LOCUS       NM_006727               3438 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens cadherin 10 (CDH10), transcript variant 1, mRNA.
ACCESSION   NM_006727
VERSION     NM_006727.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3438)
  AUTHORS   Casciello,F., Al-Ejeh,F., Miranda,M., Kelly,G., Baxter,E.,
            Windloch,K., Gannon,F. and Lee,J.S.
  TITLE     G9a-mediated repression of CDH10 in hypoxia enhances breast tumour
            cell motility and associates with poor survival outcome
  JOURNAL   Theranostics 10 (10), 4515-4529 (2020)
   PUBMED   32292512
  REMARK    GeneRIF: G9a-mediated repression of CDH10 in hypoxia enhances
            breast tumour cell motility and associates with poor survival
            outcome.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3438)
  AUTHORS   Jinawath,N., Shiao,M.S., Norris,A., Murphy,K., Klein,A.P.,
            Yonescu,R., Iacobuzio-Donahue,C., Meeker,A., Jinawath,A., Yeo,C.J.,
            Eshleman,J.R., Hruban,R.H., Brody,J.R., Griffin,C.A. and Harada,S.
  TITLE     Alterations of type II classical cadherin, cadherin-10 (CDH10), is
            associated with pancreatic ductal adenocarcinomas
  JOURNAL   Genes Chromosomes Cancer 56 (5), 427-435 (2017)
   PUBMED   28124395
  REMARK    GeneRIF: Loss of CDH10 gene is associated with pancreatic ductal
            adenocarcinomas.
REFERENCE   3  (bases 1 to 3438)
  AUTHORS   Li,C., Gao,Z., Li,F., Li,X., Sun,Y., Wang,M., Li,D., Wang,R.,
            Li,F., Fang,R., Pan,Y., Luo,X., He,J., Zheng,L., Xia,J., Qiu,L.,
            He,J., Ye,T., Zhang,R., He,M., Zhu,M., Hu,H., Shi,T., Zhou,X.,
            Sun,M., Tian,S., Zhou,Y., Wang,Q., Chen,L., Yin,G., Lu,J., Wu,R.,
            Guo,G., Li,Y., Hu,X., Li,L., Asan, Wang,Q., Yin,Y., Feng,Q.,
            Wang,B., Wang,H., Wang,M., Yang,X., Zhang,X., Yang,H., Jin,L.,
            Wang,C.Y., Ji,H., Chen,H., Wang,J. and Wei,Q.
  TITLE     Whole Exome Sequencing Identifies Frequent Somatic Mutations in
            Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous
            Cell Carcinoma
  JOURNAL   Sci Rep 5, 14237 (2015)
   PUBMED   26503331
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3438)
  AUTHORS   Liu,H., Wang,Y., Sharma,A., Mao,R., Jiang,N., Dun,B. and She,J.X.
  TITLE     Derivatives containing both coumarin and benzimidazole potently
            induce caspase-dependent apoptosis of cancer cells through
            inhibition of PI3K-AKT-mTOR signaling
  JOURNAL   Anticancer Drugs 26 (6), 667-677 (2015)
   PUBMED   25811964
REFERENCE   5  (bases 1 to 3438)
  AUTHORS   Yu,J., Wu,W.K., Li,X., He,J., Li,X.X., Ng,S.S., Yu,C., Gao,Z.,
            Yang,J., Li,M., Wang,Q., Liang,Q., Pan,Y., Tong,J.H., To,K.F.,
            Wong,N., Zhang,N., Chen,J., Lu,Y., Lai,P.B., Chan,F.K., Li,Y.,
            Kung,H.F., Yang,H., Wang,J. and Sung,J.J.
  TITLE     Novel recurrently mutated genes and a prognostic mutation signature
            in colorectal cancer
  JOURNAL   Gut 64 (4), 636-645 (2015)
   PUBMED   24951259
REFERENCE   6  (bases 1 to 3438)
  AUTHORS   Gil,O.D., Needleman,L. and Huntley,G.W.
