQNWGPRFKKLADLYGSKDTFDDDS"
     exon            710..1004
                     /gene="CDH11"
                     /gene_synonym="CAD11; CDHOB; ESWS; OB; OSF-4; TBHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1124
                     /gene="CDH11"
                     /gene_synonym="CAD11; CDHOB; ESWS; OB; OSF-4; TBHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1292
                     /gene="CDH11"
                     /gene_synonym="CAD11; CDHOB; ESWS; OB; OSF-4; TBHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1480
                     /gene="CDH11"
                     /gene_synonym="CAD11; CDHOB; ESWS; OB; OSF-4; TBHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1734
                     /gene="CDH11"
                     /gene_synonym="CAD11; CDHOB; ESWS; OB; OSF-4; TBHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1871
                     /gene="CDH11"
                     /gene_synonym="CAD11; CDHOB; ESWS; OB; OSF-4; TBHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2005
                     /gene="CDH11"
                     /gene_synonym="CAD11; CDHOB; ESWS; OB; OSF-4; TBHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2123
                     /gene="CDH11"
                     /gene_synonym="CAD11; CDHOB; ESWS; OB; OSF-4; TBHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2375
                     /gene="CDH11"
                     /gene_synonym="CAD11; CDHOB; ESWS; OB; OSF-4; TBHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..6722
                     /gene="CDH11"
                     /gene_synonym="CAD11; CDHOB; ESWS; OB; OSF-4; TBHS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3673..3678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH11"
                     /gene_synonym="CAD11; CDHOB; ESWS; OB; OSF-4; TBHS2"
                     /note="hexamer: AATAAA"
     polyA_site      3695
                     /gene="CDH11"
                     /gene_synonym="CAD11; CDHOB; ESWS; OB; OSF-4; TBHS2"
                     /note="major polyA site"
     regulatory      5231..5236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH11"
                     /gene_synonym="CAD11; CDHOB; ESWS; OB; OSF-4; TBHS2"
                     /note="hexamer: AATAAA"
     polyA_site      5252
                     /gene="CDH11"
                     /gene_synonym="CAD11; CDHOB; ESWS; OB; OSF-4; TBHS2"
     regulatory      6696..6701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH11"
                     /gene_synonym="CAD11; CDHOB; ESWS; OB; OSF-4; TBHS2"
                     /note="hexamer: AATAAA"
     polyA_site      6722
                     /gene="CDH11"
                     /gene_synonym="CAD11; CDHOB; ESWS; OB; OSF-4; TBHS2"
ORIGIN      
        1 attccgcggc cgccgccagc tgaggggagc gtcgcgggcc gaggagcaga tgccgcgggg
       61 gccgctcgca gccgccgctg acttgtgaat gggaccggga ctggggccgg gactgacacc
      121 gcagcgcttg ccctgcgcca gggactggcg gctcggaggt tgcgtccacc ctcaagggcc
      181 ccagaaatca ctgtgttttc agctcagcgg ccctgtgaca ttccttcgtg ttgtcatttg
      241 ttgagtgacc aatcagatgg gtggagtgtg ttacagaaat tggcagcaag tatccaatgg
      301 gtgaagaaga agctaactgg ggacgtgggc agccctgacg tgatgagctc aaccagcaga
      361 gacattccat cccaagagag gtctgcgtga cgcgtccggg aggccaccct cagcaagacc
      421 accgtacagt tggtggaagg ggtgacagct gcattctcct gtgcctacca cgtaaccaaa
      481 aatgaaggag aactactgtt tacaagccgc cctggtgtgc ctgggcatgc tgtgccacag
      541 ccatgccttt gccccagagc ggcgggggca cctgcggccc tccttccatg ggcaccatga
      601 gaagggcaag gaggggcagg tgctacagcg ctccaagcgt ggctgggtct ggaaccagtt
      661 cttcgtgata gaggagtaca ccgggcctga ccccgtgctt gtgggcaggc ttcattcaga
      721 tattgactct ggtgatggga acattaaata cattctctca ggggaaggag ctggaaccat
