LOCUS       NM_004360               4811 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens cadherin 1 (CDH1), transcript variant 1, mRNA.
ACCESSION   NM_004360
VERSION     NM_004360.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4811)
  AUTHORS   Si,W., Liu,J., Wang,Y., Mao,Y., Zhang,Y., Xu,S., Guo,K., Zhang,Y.,
            Hu,Y. and Zhang,F.
  TITLE     IL-8 promotes lens capsular residual cells migration by
            down-regulates expression of E-cadherin and ZO-1 via the
            CXCR1/2-NF-kappaB-RhoA signal pathway
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113074 (2024)
   PUBMED   39244903
  REMARK    GeneRIF: IL-8 promotes lens capsular residual cells migration by
            down-regulates expression of E-cadherin and ZO-1 via the
            CXCR1/2-NF-kappaB-RhoA signal pathway.
REFERENCE   2  (bases 1 to 4811)
  AUTHORS   Dash,S., Biswas,J., Goswami,S., Mukherjee,S., Ganguli,N.,
            Duraivelan,K., Mondal,S., Mukhopadhyay,R. and Samanta,D.
  TITLE     Molecular Crosstalk Between Adherens Junction Proteins, E-cadherin
            and Nectin-4
  JOURNAL   J Mol Biol 436 (18), 168709 (2024)
   PUBMED   39009071
  REMARK    GeneRIF: Molecular Crosstalk Between Adherens Junction Proteins,
            E-cadherin and Nectin-4.
REFERENCE   3  (bases 1 to 4811)
  AUTHORS   Peng,Y., Zhang,Y., Fang,R., Jiang,H., Lan,G., Xu,Z., Liu,Y.,
            Nie,Z., Ren,L., Wang,F., Zhang,S.D., Ma,Y., Yang,P., Ge,H.H.,
            Zhang,W.D., Luo,C., Li,A. and He,W.
  TITLE     Target Identification and Mechanistic Characterization of Indole
            Terpenoid Mimics: Proper Spindle Microtubule Assembly Is Essential
            for Cdh1-Mediated Proteolysis of CENP-A
  JOURNAL   Adv Sci (Weinh) 11 (29), e2305593 (2024)
   PUBMED   38873820
REFERENCE   4  (bases 1 to 4811)
  AUTHORS   Yim,I.S. and Laronde,D.M.
  TITLE     Biomarkers of epithelial-mesenchymal transition: E-cadherin and
            beta-catenin in malignant transformation of oral lesions
  JOURNAL   Can J Dent Hyg 58 (2), 111-119 (2024)
   PUBMED   38974823
  REMARK    GeneRIF: Biomarkers of epithelial-mesenchymal transition:
            E-cadherin and beta-catenin in malignant transformation of oral
            lesions.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4811)
  AUTHORS   Lecuit,T. and Yap,A.S.
  TITLE     E-cadherin junctions as active mechanical integrators in tissue
            dynamics
  JOURNAL   Nat Cell Biol 17 (5), 533-539 (2015)
   PUBMED   25925582
  REMARK    Review article
REFERENCE   6  (bases 1 to 4811)
  AUTHORS   Barbosa-Matos,R., Cordova,L., Schrader,K. and Oliveira,C.
  TITLE     Diffuse Gastric and Lobular Breast Cancer Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301318
REFERENCE   7  (bases 1 to 4811)
  AUTHORS   Knudsen,K.A. and Wheelock,M.J.
  TITLE     Plakoglobin, or an 83-kD homologue distinct from beta-catenin,
            interacts with E-cadherin and N-cadherin
  JOURNAL   J Cell Biol 118 (3), 671-679 (1992)
   PUBMED   1639850
REFERENCE   8  (bases 1 to 4811)
  AUTHORS   La Vecchia,C., Negri,E., Franceschi,S. and Gentile,A.
  TITLE     Family history and the risk of stomach and colorectal cancer
  JOURNAL   Cancer 70 (1), 50-55 (1992)
   PUBMED   1606546
REFERENCE   9  (bases 1 to 4811)
  AUTHORS   Zanghieri,G., Di Gregorio,C., Sacchetti,C., Fante,R.,
            Sassatelli,R., Cannizzo,G., Carriero,A. and Ponz de Leon,M.
  TITLE     Familial occurrence of gastric cancer in the 2-year experience of a
            population-based registry
  JOURNAL   Cancer 66 (9), 2047-2051 (1990)
   PUBMED   2224804
REFERENCE   10 (bases 1 to 4811)
  AUTHORS   Mansouri,A., Spurr,N., Goodfellow,P.N. and Kemler,R.