  TITLE     Developmental patterns of cadherin expression and localization in
            relation to compartmentalized thalamocortical terminations in rat
            barrel cortex
  JOURNAL   J Comp Neurol 453 (4), 372-388 (2002)
   PUBMED   12389209
REFERENCE   7  (bases 1 to 3438)
  AUTHORS   Shimoyama,Y., Tsujimoto,G., Kitajima,M. and Natori,M.
  TITLE     Identification of three human type-II classic cadherins and
            frequent heterophilic interactions between different subclasses of
            type-II classic cadherins
  JOURNAL   Biochem J 349 (Pt 1), 159-167 (2000)
   PUBMED   10861224
REFERENCE   8  (bases 1 to 3438)
  AUTHORS   Kools,P., Vanhalst,K., Van den Eynde,E. and van Roy,F.
  TITLE     The human cadherin-10 gene: complete coding sequence, predominant
            expression in the brain, and mapping on chromosome 5p13-14
  JOURNAL   FEBS Lett 452 (3), 328-334 (1999)
   PUBMED   10386616
REFERENCE   9  (bases 1 to 3438)
  AUTHORS   Hulsken,J., Birchmeier,W. and Behrens,J.
  TITLE     E-cadherin and APC compete for the interaction with beta-catenin
            and the cytoskeleton
  JOURNAL   J Cell Biol 127 (6 Pt 2), 2061-2069 (1994)
   PUBMED   7806582
REFERENCE   10 (bases 1 to 3438)
  AUTHORS   Suzuki,S., Sano,K. and Tanihara,H.
  TITLE     Diversity of the cadherin family: evidence for eight new cadherins
            in nervous tissue
  JOURNAL   Cell Regul 2 (4), 261-270 (1991)
   PUBMED   2059658
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA531048.1, DA316487.1,
            AB035303.1 and BM669374.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006727.4.
            
            Summary: This gene encodes a type II classical cadherin of the
            cadherin superfamily. Alternative splicing of this gene results in
            multiple transcript variants. At least one of these variants
            encodes a preproprotein that is proteolytically processed to
            generate the mature cadherin protein. These integral membrane
            proteins mediate calcium-dependent cell-cell adhesion and are
            composed of a large N-terminal extracellular domain, a single
            membrane-spanning domain, and a small, highly conserved C-terminal
            cytoplasmic domain. The extracellular domain consists of 5
            subdomains, each containing a cadherin motif, and appears to
            determine the specificity of the protein's homophilic cell adhesion
            activity. Type II (atypical) cadherins are defined based on their
            lack of a histidine-alanine-valine (HAV) cell adhesion recognition
            sequence specific to type I cadherins. This particular cadherin is
            predominantly expressed in brain and is putatively involved in
            synaptic adhesions, axon outgrowth and guidance. Mutations in this
            gene may be associated with lung squamous cell carcinoma and
            colorectal cancer in human patients. [provided by RefSeq, Nov
            2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.163308.1,
                                           SRR1660809.169164.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264463.8/ ENSP00000264463.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               DA531048.1         1-130
            131-240             DA316487.1         89-198
            241-3437            AB035303.1         65-3261
            3438-3438           BM669374.1         18-18               c
FEATURES             Location/Qualifiers
     source          1..3438
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p14.2-p14.1"
     gene            1..3438
                     /gene="CDH10"
                     /note="cadherin 10"
                     /db_xref="GeneID:1008"