      781 ttttgtgatt gatgacaaat cagggaacat tcatgccacc aagacgttgg atcgagaaga
      841 gagagcccag tacacgttga tggctcaggc ggtggacagg gacaccaatc ggccactgga
      901 gccaccgtcg gaattcattg tcaaggtcca ggacattaat gacaaccctc cggagttcct
      961 gcacgagacc tatcatgcca acgtgcctga gaggtccaat gtgggaacgt cagtaatcca
     1021 ggtgacagct tcagatgcag atgaccccac ttatggaaat agcgccaagt tagtgtacag
     1081 tatcctcgaa ggacaaccct atttttcggt ggaagcacag acaggtatca tcagaacagc
     1141 cctacccaac atggacaggg aggccaagga ggagtaccac gtggtgatcc aggccaagga
     1201 catgggtgga catatgggcg gactctcagg gacaaccaaa gtgacgatca cactgaccga
     1261 tgtcaatgac aacccaccaa agtttccgca gagcgtatac cagatgtctg tgtcagaagc
     1321 agccgtccct ggggaggaag taggaagagt gaaagctaaa gatccagaca ttggagaaaa
     1381 tggcttagtc acatacaata ttgttgatgg agatggtatg gaatcgtttg aaatcacaac
     1441 ggactatgaa acacaggagg gggtgataaa gctgaaaaag cctgtagatt ttgaaaccaa
     1501 aagagcctat agcttgaagg tagaggcagc caacgtgcac atcgacccga agtttatcag
     1561 caatggccct ttcaaggaca ctgtgaccgt caagatctca gtagaagatg ctgatgagcc
     1621 ccctatgttc ttggccccaa gttacatcca cgaagtccaa gaaaatgcag ctgctggcac
     1681 cgtggttggg agagtgcatg ccaaagaccc tgatgctgcc aacagcccga taaggtattc
     1741 catcgatcgt cacactgacc tcgacagatt tttcactatt aatccagagg atggttttat
     1801 taaaactaca aaacctctgg atagagagga aacagcctgg ctcaacatca ctgtctttgc
     1861 agcagaaatc cacaatcggc atcaggaagc caaagtccca gtggccatta gggtccttga
     1921 tgtcaacgat aatgctccca agtttgctgc cccttatgaa ggtttcatct gtgagagtga
     1981 tcagaccaag ccactttcca accagccaat tgttacaatt agtgcagatg acaaggatga
     2041 cacggccaat ggaccaagat ttatcttcag cctaccccct gaaatcattc acaatccaaa
     2101 tttcacagtc agagacaacc gagataacac agcaggcgtg tacgcccggc gtggagggtt
     2161 cagtcggcag aagcaggact tgtaccttct gcccatagtg atcagcgatg gcggcatccc
     2221 gcccatgagt agcaccaaca ccctcaccat caaagtctgc gggtgcgacg tgaacggggc
     2281 actgctctcc tgcaacgcag aggcctacat tctgaacgcc ggcctgagca caggcgccct
     2341 gatcgccatc ctcgcctgca tcgtcattct cctggtcatt gtagtattgt ttgtgaccct
     2401 gagaaggcaa aagaaagaac cactcattgt ctttgaggaa gaagatgtcc gtgagaacat
     2461 cattacttat gatgatgaag ggggtgggga agaagacaca gaagcctttg atattgccac
     2521 cctccagaat cctgatggta tcaatggatt tatcccccgc aaagacatca aacctgagta
     2581 tcagtacatg cctagacctg ggctccggcc agcgcccaac agcgtggatg tcgatgactt
     2641 catcaacacg agaatacagg aggcagacaa tgaccccacg gctcctcctt atgactccat
     2701 tcaaatctac ggttatgaag gcaggggctc agtggccggg tccctgagct ccctagagtc
     2761 ggccaccaca gattcagact tggactatga ttatctacag aactggggac ctcgttttaa
     2821 gaaactagca gatttgtatg gttccaaaga cacttttgat gacgattctt aacaataacg
     2881 atacaaattt ggccttaaga actgtgtctg gcgttctcaa gaatctagaa gatgtgtaaa
     2941 caggtatttt tttaaatcaa ggaaaggctc atttaaaaca ggcaaagttt tacagagagg
     3001 atacatttaa taaaactgcg aggacatcaa agtggtaaat actgtgaaat accttttctc
     3061 acaaaaaggc aaatattgaa gttgtttatc aacttcgcta gaaaaaaaaa acacttggca
     3121 tacaaaatat ttaagtgaag gagaagtcta acgctgaact gacaatgaag ggaaattgtt
     3181 tatgtgttat gaacatccaa gtctttcttc ttttttaagt tgtcaaagaa gcttccacaa
     3241 aattagaaag gacaacagtt ctgagctgta atttcgcctt aaactctgga cactctatat
     3301 gtagtgcatt tttaaacttg aaatatataa tattcagcca gcttaaaccc atacaatgta
     3361 tgtacaatac aatgtacaat tatgtctctt gagcatcaat cttgttactg ctgattcttg
     3421 taaatctttt tgcttctact ttcatcttaa actaatacgt gccagatata actgtcttgt
     3481 ttcagtgaga gacgccctat ttctatgtca tttttaatgt atctatttgt acaattttaa
     3541 agttcttatt ttagtatacg tataaatatc agtattctga catgtaagaa aatgttacgg
     3601 catcacactt atattttatg aacattgtac tgttgcttta atatgagctt caatataaga
     3661 agcaatcttt gaaataaaaa aagatttttt tttaattctg ggtttgattc ttaacattga
     3721 aacaaacgtt aagtatttct aatgatccat ttatatttct aatttaattg tgatctttta