  TITLE     Characterization and chromosomal localization of the gene encoding
            the human cell adhesion molecule uvomorulin
  JOURNAL   Differentiation 38 (1), 67-71 (1988)
   PUBMED   3263290
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312551.1, AK290012.1 and
            EU709494.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004360.4.
            
            Summary: This gene encodes a classical cadherin of the cadherin
            superfamily. Alternative splicing results in multiple transcript
            variants, at least one of which encodes a preproprotein that is
            proteolytically processed to generate the mature glycoprotein. This
            calcium-dependent cell-cell adhesion protein is comprised of five
            extracellular cadherin repeats, a transmembrane region and a highly
            conserved cytoplasmic tail. Mutations in this gene are correlated
            with gastric, breast, colorectal, thyroid and ovarian cancer. Loss
            of function of this gene is thought to contribute to cancer
            progression by increasing proliferation, invasion, and/or
            metastasis. The ectodomain of this protein mediates bacterial
            adhesion to mammalian cells and the cytoplasmic domain is required
            for internalization. This gene is present in a gene cluster with
            other members of the cadherin family on chromosome 16. [provided by
            RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU709494.1, GQ891411.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261769.10/ ENSP00000261769.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1929              AK312551.1         3-1931
            1930-2953           AK290012.1         1904-2927
            2954-4811           EU709494.1         2954-4811
FEATURES             Location/Qualifiers
     source          1..4811
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..4811
                     /gene="CDH1"
                     /gene_synonym="Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO"
                     /note="cadherin 1"
                     /db_xref="GeneID:999"
                     /db_xref="HGNC:HGNC:1748"
                     /db_xref="MIM:192090"
     exon            1..172
                     /gene="CDH1"
                     /gene_synonym="Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2773
                     /gene="CDH1"
                     /gene_synonym="Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; calcium-dependent adhesion protein, epithelial;
                     cadherin 1, E-cadherin (epithelial); cell-CAM 120/80;
                     uvomorulin; epithelial cadherin; cadherin 1, type 1,
                     E-cadherin (epithelial); E-cadherin 1; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="cadherin-1 isoform 1 preproprotein"
                     /protein_id="NP_004351.1"
                     /db_xref="CCDS:CCDS10869.1"
                     /db_xref="GeneID:999"
                     /db_xref="HGNC:HGNC:1748"
                     /db_xref="MIM:192090"
                     /translation="MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRR
                     HLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYA
                     WDSTYRKFSTKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPP
                     ISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTE
                     PLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGAL
                     PGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLD
                     RESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVV
                     ITTLKVTDADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQY
                     ILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSY
                     TAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALII
                     ATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTS
                     PFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLE
                     VSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILALLILILLLLLFLRRRAVVKEP
                     LLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYL
                     PRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKD
                     QDYDYLNEWGNRFKKLADMYGGGEDD"
     exon            173..287
                     /gene="CDH1"
                     /gene_synonym="Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            288..511
                     /gene="CDH1"
                     /gene_synonym="Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            512..655
                     /gene="CDH1"
                     /gene_synonym="Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            656..811
                     /gene="CDH1"
                     /gene_synonym="Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            812..956
                     /gene="CDH1"
                     /gene_synonym="Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1132
                     /gene="CDH1"
                     /gene_synonym="Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1261
                     /gene="CDH1"
                     /gene_synonym="Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1444
                     /gene="CDH1"
                     /gene_synonym="Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1689
                     /gene="CDH1"
                     /gene_synonym="Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1835
                     /gene="CDH1"
                     /gene_synonym="Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..2060
                     /gene="CDH1"
                     /gene_synonym="Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2288
                     /gene="CDH1"
                     /gene_synonym="Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2419
                     /gene="CDH1"
                     /gene_synonym="Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2563
                     /gene="CDH1"
                     /gene_synonym="Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..4811
                     /gene="CDH1"
                     /gene_synonym="Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4793..4798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDH1"
                     /gene_synonym="Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO"
                     /note="hexamer: ATTAAA"
     polyA_site      4811
                     /gene="CDH1"
                     /gene_synonym="Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO"
                     /note="major polyA site"
ORIGIN      
        1 agtggcgtcg gaactgcaaa gcacctgtga gcttgcggaa gtcagttcag actccagccc
       61 gctccagccc ggcccgaccc gaccgcaccc ggcgcctgcc ctcgctcggc gtccccggcc
      121 agccatgggc ccttggagcc gcagcctctc ggcgctgctg ctgctgctgc aggtctcctc
      181 ttggctctgc caggagccgg agccctgcca ccctggcttt gacgccgaga gctacacgtt
      241 cacggtgccc cggcgccacc tggagagagg ccgcgtcctg ggcagagtga attttgaaga
      301 ttgcaccggt cgacaaagga cagcctattt ttccctcgac acccgattca aagtgggcac
      361 agatggtgtg attacagtca aaaggcctct acggtttcat aacccacaga tccatttctt
      421 ggtctacgcc tgggactcca cctacagaaa gttttccacc aaagtcacgc tgaatacagt
      481 ggggcaccac caccgccccc cgccccatca ggcctccgtt tctggaatcc aagcagaatt
      541 gctcacattt cccaactcct ctcctggcct cagaagacag aagagagact gggttattcc
      601 tcccatcagc tgcccagaaa atgaaaaagg cccatttcct aaaaacctgg ttcagatcaa
      661 atccaacaaa gacaaagaag gcaaggtttt ctacagcatc actggccaag gagctgacac
      721 accccctgtt ggtgtcttta ttattgaaag agaaacagga tggctgaagg tgacagagcc
      781 tctggataga gaacgcattg ccacatacac tctcttctct cacgctgtgt catccaacgg
      841 gaatgcagtt gaggatccaa tggagatttt gatcacggta accgatcaga atgacaacaa
      901 gcccgaattc acccaggagg tctttaaggg gtctgtcatg gaaggtgctc ttccaggaac
      961 ctctgtgatg gaggtcacag ccacagacgc ggacgatgat gtgaacacct acaatgccgc
     1021 catcgcttac accatcctca gccaagatcc tgagctccct gacaaaaata tgttcaccat
     1081 taacaggaac acaggagtca tcagtgtggt caccactggg ctggaccgag agagtttccc
     1141 tacgtatacc ctggtggttc aagctgctga ccttcaaggt gaggggttaa gcacaacagc
     1201 aacagctgtg atcacagtca ctgacaccaa cgataatcct ccgatcttca atcccaccac
     1261 gtacaagggt caggtgcctg agaacgaggc taacgtcgta atcaccacac tgaaagtgac
     1321 tgatgctgat gcccccaata ccccagcgtg ggaggctgta tacaccatat tgaatgatga
     1381 tggtggacaa tttgtcgtca ccacaaatcc agtgaacaac gatggcattt tgaaaacagc