                     /db_xref="HGNC:HGNC:1749"
                     /db_xref="MIM:604555"
     exon            1..385
                     /gene="CDH10"
                     /inference="alignment:Splign:2.1.0"
     exon            386..739
                     /gene="CDH10"
                     /inference="alignment:Splign:2.1.0"
     CDS             509..2875
                     /gene="CDH10"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; T2-cadherin; cadherin 10 type 2"
                     /codon_start=1
                     /product="cadherin-10 isoform 1 preproprotein"
                     /protein_id="NP_006718.2"
                     /db_xref="CCDS:CCDS3892.1"
                     /db_xref="GeneID:1008"
                     /db_xref="HGNC:HGNC:1749"
                     /db_xref="MIM:604555"
                     /translation="MTIHQFLLLFLFWVCLPHFCSPEIMFRRTPVPQQRILSSRVPRS
                     DGKILHRQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAGTLF
                     IIDEKTGDIHATRRIDREEKAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTF
                     PEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQGQPYFSVEPETGII
                     RTALPNMNRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQNTIHL
                     RVLESSPVGTAIGSVKATDADTGKNAEVEYRIIDGDGTDMFDIVTEKDTQEGIITVKK
                     PLDYESRRLYTLKVEAENTHVDPRFYYLGPFKDTTIVKISIEDVDEPPVFSRSSYLFE
                     VHEDIEVGTIIGTVMARDPDSISSPIRFSLDRHTDLDRIFNIHSGNGSLYTSKPLDRE
                     LSQWHNLTVIAAEINNPKETTRVAVFVRILDVNDNAPQFAVFYDTFVCENARPGQLIQ
                     TISAVDKDDPLGGQKFFFSLAAVNPNFTVQDNEDNTARILTRKNGFNRHEISTYLLPV
                     VISDNDYPIQSSTGTLTIRVCACDSQGNMQSCSAEALLLPAGLSTGALIAILLCIIIL
                     LVIVVLFAALKRQRKKEPLILSKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPAAIE
                     EKKLRRDIIPETLFIPRRTPTAPDNTDVRDFINERLKEHDLDPTAPPYDSLATYAYEG
                     NDSIAESLSSLESGTTEGDQNYDYLREWGPRFNKLAEMYGGGESDKDS"
     exon            740..1034
                     /gene="CDH10"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1154
                     /gene="CDH10"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1322
                     /gene="CDH10"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1510
                     /gene="CDH10"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1764
                     /gene="CDH10"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1901
                     /gene="CDH10"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2023
                     /gene="CDH10"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2132
                     /gene="CDH10"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2384
                     /gene="CDH10"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..3438
                     /gene="CDH10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3417..3422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH10"
                     /note="hexamer: AATAAA"
     polyA_site      3438
                     /gene="CDH10"
                     /note="major polyA site"
ORIGIN      
        1 acttgcaaat cgctgtgtgc tcgcagaagc cagcacttcc acagtctcta accttcccat
       61 ggcgagtgct gcagctctat cagcagaacc tttctctccg tgtgaggaag agcttttttc
      121 ccccctttcc tttttttttt ttttcctttc cccttaatca gaagcactga atgaaagcca
      181 atcagagaga gctcgccccc gttttcttcg gttccctgct gtccagagtt aaaagtgatg
      241 ctgagaaaga gcttgagtta gattgaagta gaatcagtga tagaaaataa cagccgaaaa
      301 caaacaaaaa ggggacatag tgacaatttc tcctgggtta ttttggctgg aaccaacttc
      361 cattatccag aagctgataa aaaagctttg ggaaacatga acaaaacatt gatgaaatgt
      421 tggaaaccag ttgaaacaca gtaaaaccaa ctgggtaaaa taggaccact tctcttcatc