     3781 ataaccctat ttatgatctg ttgttgtctg tctgctgctt ttattgttta tttaaaatca
     3841 aatatgtttt acaaatgttt tttcagacaa gattctgtaa catcatgtaa agcttttttg
     3901 tacattcttg gtgttaacct cctggcttct cttcacacac atcttctaaa aaagaaggat
     3961 gtgaaagaac taggtcagtc tatgactttg caatatgtgt tatatagtat gcatttatct
     4021 tgtatatcag taatttgatg gttatgagag atgaatccat gagggaatgg agctatcaga
     4081 actctaatgt tccaggtata cattctatgc cccacactga gcactgggga actgggggac
     4141 tagagtcaaa aatataaatt tgcccagact ctaatgttat tctatttttt cttctgttga
     4201 acttaccagg ctattgtaag actcttgata gttgaaactg cttatttttc ctcctgtaat
     4261 tttaactaat tgtaaaatga tgtggcattt tatgttttaa tgagaatggg cgattcattt
     4321 aaaaaagctt tgtttagaat atgcttgggg ccgtaagctc agaatgaggg cagggaccat
     4381 tttggattct gagagtcgat gccatttggt ccaggagtgt gtctacagtc ccctgcattc
     4441 cagctagttt cttggggatt gaaacttatg tgaagggcat ttcacctgtt cagttgggcc
     4501 aaaggtcaaa acgtagcaat acttggggaa agaccacata aagtcacact gcaagtgctt
     4561 tccctctttc cccctacaca cagggcacgt gctttttctt ggattgcaga caatttttac
     4621 agtttttttc tgactttatt gtgaaagttt gtttcaagca tttcttgata tcatgttatg
     4681 tactattttt atgatttagt caacatgcat acaaagaaat gttttttatg aagtgctcac
     4741 ttccatttta ctttgcattg aaatcaaatt gggctgaaca cttcaatgga atacattttg
     4801 tggacaatgt cactttagaa tctttcatct cagtgaagga ttacacattc tcaatacttc
     4861 cataattgca ggttgtgttc atttttttat atagtttttg taatccaaag aatattttgc
     4921 tagatttgca cagatctcca attgaatttg caatgaagaa ataactcaaa aggaatatga
     4981 atagcattta aataagtata cagctgtaag taaccctgtc accatggatg atccttttct
     5041 ctaggaatgt atttggatta gagatgacaa ctacattttc gcatttttat gttgaagtct
     5101 tttttaaaaa ggctgtttac ttttcagtag ttaagaatac ttgtttttct ttttcttttt
     5161 tttttttttt tttacctttt attttttcgt taagcctcta ttgtttgtag aacactctta
     5221 gaaacttgga aataaaatgt ctttcccaac tagtggagtc ctttttcatt tggagcacat
     5281 tgccttaaaa gaagtcttaa tttaaacggt ccttccttat tctaaagtaa tcactgtttt
     5341 ataccatcta tgcagctaaa agaaggaaca tgcttctgtt cttttcctca agtaatggtt
     5401 attgtttcta gtcatcattc attcattgat tcattcatta attcatcaaa atcttatttt
     5461 ataaaccctg ttccacttac tggaggattc agaatgaatc ttactacctt ttctgacatc
     5521 ttttgataat tcagccctgt accaaagtat ccaccttgtt gtcttataat cacctattta
     5581 cctatttgcc ctcctagaaa atgcaagaag atattttctc tccttccaaa ttgaaggaag
     5641 aacataaaag atataacagg aaggagatgg tgagatatag agtgtgagcg gaaattaggc
     5701 cagctgtggc aattctggac agatcttggg tttagctaag ttatttcttt taggcctggg
     5761 tttctggggg tgacagggaa gataaaagag tagtttattt gcacctcttg gagaattgct
     5821 taaaaatata gagatcatgg ctctgtatgt caggtggaac caggtcagga gtatttgaaa
     5881 ctgctcctgg gtcattgtga catatccttc acatcttttt gagaaacttt ataagacaat
     5941 gggggtgaat gggggctggg cagttggagt ctctgagcag aagaggggca aaatttattt
     6001 ggcaggcagt gtggaggaca gattaggagc atataaaccc agaggtgtgc cccaggaggg
     6061 cttttgcaaa ggtcaatatg agatagaatg agggcctgaa ataattcagt aatttggaga
     6121 tggagaagag gaaagacttc tctgctcttg cactgccatc agcctggtct gggccatggt
     6181 catctctgac ccggaagact gaccccacct cttggctcac cctctgcctc ccaacctcct
     6241 cttcacaaag aagccagagg gatactttta acacacaacc cagatcacat gacttcgtaa
     6301 cttaaacctc ttcactggct tcccaaagac ttaaaatgaa ttctgatgcc tttattttat
     6361 tgctttacat gaacagggcc ctgcgaacct ctccagtgtc attccactcc atcctccttt
     6421 cagtgcacga tgctccagcc acactggcca tctttcggtt cctgatacaa aaaaaaacac
     6481 gttccttttc catggaaagc aggtcaccct tgttattttg tatcgatgac aactctttaa
     6541 acttattttg ctttttggct ttatgtatgt gtgtgggtgg gtgggactga ctgccccact
     6601 agaatgtaag ctccatgagg gcagggaatc ttgctttctt gtttaccatt gtatactcag
     6661 ttctttacac agtgcctgaa acataacagg tacacaataa atatctattg aatgaaagca
     6721 aa
//
