LOCUS       NM_001353655            1982 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens CUB domain containing protein 2 (CDCP2), transcript
            variant 1, mRNA.
ACCESSION   NM_001353655
VERSION     NM_001353655.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1982)
  AUTHORS   Li,Y.J., Deng,J., Mayhew,G.M., Grimsley,J.W., Huo,X. and Vance,J.M.
  TITLE     Investigation of the PARK10 gene in Parkinson disease
  JOURNAL   Ann Hum Genet 71 (Pt 5), 639-647 (2007)
   PUBMED   17388942
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL357673.12.
            
            On May 28, 2021 this sequence version replaced NM_001353655.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2197857.1,
                                           SRR1660809.210190.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000530059.3/ ENSP00000489959.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AL357673.12        30035-30191         c
            158-505             AL357673.12        21657-22004         c
            506-841             AL357673.12        18289-18624         c
            842-1195            AL357673.12        16944-17297         c
            1196-1374           AL357673.12        13821-13999         c
            1375-1982           AL357673.12        9878-10485          c
FEATURES             Location/Qualifiers
     source          1..1982
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..1982
                     /gene="CDCP2"
                     /note="CUB domain containing protein 2"
                     /db_xref="GeneID:200008"
                     /db_xref="HGNC:HGNC:27297"
                     /db_xref="MIM:612320"
     exon            1..157
                     /gene="CDCP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1701
                     /gene="CDCP2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="CUB domain-containing protein 2 isoform 1
                     precursor"
                     /protein_id="NP_001340584.1"
                     /db_xref="CCDS:CCDS85977.1"
                     /db_xref="GeneID:200008"
                     /db_xref="HGNC:HGNC:27297"
                     /db_xref="MIM:612320"
                     /translation="MLAEWGACLLLAVALLGPGLQAQAMEGVKCGGVLSAPSGNFSSP
                     NFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLEIYNGASPDKGNLL
                     GRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGGVLTGLSGVLTSPE
                     YPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGGPGPTRGHHYC
                     GSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYMAMRGNFSSPQYPSS
                     YPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEEAPLLGN
                     WCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGVVPMNVSCSRTDFQILISTQ
                     ALAPLERTKVYLGSRSCAAQEVGGNLRIQARFDTCGTESQRRNNTSVIVSVLYIDFSA
                     AGREDIHEYEVRCEPRRKEASVHLLSGSHWLGPYAATAEHLQEAPPMDEAEALEGPVS
                     MVAQDTSDIVFLGLCILAGILMVIAIVVLMLL"
     exon            158..505
                     /gene="CDCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            506..841
                     /gene="CDCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1195
                     /gene="CDCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1374
                     /gene="CDCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1982
                     /gene="CDCP2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1982
                     /gene="CDCP2"
                     /note="major polyA site"
ORIGIN      
        1 ctctctttcc cttgctccgg accctgagat cctggcctac ctgagctcgg cagacctgtg
       61 ggggcccctg gtgaggagat gctggcagag tggggggctt gcctgctgct ggcagtggca
      121 ctgctgggcc cagggctcca ggcccaagcc atggaaggtg tcaaatgtgg gggtgtgctc
      181 tcagcacctt ctggaaactt ctccagcccc aacttcccta gactgtaccc ctacaacaca
      241 gagtgcagct ggctgatcgt ggtggccgag ggatcctcgg tgctgctcac cttccatgcc
      301 tttgacctag agtaccacga cacctgcagc ttcgactttc tggagatcta caatggggcc
      361 tcaccagaca agggcaacct gctggggagg ttctgcggca aggtgccccc gccgcccttc
      421 acctcctcct ggcatgtcat gtctgtcatc ttccactcgg acaagcatgt ggccagccat
      481 ggcttttctg cgggctacca gaaagatgtg tgtggcggcg tcctgactgg cctgtcaggg
      541 gtcctcacca gtcctgagta tcccaacaac tacccgaaca gcatggagtg ccactgggtg
      601 atccgggccg ctggccctgc ccacgtcaag ctggtgttcg tggacttcca ggtggagggc
      661 aatgaagagt gcacctatga ctacgtggct gtgcttgggg ggcctggccc cacccgtggg
      721 caccactact gtggcagcac caggcccccc accctcgtgt ctctgggcca cgaactgcag
      781 gtggtcttca agtccgactt caacatcgga ggccgtggct tcaaggccta ctacttctca
      841 ggagaatgcc aggaggtata catggccatg cggggcaact tctccagccc acagtacccc
      901 agctcctacc ccaacaacat ccgctgccac tggaccatcc gcctgccccc gggctaccag
      961 gtcaaggtgt tcttcctgga cctggacctg gaggagccca acagcctgac caagacctgt
     1021 gactttgacc atctggcggc cttcgatggg gccagcgagg aggcacccct gctggggaat
     1081 tggtgtggac accacctgcc accacccgtg acctcaagcc acaaccagct tctgcttctg
     1141 ctgcacacag accgcagcac cacccgcagg ggcttctctg tggcctacat cggagtggtg
     1201 cccatgaacg tgagctgctc ccgcacggac ttccagatcc tgatctccac gcaggcgctg
     1261 gccccgctgg agcggaccaa ggtctacctg ggcagccgga gctgtgccgc ccaggaggtc
     1321 ggcggcaacc tcaggatcca ggcccgcttt gatacctgcg gcactgagtc tcagagaaga
     1381 aacaacactt cagtgattgt cagcgtgctg tacatcgact tctcagccgc ggggcgggag
     1441 gacatccatg agtacgaggt ccgctgtgag ccacggcgca aggaggcttc tgtccacctg
     1501 ctgtctggct ctcactggct ggggccctat gctgccactg cggagcacct tcaggaagca
     1561 ccacccatgg atgaggcgga ggcactggag ggcccagtga gcatggtggc ccaggatacc
     1621 agtgacatcg tcttcctggg cctttgcatc ctggctggaa tcctcatggt tattgccatc
     1681 gtggtcttga tgctgctttg aatagacagc atagggacct ggcatctgac atgcctggga
     1741 ggcagcttag ggacccataa caggggtggg acggggactt gctgacttgg tgaccattgg
     1801 caggtcatat ccctctctga gcctccattt cctagggaca gtcattctgc cctgctatct
     1861 cacagggctg gcatgaggct cagaggcggg cagagatgga taagagcttt gtaatctgta
     1921 gcatgctgtg tatgtatatg caattgctgt tattaatttt aaagatattc tgctgtagaa
     1981 aa
//