      481 tacactggga tttgtcaaga agtgaactat gacaatacat caatttttgc tactgtttct
      541 attctgggta tgcctgccac atttctgctc tccagaaata atgttcagaa ggacgcctgt
      601 gccacagcaa agaattttaa gttcacgtgt accaaggagt gatggcaaaa ttctccatcg
      661 tcaaaaacgt ggttggatgt ggaatcaatt tttcttactt gaagaatata caggatctga
      721 ttatcagtac gtaggcaagc tacattcaga ccaagataaa ggagatggat cactcaaata
      781 tatcttatct ggagatggag ctggtactct ttttattatt gatgaaaaaa caggtgatat
      841 tcatgccaca aggcgaattg atagggagga aaaggccttt tatactctac gcgcacaagc
      901 tattaacaga agaactctga ggccagtaga gccagagtca gagtttgtga tcaaaattca
      961 tgatatcaat gacaatgagc caacgttccc agaagaaatc tatacagcta gtgttcccga
     1021 aatgtctgtt gtaggtactt ctgtggtgca agtcacagct acagatgccg atgacccttc
     1081 atatgggaac agcgccagag tcatttacag catacttcaa gggcagccct atttctctgt
     1141 ggagcctgaa acaggtatca tcaggactgc tttaccgaac atgaacagag aaaacagaga
     1201 gcaataccaa gtggtcatcc aggccaaaga catgggcggc cagatgggag gcttatcggg
     1261 gacaaccact gtgaacatca cgctgacaga tgtcaatgac aacccaccac gtttccccca
     1321 gaacactatt catcttcgag ttcttgaatc ctccccagtt ggcacagcca ttggaagtgt
     1381 caaagcaact gatgctgaca ctgggaaaaa tgctgaagta gaataccgaa ttattgatgg
     1441 tgacggtact gatatgtttg acatcgtgac tgagaaggac acacaggaag gcatcatcac
     1501 tgtgaaaaag ccactcgact atgagagccg aagactttat actctgaaag tcgaagcaga
     1561 aaacacccat gtagatcccc gtttttatta cctaggacca tttaaagata ctaccatagt
     1621 gaaaatctct atagaagatg tggatgaacc tcctgttttt agtaggtcct cctatctgtt
     1681 tgaagttcat gaagatattg aagtgggcac aatcattggt actgtaatgg caagggaccc
     1741 agattctatt tccagcccca ttagattttc cttggatcgc catactgacc ttgacagaat
     1801 ctttaacatt cattcaggaa atggatctct ttatacatca aaacctcttg accgtgaact
     1861 atctcagtgg cataatctta ctgttattgc tgctgaaatc aacaatccca aagagacaac
     1921 acgcgtggct gtttttgtga gaattttgga tgttaatgac aatgccccac agtttgctgt
     1981 gttctatgac acttttgtat gtgaaaatgc cagaccaggg cagctaatac agactataag
     2041 tgcagtagac aaagatgacc ctttaggtgg acagaaattt tttttcagtt tagctgctgt
     2101 caatccaaac ttcacagtac aggataatga agataatact gccagaatct taaccagaaa
     2161 aaatggattc aatagacatg aaatcagtac ctatctcttg cctgtggtga tatcagacaa
     2221 tgattaccca attcagagca gcacaggcac actgaccatt cgagtgtgtg cttgtgacag
     2281 ccaaggcaac atgcaatcct gcagtgctga agccctgctc ctccctgccg gcctcagcac
     2341 tggggccttg atcgccatcc tcctctgcat catcattcta ctggttatag tagtactgtt
     2401 tgcagctctg aaaagacagc gaaaaaaaga gcctctgatc ttgtcaaaag aagatatcag
     2461 agacaacatt gtgagctata acgatgaggg tggtggagag gaggacaccc aggcctttga
     2521 tatcggcacc ctgaggaatc ctgcagccat tgaggaaaaa aagctccggc gagatattat
     2581 tccagaaacg ttatttattc ctcggaggac tcctacagct ccagataaca cggacgtccg
     2641 ggatttcatt aatgaaaggc taaaagagca tgatcttgac cccaccgcac ccccctacga
     2701 ctcacttgca acctatgcct atgaaggaaa tgattccatt gctgaatctc tgagttcatt
     2761 agaatcaggt actactgaag gagaccaaaa ctacgattac ctccgagaat ggggccctcg
     2821 gtttaataag ctagcagaaa tgtatggtgg tggggaaagt gacaaagact cttaacgtag
     2881 gatatatgtt ctgttcaaac aagagaaagt aactctaccc atgctgtctc cacttcacaa
     2941 tatttgatat tcaggagcat tttcctgcca gtcagcacaa ttttttttct catttacttc
     3001 ttaatttgtt cattaattac attaattctt tcctgtagga tgtctcatgg aatatatatg
     3061 acattttatt taatcacttc caagagccaa agctatggaa atacagtgtt gtccatctta
     3121 gtaaataaaa gataatttca gaaacatgaa caggatagtt ctcccttaag caacctcaca
     3181 aacaagccgc ttctgttagg tacatgtcct gcccttgcaa atgaagcttt taaaaaggtg
     3241 aagaaaaatt ttacagtata tcctgttctg tacattaaat taaaaaaaca aaaatgtaca
     3301 tgtgatgtta gtaggtgtga tatgcaacct ggtatacaga catttgtgca atttcatttc
     3361 atcaaattct atctgctaat gttttatatt tatatttttg tatttatttt taaaaaaata
     3421 aaccagtttt tacaacta
//