     1441 aaagggcttg gattttgagg ccaagcagca gtacattcta cacgtagcag tgacgaatgt
     1501 ggtacctttt gaggtctctc tcaccacctc cacagccacc gtcaccgtgg atgtgctgga
     1561 tgtgaatgaa gcccccatct ttgtgcctcc tgaaaagaga gtggaagtgt ccgaggactt
     1621 tggcgtgggc caggaaatca catcctacac tgcccaggag ccagacacat ttatggaaca
     1681 gaaaataaca tatcggattt ggagagacac tgccaactgg ctggagatta atccggacac
     1741 tggtgccatt tccactcggg ctgagctgga cagggaggat tttgagcacg tgaagaacag
     1801 cacgtacaca gccctaatca tagctacaga caatggttct ccagttgcta ctggaacagg
     1861 gacacttctg ctgatcctgt ctgatgtgaa tgacaacgcc cccataccag aacctcgaac
     1921 tatattcttc tgtgagagga atccaaagcc tcaggtcata aacatcattg atgcagacct
     1981 tcctcccaat acatctccct tcacagcaga actaacacac ggggcgagtg ccaactggac
     2041 cattcagtac aacgacccaa cccaagaatc tatcattttg aagccaaaga tggccttaga
     2101 ggtgggtgac tacaaaatca atctcaagct catggataac cagaataaag accaagtgac
     2161 caccttagag gtcagcgtgt gtgactgtga aggggccgct ggcgtctgta ggaaggcaca
     2221 gcctgtcgaa gcaggattgc aaattcctgc cattctgggg attcttggag gaattcttgc
     2281 tttgctaatt ctgattctgc tgctcttgct gtttcttcgg aggagagcgg tggtcaaaga
     2341 gcccttactg cccccagagg atgacacccg ggacaacgtt tattactatg atgaagaagg
     2401 aggcggagaa gaggaccagg actttgactt gagccagctg cacaggggcc tggacgctcg
     2461 gcctgaagtg actcgtaacg acgttgcacc aaccctcatg agtgtccccc ggtatcttcc
     2521 ccgccctgcc aatcccgatg aaattggaaa ttttattgat gaaaatctga aagcggctga
     2581 tactgacccc acagccccgc cttatgattc tctgctcgtg tttgactatg aaggaagcgg
     2641 ttccgaagct gctagtctga gctccctgaa ctcctcagag tcagacaaag accaggacta
     2701 tgactacttg aacgaatggg gcaatcgctt caagaagctg gctgacatgt acggaggcgg
     2761 cgaggacgac taggggactc gagagaggcg ggccccagac ccatgtgctg ggaaatgcag
     2821 aaatcacgtt gctggtggtt tttcagctcc cttcccttga gatgagtttc tggggaaaaa
     2881 aaagagactg gttagtgatg cagttagtat agctttatac tctctccact ttatagctct
     2941 aataagtttg tgttagaaaa gtttcgactt atttcttaaa gctttttttt ttttcccatc
     3001 actctttaca tggtggtgat gtccaaaaga tacccaaatt ttaatattcc agaagaacaa
     3061 ctttagcatc agaaggttca cccagcacct tgcagatttt cttaaggaat tttgtctcac
     3121 ttttaaaaag aaggggagaa gtcagctact ctagttctgt tgttttgtgt atataatttt
     3181 ttaaaaaaaa tttgtgtgct tctgctcatt actacactgg tgtgtccctc tgcctttttt
     3241 ttttttttaa gacagggtct cattctatcg gccaggctgg agtgcagtgg tgcaatcaca
     3301 gctcactgca gccttgtcct cccaggctca agctatcctt gcacctcagc ctcccaagta
     3361 gctgggacca caggcatgca ccactacgca tgactaattt tttaaatatt tgagacgggg
     3421 tctccctgtg ttacccaggc tggtctcaaa ctcctgggct caagtgatcc tcccatcttg
     3481 gcctcccaga gtattgggat tacagacatg agccactgca cctgcccagc tccccaactc
     3541 cctgccattt tttaagagac agtttcgctc catcgcccag gcctgggatg cagtgatgtg
     3601 atcatagctc actgtaacct caaactctgg ggctcaagca gttctcccac cagcctcctt
     3661 tttatttttt tgtacagatg gggtcttgct atgttgccca agctggtctt aaactcctgg
     3721 cctcaagcaa tccttctgcc ttggcccccc aaagtgctgg gattgtgggc atgagctgct
     3781 gtgcccagcc tccatgtttt aatatcaact ctcactcctg aattcagttg ctttgcccaa
     3841 gataggagtt ctctgatgca gaaattattg ggctctttta gggtaagaag tttgtgtctt
     3901 tgtctggcca catcttgact aggtattgtc tactctgaag acctttaatg gcttccctct
     3961 ttcatctcct gagtatgtaa cttgcaatgg gcagctatcc agtgacttgt tctgagtaag
     4021 tgtgttcatt aatgtttatt tagctctgaa gcaagagtga tatactccag gacttagaat
     4081 agtgcctaaa gtgctgcagc caaagacaga gcggaactat gaaaagtggg cttggagatg
     4141 gcaggagagc ttgtcattga gcctggcaat ttagcaaact gatgctgagg atgattgagg
     4201 tgggtctacc tcatctctga aaattctgga aggaatggag gagtctcaac atgtgtttct
     4261 gacacaagat ccgtggtttg tactcaaagc ccagaatccc caagtgcctg cttttgatga
     4321 tgtctacaga aaatgctggc tgagctgaac acatttgccc aattccaggt gtgcacagaa
     4381 aaccgagaat attcaaaatt ccaaattttt ttcttaggag caagaagaaa atgtggccct
     4441 aaagggggtt agttgagggg tagggggtag tgaggatctt gatttggatc tctttttatt
     4501 taaatgtgaa tttcaacttt tgacaatcaa agaaaagact tttgttgaaa tagctttact
     4561 gtttctcaag tgttttggag aaaaaaatca accctgcaat cactttttgg aattgtcttg
     4621 atttttcggc agttcaagct atatcgaata tagttctgtg tagagaatgt cactgtagtt
     4681 ttgagtgtat acatgtgtgg gtgctgataa ttgtgtattt tctttggggg tggaaaagga
     4741 aaacaattca agctgagaaa agtattctca aagatgcatt tttataaatt ttattaaaca
     4801 attttgttaa a
//
